fibrillin 3 (FBN3) - coding DNA reference sequence

(used for variant description)

(last modified March 7, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_032447.3 in the FBN3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering FBN3 transcript NM_032447.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        gcagcctccaggggacacgcc       c.-1

          .         .         .         .         .         .       g.5081
 ATGACTCTGGAGGGTCTGTATTTGGCAAGGGGCCCCCTGGCCCGGCTCCTGCTGGCCTGG       c.60
 M  T  L  E  G  L  Y  L  A  R  G  P  L  A  R  L  L  L  A  W         p.20

          .         .         .         .         .         .       g.5141
 TCGGCCCTGTTGTGCATGGCAGGTGGCCAAGGCCGCTGGGACGGGGCCTTGGAGGCTGCA       c.120
 S  A  L  L  C  M  A  G  G  Q  G  R  W  D  G  A  L  E  A  A         p.40

          .         .         .         .        | 02.         .    g.5328
 GGTCCTGGACGTGTGCGGAGGCGGGGCAGCCCAGGCATCTTGCAGGG | GCCGAATGTGTGC    c.180
 G  P  G  R  V  R  R  R  G  S  P  G  I  L  Q  G  |  P  N  V  C      p.60

          .         .         .         .         .         .       g.5388
 GGCTCCCGGTTCCATGCCTACTGCTGTCCAGGCTGGAGGACATTCCCTGGCAGGAGCCAG       c.240
 G  S  R  F  H  A  Y  C  C  P  G  W  R  T  F  P  G  R  S  Q         p.80

          . | 03       .         .         .         .         .    g.6326
 TGTGTCGTAC | CCATCTGTAGGCGCGCCTGCGGTGAAGGCTTCTGCTCCCAGCCCAACCTG    c.300
 C  V  V  P |   I  C  R  R  A  C  G  E  G  F  C  S  Q  P  N  L      p.100

          .         .         .         .          | 04        .    g.6574
 TGCACCTGTGCGGATGGGACGCTGGCTCCCAGCTGCGGGGTGAGCCGAG | GGTCAGGGTGC    c.360
 C  T  C  A  D  G  T  L  A  P  S  C  G  V  S  R  G |   S  G  C      p.120

          .         .         .         .         .         .       g.6634
 AGTGTGAGCTGTATGAATGGGGGCACCTGCCGGGGGGCGTCCTGTCTGTGTCAGAAGGGC       c.420
 S  V  S  C  M  N  G  G  T  C  R  G  A  S  C  L  C  Q  K  G         p.140

          .         .      | 05  .         .         .         .    g.7564
 TACACAGGCACCGTGTGTGGGCAGC | CCATCTGTGACCGCGGCTGCCACAATGGGGGTCGC    c.480
 Y  T  G  T  V  C  G  Q  P |   I  C  D  R  G  C  H  N  G  G  R      p.160

          .         .         .         .         .         .       g.7624
 TGCATTGGGCCCAACCGCTGCGCCTGTGTGTATGGCTTCATGGGACCTCAATGTGAGAGA       c.540
 C  I  G  P  N  R  C  A  C  V  Y  G  F  M  G  P  Q  C  E  R         p.180

   | 06      .         .         .         .         .         .    g.10423
 G | ATTACCGGACGGGACCCTGCTTTGGCCAAGTAGGCCCCGAGGGGTGCCAGCATCAGCTG    c.600
 D |   Y  R  T  G  P  C  F  G  Q  V  G  P  E  G  C  Q  H  Q  L      p.200

          .         .         .         .         .         .       g.10483
 ACGGGCCTCGTGTGCACCAAGGCACTTTGCTGTGCCACTGTGGGCCGTGCCTGGGGCCTT       c.660
 T  G  L  V  C  T  K  A  L  C  C  A  T  V  G  R  A  W  G  L         p.220

          .         .         .         .         .         .       g.10543
 CCATGTGAACTTTGCCCTGCACAGCCACACCCCTGCCGCCGCGGCTTCATCCCCAATATC       c.720
 P  C  E  L  C  P  A  Q  P  H  P  C  R  R  G  F  I  P  N  I         p.240

          .          | 07        .         .         .         .    g.10700
 CACACGGGGGCCTGCCAAG | ATGTGGATGAGTGCCAGGCTGTGCCAGGCCTGTGCCAGGGA    c.780
 H  T  G  A  C  Q  D |   V  D  E  C  Q  A  V  P  G  L  C  Q  G      p.260

          .         .         .         .         .         .       g.10760
 GGCAGCTGCGTCAACATGGTGGGCTCCTTCCATTGCCGCTGTCCAGTTGGACACCGGCTC       c.840
 G  S  C  V  N  M  V  G  S  F  H  C  R  C  P  V  G  H  R  L         p.280

          .         .      | 08  .         .         .         .    g.13972
 AGTGACAGCAGCGCCGCATGTGAAG | ACTACCGGGCCGGCGCCTGCTTCTCAGTGCTTTTC    c.900
 S  D  S  S  A  A  C  E  D |   Y  R  A  G  A  C  F  S  V  L  F      p.300

          .         .         .         .         .         .       g.14032
 GGGGGCCGCTGTGCTGGAGACCTCGCCGGCCACTACACTCGCAGGCAGTGCTGCTGTGAC       c.960
 G  G  R  C  A  G  D  L  A  G  H  Y  T  R  R  Q  C  C  C  D         p.320

          .         .         .         .         .         | 09    g.14180
 AGGGGCAGGTGCTGGGCAGCTGGCCCGGTCCCTGAGCTGTGTCCTCCTCGGGGCTCCA | AT    c.1020
 R  G  R  C  W  A  A  G  P  V  P  E  L  C  P  P  R  G  S  N |       p.340

          .         .         .         .         .         .       g.14240
 GAATTCCAGCAACTGTGCGCCCAGCGGCTGCCGCTGCTACCCGGCCACCCTGGCCTCTTC       c.1080
 E  F  Q  Q  L  C  A  Q  R  L  P  L  L  P  G  H  P  G  L  F         p.360

