fibrillin 2 (FBN2) - coding DNA reference sequence

(used for variant description)

(last modified May 19, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001999.3 in the FBN2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008750.1, covering FBN2 transcript NM_001999.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          ctttccaatatccgtcttc       c.-421

 .         .         .         .         .         .                g.5079
 ggagcgcacgggaatccgccgagctctgcgtgcaggcccttttttcttttgaggttcaca       c.-361

 .         .         .         .         .         .                g.5139
 ttttttgaaattttacgccagggcttttgtaatttcctcccccgcccgctgacggtcctg       c.-301

 .         .         .         .         .         .                g.5199
 gagtcgctcggggctttaggccggttatgcaacgtgtaccgctcggggctgccggctgca       c.-241

 .         .         .         .         .         .                g.5259
 cctccgccgcgcctcgccgctcactgcgctagacccggcgccccgcgtctcgcttcgcgg       c.-181

 .         .         .         .         .         .                g.5319
 gcagtcagggggccggcgctctgtcgaggtctccagctagagcagggagcccgagcccga       c.-121

 .         .         .         .         .         .                g.5379
 gggagtccccggagccgacgaagggcttattagaccctgactcttttctgaggcgcgcag       c.-61

 .         .         .         .         .         .                g.5439
 attttgtctttgatcactccctctccgcgggtctacggccgcgcgctttcggcgccggcg       c.-1

          .         .         .         .         .         .       g.5499
 ATGGGGAGAAGACGGAGGCTGTGTCTCCAGCTCTACTTCCTGTGGCTGGGCTGTGTGGTG       c.60
 M  G  R  R  R  R  L  C  L  Q  L  Y  F  L  W  L  G  C  V  V         p.20

          .         .         .         .         .         .       g.5559
 CTCTGGGCGCAGGGCACGGCCGGCCAGCCTCAGCCTCCTCCGCCCAAGCCGCCCCGGCCC       c.120
 L  W  A  Q  G  T  A  G  Q  P  Q  P  P  P  P  K  P  P  R  P         p.40

          .         .         .         .         .         .       g.5619
 CAGCCGCCGCCGCAACAGGTTCGGTCCGCTACAGCAGGCTCTGAAGGCGGGTTTCTAGCG       c.180
 Q  P  P  P  Q  Q  V  R  S  A  T  A  G  S  E  G  G  F  L  A         p.60

          .         .         .         .         .         .       g.5679
 CCCGAGTATCGCGAGGAGGGTGCCGCAGTGGCCAGCCGCGTCCGCCGGCGAGGACAGCAG       c.240
 P  E  Y  R  E  E  G  A  A  V  A  S  R  V  R  R  R  G  Q  Q         p.80

          .     | 02   .         .         .         .         .    g.6604
 GACGTGCTCCGAGG | GCCCAACGTGTGCGGCTCCAGATTCCACTCCTACTGCTGCCCTGGA    c.300
 D  V  L  R  G  |  P  N  V  C  G  S  R  F  H  S  Y  C  C  P  G      p.100

          .         .         .        | 03.         .         .    g.12372
 TGGAAGACGCTCCCTGGAGGAAACCAGTGCATTGTCC | CGATTTGTAGAAATAGTTGTGGA    c.360
 W  K  T  L  P  G  G  N  Q  C  I  V  P |   I  C  R  N  S  C  G      p.120

          .         .         .         .         .         .       g.12432
 GATGGATTTTGTTCCCGTCCTAACATGTGTACTTGTTCCAGTGGGCAAATATCATCAACC       c.420
 D  G  F  C  S  R  P  N  M  C  T  C  S  S  G  Q  I  S  S  T         p.140

          .       | 04 .         .         .         .         .    g.15119
 TGTGGATCAAAATCAA | TTCAGCAGTGCAGTGTGAGATGCATGAATGGTGGGACCTGTGCA    c.480
 C  G  S  K  S  I |   Q  Q  C  S  V  R  C  M  N  G  G  T  C  A      p.160

          .         .         .         .         .   | 05     .    g.23682
 GATGACCACTGCCAGTGCCAGAAAGGATATATTGGAACTTATTGTGGACAAC | CTGTCTGT    c.540
 D  D  H  C  Q  C  Q  K  G  Y  I  G  T  Y  C  G  Q  P |   V  C      p.180

          .         .         .         .         .         .       g.23742
 GAAAATGGATGTCAGAATGGTGGACGTTGCATCGGACCCAACCGCTGTGCTTGTGTTTAT       c.600
 E  N  G  C  Q  N  G  G  R  C  I  G  P  N  R  C  A  C  V  Y         p.200

          .         .         | 06         .         .         .    g.78153
 GGGTTCACTGGTCCACAGTGTGAAAGAG | ATTACAGGACAGGCCCGTGTTTCACTCAGGTC    c.660
 G  F  T  G  P  Q  C  E  R  D |   Y  R  T  G  P  C  F  T  Q  V      p.220

          .         .         .         .         .         .       g.78213
 AACAACCAGATGTGCCAAGGGCAGCTGACAGGCATTGTCTGCACGAAGACTCTGTGCTGT       c.720
 N  N  Q  M  C  Q  G  Q  L  T  G  I  V  C  T  K  T  L  C  C         p.240

          .         .         .         .         .         .       g.78273
 GCCACCATTGGACGGGCGTGGGGCCATCCCTGTGAGATGTGTCCAGCCCAGCCTCAGCCC       c.780
 A  T  I  G  R  A  W  G  H  P  C  E  M  C  P  A  Q  P  Q  P         p.260

          .         .         .         .       | 07 .         .    g.96450
 TGCCGACGGGGTTTCATCCCCAACATCCGCACTGGAGCTTGCCAAG | ATGTTGATGAATGC    c.840
 C  R  R  G  F  I  P  N  I  R  T  G  A  C  Q  D |   V  D  E  C      p.280

          .         .         .         .         .         .       g.96510
 CAGGCTATCCCAGGGATATGCCAAGGAGGAAACTGTATCAATACAGTGGGCTCTTTTGAA       c.900
 Q  A  I  P  G  I  C  Q  G  G  N  C  I  N  T  V  G  S  F  E         p.300

          .         .         .         .         .   | 08     .    g.134251
 TGCAGATGCCCTGCTGGTCACAAACAGAGTGAAACTACTCAGAAATGTGAAG | ACATTGAT    c.960
 C  R  C  P  A  G  H  K  Q  S  E  T  T  Q  K  C  E  D |   I  D      p.320

