F-box and leucine-rich repeat protein 4 (FBXL4) - coding DNA reference sequence

(used for variant description)

(last modified July 21, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_012160.4 in the FBXL4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033903.1, covering FBXL4 transcript NM_012160.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.4998
                              ctcctccccggctccgccccgcctccccggg       c.-361

 .         .         .         .         .         .                g.5058
 cccgccgctcctcgcggcctccgcgtcttccttccgggtcgcgctaggccgggcttgcgg       c.-301

 .         .         .         .         .         .                g.5118
 cggttgtgccgcatctagagagtcggggagccgcccccgcacccaggccttctcgcgctg       c.-241

 .         .         .         .         .          | 02            g.25161
 cctggtcgctggtgaagcccgcggcgcgcgcctctcccggaccctgcagg | gtaaaagaat    c.-181

 .         .         .         .         .         .                g.25221
 gtcacatgtcagcatttgtacctgaagtcagcatgcaaagttcagggtacctggatgaat       c.-121

 .         .         .         .         .        | 03.             g.25925
 gccaacttttgcatttcccatgtgtatcctgtgaccattctatctggg | aacatccttcaa    c.-61

 .         .         .         .         .         .                g.25985
 agagttcatgcatcttactgaggacacctgaccttttgaagcttcataattcacatctag       c.-1

          .         .         .         .         .         .       g.26045
 ATGTCACCGGTCTTTCCCATGTTAACAGTTCTGACCATGTTTTATTATATATGCCTTCGG       c.60
 M  S  P  V  F  P  M  L  T  V  L  T  M  F  Y  Y  I  C  L  R         p.20

          .         .         .         .         .         .       g.26105
 CGCCGAGCCAGGACAGCTACAAGAGGAGAAATGATGAACACCCATAGAGCTATAGAATCA       c.120
 R  R  A  R  T  A  T  R  G  E  M  M  N  T  H  R  A  I  E  S         p.40

          .         .         .         .         .         .       g.26165
 AACAGCCAGACTTCCCCTCTCAATGCAGAGGTAGTCCAGTATGCCAAAGAAGTAGTGGAT       c.180
 N  S  Q  T  S  P  L  N  A  E  V  V  Q  Y  A  K  E  V  V  D         p.60

          .         .         .         .         .         .       g.26225
 TTCAGTTCCCATTATGGAAGTGAGAATAGTATGTCCTATACTATGTGGAATTTGGCTGGT       c.240
 F  S  S  H  Y  G  S  E  N  S  M  S  Y  T  M  W  N  L  A  G         p.80

          .         .         .         .         .         .       g.26285
 GTACCAAATGTATTCCCAAGTTCTGGTGACTTTACTCAGACAGCTGTGTTTCGAACTTAT       c.300
 V  P  N  V  F  P  S  S  G  D  F  T  Q  T  A  V  F  R  T  Y         p.100

          .         .         .         .         .         .       g.26345
 GGGACATGGTGGGATCAGTGTCCTAGTGCTTCCTTGCCATTCAAGAGGACGCCACCTAAT       c.360
 G  T  W  W  D  Q  C  P  S  A  S  L  P  F  K  R  T  P  P  N         p.120

          .         .         .         .         .         .       g.26405
 TTTCAGAGCCAGGACTATGTGGAACTTACTTTTGAACAACAGGTGTATCCTACAGCTGTA       c.420
 F  Q  S  Q  D  Y  V  E  L  T  F  E  Q  Q  V  Y  P  T  A  V         p.140

          .         .         .         .         .         .       g.26465
 CATGTTCTAGAAACCTATCATCCCGGAGCAGTCATTAGAATTCTCGCTTGTTCTGCAAAT       c.480
 H  V  L  E  T  Y  H  P  G  A  V  I  R  I  L  A  C  S  A  N         p.160

          .         .         .   | 04     .         .         .    g.35282
 CCTTATTCCCCAAATCCACCAGCTGAAGTAAG | ATGGGAGATTCTTTGGTCAGAGAGACCT    c.540
 P  Y  S  P  N  P  P  A  E  V  R  |  W  E  I  L  W  S  E  R  P      p.180