          .         .         .         .         .         .       g.14300
 CCTGGCCTCCTGGGCTTCGGATCCAATGGCATGGGTCCCCCTCTTGGGCCAGCGCGACTC       c.1140
 P  G  L  L  G  F  G  S  N  G  M  G  P  P  L  G  P  A  R  L         p.380

          .         .         .         .         .         .       g.14360
 AACCCCCATGGCTCTGATGCGCGTGGGATCCCCAGCCTGGGCCCTGGCAACTCTAATATT       c.1200
 N  P  H  G  S  D  A  R  G  I  P  S  L  G  P  G  N  S  N  I         p.400

   | 10      .         .         .         .         .         .    g.16029
 G | GCACTGCTACCCTGAACCAGACCATTGACATCTGCCGACACTTCACCAACCTGTGTCTG    c.1260
 G |   T  A  T  L  N  Q  T  I  D  I  C  R  H  F  T  N  L  C  L      p.420

          .         .         .         .         .         .       g.16089
 AATGGCCGCTGCCTGCCCACGCCTTCCAGCTACCGCTGCGAGTGTAACGTGGGCTACACC       c.1320
 N  G  R  C  L  P  T  P  S  S  Y  R  C  E  C  N  V  G  Y  T         p.440

          .         .      | 11  .         .         .         .    g.16227
 CAGGACGTGCGCGGCGAGTGCATTG | ATGTAGACGAATGCACCAGCAGCCCCTGCCACCAC    c.1380
 Q  D  V  R  G  E  C  I  D |   V  D  E  C  T  S  S  P  C  H  H      p.460

          .         .         .         .         .         .       g.16287
 GGTGACTGCGTCAACATCCCCGGCACCTACCACTGCCGGTGCTACCCGGGCTTCCAGGCC       c.1440
 G  D  C  V  N  I  P  G  T  Y  H  C  R  C  Y  P  G  F  Q  A         p.480

          .         .      | 12  .         .         .         .    g.16450
 ACGCCCACCAGGCAGGCATGCGTGG | ATGTGGACGAGTGCATTGTCAGTGGTGGCCTTTGT    c.1500
 T  P  T  R  Q  A  C  V  D |   V  D  E  C  I  V  S  G  G  L  C      p.500

          .         .         .         .         .         .       g.16510
 CACCTGGGCCGCTGTGTCAACACAGAGGGCAGCTTCCAGTGTGTCTGCAATGCAGGCTTC       c.1560
 H  L  G  R  C  V  N  T  E  G  S  F  Q  C  V  C  N  A  G  F         p.520

          .         .         .  | 13      .         .         .    g.19424
 GAGCTCAGCCCTGACGGCAAGAACTGTGTGG | ACCACAACGAGTGTGCCACCAGCACCATG    c.1620
 E  L  S  P  D  G  K  N  C  V  D |   H  N  E  C  A  T  S  T  M      p.540

          .         .         .         .         .         .       g.19484
 TGCGTCAACGGCGTGTGTCTCAACGAGGATGGCAGCTTCTCCTGCCTCTGCAAACCCGGC       c.1680
 C  V  N  G  V  C  L  N  E  D  G  S  F  S  C  L  C  K  P  G         p.560

          .         .         .     | 14   .         .         .    g.20698
 TTCCTGCTGGCGCCTGGCGGCCACTACTGCATGG | ACATTGACGAGTGCCAGACGCCCGGC    c.1740
 F  L  L  A  P  G  G  H  Y  C  M  D |   I  D  E  C  Q  T  P  G      p.580

          .         .         .         .         .         .       g.20758
 ATCTGCGTGAACGGCCACTGTACCAACACCGAGGGCTCCTTCCGCTGCCAGTGCCTGGGG       c.1800
 I  C  V  N  G  H  C  T  N  T  E  G  S  F  R  C  Q  C  L  G         p.600

          .         .         .         .         .         .       g.20818
 GGGCTGGCGGTAGGCACGGATGGCCGCGTGTGCGTGGACACCCACGTGCGCAGCACCTGC       c.1860
 G  L  A  V  G  T  D  G  R  V  C  V  D  T  H  V  R  S  T  C         p.620

          .         .         .         .         .         .       g.20878
 TATGGGGCCATCGAGAAGGGCTCCTGTGCCCGCCCCTTCCCTGGCACTGTCACCAAGTCC       c.1920
 Y  G  A  I  E  K  G  S  C  A  R  P  F  P  G  T  V  T  K  S         p.640

          .         .         .         .         .         .       g.20938
 GAGTGCTGCTGTGCCAATCCGGACCACGGTTTTGGGGAGCCCTGCCAGCTTTGTCCTGCC       c.1980
 E  C  C  C  A  N  P  D  H  G  F  G  E  P  C  Q  L  C  P  A         p.660

          . | 15       .         .         .         .         .    g.21263
 AAAGACTCCG | CTGAGTTCCAGGCACTGTGCAGCAGTGGGCTTGGCATTACCACGGATGGT    c.2040
 K  D  S  A |   E  F  Q  A  L  C  S  S  G  L  G  I  T  T  D  G      p.680

      | 16   .         .         .         .         .         .    g.23192
 CGAG | ACATCAACGAGTGTGCTCTGGATCCTGAGGTTTGTGCCAATGGCGTGTGCGAGAAC    c.2100
 R  D |   I  N  E  C  A  L  D  P  E  V  C  A  N  G  V  C  E  N      p.700

          .         .         .         .         .         .       g.23252
 CTTCGGGGCAGCTACCGCTGTGTCTGCAACCTGGGTTATGAGGCAGGTGCCTCAGGCAAG       c.2160
 L  R  G  S  Y  R  C  V  C  N  L  G  Y  E  A  G  A  S  G  K         p.720

