F-box and WD repeat domain containing 10 (FBXW10) - coding DNA reference sequence

(used for variant description)

(last modified June 21, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001267585.1 in the FBXW10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering FBXW10 transcript NM_001267585.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         acggtaaagccatgtttccaaggaggtctgtacaaaaagccagacttctgct       c.-181

 .         .         .         .         .         .                g.5112
 ggcagttactgagagagataggctttccatccatggcagccatttacttttgctctggga       c.-121

 .         .         .         .         .         .                g.5172
 gacgtttgtaatagaaaaggcacaactggggtatttattcattccccccgttcctctagt       c.-61

 .         .         .         .         .         .                g.5232
 gtttggtggcgttgccgttgcaagtgcgcagggctaaaatggactggttatcttaggatc       c.-1

          .         .         .         .         .         .       g.5292
 ATGGAAAACCTGGAATCAAGGCTCAAGAATGCCCCCTATTTTCGTTGTGAGAAGGGAACC       c.60
 M  E  N  L  E  S  R  L  K  N  A  P  Y  F  R  C  E  K  G  T         p.20

          .         .         .         .         .         .       g.5352
 GATTCCATCCCTCTATGCCGGAAGTGTGAGACGTGTGTCTTAGCCTGGAAGATCTTCTCT       c.120
 D  S  I  P  L  C  R  K  C  E  T  C  V  L  A  W  K  I  F  S         p.40

          .         .         .         .         .         .       g.5412
 ACCAAAGAGTGGTTCTGCAGGATCAATGACATATCACAGAGGAGGTTTCTAGTTGGCATT       c.180
 T  K  E  W  F  C  R  I  N  D  I  S  Q  R  R  F  L  V  G  I         p.60

          .         .         .         .         .         .       g.5472
 CTGAAGCAGTTAAATAGCTTATATTTGTTACACTATTTCCAAAATATCCTTCAGACCACA       c.240
 L  K  Q  L  N  S  L  Y  L  L  H  Y  F  Q  N  I  L  Q  T  T         p.80

          .         .         .         .         .         .       g.5532
 CAGGGAAAGGATTTCATCTATAACAGGTCCCGGATCAACCTCAGCAAGAAAGAGGGGAAA       c.300
 Q  G  K  D  F  I  Y  N  R  S  R  I  N  L  S  K  K  E  G  K         p.100

          .         .         .         .         .         .       g.5592
 GTTGTGAAGTCCTCCTTGAACCAAATGTTGGATAAAACAGTAGAACAGAAGATGAAAGAG       c.360
 V  V  K  S  S  L  N  Q  M  L  D  K  T  V  E  Q  K  M  K  E         p.120

          .         .         .         .         .         .       g.5652
 ATCTTGTACTGGTTTGCGAACAGCACCCAGTGGACCAAGGCGAATTATACTCTCTTACTG       c.420
 I  L  Y  W  F  A  N  S  T  Q  W  T  K  A  N  Y  T  L  L  L         p.140

          .         .         .         .         .         .       g.5712
 CTGCAGATGTGCAACCCCAAATTACTGCTCACTGCTGCCAATGTGATCAGAGTCCTGTTT       c.480
 L  Q  M  C  N  P  K  L  L  L  T  A  A  N  V  I  R  V  L  F         p.160

          .         .      | 02  .         .         .         .    g.8963
 CTGAGAGAGGAGAACAATATCTCAG | GGCTCAATCAAGACATCACAGATGTGTGTTTTTCC    c.540
 L  R  E  E  N  N  I  S  G |   L  N  Q  D  I  T  D  V  C  F  S      p.180

          .         .         .         .         .         .       g.9023
 CCTGAGAAAGACCACAGCTCCAAGTCTGCGACCTCACAAGTCTATTGGACAGCCAAAACT       c.600
 P  E  K  D  H  S  S  K  S  A  T  S  Q  V  Y  W  T  A  K  T         p.200

          .         .         .         .         .         .       g.9083
 CAGCACACATCCCTTCCTTTGTCCAAAGCCCCAGAAAATGAACACTTGCTTGGGGCAGCA       c.660
 Q  H  T  S  L  P  L  S  K  A  P  E  N  E  H  L  L  G  A  A         p.220

          . | 03       .         .         .         .         .    g.10759
 TCTAACCCTG | AGGAACCATGGAGGAATTCACTCCGGTGTATATCCGAAATGAATAGGCTG    c.720
 S  N  P  E |   E  P  W  R  N  S  L  R  C  I  S  E  M  N  R  L      p.240