          .         .         .         .         .         .       g.35342
 ACGAAGGTGAATGCTTCCCAAGCTCGCCAGTTTAAACCTTGTATTAAGCAGATAAATTTC       c.600
 T  K  V  N  A  S  Q  A  R  Q  F  K  P  C  I  K  Q  I  N  F         p.200

          .         .         .         .         .         .       g.35402
 CCCACAAATCTTATACGACTGGAAGTAAATAGTTCTCTTCTGGAATATTACACTGAATTA       c.660
 P  T  N  L  I  R  L  E  V  N  S  S  L  L  E  Y  Y  T  E  L         p.220

          .         .         .         .         .         .       g.35462
 GATGCAGTTGTGCTACATGGTGTGAAGGACAAGCCAGTGCTTTCTCTCAAGACTTCACTT       c.720
 D  A  V  V  L  H  G  V  K  D  K  P  V  L  S  L  K  T  S  L         p.240

          .         .         .         .         .         .       g.35522
 ATTGACATGAATGATATAGAAGATGATGCCTATGCAGAAAAGGATGGTTGTGGAATGGAC       c.780
 I  D  M  N  D  I  E  D  D  A  Y  A  E  K  D  G  C  G  M  D         p.260

          .         .         .         .         .         .       g.35582
 AGTCTTAACAAAAAGTTTAGCAGTGCTGTCCTCGGGGAAGGGCCAAATAATGGGTATTTT       c.840
 S  L  N  K  K  F  S  S  A  V  L  G  E  G  P  N  N  G  Y  F         p.280

          .         | 05         .         .         .         .    g.47345
 GATAAACTACCTTATGAG | CTTATTCAGCTGATTCTGAATCATCTTACACTACCAGACCTG    c.900
 D  K  L  P  Y  E   | L  I  Q  L  I  L  N  H  L  T  L  P  D  L      p.300

          .         .         .         .         .         .       g.47405
 TGTAGATTAGCACAGACTTGCAAACTACTGAGCCAGCATTGCTGTGATCCTCTGCAATAC       c.960
 C  R  L  A  Q  T  C  K  L  L  S  Q  H  C  C  D  P  L  Q  Y         p.320

          .         .         .         .         .         .       g.47465
 ATCCACCTCAATCTGCAACCATACTGGGCAAAACTAGATGACACTTCTCTGGAATTTCTA       c.1020
 I  H  L  N  L  Q  P  Y  W  A  K  L  D  D  T  S  L  E  F  L         p.340

          .         .         .         .         .         .       g.47525
 CAGTCTCGCTGCACTCTTGTCCAGTGGCTTAATTTATCTTGGACTGGCAATAGAGGCTTC       c.1080
 Q  S  R  C  T  L  V  Q  W  L  N  L  S  W  T  G  N  R  G  F         p.360

          .         .    | 06    .         .         .         .    g.53529
 ATCTCTGTTGCAGGATTTAGCAG | GTTTCTGAAGGTTTGTGGATCCGAATTAGTACGCCTT    c.1140
 I  S  V  A  G  F  S  R  |  F  L  K  V  C  G  S  E  L  V  R  L      p.380

          .         .         .         .         .         .       g.53589
 GAATTGTCTTGCAGCCACTTTCTTAATGAAACTTGCTTAGAAGTTATTTCTGAGATGTGT       c.1200
 E  L  S  C  S  H  F  L  N  E  T  C  L  E  V  I  S  E  M  C         p.400

          .         .         .         .         .         .       g.53649
 CCAAATCTACAGGCCTTAAATCTCTCCTCCTGTGATAAGCTACCACCTCAAGCTTTCAAC       c.1260
 P  N  L  Q  A  L  N  L  S  S  C  D  K  L  P  P  Q  A  F  N         p.420

          .         .         .         .         .        | 07.    g.72352
 CACATTGCCAAGTTATGCAGCCTTAAACGACTTGTTCTCTATCGAACAAAAGTAGAG | CAA    c.1320
 H  I  A  K  L  C  S  L  K  R  L  V  L  Y  R  T  K  V  E   | Q      p.440