          . | 17       .         .         .         .         .    g.23398
 GACTGCACAG | ACGTGGATGAGTGTGCCCTCAACAGCCTCCTGTGTGACAACGGGTGGTGC    c.2220
 D  C  T  D |   V  D  E  C  A  L  N  S  L  L  C  D  N  G  W  C      p.740

          .         .         .         .         .         .       g.23458
 CAGAATAGCCCTGGCAGCTACAGCTGCTCCTGCCCCCCCGGCTTCCACTTCTGGCAGGAC       c.2280
 Q  N  S  P  G  S  Y  S  C  S  C  P  P  G  F  H  F  W  Q  D         p.760

          .       | 18 .         .         .         .         .    g.25713
 ACGGAGATCTGCAAAG | ATGTCGACGAATGCCTGTCCAGCCCGTGTGTGAGTGGCGTCTGT    c.2340
 T  E  I  C  K  D |   V  D  E  C  L  S  S  P  C  V  S  G  V  C      p.780

          .         .         .         .         .         .       g.25773
 CGGAACCTGGCCGGCTCCTACACCTGCAAATGTGGCCCTGGCAGCCGGCTGGACCCCTCT       c.2400
 R  N  L  A  G  S  Y  T  C  K  C  G  P  G  S  R  L  D  P  S         p.800

          .       | 19 .         .         .         .         .    g.25940
 GGTACCTTCTGTCTAG | ACAGCACCAAGGGCACCTGCTGGCTGAAGATCCAGGAGAGCCGC    c.2460
 G  T  F  C  L  D |   S  T  K  G  T  C  W  L  K  I  Q  E  S  R      p.820

          .         .         .         .         .         .       g.26000
 TGTGAGGTGAACCTTCAGGGAGCCAGCCTGCGGTCTGAGTGCTGCGCCACCCTCGGGGCA       c.2520
 C  E  V  N  L  Q  G  A  S  L  R  S  E  C  C  A  T  L  G  A         p.840

          .         .         .     | 20   .         .         .    g.26180
 GCCTGGGGGAGCCCCTGCGAACGCTGCGAGATCG | ACCCTGCCTGTGCCCGGGGCTTTGCC    c.2580
 A  W  G  S  P  C  E  R  C  E  I  D |   P  A  C  A  R  G  F  A      p.860

          .         .      | 21  .         .         .         .    g.26519
 CGGATGACGGGTGTCACCTGCGATG | ATGTGAACGAGTGTGAGTCCTTCCCGGGAGTCTGT    c.2640
 R  M  T  G  V  T  C  D  D |   V  N  E  C  E  S  F  P  G  V  C      p.880

          .         .         .         .         .         .       g.26579
 CCCAACGGGCGTTGCGTCAACACTGCTGGGTCTTTCCGCTGTGAGTGTCCAGAGGGCCTG       c.2700
 P  N  G  R  C  V  N  T  A  G  S  F  R  C  E  C  P  E  G  L         p.900

          .         .         .  | 22      .         .         .    g.28522
 ATGCTGGACGCCTCAGGCCGGCTGTGCGTGG | ATGTGAGATTGGAACCATGTTTCCTGCGA    c.2760
 M  L  D  A  S  G  R  L  C  V  D |   V  R  L  E  P  C  F  L  R      p.920

          .         .         .         .         .         .       g.28582
 TGGGATGAGGATGAGTGTGGGGTCACCCTGCCTGGCAAGTACCGGATGGACGTCTGCTGC       c.2820
 W  D  E  D  E  C  G  V  T  L  P  G  K  Y  R  M  D  V  C  C         p.940

          .         .         .         .         .         .       g.28642
 TGCTCCATCGGGGCCGTGTGGGGAGTCGAGTGCGAGGCCTGCCCGGATCCCGAGTCTCTG       c.2880
 C  S  I  G  A  V  W  G  V  E  C  E  A  C  P  D  P  E  S  L         p.960

          .         .         .         .         .         .       g.28702
 GAGTTCGCCAGCCTGTGCCCGCGGGGGCTGGGCTTCGCCAGCCGGGACTTCCTGTCTGGC       c.2940
 E  F  A  S  L  C  P  R  G  L  G  F  A  S  R  D  F  L  S  G         p.980

          .       | 23 .         .         .         .         .    g.28956
 CGACCATTCTATAAAG | ATGTGAATGAATGCAAGGTGTTCCCTGGCCTCTGCACGCACGGT    c.3000
 R  P  F  Y  K  D |   V  N  E  C  K  V  F  P  G  L  C  T  H  G      p.1000

          .         .         .         .         .         .       g.29016
 ACCTGCAGAAACACGGTGGGCAGCTTCCACTGCGCCTGTGCGGGGGGCTTCGCCCTGGAT       c.3060
 T  C  R  N  T  V  G  S  F  H  C  A  C  A  G  G  F  A  L  D         p.1020

          .         .   | 24     .         .         .         .    g.31153
 GCCCAGGAACGGAACTGCACAG | ATATCGACGAGTGTCGCATCTCTCCTGACCTCTGCGGC    c.3120
 A  Q  E  R  N  C  T  D |   I  D  E  C  R  I  S  P  D  L  C  G      p.1040

          .         .         .         .         .         .       g.31213
 CAGGGCACCTGTGTCAACACGCCGGGCAGCTTTGAGTGCGAGTGTTTTCCCGGCTACGAG       c.3180
 Q  G  T  C  V  N  T  P  G  S  F  E  C  E  C  F  P  G  Y  E         p.1060

          .         .         .  | 25      .         .         .    g.33508
 AGTGGCTTCATGCTGATGAAGAACTGCATGG | ACGTGGACGAGTGTGCAAGGGACCCGCTG    c.3240
 S  G  F  M  L  M  K  N  C  M  D |   V  D  E  C  A  R  D  P  L      p.1080