          .         .         .         .         .         .       g.10819
 TTTTCTGGAAAAGGAGACATAACCAAGCCAGGGTACGATCCCTGCAATCTATTGGTTGAC       c.780
 F  S  G  K  G  D  I  T  K  P  G  Y  D  P  C  N  L  L  V  D         p.260

          .         .         .         .         .         .       g.10879
 CTGGATGACATCAGAGACCTGTCTTCTGGGTTCAGCAAATACCGAGACTTCATCCGTTAC       c.840
 L  D  D  I  R  D  L  S  S  G  F  S  K  Y  R  D  F  I  R  Y         p.280

          .         .         .  | 04      .         .         .    g.11026
 CTGCCCATCCACCTCTCCAAGTACATTCTAA | GAATGCTGGATAGACACACCCTGAACAAG    c.900
 L  P  I  H  L  S  K  Y  I  L  R |   M  L  D  R  H  T  L  N  K      p.300

          .         .         .         .         .         .       g.11086
 TGCGCCTCTGTGAGCCAGCACTGGGCCGCCATGGCTCAACAGGTCAAGATGGACTTGTCA       c.960
 C  A  S  V  S  Q  H  W  A  A  M  A  Q  Q  V  K  M  D  L  S         p.320

          .         .         .          | 05        .         .    g.11939
 GCGCACGGCTTCATTCAGAACCAGATTACCTTCTTGCAG | GGGTCCTACACAAGAGGAATT    c.1020
 A  H  G  F  I  Q  N  Q  I  T  F  L  Q   | G  S  Y  T  R  G  I      p.340

          .         .         .         .         .         .       g.11999
 GATCCTAATTATGCCAATAAGGTTTCTATCCCAGTTCCTAAAATGGTAGATGACGGGAAG       c.1080
 D  P  N  Y  A  N  K  V  S  I  P  V  P  K  M  V  D  D  G  K         p.360

          .         .         .         .   | 06     .         .    g.17050
 AGCATGCGTGTGAAACATCCGAAGTGGAAGCTGAGAACGAAG | AATGAGTACAACCTGTGG    c.1140
 S  M  R  V  K  H  P  K  W  K  L  R  T  K   | N  E  Y  N  L  W      p.380

          .         .         .         .         .         .       g.17110
 ACTGCATACCAGAACGAGGAAACGCAGCAGGTCCTGATAGAGGAGAGAAATGTTTTCTGT       c.1200
 T  A  Y  Q  N  E  E  T  Q  Q  V  L  I  E  E  R  N  V  F  C         p.400

          .         .         .   | 07     .         .         .    g.19320
 GGGACCTACAATGTTCGCATTCTCTCTGACAC | GTGGGATCAAAACCGAGTCATCCACTAT    c.1260
 G  T  Y  N  V  R  I  L  S  D  T  |  W  D  Q  N  R  V  I  H  Y      p.420

          .         .         .         .         .         .       g.19380
 TCCGGGGGAGATCTGATAGCTGTGTCATCTAATCGAAAGATCCATCTTCTGGACATCATA       c.1320
 S  G  G  D  L  I  A  V  S  S  N  R  K  I  H  L  L  D  I  I         p.440

          .         .         .         .         .         .       g.19440
 CAAGTGAAAGCGATACCCGTTGAATTCCGAGGCCATGCTGGGAGTGTCCGGGCCCTCTTC       c.1380
 Q  V  K  A  I  P  V  E  F  R  G  H  A  G  S  V  R  A  L  F         p.460

          .         .         .         .         .    | 08    .    g.25736
 CTGTGTGAGGAGGAAAACTTTCTCCTAAGCGGGAGCTATGACCTAAGTATCAG | ATACTGG    c.1440
 L  C  E  E  E  N  F  L  L  S  G  S  Y  D  L  S  I  R  |  Y  W      p.480

          .         .         .         .         .         .       g.25796
 GATCTGAAAAGTGGGGTTTGCACACGAATCTTCGGTGGTCACCAGGGGACTATCACTTGC       c.1500
 D  L  K  S  G  V  C  T  R  I  F  G  G  H  Q  G  T  I  T  C         p.500

          .         .         .         .         .      | 09  .    g.27706
 ATGGACTTGTGTAAGAACAGGCTCGTATCTGGAGGAAGAGATTGCCAGGTAAAAG | TATGG    c.1560
 M  D  L  C  K  N  R  L  V  S  G  G  R  D  C  Q  V  K  V |   W      p.520