          .         .         .         .         .         .       g.134311
 GAGTGCAGCATCATTCCTGGGATATGTGAAACTGGTGAATGTTCCAACACCGTGGGAAGC       c.1020
 E  C  S  I  I  P  G  I  C  E  T  G  E  C  S  N  T  V  G  S         p.340

          .         .         .         .         .         | 09    g.147770
 TATTTTTGTGTTTGTCCACGTGGATATGTAACCTCAACAGATGGCTCTCGATGCATCG | AT    c.1080
 Y  F  C  V  C  P  R  G  Y  V  T  S  T  D  G  S  R  C  I  D |       p.360

          .         .         .         .         .         .       g.147830
 CAGAGAACAGGCATGTGTTTCTCGGGCCTGGTGAATGGCCGCTGTGCACAAGAGCTCCCG       c.1140
 Q  R  T  G  M  C  F  S  G  L  V  N  G  R  C  A  Q  E  L  P         p.380

          .         .         .         .         .         .       g.147890
 GGGAGAATGACGAAAATGCAGTGCTGCTGTGAGCCTGGCCGCTGCTGGGGCATCGGAACC       c.1200
 G  R  M  T  K  M  Q  C  C  C  E  P  G  R  C  W  G  I  G  T         p.400

          .         .         .  | 10      .         .         .    g.149703
 ATTCCTGAAGCCTGTCCTGTCAGAGGTTCTG | AGGAATATCGCAGACTTTGCATGGATGGA    c.1260
 I  P  E  A  C  P  V  R  G  S  E |   E  Y  R  R  L  C  M  D  G      p.420

          .         .         .         .         .         .       g.149763
 CTTCCAATGGGAGGAATTCCAGGGAGTGCTGGTTCCAGACCTGGAGGCACTGGGGGAAAT       c.1320
 L  P  M  G  G  I  P  G  S  A  G  S  R  P  G  G  T  G  G  N         p.440

          .         .         .         .         .         .       g.149823
 GGCTTTGCCCCAAGTGGCAATGGCAATGGCTATGGCCCAGGAGGGACAGGCTTCATCCCC       c.1380
 G  F  A  P  S  G  N  G  N  G  Y  G  P  G  G  T  G  F  I  P         p.460

          .         .         .         .         .         .       g.149883
 ATCCCTGGAGGCAATGGCTTTTCTCCTGGCGTTGGGGGAGCCGGTGTGGGGGCCGGGGGA       c.1440
 I  P  G  G  N  G  F  S  P  G  V  G  G  A  G  V  G  A  G  G         p.480

          .         .      | 11  .         .         .         .    g.150922
 CAGGGACCTATCATCACTGGACTAA | CAATTCTGAACCAGACAATAGATATCTGTAAGCAT    c.1500
 Q  G  P  I  I  T  G  L  T |   I  L  N  Q  T  I  D  I  C  K  H      p.500

          .         .         .         .         .         .       g.150982
 CATGCTAACCTTTGTTTAAATGGACGCTGTATACCAACTGTCTCAAGCTACCGATGTGAA       c.1560
 H  A  N  L  C  L  N  G  R  C  I  P  T  V  S  S  Y  R  C  E         p.520

          .         .         .         .    | 12    .         .    g.164169
 TGCAACATGGGTTATAAGCAGGATGCAAATGGAGATTGTATAG | ATGTTGATGAATGCACA    c.1620
 C  N  M  G  Y  K  Q  D  A  N  G  D  C  I  D |   V  D  E  C  T      p.540

          .         .         .         .         .         .       g.164229
 TCAAATCCCTGCACTAATGGAGATTGTGTTAACACACCTGGTTCCTATTATTGTAAATGT       c.1680
 S  N  P  C  T  N  G  D  C  V  N  T  P  G  S  Y  Y  C  K  C         p.560

          .         .         .         .    | 13    .         .    g.165182
 CATGCTGGATTCCAGAGGACTCCTACCAAGCAAGCATGCATTG | ATATTGATGAGTGCATC    c.1740
 H  A  G  F  Q  R  T  P  T  K  Q  A  C  I  D |   I  D  E  C  I      p.580

          .         .         .         .         .         .       g.165242
 CAGAATGGGGTTCTTTGTAAAAACGGTCGATGCGTGAACACAGATGGAAGTTTCCAGTGC       c.1800
 Q  N  G  V  L  C  K  N  G  R  C  V  N  T  D  G  S  F  Q  C         p.600

          .         .         .         .          | 14        .    g.166200
 ATTTGCAATGCCGGCTTTGAATTAACTACAGATGGAAAAAACTGTGTTG | ATCATGATGAA    c.1860
 I  C  N  A  G  F  E  L  T  T  D  G  K  N  C  V  D |   H  D  E      p.620

          .         .         .         .         .         .       g.166260
 TGTACAACTACCAACATGTGTTTGAATGGAATGTGCATCAATGAAGATGGCAGCTTCAAG       c.1920
 C  T  T  T  N  M  C  L  N  G  M  C  I  N  E  D  G  S  F  K         p.640

          .         .         .         .         .   | 15     .    g.168300
 TGCATCTGCAAACCAGGATTTGTCTTGGCTCCAAATGGGCGTTACTGTACTG | ATGTTGAT    c.1980
 C  I  C  K  P  G  F  V  L  A  P  N  G  R  Y  C  T  D |   V  D      p.660

          .         .         .         .         .         .       g.168360
 GAATGCCAGACCCCAGGAATCTGCATGAATGGGCACTGCATCAACAGTGAAGGGTCCTTC       c.2040
 E  C  Q  T  P  G  I  C  M  N  G  H  C  I  N  S  E  G  S  F         p.680

          .         .         .         .         .      | 16  .    g.173713
 CGCTGTGACTGTCCCCCAGGCCTGGCTGTGGGCATGGATGGACGTGTGTGTGTTG | ATACT    c.2100
 R  C  D  C  P  P  G  L  A  V  G  M  D  G  R  V  C  V  D |   T      p.700

          .         .         .         .         .         .       g.173773
 CACATGCGCAGTACCTGCTATGGAGGAATCAAGAAAGGAGTGTGTGTGCGTCCTTTCCCC       c.2160
 H  M  R  S  T  C  Y  G  G  I  K  K  G  V  C  V  R  P  F  P         p.720

          .         .         .         .         .         .       g.173833
 GGTGCAGTGACCAAGTCCGAATGCTGCTGTGCCAATCCAGACTATGGTTTTGGAGAACCC       c.2220
 G  A  V  T  K  S  E  C  C  C  A  N  P  D  Y  G  F  G  E  P         p.740