          .         .         .         .         .         .       g.72412
 ACAGCACTGCTCAGCATTTTGAACTTCTGTTCAGAGCTTCAGCACCTCAGTTTAGGCAGT       c.1380
 T  A  L  L  S  I  L  N  F  C  S  E  L  Q  H  L  S  L  G  S         p.460

           | 08        .         .         .         .         .    g.77297
 TGTGTCATG | ATTGAAGACTATGATGTGATAGCTAGCATGATAGGAGCCAAGTGTAAAAAA    c.1440
 C  V  M   | I  E  D  Y  D  V  I  A  S  M  I  G  A  K  C  K  K      p.480

          .         .         .         .         .         .       g.77357
 CTCCGGACCCTGGATCTGTGGAGATGTAAGAATATTACTGAGAATGGAATAGCAGAACTG       c.1500
 L  R  T  L  D  L  W  R  C  K  N  I  T  E  N  G  I  A  E  L         p.500

          .         .         .         .         .         .       g.77417
 GCTTCTGGGTGTCCACTACTGGAGGAGCTTGACCTTGGCTGGTGCCCAACTCTGCAGAGC       c.1560
 A  S  G  C  P  L  L  E  E  L  D  L  G  W  C  P  T  L  Q  S         p.520

          .         .         .         .         .         .       g.77477
 AGCACCGGGTGCTTCACCAGACTGGCACACCAGCTCCCAAACTTGCAAAAACTCTTTCTT       c.1620
 S  T  G  C  F  T  R  L  A  H  Q  L  P  N  L  Q  K  L  F  L         p.540

          .         .         .         .         .         .       g.77537
 ACAGCTAATAGATCTGTGTGTGACACAGACATTGATGAATTGGCATGTAATTGTACCAGG       c.1680
 T  A  N  R  S  V  C  D  T  D  I  D  E  L  A  C  N  C  T  R         p.560

          .         .   | 09     .         .         .         .    g.78570
 TTACAGCAGCTGGACATATTAG | GAACAAGAATGGTAAGTCCGGCATCCTTAAGAAAACTC    c.1740
 L  Q  Q  L  D  I  L  G |   T  R  M  V  S  P  A  S  L  R  K  L      p.580

          .         .         .         .         .         .       g.78630
 CTGGAATCTTGTAAAGATCTTTCTTTACTTGATGTGTCCTTCTGTTCGCAGATTGATAAC       c.1800
 L  E  S  C  K  D  L  S  L  L  D  V  S  F  C  S  Q  I  D  N         p.600

          .         .         .         .         .         .       g.78690
 AGAGCTGTGCTAGAACTGAATGCAAGCTTTCCAAAAGTGTTCATAAAAAAGAGCTTTACT       c.1860
 R  A  V  L  E  L  N  A  S  F  P  K  V  F  I  K  K  S  F  T         p.620

                                                                    g.78696
 CAGTGA                                                             c.1866
 Q  X                                                               p.621

          .         .         .         .         .         .       g.78756
 cttaatatatgttctgtattaaaattaatgtgctttgttggggtttaattttgggattgg       c.*60

          .         .         .         .         .         .       g.78816
 ttttgggttttgtttttagttgttttaatggtaagaattaagacatttgtagattttaaa       c.*120

          .         .         .         .         .         .       g.78876
 gaaaaatatgaaattgtccattaaatcaagtaaaaatgtgcacaaatgttttcataaaat       c.*180

          .         .         .         .         .         .       g.78936
 actgcaagcacttctcttcaagaatatgagtggatattatttttaccttatgttaatcag       c.*240

          .         .         .         .         .         .       g.78996
 tgatatgctttagtcaataatatgattgataaaagaataacatggaatcatgctaactta       c.*300

          .         .         .         .         .         .       g.79056
 ttttcaaaggaacactgagcaataaagtatcgtggcatttatgcaaaaaaaaaagttaat       c.*360

          .         .         .         .         .         .       g.79116
 tttttacaccttcatgtaaggatgtcttattaagcctgtgacctggcaagtgttttgttt       c.*420

          .         .         .         .         .         .       g.79176
 ggtatgtacaaaatggtcagagctagttggagaatgagacatgcttttccagctgtttgg       c.*480

          .         .         .         .         .         .       g.79236
 ttatttctctggattaactgttcaactggaaaatttttagtttttctagccaggtgtggt       c.*540

          .                                                         g.79249
 ggcacacacttgt                                                      c.*553

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The F-box and leucine-rich repeat protein 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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