          .         .         .         .         .         .       g.33568
 CTCTGCCGGGGAGGCACTTGCACCAACACGGATGGGAGCTACAAGTGCCAGTGTCCCCCT       c.3300
 L  C  R  G  G  T  C  T  N  T  D  G  S  Y  K  C  Q  C  P  P         p.1100

          .         .         .        | 26.         .         .    g.34935
 GGGCATGAGCTGACGGCCAAGGGCACTGCCTGTGAGG | ACATCGATGAGTGCTCCCTGAGT    c.3360
 G  H  E  L  T  A  K  G  T  A  C  E  D |   I  D  E  C  S  L  S      p.1120

          .         .         .         .         .         .       g.34995
 GATGGCCTGTGTCCCCATGGCCAGTGTGTCAATGTCATCGGTGCCTTCCAGTGCTCCTGC       c.3420
 D  G  L  C  P  H  G  Q  C  V  N  V  I  G  A  F  Q  C  S  C         p.1140

          .         .         .         .    | 27    .         .    g.35227
 CATGCCGGCTTCCAGAGCACACCTGACCGCCAGGGCTGCGTGG | ACATCAACGAATGCCGG    c.3480
 H  A  G  F  Q  S  T  P  D  R  Q  G  C  V  D |   I  N  E  C  R      p.1160

          .         .         .         .         .         .       g.35287
 GTCCAGAATGGTGGGTGTGACGTGCACTGTATTAACACTGAGGGCAGCTACCGGTGCAGC       c.3540
 V  Q  N  G  G  C  D  V  H  C  I  N  T  E  G  S  Y  R  C  S         p.1180

          .         .         .         .       | 28 .         .    g.35716
 TGTGGGCAGGGCTACTCGCTGATGCCCGACGGAAGGGCATGTGCAG | ACGTGGACGAGTGT    c.3600
 C  G  Q  G  Y  S  L  M  P  D  G  R  A  C  A  D |   V  D  E  C      p.1200

          .         .         .         .         .         .       g.35776
 GAAGAGAACCCCCGCGTTTGTGACCAAGGCCACTGCACCAACATGCCAGGGGGTCACCGC       c.3660
 E  E  N  P  R  V  C  D  Q  G  H  C  T  N  M  P  G  G  H  R         p.1220

          .         .         .         .         .   | 29     .    g.36869
 TGCCTGTGCTATGATGGCTTCATGGCCACGCCAGACATGAGGACATGTGTTG | ATGTGGAT    c.3720
 C  L  C  Y  D  G  F  M  A  T  P  D  M  R  T  C  V  D |   V  D      p.1240

          .         .         .         .         .         .       g.36929
 GAGTGTGACCTGAACCCTCACATCTGCCTCCATGGGGACTGCGAGAACACGAAGGGTTCC       c.3780
 E  C  D  L  N  P  H  I  C  L  H  G  D  C  E  N  T  K  G  S         p.1260

          .         .         .         .         .         | 30    g.40404
 TTTGTCTGCCACTGTCAGCTGGGCTACATGGTCAGGAAGGGGGCCACAGGCTGCTCTG | AT    c.3840
 F  V  C  H  C  Q  L  G  Y  M  V  R  K  G  A  T  G  C  S  D |       p.1280

          .         .         .         .         .         .       g.40464
 GTGGATGAATGCGAGGTTGGAGGACACAACTGTGACAGTCACGCCTCCTGTCTCAACATC       c.3900
 V  D  E  C  E  V  G  G  H  N  C  D  S  H  A  S  C  L  N  I         p.1300

          .         .         .         .         .         .       g.40524
 CCGGGGAGTTTCAGCTGTAGGTGCCTGCCAGGCTGGGTGGGGGATGGCTTCGAATGTCAC       c.3960
 P  G  S  F  S  C  R  C  L  P  G  W  V  G  D  G  F  E  C  H         p.1320

   | 31      .         .         .         .         .         .    g.40790
 G | ACCTGGATGAATGCGTCTCCCAGGAGCACCGGTGCAGCCCAAGAGGTGACTGTCTCAAT    c.4020
 D |   L  D  E  C  V  S  Q  E  H  R  C  S  P  R  G  D  C  L  N      p.1340

          .         .         .         .         .         .       g.40850
 GTCCCTGGCTCCTACCGCTGCACCTGCCGCCAGGGCTTTGCCGGGGATGGCTTCTTCTGC       c.4080
 V  P  G  S  Y  R  C  T  C  R  Q  G  F  A  G  D  G  F  F  C         p.1360

      | 32   .         .         .         .         .         .    g.41374
 GAAG | ACAGGGATGAATGTGCCGAGAACGTGGACCTCTGTGACAACGGGCAGTGCCTCAAT    c.4140
 E  D |   R  D  E  C  A  E  N  V  D  L  C  D  N  G  Q  C  L  N      p.1380

          .         .         .         .         .         .       g.41434
 GCGCCCGGCGGGTACCGCTGTGAATGTGAGATGGGCTTTGACCCCACCGAGGACCACCGG       c.4200
 A  P  G  G  Y  R  C  E  C  E  M  G  F  D  P  T  E  D  H  R         p.1400

          . | 33       .         .         .         .         .    g.41584
 GCCTGCCAGG | ATGTGGACGAGTGTGCGCAAGGGAACCTCTGTGCATTTGGGAGCTGTGAG    c.4260
 A  C  Q  D |   V  D  E  C  A  Q  G  N  L  C  A  F  G  S  C  E      p.1420

          .         .         .         .         .         .       g.41644
 AACCTGCCTGGAATGTTCCGCTGCATCTGCAATGGTGGCTACGAACTGGACCGAGGGGGT       c.4320
 N  L  P  G  M  F  R  C  I  C  N  G  G  Y  E  L  D  R  G  G         p.1440