          .         .         | 17         .         .         .    g.176644
 TGCCAGCCATGCCCTGCAAAAAATTCAG | CTGAATTCCACGGCCTTTGTAGTAGTGGAGTA    c.2280
 C  Q  P  C  P  A  K  N  S  A |   E  F  H  G  L  C  S  S  G  V      p.760

          .         .   | 18     .         .         .         .    g.178355
 GGTATCACTGTGGATGGAAGAG | ATATCAATGAATGTGCTTTGGATCCTGATATATGTGCC    c.2340
 G  I  T  V  D  G  R  D |   I  N  E  C  A  L  D  P  D  I  C  A      p.780

          .         .         .         .         .         .       g.178415
 AATGGGATTTGTGAAAACTTACGTGGTAGTTACCGTTGTAATTGCAACAGTGGCTATGAA       c.2400
 N  G  I  C  E  N  L  R  G  S  Y  R  C  N  C  N  S  G  Y  E         p.800

          .         .         | 19         .         .         .    g.181226
 CCAGATGCCTCTGGAAGAAACTGTATTG | ACATTGATGAATGTTTAGTAAACAGACTGCTT    c.2460
 P  D  A  S  G  R  N  C  I  D |   I  D  E  C  L  V  N  R  L  L      p.820

          .         .         .         .         .         .       g.181286
 TGTGATAACGGATTGTGCCGAAACACGCCAGGAAGTTACAGCTGTACGTGCCCACCAGGG       c.2520
 C  D  N  G  L  C  R  N  T  P  G  S  Y  S  C  T  C  P  P  G         p.840

          .         .         .     | 20   .         .         .    g.185674
 TATGTGTTCAGGACTGAGACAGAGACCTGTGAAG | ATATAAATGAATGTGAAAGCAACCCA    c.2580
 Y  V  F  R  T  E  T  E  T  C  E  D |   I  N  E  C  E  S  N  P      p.860

          .         .         .         .         .         .       g.185734
 TGTGTCAATGGGGCCTGCAGAAACAACCTTGGATCTTTCAATTGTGAATGTTCGCCCGGC       c.2640
 C  V  N  G  A  C  R  N  N  L  G  S  F  N  C  E  C  S  P  G         p.880

          .         .         .     | 21   .         .         .    g.192064
 AGCAAACTCAGCTCCACAGGATTGATCTGTATTG | ACAGCCTGAAGGGGACCTGTTGGCTC    c.2700
 S  K  L  S  S  T  G  L  I  C  I  D |   S  L  K  G  T  C  W  L      p.900

          .         .         .         .         .         .       g.192124
 AACATCCAGGACAGCCGCTGTGAGGTGAATATTAATGGAGCCACTCTGAAATCTGAATGC       c.2760
 N  I  Q  D  S  R  C  E  V  N  I  N  G  A  T  L  K  S  E  C         p.920

          .         .         .         .         .   | 22     .    g.193046
 TGTGCCACCCTCGGAGCCGCCTGGGGGAGCCCCTGTGAGCGGTGTGAACTAG | ATACAGCT    c.2820
 C  A  T  L  G  A  A  W  G  S  P  C  E  R  C  E  L  D |   T  A      p.940

          .         .         .         .    | 23    .         .    g.193588
 TGCCCAAGAGGGCTTGCCAGGATTAAAGGTGTTACGTGTGAAG | ATGTTAATGAGTGTGAG    c.2880
 C  P  R  G  L  A  R  I  K  G  V  T  C  E  D |   V  N  E  C  E      p.960

          .         .         .         .         .         .       g.193648
 GTGTTCCCTGGCGTTTGTCCAAATGGACGCTGTGTCAACAGTAAGGGATCTTTTCATTGC       c.2940
 V  F  P  G  V  C  P  N  G  R  C  V  N  S  K  G  S  F  H  C         p.980

          .         .         .         .          | 24        .    g.197470
 GAGTGCCCTGAAGGCCTTACGTTGGATGGGACTGGCCGTGTATGTTTGG | ATATTCGCATG    c.3000
 E  C  P  E  G  L  T  L  D  G  T  G  R  V  C  L  D |   I  R  M      p.1000

          .         .         .         .         .         .       g.197530
 GAGCAGTGTTACTTGAAGTGGGATGAAGATGAATGCATCCACCCCGTTCCTGGAAAGTTC       c.3060
 E  Q  C  Y  L  K  W  D  E  D  E  C  I  H  P  V  P  G  K  F         p.1020

          .         .         .         .         .         .       g.197590
 CGCATGGATGCCTGCTGCTGTGCTGTCGGGGCGGCTTGGGGCACCGAGTGTGAGGAGTGC       c.3120
 R  M  D  A  C  C  C  A  V  G  A  A  W  G  T  E  C  E  E  C         p.1040

          .         .         .         .         .         .       g.197650
 CCCAAACCTGGCACCAAGGAATACGAGACGCTGTGCCCCCGCGGGGCTGGCTTTGCTAAC       c.3180
 P  K  P  G  T  K  E  Y  E  T  L  C  P  R  G  A  G  F  A  N         p.1060

          .         .         .        | 25.         .         .    g.198556
 CGAGGGGATGTTCTTACTGGGCGGCCATTTTACAAAG | ACATCAATGAATGCAAAGCATTT    c.3240
 R  G  D  V  L  T  G  R  P  F  Y  K  D |   I  N  E  C  K  A  F      p.1080

          .         .         .         .         .         .       g.198616
 CCTGGGATGTGCACTTATGGGAAGTGCAGAAATACAATCGGAAGCTTCAAATGCCGTTGC       c.3300
 P  G  M  C  T  Y  G  K  C  R  N  T  I  G  S  F  K  C  R  C         p.1100

          .         .         .         .    | 26    .         .    g.203999
 AATAGTGGCTTTGCTCTAGACATGGAGGAAAGAAACTGCACGG | ACATCGACGAGTGCAGG    c.3360
 N  S  G  F  A  L  D  M  E  E  R  N  C  T  D |   I  D  E  C  R      p.1120

          .         .         .         .         .         .       g.204059
 ATTTCTCCTGACCTCTGTGGCAGTGGAATCTGCGTCAATACACCGGGCAGCTTTGAGTGC       c.3420
 I  S  P  D  L  C  G  S  G  I  C  V  N  T  P  G  S  F  E  C         p.1140