          .         .         .         .         .         .       g.27766
 GATGTAGACACAGGGAAGTGCCTGAAGACGTTTAGACACAAAGACCCCATCTTGGCCACC       c.1620
 D  V  D  T  G  K  C  L  K  T  F  R  H  K  D  P  I  L  A  T         p.540

          .         .         .         .         .         .       g.27826
 AGGATCAATGATACCTACATTGTGAGCAGCTGTGAGCGAGGGCTGGTGAAAGTGTGGCAC       c.1680
 R  I  N  D  T  Y  I  V  S  S  C  E  R  G  L  V  K  V  W  H         p.560

          .         .     | 10   .         .         .         .    g.29557
 ATTGCCATGGCCCAGTTGGTAAAG | ACTCTCAGTGGCCATGAGGGAGCCGTGAAATGCCTG    c.1740
 I  A  M  A  Q  L  V  K   | T  L  S  G  H  E  G  A  V  K  C  L      p.580

          .         .         .         .         .         .       g.29617
 TTCTTTGACCAGTGGCATCTCCTCTCAGGAAGTACTGATGGCCTGGTCATGGCCTGGAGC       c.1800
 F  F  D  Q  W  H  L  L  S  G  S  T  D  G  L  V  M  A  W  S         p.600

          .         .         .         .        | 11.         .    g.30927
 ATGGTGGGGAAGTACGAGCGCTGCCTGATGGCCTTCAAGCATCCCAA | GGAGGTGCTCGAC    c.1860
 M  V  G  K  Y  E  R  C  L  M  A  F  K  H  P  K  |  E  V  L  D      p.620

          .         .         .         .         .         .       g.30987
 GTGTCCCTTCTCTTCCTCCGGGTCATCAGCGCCTGTGCAGATGGCAAGATCCGAATTTAC       c.1920
 V  S  L  L  F  L  R  V  I  S  A  C  A  D  G  K  I  R  I  Y         p.640

          .         .         .         .         .         .       g.31047
 AATTTCCTCAACGGGAACTGTATGAAGGTGTTAAAAGCCAATGGCAGAGGTGATCCTGTG       c.1980
 N  F  L  N  G  N  C  M  K  V  L  K  A  N  G  R  G  D  P  V         p.660

          .         .       | 12 .         .         .         .    g.33433
 CTGTCCTTCTTTATTCAGGGCAACAG | GATGGTGGTCAACACAGAGAGCAATGTTCTCATG    c.2040
 L  S  F  F  I  Q  G  N  R  |  M  V  V  N  T  E  S  N  V  L  M      p.680

          .         .         .         .         .         .       g.33493
 TTCCAGTTTGAGCACATAAAGTGGCAGTATGCCGTGGAAAAAACGAAACAAAAGAAGAAT       c.2100
 F  Q  F  E  H  I  K  W  Q  Y  A  V  E  K  T  K  Q  K  K  N         p.700

          .         .         .         .         .         .       g.33553
 AAGGAGAAAGAGGAGGAAAAAGAAGAAAATAGTCTCATGGAAATTCTCTCTAAGTGTAAT       c.2160
 K  E  K  E  E  E  K  E  E  N  S  L  M  E  I  L  S  K  C  N         p.720

          .         .         .         .         .         .       g.33613
 ATTCAGGTTCACAGCCCAAGAGAGTCTGTATCCAGTAAACAAACTGTGATCCAAGAGCTC       c.2220
 I  Q  V  H  S  P  R  E  S  V  S  S  K  Q  T  V  I  Q  E  L         p.740

          .         .         .         .         .         | 13    g.36125
 CTACCAGGCAAACCTCCCAAGTCCCGAGTACTCCTGAAGCCGGCCAAGTTCTCTTCAG | CA    c.2280
 L  P  G  K  P  P  K  S  R  V  L  L  K  P  A  K  F  S  S  A |       p.760

          .         .         .         .         .      | 14  .    g.39467
 GTGTTAATAGAGGAACTTCAAAGTCAAGGAAAGTCAAAATCACCCCGAAGAGATG | CAGAT    c.2340
 V  L  I  E  E  L  Q  S  Q  G  K  S  K  S  P  R  R  D  A |   D      p.780