          .    | 34    .         .         .         .         .    g.42795
 GGCAACTGCACAG | ACATCAACGAGTGTGCAGACCCAGTAAACTGCATCAACGGCGTGTGC    c.4380
 G  N  C  T  D |   I  N  E  C  A  D  P  V  N  C  I  N  G  V  C      p.1460

          .         .         .         .         .         .       g.42855
 ATTAACACCCCCGGCAGCTACCTCTGCAGCTGCCCCCAGGATTTTGAGCTGAACCCCAGC       c.4440
 I  N  T  P  G  S  Y  L  C  S  C  P  Q  D  F  E  L  N  P  S         p.1480

          .       | 35 .         .         .         .         .    g.43157
 GGAGTGGGCTGCGTGG | ACACTCGGGCCGGGAACTGTTTCCTGGAGACGCATGACCGAGGG    c.4500
 G  V  G  C  V  D |   T  R  A  G  N  C  F  L  E  T  H  D  R  G      p.1500

          .         .         .         .         .         .       g.43217
 GACAGTGGCATTTCCTGCAGTGCCGAGATCGGAGTTGGTGTCACCCGAGCTTCCTGCTGT       c.4560
 D  S  G  I  S  C  S  A  E  I  G  V  G  V  T  R  A  S  C  C         p.1520

          .         .         .         .         .         | 36    g.44265
 TGCTCCCTGGGCCGGGCTTGGGGCAATCCCTGTGAGCTGTGCCCTATGGCCAACACCA | CT    c.4620
 C  S  L  G  R  A  W  G  N  P  C  E  L  C  P  M  A  N  T  T |       p.1540

          .         .         .         .         .         .       g.44325
 GAGTACAGAACCCTGTGCCCGGGTGGTGAGGGCTTCCAGCCTAACCGCATCACTGTCATT       c.4680
 E  Y  R  T  L  C  P  G  G  E  G  F  Q  P  N  R  I  T  V  I         p.1560

         | 37.         .         .         .         .         .    g.46321
 CTGGAAG | ACATCGACGAGTGCCAAGAGCTGCCAGGGCTGTGTCAGGGGGGTGACTGCGTC    c.4740
 L  E  D |   I  D  E  C  Q  E  L  P  G  L  C  Q  G  G  D  C  V      p.1580

          .         .         .         .         .         .       g.46381
 AACACGTTTGGCAGTTTCCAGTGTGAGTGCCCACCTGGCTACCACCTCAGTGAGCACACC       c.4800
 N  T  F  G  S  F  Q  C  E  C  P  P  G  Y  H  L  S  E  H  T         p.1600

          .    | 38    .         .         .         .         .    g.48861
 CGCATCTGTGAGG | ATATTGACGAATGCTCCACACACTCCGGCATCTGTGGCCCTGGCACC    c.4860
 R  I  C  E  D |   I  D  E  C  S  T  H  S  G  I  C  G  P  G  T      p.1620

          .         .         .         .         .         .       g.48921
 TGCTACAACACCCTGGGGAACTACACCTGTGTCTGCCCTGCAGAGTACCTCCAAGTCAAT       c.4920
 C  Y  N  T  L  G  N  Y  T  C  V  C  P  A  E  Y  L  Q  V  N         p.1640

          .          | 39        .         .         .         .    g.49669
 GGTGGCAACAACTGCATGG | ATATGAGGAAGAGTGTCTGCTTCCGGCACTATAACGGCACA    c.4980
 G  G  N  N  C  M  D |   M  R  K  S  V  C  F  R  H  Y  N  G  T      p.1660

          .         .         .         .         .         .       g.49729
 TGTCAAAATGAGCTGGCCTTCAACGTGACCCGGAAAATGTGTTGCTGCTCCTACAACATT       c.5040
 C  Q  N  E  L  A  F  N  V  T  R  K  M  C  C  C  S  Y  N  I         p.1680

          .         .         .         .          | 40        .    g.51540
 GGCCAGGCCTGGAATAGACCCTGTGAGGCCTGCCCCACTCCCATCAGTC | CTGACTACCAG    c.5100
 G  Q  A  W  N  R  P  C  E  A  C  P  T  P  I  S  P |   D  Y  Q      p.1700

          .         .         .         .         .         .       g.51600
 ATCCTGTGTGGAAATCAGGCCCCGGGATTCCTCACTGACATCCACACGGGGAAGCCCCTT       c.5160
 I  L  C  G  N  Q  A  P  G  F  L  T  D  I  H  T  G  K  P  L         p.1720

   | 41      .         .         .         .         .         .    g.55146
 G | ACATTGATGAGTGTGGGGAGATCCCCGCCATCTGTGCCAATGGCATCTGCATAAACCAG    c.5220
 D |   I  D  E  C  G  E  I  P  A  I  C  A  N  G  I  C  I  N  Q      p.1740

          .         .         .         .         .         .       g.55206
 ATCGGGAGTTTCCGCTGCGAGTGCCCCGCAGGCTTCAACTACAACAGCATCCTGCTGGCT       c.5280
 I  G  S  F  R  C  E  C  P  A  G  F  N  Y  N  S  I  L  L  A         p.1760

         | 42.         .         .         .         .         .    g.55548
 TGTGAAG | ATGTCGATGAGTGTGGCAGCAGGGAGAGTCCCTGCCAGCAGAATGCTGACTGC    c.5340
 C  E  D |   V  D  E  C  G  S  R  E  S  P  C  Q  Q  N  A  D  C      p.1780

          .         .         .         .         .         .       g.55608
 ATCAACATCCCCGGTAGCTACCGCTGCAAGTGCACCCGAGGGTACAAACTGTCGCCAGGC       c.5400
 I  N  I  P  G  S  Y  R  C  K  C  T  R  G  Y  K  L  S  P  G         p.1800

          .    | 43    .         .         .         .         .    g.55979
 GGGGCTTGTGTGG | GACGGAATGAGTGTCGGGAGATCCCGAATGTCTGTAGCCATGGTGAC    c.5460
 G  A  C  V  G |   R  N  E  C  R  E  I  P  N  V  C  S  H  G  D      p.1820