          .         .         .         .         .   | 27     .    g.204929
 GAGTGCTTCGAAGGCTATGAAAGTGGCTTCATGATGATGAAGAACTGCATGG | ACATTGAC    c.3480
 E  C  F  E  G  Y  E  S  G  F  M  M  M  K  N  C  M  D |   I  D      p.1160

          .         .         .         .         .         .       g.204989
 GAATGTGAACGTAACCCTCTCCTTTGTAGGGGTGGCACCTGTGTGAACACTGAGGGCAGC       c.3540
 E  C  E  R  N  P  L  L  C  R  G  G  T  C  V  N  T  E  G  S         p.1180

          .         .         .         .         .         | 28    g.206932
 TTTCAGTGTGACTGCCCACTGGGACACGAGCTGTCACCATCCCGTGAGGACTGTGTGG | AT    c.3600
 F  Q  C  D  C  P  L  G  H  E  L  S  P  S  R  E  D  C  V  D |       p.1200

          .         .         .         .         .         .       g.206992
 ATTAATGAATGCTCCCTGAGTGACAATCTCTGCAGAAATGGAAAATGTGTGAACATGATT       c.3660
 I  N  E  C  S  L  S  D  N  L  C  R  N  G  K  C  V  N  M  I         p.1220

          .         .         .         .         .         .       g.207052
 GGAACCTATCAGTGCTCTTGCAATCCTGGATATCAGGCTACGCCAGACCGCCAGGGCTGT       c.3720
 G  T  Y  Q  C  S  C  N  P  G  Y  Q  A  T  P  D  R  Q  G  C         p.1240

      | 29   .         .         .         .         .         .    g.207522
 ACAG | ATATTGATGAATGTATGATAATGAACGGAGGCTGTGACACCCAGTGCACAAATTCA    c.3780
 T  D |   I  D  E  C  M  I  M  N  G  G  C  D  T  Q  C  T  N  S      p.1260

          .         .         .         .         .         .       g.207582
 GAGGGAAGCTACGAATGCAGCTGCAGTGAGGGTTATGCCCTGATGCCAGATGGGAGATCG       c.3840
 E  G  S  Y  E  C  S  C  S  E  G  Y  A  L  M  P  D  G  R  S         p.1280

         | 30.         .         .         .         .         .    g.207801
 TGTGCAG | ACATTGATGAATGTGAAAACAATCCTGATATCTGTGATGGCGGCCAGTGTACC    c.3900
 C  A  D |   I  D  E  C  E  N  N  P  D  I  C  D  G  G  Q  C  T      p.1300

          .         .         .         .         .         .       g.207861
 AACATTCCTGGAGAGTATCGCTGCCTCTGCTATGATGGCTTCATGGCTTCCATGGACATG       c.3960
 N  I  P  G  E  Y  R  C  L  C  Y  D  G  F  M  A  S  M  D  M         p.1320

          .    | 31    .         .         .         .         .    g.208246
 AAAACATGCATTG | ATGTCAATGAATGTGACCTAAATTCAAATATCTGCATGTTTGGGGAA    c.4020
 K  T  C  I  D |   V  N  E  C  D  L  N  S  N  I  C  M  F  G  E      p.1340

          .         .         .         .         .         .       g.208306
 TGTGAGAACACAAAGGGATCCTTCATTTGCCACTGTCAGCTGGGTTACTCAGTGAAGAAG       c.4080
 C  E  N  T  K  G  S  F  I  C  H  C  Q  L  G  Y  S  V  K  K         p.1360

          .          | 32        .         .         .         .    g.210050
 GGGACCACAGGATGTACAG | ATGTGGATGAGTGTGAAATTGGTGCTCATAACTGCGACATG    c.4140
 G  T  T  G  C  T  D |   V  D  E  C  E  I  G  A  H  N  C  D  M      p.1380

          .         .         .         .         .         .       g.210110
 CATGCCTCATGTCTGAATATCCCAGGAAGCTTCAAGTGTAGCTGCAGAGAAGGCTGGATT       c.4200
 H  A  S  C  L  N  I  P  G  S  F  K  C  S  C  R  E  G  W  I         p.1400

          .         .   | 33     .         .         .         .    g.212386
 GGAAACGGCATCAAGTGTATTG | ATCTGGACGAATGTTCTAATGGAACCCACCAGTGTAGC    c.4260
 G  N  G  I  K  C  I  D |   L  D  E  C  S  N  G  T  H  Q  C  S      p.1420

          .         .         .         .         .         .       g.212446
 ATCAATGCTCAGTGTGTAAATACCCCGGGCTCATACCGCTGTGCCTGCTCCGAAGGTTTC       c.4320
 I  N  A  Q  C  V  N  T  P  G  S  Y  R  C  A  C  S  E  G  F         p.1440

          .         .      | 34  .         .         .         .    g.214257
 ACTGGTGATGGCTTTACCTGCTCAG | ATGTTGATGAGTGTGCAGAAAACATAAACCTCTGT    c.4380
 T  G  D  G  F  T  C  S  D |   V  D  E  C  A  E  N  I  N  L  C      p.1460

          .         .         .         .         .         .       g.214317
 GAGAACGGACAGTGCCTTAATGTCCCGGGTGCATATCGCTGCGAGTGTGAGATGGGCTTC       c.4440
 E  N  G  Q  C  L  N  V  P  G  A  Y  R  C  E  C  E  M  G  F         p.1480

          .         .         .  | 35      .         .         .    g.224071
 ACTCCAGCCTCAGACAGCAGATCCTGCCAAG | ATATTGATGAATGCTCCTTCCAAAACATT    c.4500
 T  P  A  S  D  S  R  S  C  Q  D |   I  D  E  C  S  F  Q  N  I      p.1500

          .         .         .         .         .         .       g.224131
 TGTGTCTTTGGAACATGTAATAACCTGCCTGGAATGTTTCATTGCATCTGCGATGATGGT       c.4560
 C  V  F  G  T  C  N  N  L  P  G  M  F  H  C  I  C  D  D  G         p.1520

          .         .         .     | 36   .         .         .    g.224798
 TATGAATTGGACAGAACAGGAGGGAACTGTACAG | ATATTGATGAGTGTGCAGATCCTATA    c.4620
 Y  E  L  D  R  T  G  G  N  C  T  D |   I  D  E  C  A  D  P  I      p.1540