          .         .         .         .         .         .       g.39527
 GATGTGGAGAAAGCACAAAAACAAGGACAATTGGAAACTCCTGGAAAACTGCCCAGTCAC       c.2400
 D  V  E  K  A  Q  K  Q  G  Q  L  E  T  P  G  K  L  P  S  H         p.800

          .         .         .         .         .         .       g.39587
 CCAAAGAAAAAGTCTTGGAAAATCCCTATGTCACCTGACCAATTCCTCCTGACTGTTAGC       c.2460
 P  K  K  K  S  W  K  I  P  M  S  P  D  Q  F  L  L  T  V  S         p.820

          .         .         .         .         .         .       g.39647
 GCCCTGCAGCACGCCCATAATTCCGGGGAATTTGCCTATCCCTGTAGGCCCCAAACAGAA       c.2520
 A  L  Q  H  A  H  N  S  G  E  F  A  Y  P  C  R  P  Q  T  E         p.840

          .         .         .         .         .         .       g.39707
 ATTACTGATGTCTGGGGACCTTCAATTTCATACCCAAGGAAGGTCTTGAATTTCAAAGGA       c.2580
 I  T  D  V  W  G  P  S  I  S  Y  P  R  K  V  L  N  F  K  G         p.860

          .         .         .         .         .         .       g.39767
 AAATCAATCCAACGTGCAGTTGATCGGTTGAGATTGAGCAATCCTCCTATAGATGTGAAA       c.2640
 K  S  I  Q  R  A  V  D  R  L  R  L  S  N  P  P  I  D  V  K         p.880

          .         .         .         .         .         .       g.39827
 CGAACCAGTATTCCCCTTGAAATCCAGAAACTGCAGCCCAACTTGAAGATCTCTTTGCAC       c.2700
 R  T  S  I  P  L  E  I  Q  K  L  Q  P  N  L  K  I  S  L  H         p.900

          .         .         .         .         .         .       g.39887
 AGTCCTAGAGTCCAGTCCACCATACCCCAGCCCATGATTATCCGCTCCAGGTTCTCTGGC       c.2760
 S  P  R  V  Q  S  T  I  P  Q  P  M  I  I  R  S  R  F  S  G         p.920

          .         .         .         .         .         .       g.39947
 AGCTTAAAGGGTGGAGACCAAGTGACCAGTTCAATTGAAAGGGCTGTGTGCAGTACGGGT       c.2820
 S  L  K  G  G  D  Q  V  T  S  S  I  E  R  A  V  C  S  T  G         p.940

          .         .         .         .         .         .       g.40007
 CCCCTGACCAGTATGCAGGTCATTAAACCAAACCGCATGCTAGCTCCACAAGTGGGCACA       c.2880
 P  L  T  S  M  Q  V  I  K  P  N  R  M  L  A  P  Q  V  G  T         p.960

          .         .         .         .         .         .       g.40067
 GCCACCCTGTCTCTTAAGAAAGAACGGCCTCGCATCTATACAGCCCTTGATCCTTTTAGA       c.2940
 A  T  L  S  L  K  K  E  R  P  R  I  Y  T  A  L  D  P  F  R         p.980

          .         .         .         .         .         .       g.40127
 GTGAACACTGAGTTCGTGCTGTTGACCGTGAAGGAGGAGAAGGAGCACCAGGAAGCCAAG       c.3000
 V  N  T  E  F  V  L  L  T  V  K  E  E  K  E  H  Q  E  A  K         p.1000

          .         .         .         .         .         .       g.40187
 ATGAAGGAATATCAGGCCAGGGAGTCCACTGGAGTGGTTGATCCAGGAAAAGTCAGCAAA       c.3060
 M  K  E  Y  Q  A  R  E  S  T  G  V  V  D  P  G  K  V  S  K         p.1020

          .         .         .         .         .         .       g.40247
 GCTGCATGGATCAGGAAGATCAAAGGCCTGCCTATTGATAATTTCACGAAGCAAGGGAAA       c.3120
 A  A  W  I  R  K  I  K  G  L  P  I  D  N  F  T  K  Q  G  K         p.1040

          .         .         .                                     g.40286
 ACAGCGGCCCCTGAACTTGGACAAAATGTATTTATCTAA                            c.3159
 T  A  A  P  E  L  G  Q  N  V  F  I  X                              p.1052

          .         .         .         .         .                 g.40337
 accagccttgggaaattacaatgttttacaataaacagaaagccaagcgga                c.*51

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The F-box and WD repeat domain containing 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center