          .         .         .         .         .         .       g.56039
 TGCATGGACACAGAAGGCAGCTACATGTGTCTGTGTCACCGTGGATTCCAGGCCTCTGCA       c.5520
 C  M  D  T  E  G  S  Y  M  C  L  C  H  R  G  F  Q  A  S  A         p.1840

          .          | 44        .         .         .         .    g.56462
 GACCAGACCCTGTGCATGG | ACATTGACGAGTGTGACCGGCAGCCTTGTGGAAATGGGACC    c.5580
 D  Q  T  L  C  M  D |   I  D  E  C  D  R  Q  P  C  G  N  G  T      p.1860

          .         .         .         .         .         .       g.56522
 TGCAAGAACATCATTGGCTCCTACAACTGCCTCTGCTTCCCTGGCTTTGTGGTGACACAC       c.5640
 C  K  N  I  I  G  S  Y  N  C  L  C  F  P  G  F  V  V  T  H         p.1880

          .       | 45 .         .         .         .         .    g.57042
 AATGGGGATTGTGTGG | ATTTTGATGAGTGTACTACCCTGGTGGGGCAGGTGTGCCGATTT    c.5700
 N  G  D  C  V  D |   F  D  E  C  T  T  L  V  G  Q  V  C  R  F      p.1900

          .         .         .         .         .         .       g.57102
 GGCCATTGCCTCAACACAGCTGGTTCCTTCCACTGCCTCTGCCAGGATGGCTTTGAGCTC       c.5760
 G  H  C  L  N  T  A  G  S  F  H  C  L  C  Q  D  G  F  E  L         p.1920

          .         .      | 46  .         .         .         .    g.57971
 ACAGCTGATGGGAAGAACTGTGTGG | ACACCAATGAGTGCCTCAGCCTTGCAGGAACCTGC    c.5820
 T  A  D  G  K  N  C  V  D |   T  N  E  C  L  S  L  A  G  T  C      p.1940

          .         .         .         .         .         .       g.58031
 CTACCCGGCACTTGCCAGAACCTCGAGGGCTCCTTCCGCTGCATCTGTCCCCCTGGCTTC       c.5880
 L  P  G  T  C  Q  N  L  E  G  S  F  R  C  I  C  P  P  G  F         p.1960

          .         .      | 47  .         .         .         .    g.60946
 CAGGTGCAGAGTGACCACTGCATTG | ATATCGACGAGTGCTCAGAGGAGCCCAACCTCTGC    c.5940
 Q  V  Q  S  D  H  C  I  D |   I  D  E  C  S  E  E  P  N  L  C      p.1980

          .         .         .         .         .         .       g.61006
 CTCTTTGGCACCTGTACCAACAGCCCTGGGAGCTTCCAGTGCCTCTGCCCACCTGGCTTT       c.6000
 L  F  G  T  C  T  N  S  P  G  S  F  Q  C  L  C  P  P  G  F         p.2000

          .         .         .  | 48      .         .         .    g.62279
 GTCCTCTCTGACAATGGGCACCGTTGCTTTG | ACACACGGCAGAGTTTCTGCTTCACCCGT    c.6060
 V  L  S  D  N  G  H  R  C  F  D |   T  R  Q  S  F  C  F  T  R      p.2020

          .         .         .         .         .         .       g.62339
 TTTGAGGCTGGGAAGTGCTCGGTGCCCAAAGCTTTCAACACCACCAAGACCCGCTGCTGC       c.6120
 F  E  A  G  K  C  S  V  P  K  A  F  N  T  T  K  T  R  C  C         p.2040

          .         .         .         .         .         .       g.62399
 TGCAGTAAGAGGCCTGGGGAGGGCTGGGGAGACCCCTGCGAACTGTGTCCCCAGGAGGGC       c.6180
 C  S  K  R  P  G  E  G  W  G  D  P  C  E  L  C  P  Q  E  G         p.2060

      | 49   .         .         .         .         .         .    g.62598
 AGCG | CTGCCTTTCAGGAGCTCTGCCCCTTTGGCCACGGGGCAGTCCCAGGCCCGGATGAC    c.6240
 S  A |   A  F  Q  E  L  C  P  F  G  H  G  A  V  P  G  P  D  D      p.2080

          . | 50       .         .         .         .         .    g.62881
 TCCCGAGAAG | ACGTGAATGAGTGTGCAGAGAACCCTGGCGTCTGCACTAACGGCGTCTGT    c.6300
 S  R  E  D |   V  N  E  C  A  E  N  P  G  V  C  T  N  G  V  C      p.2100

          .         .         .         .         .         .       g.62941
 GTCAACACCGATGGATCCTTCCGCTGTGAGTGTCCCTTTGGCTACAGCCTGGACTTCACT       c.6360
 V  N  T  D  G  S  F  R  C  E  C  P  F  G  Y  S  L  D  F  T         p.2120

          .       | 51 .         .         .         .         .    g.64366
 GGCATCAACTGTGTGG | ACACAGACGAGTGCTCTGTCGGCCACCCCTGTGGGCAAGGGACA    c.6420
 G  I  N  C  V  D |   T  D  E  C  S  V  G  H  P  C  G  Q  G  T      p.2140

          .         .         .         .         .         .       g.64426
 TGCACCAATGTCATCGGAGGCTTCGAATGTGCCTGTGCTGACGGCTTTGAGCCTGGCCTC       c.6480
 C  T  N  V  I  G  G  F  E  C  A  C  A  D  G  F  E  P  G  L         p.2160

          .       | 52 .         .         .         .         .    g.64598
 ATGATGACCTGCGAGG | ACATCGACGAATGCTCCCTGAACCCGCTGCTCTGTGCCTTCCGC    c.6540
 M  M  T  C  E  D |   I  D  E  C  S  L  N  P  L  L  C  A  F  R      p.2180

