F-box and WD repeat domain containing 11 (FBXW11) - coding DNA reference sequence

(used for variant description)

(last modified August 11, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_012300.2 in the FBXW11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009275.2, covering FBXW11 transcript NM_012300.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5011
                                                  gtagtcgtggc       c.-361

 .         .         .         .         .         .                g.5071
 gctctcgaggccctgccatgagcaagctcttaactcttcaggtctgcacgtcctacgccc       c.-301

 .         .         .         .         .         .                g.5131
 accgtccagtgctactctcagctcggagttcagcttcgggctgccaagagccagcaacct       c.-241

 .         .         .         .         .         .                g.5191
 ggtgtcagaggctcggtcccacaacgctctgcgggccgcggcgcctgctgggaggtgtag       c.-181

 .         .         .         .         .         .                g.5251
 tccccgatctgcgtactgcgttcgccgagggggagggcggagctgccggcggcccgggcg       c.-121

 .         .         .         .         .         .                g.5311
 ggctggcagctagagtgggtgcgatagccgcctccgcctctgccgcctccgccgtcgcct       c.-61

 .         .         .         .         .         .                g.5371
 cctccgcccgggccgttcgctgctgcgcggggagagcgaggcggggccgccggggccgcc       c.-1

          .         .         .         .      | 02  .         .    g.54190
 ATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATG | TGTTCTGTGCCAAGG    c.60
 M  E  P  D  S  V  I  E  D  K  T  I  E  L  M   | C  S  V  P  R      p.20

          .         .         .         .         .         .       g.54250
 TCTTTGTGGCTAGGCTGCGCCAACCTGGTAGAGAGCATGTGCGCACTGAGTTGCCTGCAG       c.120
 S  L  W  L  G  C  A  N  L  V  E  S  M  C  A  L  S  C  L  Q         p.40

          .         .        | 03.         .         .         .    g.101109
 AGCATGCCCAGTGTCAGATGTCTCCAG | ATAAGTAATGGAACATCATCTGTGATCGTCTCC    c.180
 S  M  P  S  V  R  C  L  Q   | I  S  N  G  T  S  S  V  I  V  S      p.60

          .         .         .         .         .         .       g.101169
 AGAAAGAGGCCATCAGAAGGAAACTATCAAAAAGAAAAAGACTTGTGTATTAAATATTTT       c.240
 R  K  R  P  S  E  G  N  Y  Q  K  E  K  D  L  C  I  K  Y  F         p.80

          .         .         .         .         .         .       g.101229
 GACCAGTGGTCTGAATCAGATCAAGTGGAATTTGTGGAACATCTTATTTCACGAATGTGT       c.300
 D  Q  W  S  E  S  D  Q  V  E  F  V  E  H  L  I  S  R  M  C         p.100

          .         .         .         .         .         .       g.101289
 CATTATCAGCATGGACATATTAACTCTTACCTGAAGCCCATGTTGCAGCGGGACTTTATT       c.360
 H  Y  Q  H  G  H  I  N  S  Y  L  K  P  M  L  Q  R  D  F  I         p.120

          .    | 04    .         .         .         .         .    g.111820
 ACCGCTTTACCAG | AGCAAGGCTTAGATCACATAGCAGAAAACATTCTTTCGTACCTGGAT    c.420
 T  A  L  P  E |   Q  G  L  D  H  I  A  E  N  I  L  S  Y  L  D      p.140

          .         .         .         .         .         .       g.111880
 GCCAGGTCTCTGTGTGCAGCAGAGCTGGTATGTAAAGAATGGCAGCGAGTGATCTCAGAA       c.480
 A  R  S  L  C  A  A  E  L  V  C  K  E  W  Q  R  V  I  S  E         p.160

          .         .         .         .         .         .       g.111940
 GGAATGCTTTGGAAGAAGCTGATTGAACGAATGGTACGCACTGATCCCCTATGGAAAGGA       c.540
 G  M  L  W  K  K  L  I  E  R  M  V  R  T  D  P  L  W  K  G         p.180