          .         .         .         .         .         .       g.224858
 AACTGTGTCAATGGCCTATGTGTCAACACGCCTGGTCGCTATGAGTGTAACTGCCCACCC       c.4680
 N  C  V  N  G  L  C  V  N  T  P  G  R  Y  E  C  N  C  P  P         p.1560

          .         .         .        | 37.         .         .    g.230271
 GATTTTCAGTTGAACCCAACTGGTGTGGGTTGTGTTG | ACAACCGTGTGGGCAACTGCTAC    c.4740
 D  F  Q  L  N  P  T  G  V  G  C  V  D |   N  R  V  G  N  C  Y      p.1580

          .         .         .         .         .         .       g.230331
 CTGAAGTTTGGACCTCGAGGAGATGGGAGTCTGTCTTGCAACACCGAGATCGGGGTGGGC       c.4800
 L  K  F  G  P  R  G  D  G  S  L  S  C  N  T  E  I  G  V  G         p.1600

          .         .         .         .         .         .       g.230391
 GTCAGTCGCTCTTCATGCTGCTGCTCTCTGGGAAAGGCCTGGGGAAACCCCTGTGAGACA       c.4860
 V  S  R  S  S  C  C  C  S  L  G  K  A  W  G  N  P  C  E  T         p.1620

          .          | 38        .         .         .         .    g.231131
 TGCCCCCCTGTCAATAGCA | CTGAATATTACACCCTGTGTCCCGGAGGTGAAGGCTTCAGA    c.4920
 C  P  P  V  N  S  T |   E  Y  Y  T  L  C  P  G  G  E  G  F  R      p.1640

          .         .         | 39         .         .         .    g.231650
 CCTAACCCCATCACAATCATTTTAGAAG | ACATTGACGAATGCCAGGAGTTACCAGGTCTC    c.4980
 P  N  P  I  T  I  I  L  E  D |   I  D  E  C  Q  E  L  P  G  L      p.1660

          .         .         .         .         .         .       g.231710
 TGCCAGGGTGGAAACTGCATCAACACTTTTGGGAGCTTCCAGTGTGAGTGCCCACAAGGC       c.5040
 C  Q  G  G  N  C  I  N  T  F  G  S  F  Q  C  E  C  P  Q  G         p.1680

          .         .         .     | 40   .         .         .    g.232961
 TACTACCTCAGCGAGGATACCCGCATCTGTGAAG | ATATTGATGAGTGTTTTGCACATCCT    c.5100
 Y  Y  L  S  E  D  T  R  I  C  E  D |   I  D  E  C  F  A  H  P      p.1700

          .         .         .         .         .         .       g.233021
 GGTGTGTGTGGGCCTGGGACCTGCTATAACACCCTGGGAAATTACACCTGCATTTGCCCA       c.5160
 G  V  C  G  P  G  T  C  Y  N  T  L  G  N  Y  T  C  I  C  P         p.1720

          .         .         .         . | 41       .         .    g.233664
 CCTGAGTACATGCAGGTCAATGGAGGCCACAACTGCATGG | ACATGAGAAAAAGCTTTTGC    c.5220
 P  E  Y  M  Q  V  N  G  G  H  N  C  M  D |   M  R  K  S  F  C      p.1740

          .         .         .         .         .         .       g.233724
 TACCGAAGCTATAATGGAACCACTTGTGAGAATGAGTTGCCTTTCAATGTGACAAAAAGG       c.5280
 Y  R  S  Y  N  G  T  T  C  E  N  E  L  P  F  N  V  T  K  R         p.1760

          .         .         .         .         .         .       g.233784
 ATGTGCTGCTGCACATATAATGTGGGCAAAGCCTGGAACAAACCTTGTGAACCATGCCCA       c.5340
 M  C  C  C  T  Y  N  V  G  K  A  W  N  K  P  C  E  P  C  P         p.1780

          .    | 42    .         .         .         .         .    g.235887
 ACTCCAGGAACAG | CTGACTTTAAAACCATATGTGGAAATATTCCTGGATTCACCTTTGAC    c.5400
 T  P  G  T  A |   D  F  K  T  I  C  G  N  I  P  G  F  T  F  D      p.1800

          .         .   | 43     .         .         .         .    g.237133
 ATTCACACAGGAAAAGCTGTTG | ACATTGATGAATGTAAAGAGATTCCAGGCATTTGTGCA    c.5460
 I  H  T  G  K  A  V  D |   I  D  E  C  K  E  I  P  G  I  C  A      p.1820

          .         .         .         .         .         .       g.237193
 AATGGTGTGTGCATTAACCAGATTGGCAGTTTCCGCTGTGAATGCCCTACAGGATTCAGT       c.5520
 N  G  V  C  I  N  Q  I  G  S  F  R  C  E  C  P  T  G  F  S         p.1840

          .         .         | 44         .         .         .    g.237439
 TACAATGACCTGCTGTTGGTTTGTGAAG | ATATAGATGAGTGCAGCAATGGTGATAATCTC    c.5580
 Y  N  D  L  L  L  V  C  E  D |   I  D  E  C  S  N  G  D  N  L      p.1860

          .         .         .         .         .         .       g.237499
 TGCCAGCGGAATGCAGACTGCATCAATAGTCCTGGTAGTTACCGCTGTGAATGTGCCGCG       c.5640
 C  Q  R  N  A  D  C  I  N  S  P  G  S  Y  R  C  E  C  A  A         p.1880

          .         .         .     | 45   .         .         .    g.237987
 GGTTTCAAACTTTCACCCAATGGGGCCTGTGTAG | ATCGCAATGAATGTTTAGAAATTCCT    c.5700
 G  F  K  L  S  P  N  G  A  C  V  D |   R  N  E  C  L  E  I  P      p.1900

          .         .         .         .         .         .       g.238047
 AACGTTTGCAGTCATGGCTTGTGTGTTGATCTGCAAGGAAGTTACCAGTGCATCTGCCAC       c.5760
 N  V  C  S  H  G  L  C  V  D  L  Q  G  S  Y  Q  C  I  C  H         p.1920

          .         .         .         . | 46       .         .    g.239974
 AATGGCTTTAAGGCTTCTCAGGACCAGACCATGTGCATGG | ATGTTGATGAGTGCGAGCGG    c.5820
 N  G  F  K  A  S  Q  D  Q  T  M  C  M  D |   V  D  E  C  E  R      p.1940

          .         .         .         .         .         .       g.240034
 CATCCATGTGGAAATGGAACTTGTAAAAACACCGTTGGATCCTATAACTGTCTGTGCTAC       c.5880
 H  P  C  G  N  G  T  C  K  N  T  V  G  S  Y  N  C  L  C  Y         p.1960