          .         .         .         .         .         .       g.64658
 TGCCACAATACCGAGGGCTCCTACCTGTGCACCTGTCCAGCCGGCTACACCCTGCGGGAG       c.6600
 C  H  N  T  E  G  S  Y  L  C  T  C  P  A  G  Y  T  L  R  E         p.2200

          .          | 53        .         .         .         .    g.65331
 GATGGGGCCATGTGTCGAG | ATGTGGACGAGTGTGCAGATGGTCAGCAGGACTGCCACGCC    c.6660
 D  G  A  M  C  R  D |   V  D  E  C  A  D  G  Q  Q  D  C  H  A      p.2220

          .         .         .         .         .         .       g.65391
 CGGGGCATGGAGTGCAAGAACCTCATCGGTACCTTCGCGTGCGTCTGTCCCCCAGGCATG       c.6720
 R  G  M  E  C  K  N  L  I  G  T  F  A  C  V  C  P  P  G  M         p.2240

          .         .         .     | 54   .         .         .    g.66202
 CGGCCCCTGCCTGGCTCTGGGGAGGGCTGCACAG | ATGACAATGAATGCCACGCTCAGCCT    c.6780
 R  P  L  P  G  S  G  E  G  C  T  D |   D  N  E  C  H  A  Q  P      p.2260

          .         .         .         .         .         .       g.66262
 GACCTCTGTGTCAACGGCCGCTGTGTCAACACCGCGGGCAGCTTCCGGTGCGACTGTGAT       c.6840
 D  L  C  V  N  G  R  C  V  N  T  A  G  S  F  R  C  D  C  D         p.2280

          .         .         .         . | 55       .         .    g.66952
 GAGGGATTCCAGCCCAGCCCCACCCTTACCGAGTGCCACG | ACATCCGGCAGGGGCCCTGC    c.6900
 E  G  F  Q  P  S  P  T  L  T  E  C  H  D |   I  R  Q  G  P  C      p.2300

          .         .         .         .         .         .       g.67012
 TTTGCCGAGGTGCTGCAGACCATGTGCCGGTCTCTGTCCAGCAGCAGTGAGGCTGTCACC       c.6960
 F  A  E  V  L  Q  T  M  C  R  S  L  S  S  S  S  E  A  V  T         p.2320

          .         .         .         .         .         .       g.67072
 AGGGCCGAGTGCTGCTGTGGGGGTGGCCGGGGCTGGGGGCCCCGCTGCGAGCTCTGTCCC       c.7020
 R  A  E  C  C  C  G  G  G  R  G  W  G  P  R  C  E  L  C  P         p.2340

          .         .         .         .         .         .       g.67132
 CTGCCCGGCACCTCTGCCTACAGGAAGCTGTGCCCCCATGGCTCAGGCTACACTGCTGAG       c.7080
 L  P  G  T  S  A  Y  R  K  L  C  P  H  G  S  G  Y  T  A  E         p.2360

         | 56.         .         .         .         .         .    g.69182
 GGCCGAG | ATGTAGATGAATGCCGTATGCTTGCTCACCTGTGTGCTCATGGGGAGTGCATC    c.7140
 G  R  D |   V  D  E  C  R  M  L  A  H  L  C  A  H  G  E  C  I      p.2380

          .         .         .         .         .         .       g.69242
 AACAGCCTTGGCTCCTTCCGCTGCCACTGTCAGGCCGGGTACACACCGGATGCTACTGCT       c.7200
 N  S  L  G  S  F  R  C  H  C  Q  A  G  Y  T  P  D  A  T  A         p.2400

          .    | 57    .         .         .         .         .    g.71068
 ACTACCTGCCTGG | ATATGGATGAGTGCAGCCAGGTCCCCAAGCCATGTACCTTCCTCTGC    c.7260
 T  T  C  L  D |   M  D  E  C  S  Q  V  P  K  P  C  T  F  L  C      p.2420

          .         .         .         .         .         .       g.71128
 AAAAACACGAAGGGCAGTTTCCTGTGCAGCTGTCCCCGAGGCTACCTGCTGGAGGAGGAT       c.7320
 K  N  T  K  G  S  F  L  C  S  C  P  R  G  Y  L  L  E  E  D         p.2440

          .       | 58 .         .         .         .         .    g.71426
 GGCAGGACCTGCAAAG | ACCTGGACGAATGCACCTCCCGGCAGCACAACTGTCAGTTCCTC    c.7380
 G  R  T  C  K  D |   L  D  E  C  T  S  R  Q  H  N  C  Q  F  L      p.2460

          .         .         .         .         .         .       g.71486
 TGTGTCAACACTGTGGGCGCCTTCACCTGCCGCTGTCCGCCCGGCTTCACCCAGCACCAC       c.7440
 C  V  N  T  V  G  A  F  T  C  R  C  P  P  G  F  T  Q  H  H         p.2480

          .    | 59    .         .         .         .         .    g.77137
 CAGGCCTGCTTCG | ACAATGATGAGTGCTCAGCCCAGCCTGGCCCATGTGGTGCCCACGGG    c.7500
 Q  A  C  F  D |   N  D  E  C  S  A  Q  P  G  P  C  G  A  H  G      p.2500

          .         .         .         .         .         .       g.77197
 CACTGCCACAACACCCCGGGCAGCTTCCGCTGTGAATGCCACCAAGGCTTCACCCTGGTC       c.7560
 H  C  H  N  T  P  G  S  F  R  C  E  C  H  Q  G  F  T  L  V         p.2520

          .         .   | 60     .         .         .         .    g.77349
 AGCTCAGGCCATGGCTGTGAAG | ATGTGAATGAATGTGATGGGCCCCACCGCTGCCAGCAT    c.7620
 S  S  G  H  G  C  E  D |   V  N  E  C  D  G  P  H  R  C  Q  H      p.2540