          .         . | 05       .         .         .         .    g.112819
 CTTTCAGAAAGAAGAGGGTG | GGATCAGTACCTGTTTAAAAACAGACCCACAGATGGCCCT    c.600
 L  S  E  R  R  G  W  |  D  Q  Y  L  F  K  N  R  P  T  D  G  P      p.200

          .         .         .         .         .  | 06      .    g.120278
 CCAAATTCATTTTATAGGTCATTATACCCAAAGATTATCCAGGATATAGAG | ACTATAGAA    c.660
 P  N  S  F  Y  R  S  L  Y  P  K  I  I  Q  D  I  E   | T  I  E      p.220

          .         .         .         .         .         .       g.120338
 TCTAACTGGCGGTGTGGACGACACAACTTGCAGAGGATTCAGTGCCGCTCTGAAAATAGT       c.720
 S  N  W  R  C  G  R  H  N  L  Q  R  I  Q  C  R  S  E  N  S         p.240

          .         .         .         .         .         .       g.120398
 AAAGGTGTCTACTGTTTACAGTACGATGATGAAAAAATTATCAGTGGCCTACGAGATAAT       c.780
 K  G  V  Y  C  L  Q  Y  D  D  E  K  I  I  S  G  L  R  D  N         p.260

           | 07        .         .         .         .         .    g.133795
 TCTATTAAG | ATATGGGATAAAACCAGCCTGGAATGTTTGAAAGTGTTAACAGGACACACA    c.840
 S  I  K   | I  W  D  K  T  S  L  E  C  L  K  V  L  T  G  H  T      p.280

          .         .         .         .         .         .       g.133855
 GGCTCTGTCCTCTGTCTGCAGTATGATGAGCGTGTCATTGTAACTGGCTCTTCAGATTCT       c.900
 G  S  V  L  C  L  Q  Y  D  E  R  V  I  V  T  G  S  S  D  S         p.300

          | 08         .         .         .         .         .    g.135391
 ACGGTGAG | AGTGTGGGATGTGAACACGGGTGAAGTTCTTAACACATTGATCCACCACAAT    c.960
 T  V  R  |  V  W  D  V  N  T  G  E  V  L  N  T  L  I  H  H  N      p.320

          .         .         .         .         .         .       g.135451
 GAGGCTGTATTGCACTTACGCTTCAGCAATGGACTGATGGTGACCTGTTCCAAGGACCGC       c.1020
 E  A  V  L  H  L  R  F  S  N  G  L  M  V  T  C  S  K  D  R         p.340

          .         .         .         .         .         .       g.135511
 TCCATTGCTGTGTGGGACATGGCTTCTGCGACCGACATCACTTTACGCCGTGTCCTGGTT       c.1080
 S  I  A  V  W  D  M  A  S  A  T  D  I  T  L  R  R  V  L  V         p.360

          .         .         .         .         .         .       g.135571
 GGCCACCGGGCTGCCGTCAATGTAGTAGACTTTGACGACAAGTACATCGTGTCTGCCTCT       c.1140
 G  H  R  A  A  V  N  V  V  D  F  D  D  K  Y  I  V  S  A  S         p.380

          .         | 09         .         .         .         .    g.138925
 GGTGACAGGACCATCAAA | GTCTGGAGCACGAGCACCTGTGAATTTGTTCGTACTCTCAAT    c.1200
 G  D  R  T  I  K   | V  W  S  T  S  T  C  E  F  V  R  T  L  N      p.400

          .         .         .         .         .         .       g.138985
 GGGCACAAGCGGGGCATTGCCTGTCTCCAGTACAGGGATCGCCTGGTTGTTAGTGGATCA       c.1260
 G  H  K  R  G  I  A  C  L  Q  Y  R  D  R  L  V  V  S  G  S         p.420

          .        | 10.         .         .         .         .    g.141058
 TCAGATAATACCATTAG | GCTCTGGGATATTGAATGTGGTGCCTGTTTAAGAGTCCTAGAG    c.1320
 S  D  N  T  I  R  |  L  W  D  I  E  C  G  A  C  L  R  V  L  E      p.440