          .         .         .        | 47.         .         .    g.241556
 CCAGGGTTTGAACTCACTCATAATAATGATTGCCTGG | ACATAGATGAGTGCAGTTCCTTT    c.5940
 P  G  F  E  L  T  H  N  N  D  C  L  D |   I  D  E  C  S  S  F      p.1980

          .         .         .         .         .         .       g.241616
 TTTGGTCAGGTGTGCAGAAATGGACGTTGTTTTAATGAAATTGGTTCTTTCAAGTGTCTA       c.6000
 F  G  Q  V  C  R  N  G  R  C  F  N  E  I  G  S  F  K  C  L         p.2000

          .         .         .         .       | 48 .         .    g.242121
 TGTAACGAAGGTTATGAACTTACCCCAGATGGCAAAAACTGTATAG | ACACTAATGAGTGT    c.6060
 C  N  E  G  Y  E  L  T  P  D  G  K  N  C  I  D |   T  N  E  C      p.2020

          .         .         .         .         .         .       g.242181
 GTCGCCCTTCCCGGCTCTTGCTCTCCTGGTACCTGTCAGAATTTGGAGGGATCCTTCAGA       c.6120
 V  A  L  P  G  S  C  S  P  G  T  C  Q  N  L  E  G  S  F  R         p.2040

          .         .         .         .       | 49 .         .    g.251403
 TGCATCTGTCCCCCAGGGTATGAAGTAAAAAGCGAGAACTGCATTG | ATATAAATGAATGT    c.6180
 C  I  C  P  P  G  Y  E  V  K  S  E  N  C  I  D |   I  N  E  C      p.2060

          .         .         .         .         .         .       g.251463
 GATGAAGATCCCAACATTTGTCTTTTTGGTTCCTGTACTAATACTCCAGGGGGCTTCCAG       c.6240
 D  E  D  P  N  I  C  L  F  G  S  C  T  N  T  P  G  G  F  Q         p.2080

          .         .         .         .         .   | 50     .    g.252167
 TGCCTCTGCCCCCCTGGCTTTGTACTATCTGATAATGGACGGAGATGCTTTG | ATACTCGC    c.6300
 C  L  C  P  P  G  F  V  L  S  D  N  G  R  R  C  F  D |   T  R      p.2100

          .         .         .         .         .         .       g.252227
 CAGAGCTTCTGCTTCACAAATTTTGAAAATGGAAAGTGTTCTGTACCCAAAGCTTTCAAC       c.6360
 Q  S  F  C  F  T  N  F  E  N  G  K  C  S  V  P  K  A  F  N         p.2120

          .         .         .         .         .         .       g.252287
 ACCACAAAAGCAAAATGCTGCTGTAGTAAGATGCCAGGAGAGGGCTGGGGGGACCCCTGT       c.6420
 T  T  K  A  K  C  C  C  S  K  M  P  G  E  G  W  G  D  P  C         p.2140

          .         .      | 51  .         .         .         .    g.253131
 GAGCTGTGCCCCAAAGACGATGAAG | TTGCATTTCAGGATTTGTGTCCATATGGCCATGGA    c.6480
 E  L  C  P  K  D  D  E  V |   A  F  Q  D  L  C  P  Y  G  H  G      p.2160

          .         .         .  | 52      .         .         .    g.253820
 ACTGTCCCTAGTCTTCATGATACACGTGAAG | ATGTCAATGAGTGTCTTGAGAGCCCAGGC    c.6540
 T  V  P  S  L  H  D  T  R  E  D |   V  N  E  C  L  E  S  P  G      p.2180

          .         .         .         .         .         .       g.253880
 ATTTGTTCAAATGGTCAATGTATCAACACCGACGGATCTTTTCGCTGTGAATGTCCAATG       c.6600
 I  C  S  N  G  Q  C  I  N  T  D  G  S  F  R  C  E  C  P  M         p.2200

          .         .         .        | 53.         .         .    g.254509
 GGCTACAACCTTGACTACACTGGAGTACGCTGTGTGG | ATACTGATGAGTGTTCAATCGGC    c.6660
 G  Y  N  L  D  Y  T  G  V  R  C  V  D |   T  D  E  C  S  I  G      p.2220

          .         .         .         .         .         .       g.254569
 AATCCGTGTGGAAATGGTACATGCACCAATGTTATTGGGAGTTTTGAATGCAATTGCAAT       c.6720
 N  P  C  G  N  G  T  C  T  N  V  I  G  S  F  E  C  N  C  N         p.2240

          .         .         .        | 54.         .         .    g.255636
 GAAGGCTTTGAGCCAGGGCCCATGATGAATTGTGAAG | ATATCAACGAATGTGCCCAGAAC    c.6780
 E  G  F  E  P  G  P  M  M  N  C  E  D |   I  N  E  C  A  Q  N      p.2260

          .         .         .         .         .         .       g.255696
 CCACTGCTGTGTGCTTTCCGCTGCATGAACACTTTTGGGTCCTATGAATGCACGTGCCCG       c.6840
 P  L  L  C  A  F  R  C  M  N  T  F  G  S  Y  E  C  T  C  P         p.2280

          .         .         .         . | 55       .         .    g.256214
 ATTGGCTATGCCCTCAGGGAAGATCAAAAGATGTGCAAAG | ATCTGGATGAATGTGCTGAA    c.6900
 I  G  Y  A  L  R  E  D  Q  K  M  C  K  D |   L  D  E  C  A  E      p.2300

          .         .         .         .         .         .       g.256274
 GGGTTACACGACTGTGAATCTAGGGGCATGATGTGTAAGAATCTAATCGGCACCTTCATG       c.6960
 G  L  H  D  C  E  S  R  G  M  M  C  K  N  L  I  G  T  F  M         p.2320

          .         .         .         .         .   | 56     .    g.262734
 TGCATCTGCCCTCCTGGAATGGCCCGAAGGCCCGATGGAGAAGGCTGTGTAG | ATGAAAAT    c.7020
 C  I  C  P  P  G  M  A  R  R  P  D  G  E  G  C  V  D |   E  N      p.2340

          .         .         .         .         .         .       g.262794
 GAATGCAGGACCAAGCCAGGAATCTGTGAAAATGGACGTTGTGTTAACATTATTGGAAGC       c.7080
 E  C  R  T  K  P  G  I  C  E  N  G  R  C  V  N  I  I  G  S         p.2360