          .         .         .         .         .         .       g.77409
 GGCTGTCAGAACCAGCTAGGGGGCTACCGCTGCAGCTGCCCCCAGGGTTTCACCCAGCAC       c.7680
 G  C  Q  N  Q  L  G  G  Y  R  C  S  C  P  Q  G  F  T  Q  H         p.2560

          .         .   | 61     .         .         .         .    g.79242
 TCCCAGTGGGCCCAGTGTGTGG | ATGAGAATGAGTGTGCCCTGTCGCCCCCCACCTGCGGG    c.7740
 S  Q  W  A  Q  C  V  D |   E  N  E  C  A  L  S  P  P  T  C  G      p.2580

          .         .         .         .         .         .       g.79302
 AGCGCCTCCTGTCGCAACACTCTTGGTGGCTTCCGCTGCGTCTGCCCCTCTGGCTTTGAC       c.7800
 S  A  S  C  R  N  T  L  G  G  F  R  C  V  C  P  S  G  F  D         p.2600

          .         .         .         .         .         .       g.79362
 TTTGATCAGGCCCTCGGGGGCTGCCAGGAGGTGGATGAGTGCGCCGGACGGCGTGGCCCC       c.7860
 F  D  Q  A  L  G  G  C  Q  E  V  D  E  C  A  G  R  R  G  P         p.2620

          .         .         .         .         .         .       g.79422
 TGTAGCTACAGCTGTGCCAACACGCCTGGTGGCTTCCTGTGCGGCTGTCCTCAAGGCTAC       c.7920
 C  S  Y  S  C  A  N  T  P  G  G  F  L  C  G  C  P  Q  G  Y         p.2640

          .        | 62.         .         .         .         .    g.80346
 TTCCGGGCTGGGCAAGG | GCACTGTGTCTCCGGCCTGGGCTTCAGCCCCGGACCCCAGGAC    c.7980
 F  R  A  G  Q  G  |  H  C  V  S  G  L  G  F  S  P  G  P  Q  D      p.2660

          .         .         .         .         .         .       g.80406
 ACCCCGGACAAAGAGGAGCTGCTCTCGTCTGAAGCCTGCTACGAATGCAAGATCAATGGC       c.8040
 T  P  D  K  E  E  L  L  S  S  E  A  C  Y  E  C  K  I  N  G         p.2680

          .         .         .         .         | 63         .    g.86253
 CTCTCCCCTCGGGACCGGCCACGACGCAGTGCCCACAGGGACCACCAG | GTGAACCTGGCC    c.8100
 L  S  P  R  D  R  P  R  R  S  A  H  R  D  H  Q   | V  N  L  A      p.2700

          .         .         .         .         .         .       g.86313
 ACCCTTGACTCCGAGGCCCTGCTGACCTTGGGCCTGAACCTCTCACACCTGGGCCGGGCC       c.8160
 T  L  D  S  E  A  L  L  T  L  G  L  N  L  S  H  L  G  R  A         p.2720

          .         .         .         .         .         .       g.86373
 GAGCGCATCCTGGAGCTCCGGCCGGCCCTGGAGGGTCTAGAGGGCCGGATCCGCTACGTC       c.8220
 E  R  I  L  E  L  R  P  A  L  E  G  L  E  G  R  I  R  Y  V         p.2740

          .         .         .         .         .         .       g.86433
 ATCGTCCGCGGAAACGAGCAAGGTTTCTTTCGCATGCATCACCTCCGTGGCGTCAGCTCC       c.8280
 I  V  R  G  N  E  Q  G  F  F  R  M  H  H  L  R  G  V  S  S         p.2760

          .         .         .         .         .         .       g.86493
 CTGCAGCTGGGGCGGAGGCGGCCGGGGCCTGGAACCTACCGGCTGGAGGTGGTGAGCCAC       c.8340
 L  Q  L  G  R  R  R  P  G  P  G  T  Y  R  L  E  V  V  S  H         p.2780

          .         .         .         .         .         .       g.86553
 ATGGCAGGACCCTGGGGTGTCCAGCCAGAGGGGCAGCCAGGGCCATGGGGCCAGGCCTTG       c.8400
 M  A  G  P  W  G  V  Q  P  E  G  Q  P  G  P  W  G  Q  A  L         p.2800

          .         .         .                                     g.86583
 AGGCTGAAGGTGCAGCTGCAGTTGCTTTAG                                     c.8430
 R  L  K  V  Q  L  Q  L  L  X                                       p.2809

          .         .         .         .         .         .       g.86643
 ttgggaggagcctcagtgggccccagctgtccagagaagggggattctggaactgggaag       c.*60

          .         .         .         .         .         .       g.86703
 gactgatccccagaagcgatggctgaccagattgaaccccgaaactcaggaagagtgaaa       c.*120

          .         .         .         .         .         .       g.86763
 tgctacacgacaacctcaggcaagcccggcctctgcctgggcctctgtgccagccccggg       c.*180

          .         .         .         .         .         .       g.86823
 ggccccccagttactcagtctttcctggagacagcaagaagctgcaatgtgcaatccccc       c.*240

          .         .         .         .         .         .       g.86883
 tgcccccacagccaaggtcaggaagaggccctgtggtcaccgtgtctggccaatctcagg       c.*300

          .         .         .         .         .         .       g.86943
 ctttcacttctgtactgcactgtggcttgccctggcggggggcagggggttggcaggaca       c.*360

          .         .         .         .         .         .       g.87003
 tggcaatgggcaactggggtgggcacagggcttattcctcggagtagaagggtgtacagg       c.*420

          .         .         .         .         .         .       g.87063
 gggcccagactccacagtgacttgccacatttgccccccatttggagaatgcttttatat       c.*480

          .         .         .                                     g.87099
 caaaagtggagacgataataaagttattttgggtta                               c.*516

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fibrillin 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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