          .         .         .         .         .         .       g.141118
 GGACATGAAGAATTGGTCCGATGCATCCGGTTTGATAACAAGAGGATTGTCAGTGGGGCC       c.1380
 G  H  E  E  L  V  R  C  I  R  F  D  N  K  R  I  V  S  G  A         p.460

          | 11         .         .         .         .         .    g.142118
 TATGATGG | GAAAATTAAAGTTTGGGACTTGCAAGCTGCTCTTGACCCTCGAGCCCCAGCA    c.1440
 Y  D  G  |  K  I  K  V  W  D  L  Q  A  A  L  D  P  R  A  P  A      p.480

          .         .        | 12.         .         .         .    g.143110
 AGCACATTGTGTTTGCGCACATTGGTG | GAACATTCTGGACGTGTGTTTCGGCTCCAGTTT    c.1500
 S  T  L  C  L  R  T  L  V   | E  H  S  G  R  V  F  R  L  Q  F      p.500

          .         .         .         .         .         .       g.143170
 GATGAGTTTCAGATCATCAGCAGCTCCCATGATGACACTATTTTGATTTGGGATTTCTTA       c.1560
 D  E  F  Q  I  I  S  S  S  H  D  D  T  I  L  I  W  D  F  L         p.520

          .         .         .         .         .         .       g.143230
 AATGTGCCTCCCAGTGCCCAGAATGAGACCCGTTCTCCCTCCAGAACATACACTTACATC       c.1620
 N  V  P  P  S  A  Q  N  E  T  R  S  P  S  R  T  Y  T  Y  I         p.540

                                                                g.143239
 TCTAGATAA |                                                       c.1630
 S  R  X                                                         p.542

          .         .      | 13  .         .         .         .    g.147807
 cagtctgcactttcacccgtttcag | ggttttctagtcttgaactactggctacgtggcta    c.*60

          .         .         .         .         .         .       g.147867
 ccaaatgcctaagggagttcgttcacagctgagttatgaagctggaattggttctagacg       c.*120

          .         .         .         .         .         .       g.147927
 ctgggtagatgcaaagcagcctaactcttcaagtaccgacatttctcacctctgattccg       c.*180

          .         .         .         .         .         .       g.147987
 gctctcctttgagaaggagaccttagcttccccggcttcaagtagaacagaagcccgttt       c.*240

          .         .         .         .         .         .       g.148047
 ccttccctcatcagtgaaaaaatctaatgtttcaaatgtaaattgttcatagaaaaggaa       c.*300

          .         .         .         .         .         .       g.148107
 catagaatctgttttacagaagtaaatcgaccgtcaagagaagacttggcctctaattta       c.*360

          .         .         .         .         .         .       g.148167
 tattgctttgcactttggtttgatattaagaaacagcattcttcttcagtgaaattttgg       c.*420

          .         .         .         .         .         .       g.148227
 gtgccaaacacctacccagaatgtccagggctttcattttcaaaagttagcattctcctt       c.*480

          .         .         .         .         .         .       g.148287
 ttgaccgtccaagtcattatgaattctgacttgttgtattaggaacatgttggacagtgg       c.*540

          .         .         .         .         .         .       g.148347
 aaaattttctctggattgttttagtaatatttttgggattatacttcctttctgtaccaa       c.*600

          .         .         .         .         .         .       g.148407
 tttcttttaatttaaagaactataagtcagttatattatctaccaacaggtaatatagct       c.*660

          .         .         .         .         .         .       g.148467
 ctttcttttattaactgttctctgtcccccaaccatctcctgatatttggtagagtaaca       c.*720

          .         .         .         .         .         .       g.148527
 cctttatacgtgtgcttgcctcctaatttaaaatactgtattcgcatgtagatataatgt       c.*780

          .         .         .         .         .         .       g.148587
 acataacagtttaacctcaaagttgctggagtcagggccccctgtgcttgagacactaat       c.*840

          .         .         .         .         .         .       g.148647
 acagagtgtgttcgcacttagccatgggctgggctcaagaacctgatacctgggttgatg       c.*900

          .         .         .         .         .         .       g.148707
 tggattacctagaacccttcctgcagtattcatacagtgtttttattttgttgttgtcat       c.*960

          .         .         .         .         .         .       g.148767
 tgcgtgtgtgtggtttgtgtgtgtttttaatgagaatcttgttttaaaatgtaatttcta       c.*1020