          .         .         .         .         .         | 57    g.264204
 TATAGATGTGAGTGTAATGAAGGATTCCAGTCAAGTTCTTCAGGCACTGAATGCCTTG | AC    c.7140
 Y  R  C  E  C  N  E  G  F  Q  S  S  S  S  G  T  E  C  L  D |       p.2380

          .         .         .         .         .         .       g.264264
 AATCGACAGGGTCTCTGCTTTGCAGAGGTACTGCAGACAATATGTCAAATGGCATCCAGT       c.7200
 N  R  Q  G  L  C  F  A  E  V  L  Q  T  I  C  Q  M  A  S  S         p.2400

          .         .         .         .         .         .       g.264324
 AGTCGCAATCTCGTCACTAAGTCAGAATGCTGCTGTGATGGTGGGCGAGGCTGGGGCCAC       c.7260
 S  R  N  L  V  T  K  S  E  C  C  C  D  G  G  R  G  W  G  H         p.2420

          .         .         .         .         .         .       g.264384
 CAGTGCGAGCTTTGCCCACTTCCTGGAACTGCCCAGTACAAAAAGATATGTCCTCATGGC       c.7320
 Q  C  E  L  C  P  L  P  G  T  A  Q  Y  K  K  I  C  P  H  G         p.2440

          .         .      | 58  .         .         .         .    g.265073
 CCAGGATATACAACTGATGGAAGAG | ATATTGATGAATGTAAGGTAATGCCAAACCTCTGC    c.7380
 P  G  Y  T  T  D  G  R  D |   I  D  E  C  K  V  M  P  N  L  C      p.2460

          .         .         .         .         .         .       g.265133
 ACCAATGGTCAGTGCATCAATACCATGGGCTCATTCCGATGCTTCTGCAAGGTTGGCTAC       c.7440
 T  N  G  Q  C  I  N  T  M  G  S  F  R  C  F  C  K  V  G  Y         p.2480

          .         .         .  | 59      .         .         .    g.266912
 ACCACAGACATCAGTGGAACCTCTTGTATAG | ACCTTGATGAATGCTCCCAGTCCCCGAAA    c.7500
 T  T  D  I  S  G  T  S  C  I  D |   L  D  E  C  S  Q  S  P  K      p.2500

          .         .         .         .         .         .       g.266972
 CCATGCAACTACATCTGCAAGAACACTGAGGGGAGTTATCAGTGTTCATGTCCGAGGGGG       c.7560
 P  C  N  Y  I  C  K  N  T  E  G  S  Y  Q  C  S  C  P  R  G         p.2520

          .         .         .     | 60   .         .         .    g.268386
 TATGTCCTGCAAGAGGATGGAAAGACATGCAAAG | ACCTTGATGAATGTCAAACAAAGCAG    c.7620
 Y  V  L  Q  E  D  G  K  T  C  K  D |   L  D  E  C  Q  T  K  Q      p.2540

          .         .         .         .         .         .       g.268446
 CATAACTGCCAGTTCCTCTGTGTCAACACCCTGGGGGGGTTTACCTGTAAATGTCCACCT       c.7680
 H  N  C  Q  F  L  C  V  N  T  L  G  G  F  T  C  K  C  P  P         p.2560

          .         .         .  | 61      .         .         .    g.269104
 GGTTTCACACAGCATCACACTGCTTGTATCG | ACAACAACGAATGTGGGTCTCAACCTTCG    c.7740
 G  F  T  Q  H  H  T  A  C  I  D |   N  N  E  C  G  S  Q  P  S      p.2580

          .         .         .         .         .         .       g.269164
 CTTTGTGGAGCAAAGGGAATCTGTCAAAACACTCCAGGCAGTTTCAGCTGTGAATGCCAA       c.7800
 L  C  G  A  K  G  I  C  Q  N  T  P  G  S  F  S  C  E  C  Q         p.2600

          .         .         .         . | 62       .         .    g.270945
 AGAGGGTTCTCTCTTGATGCCACCGGACTGAACTGTGAAG | ATGTTGATGAATGTGATGGG    c.7860
 R  G  F  S  L  D  A  T  G  L  N  C  E  D |   V  D  E  C  D  G      p.2620

          .         .         .         .         .         .       g.271005
 AACCACAGGTGCCAACACGGCTGCCAGAACATCCTGGGTGGCTACAGATGTGGCTGCCCC       c.7920
 N  H  R  C  Q  H  G  C  Q  N  I  L  G  G  Y  R  C  G  C  P         p.2640

          .         .         .         . | 63       .         .    g.279407
 CAAGGCTACATCCAGCACTACCAGTGGAATCAGTGTGTCG | ATGAGAATGAATGCTCCAAT    c.7980
 Q  G  Y  I  Q  H  Y  Q  W  N  Q  C  V  D |   E  N  E  C  S  N      p.2660

          .         .         .         .         .         .       g.279467
 CCCAATGCCTGTGGCTCTGCTTCCTGCTACAACACCCTGGGGAGTTACAAGTGCGCCTGC       c.8040
 P  N  A  C  G  S  A  S  C  Y  N  T  L  G  S  Y  K  C  A  C         p.2680

          .         .         .         .         .         .       g.279527
 CCCTCGGGGTTCTCCTTCGACCAGTTCTCCAGTGCCTGCCACGACGTGAATGAGTGCTCG       c.8100
 P  S  G  F  S  F  D  Q  F  S  S  A  C  H  D  V  N  E  C  S         p.2700

          .         .         .         .         .         .       g.279587
 TCCTCCAAGAACCCCTGCAATTACGGCTGCTCTAACACGGAGGGGGGCTACCTCTGTGGC       c.8160
 S  S  K  N  P  C  N  Y  G  C  S  N  T  E  G  G  Y  L  C  G         p.2720

          .         .         .   | 64     .         .         .    g.281164
 TGCCCCCCTGGGTATTACAGAGTGGGACAAGG | CCACTGTGTCTCAGGAATGGGATTTAAC    c.8220
 C  P  P  G  Y  Y  R  V  G  Q  G  |  H  C  V  S  G  M  G  F  N      p.2740

          .         .         .         .         .         .       g.281224
 AAGGGGCAGTACCTGTCACTGGATACAGAGGTCGATGAGGAAAATGCTCTGTCCCCAGAA       c.8280
 K  G  Q  Y  L  S  L  D  T  E  V  D  E  E  N  A  L  S  P  E         p.2760

          .         .         .         .         .         .       g.281284
 GCATGCTACGAGTGCAAAATCAACGGCTATTCTAAGAAAGACAGCAGGCAGAAGAGAAGT       c.8340
 A  C  Y  E  C  K  I  N  G  Y  S  K  K  D  S  R  Q  K  R  S         p.2780

          .         .     | 65   .         .         .         .    g.283250
 ATTCATGAACCTGATCCCACTGCT | GTTGAACAGATCAGCCTAGAGAGTGTCGACATGGAC    c.8400
 I  H  E  P  D  P  T  A   | V  E  Q  I  S  L  E  S  V  D  M  D      p.2800

          .         .         .         .         .         .       g.283310
 AGCCCCGTCAACATGAAGTTCAACCTCTCCCACCTCGGCTCTAAGGAGCACATCCTGGAA       c.8460
 S  P  V  N  M  K  F  N  L  S  H  L  G  S  K  E  H  I  L  E         p.2820

          .         .         .         .         .         .       g.283370
 CTAAGGCCCGCCATCCAGCCCCTCAACAACCACATCCGTTATGTCATCTCTCAAGGGAAC       c.8520
 L  R  P  A  I  Q  P  L  N  N  H  I  R  Y  V  I  S  Q  G  N         p.2840

          .         .         .         .         .         .       g.283430
 GATGACAGCGTCTTCCGCATCCACCAAAGGAATGGGCTCAGCTACTTGCACACGGCCAAG       c.8580
 D  D  S  V  F  R  I  H  Q  R  N  G  L  S  Y  L  H  T  A  K         p.2860

          .         .         .         .         .         .       g.283490
 AAGAAGCTCATGCCCGGCACATACACACTGGAAATCACTAGCATCCCTCTCTACAAGAAG       c.8640
 K  K  L  M  P  G  T  Y  T  L  E  I  T  S  I  P  L  Y  K  K         p.2880

          .         .         .         .         .         .       g.283550
 AAGGAGCTTAAGAAACTGGAAGAGAGCAATGAGGATGACTACCTCCTAGGGGAGCTTGGG       c.8700
 K  E  L  K  K  L  E  E  S  N  E  D  D  Y  L  L  G  E  L  G         p.2900

          .         .         .                                     g.283589
 GAGGCTCTCAGAATGAGGCTGCAGATTCAGCTCTATTAA                            c.8739
 E  A  L  R  M  R  L  Q  I  Q  L  Y  X                              p.2912

          .         .         .         .         .         .       g.283649
 cccttcacagacttgggcccaggctcaaatcctagcacagccagtctgcagaagcatttg       c.*60

          .         .         .         .         .         .       g.283709
 aaaagtcaaggactaattttaaagaggaaaaataataataactcttgtttctttcctccc       c.*120

          .         .         .         .         .         .       g.283769
 tgtcttagactttgaatgttgaccctcacagggagggataatttagactctggtatggcc       c.*180

          .         .         .         .         .         .       g.283829
 aaagatttgagcacaaaggcaaccgtggttactgtattttttatataacttcattttaaa       c.*240

          .         .         .         .         .         .       g.283889
 atatattaaaagaaacctaaatgttcaagatatcagcatatggcactaaatgcacaaaaa       c.*300

          .         .         .         .         .         .       g.283949
 taatgtgagctttttttttttttcctgttagcagtctgtaacactttgggtattttgcta       c.*360

          .         .         .         .         .         .       g.284009
 tagttgctaattaaaaaaatatagatgtttatttatttttaatgcagtaatatatggaga       c.*420

          .         .         .         .         .         .       g.284069
 aatgaacaaactatgtaaacaaaaagggaaactcacttgtttttctttagatttataaat       c.*480

          .         .         .         .         .         .       g.284129
 ttgagctattttttttagaggtgctttttaaaaatccaatagatacaagagatgtttcct       c.*540

          .         .         .         .         .         .       g.284189
 ttggttttctgccagtcatccagctgatacacacctgatgattttaaagaaagccacaca       c.*600

          .         .         .         .         .         .       g.284249
 gagctgaatgggcagtgtaatcaataatttaaaaaacatgaatgtcattagatcctttat       c.*660

          .         .         .         .         .         .       g.284309
 aacgtagatcgaagccaaagcagctcatttgtgacaacatttcatatcaccagacacacc       c.*720

          .         .         .         .         .         .       g.284369
 aggcaacagaagttgaagcacaaccactgtagcaaaataccttgactgcttgtgagacca       c.*780

          .         .         .         .         .         .       g.284429
 ttagcattgcaggccaaaccgtactgtatttccttctcataacctcaaggaaccatatgt       c.*840

          .         .         .         .         .         .       g.284489
 gctacccacaacacctcattcttacccagggtgcgctgcgtcctcatggtactgtaggca       c.*900

          .         .         .         .         .         .       g.284549
 gctgaagaaccgccgttcccttgaaagggaacacctggcattctgtggtgtttcgtgctg       c.*960

          .         .         .         .         .         .       g.284609
 tcttaaataatggtgcatttattatgttcaagttatttcaggattgccatatgtgcaaac       c.*1020

          .         .         .         .         .         .       g.284669
 aaatcatgcaatgcagccaaggaatatatgttgttgttgttgttttaaacccattttttt       c.*1080

          .         .         .         .         .         .       g.284729
 tttagaattttcattaatactgtagttatacaccatatgcctcattttatcatagcctat       c.*1140

          .         .         .         .         .         .       g.284789
 tgtgtatgaaagatgtttgtacaatgaattgatgtttagtttgctttagtcatttaaaaa       c.*1200

          .         .         .         .         .         .       g.284849
 gatattgtaccaggatgtgctattaagagcacgtatccattattcttctcaacccaagaa       c.*1260

          .         .         .         .         .         .       g.284909
 cctgtttcctggaccagtgaccaaacctcatatgtgaaatggccaaagcacatgcaggct       c.*1320

          .         .         .         .         .         .       g.284969
 cctggttgttcctctcaaacctgtgctgaccaaagattagtaaccagttatacccagtat       c.*1380

          .         .         .         .         .         .       g.285029
 tttgaggttttattgtttttttaataactaaaaagaaaaaaggaacagtgtaaatttgta       c.*1440

          .         .         .         .         .         .       g.285089
 atcaagagtttgtgaggaaaaacttatggtttttggttttgtttgtttttgtaggtctgt       c.*1500

          .         .         .         .                           g.285135
 gtatcaaatatgacacttttcttgcaataaagcttattttggggta                     c.*1546

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fibrillin 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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