          .         .         .         .         .         .       g.148827
 aggtttaacaccaaaatgttttatttgttgtggagtatatattatacaatagagaggtac       c.*1080

          .         .         .         .         .         .       g.148887
 cttaaacattttttgttcttattctttttctcataagtactcctgagtacaagtggtcac       c.*1140

          .         .         .         .         .         .       g.148947
 ctcccatagtattcatttggcttcgctgtcaaaaatcattattctgtgcagtcgtggccc       c.*1200

          .         .         .         .         .         .       g.149007
 tgggaaggggaaataagaaggccctgttgacgggctgtcttggctctggaattcatgcat       c.*1260

          .         .         .         .         .         .       g.149067
 cctggccttgccaaggttctggcagggcctgctggtgtgttggagcctgcagggcaggtc       c.*1320

          .         .         .         .         .         .       g.149127
 aggctggttcagaggcccatgctgaggggtgggtgctctgaagtggagtgaagcctcaag       c.*1380

          .         .         .         .         .         .       g.149187
 cccatgaatgccaccccagtcatctctggtgtcagctgctgctgtggccccagcaggttc       c.*1440

          .         .         .         .         .         .       g.149247
 tcaaagctcccaagtcctccctacgacacagcccaaatgtgtaaatggcactgttgccct       c.*1500

          .         .         .         .         .         .       g.149307
 gacagtgcatggaaaggacgttggcatccaattggcactccttctcccttattcaatatt       c.*1560

          .         .         .         .         .         .       g.149367
 aggtttgatttgcccttcgccattgtttccaaagatcaaggaatgtcaataacattttaa       c.*1620

          .         .         .         .         .         .       g.149427
 aggaccaataaacagcctcctataaagtaaacctcttcccgtggaagcacactctactac       c.*1680

          .         .         .         .         .         .       g.149487
 taaagggaaggccctgggctctgatttgtcctttgcattgagaacggtgtggggatcagt       c.*1740

          .         .         .         .         .         .       g.149547
 gtgtgtgtatgtgatttgtttattgagttggctttgcttttttagtttttcttttaaaaa       c.*1800

          .         .         .         .         .         .       g.149607
 taaaatccttccttcccatgttactaaattaatttatgtttttgagaggttgagtctcaa       c.*1860

          .         .         .         .         .         .       g.149667
 agtgtaaacaataaacctccattcataaggtggatgttgtaagcttgatggtggttgtga       c.*1920

          .         .         .         .         .         .       g.149727
 aagtgatttagctttgaccacttttcatcctacagcttcaatatcaaactggttaggaaa       c.*1980

          .         .         .         .         .         .       g.149787
 gcccagggggaagggagggggcaggggaggaggcaattctgaatgaatgaatggattttt       c.*2040

          .         .         .         .         .         .       g.149847
 tgttgtttttgcatgtttaatatagaagttcccctcgttccttgggagatgatggccttt       c.*2100

          .         .         .         .         .         .       g.149907
 gaatatgcagacaacctttgaattgtgcctactaaattatagcaggggactttggcaccc       c.*2160

          .         .         .         .         .         .       g.149967
 aaggagttctgactttctgggattataatagtaattcccagccatactctggactttatt       c.*2220

          .         .         .         .         .         .       g.150027
 ttgctaaccataactgagcaaatgtaaattactgctatattaatgttttaaagcactggg       c.*2280

          .         .         .         .         .         .       g.150087
 atagtctaattctaacttgtaattaattatgtttgccaattatctgtttgaaataaattt       c.*2340

          .         .         .         .         .         .       g.150147
 gtgtctgaacagctattgaaactgttaaattgtacagatattattcatgacagctttgta       c.*2400

          .         .         .         .         .         .       g.150207
 ctgtggaatgtgcttaataaaaaacaaaaaagtttgacttttgtccagtaaattgctaag       c.*2460

          .         .         .         .         .         .       g.150267
 taatgtcaataaatcgagtatgggtattatgcagtgcacctaatctggcttcatgcaatt       c.*2520

          .         .         .         .         .                 g.150322
 gttacttcagctactgattcaaagccaatactcttaataaagtgttgcaatactc            c.*2575

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The F-box and WD repeat domain containing 11 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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