ferredoxin reductase (FDXR) - coding DNA reference sequence

(used for variant description)

(last modified November 6, 2017)

This file was created to facilitate the description of sequence variants on transcript NM_024417.2 in the FDXR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering FDXR transcript NM_024417.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5027
                                  gcttgtgggcgggcccgggcaggagcg       c.-61

 .         .         .         .         .         .                g.5087
 ggcttgccctgcggagcagtagctaggaacagatccacttgcaggttgctgttcccagcc       c.-1

          .         .         .         .         .         .       g.5147
 ATGGCTTCGCGCTGCTGGCGCTGGTGGGGCTGGTCGGCGTGGCCTCGGACCCGGCTGCCT       c.60
 M  A  S  R  C  W  R  W  W  G  W  S  A  W  P  R  T  R  L  P         p.20

          .          | 02        .         .         .         .    g.5939
 CCCGCCGGGAGCACCCCGA | GCTTCTGCCACCATTTCTCCACACAGGAGAAGACCCCCCAG    c.120
 P  A  G  S  T  P  S |   F  C  H  H  F  S  T  Q  E  K  T  P  Q      p.40

          .         .         .         .         .        | 03.    g.11161
 ATCTGTGTGGTGGGCAGTGGCCCAGCTGGCTTCTACACGGCCCAACACCTGCTAAAG | CAC    c.180
 I  C  V  V  G  S  G  P  A  G  F  Y  T  A  Q  H  L  L  K   | H      p.60

          .         .         .         .         .         .       g.11221
 CCCCAGGCCCACGTGGACATCTACGAGAAACAGCCTGTGCCCTTTGGCCTGGTGCGCTTT       c.240
 P  Q  A  H  V  D  I  Y  E  K  Q  P  V  P  F  G  L  V  R  F         p.80

          .         .         . | 04       .         .         .    g.11496
 GGTGTGGCGCCTGATCACCCCGAGGTGAAG | AATGTCATCAACACATTTACCCAGACGGCC    c.300
 G  V  A  P  D  H  P  E  V  K   | N  V  I  N  T  F  T  Q  T  A      p.100

          .         .         .         .         .         .       g.11556
 CATTCTGGCCGCTGTGCCTTCTGGGGCAACGTGGAGGTGGGCAGGGACGTGACGGTGCCG       c.360
 H  S  G  R  C  A  F  W  G  N  V  E  V  G  R  D  V  T  V  P         p.120

          .         .         .    | 05    .         .         .    g.11817
 GAGCTGCGGGAGGCCTACCACGCTGTGGTGCTG | AGCTACGGGGCAGAGGACCATCGGGCC    c.420
 E  L  R  E  A  Y  H  A  V  V  L   | S  Y  G  A  E  D  H  R  A      p.140

          .         .         .         .         .         .       g.11877
 CTGGAAATTCCTGGTGAGGAGCTGCCAGGTGTGTGCTCCGCCCGGGCCTTCGTGGGCTGG       c.480
 L  E  I  P  G  E  E  L  P  G  V  C  S  A  R  A  F  V  G  W         p.160

          .         .        | 06.         .         .         .    g.12247
 TACAACGGGCTTCCTGAGAACCAGGAG | CTGGAGCCAGACCTGAGCTGTGACACAGCCGTG    c.540
 Y  N  G  L  P  E  N  Q  E   | L  E  P  D  L  S  C  D  T  A  V      p.180

          .         .         .         .         .         .       g.12307
 ATTCTGGGGCAGGGGAACGTGGCTCTGGACGTGGCCCGCATCCTACTGACCCCACCTGAG       c.600
 I  L  G  Q  G  N  V  A  L  D  V  A  R  I  L  L  T  P  P  E         p.200

           | 07        .         .         .         .         .    g.13154
 CACCTGGAG | AGAACGGACATCACGAAGGCAGCCCTGGGTGTACTGAGGCAGAGTCGAGTG    c.660
 H  L  E   | R  T  D  I  T  K  A  A  L  G  V  L  R  Q  S  R  V      p.220

          .         .         .         .         .        | 08.    g.13473
 AAGACAGTGTGGCTAGTGGGCCGGCGTGGACCCCTGCAAGTGGCCTTCACCATTAAG | GAG    c.720
 K  T  V  W  L  V  G  R  R  G  P  L  Q  V  A  F  T  I  K   | E      p.240

          .         .         .         .         .         .       g.13533
 CTTCGGGAGATGATTCAGTTACCGGGAGCCCGGCCCATTTTGGATCCTGTGGATTTCTTG       c.780
 L  R  E  M  I  Q  L  P  G  A  R  P  I  L  D  P  V  D  F  L         p.260

          .         .   | 09     .         .         .         .    g.13725
 GGTCTCCAGGACAAGATCAAGG | AGGTCCCCCGCCCGAGGAAGCGGCTGACGGAACTGCTG    c.840
 G  L  Q  D  K  I  K  E |   V  P  R  P  R  K  R  L  T  E  L  L      p.280

          .         .         .         .         .         .       g.13785
 CTTCGAACGGCCACAGAGAAGCCAGGGCCGGCGGAAGCTGCCCGCCAGGCATCGGCCTCC       c.900
 L  R  T  A  T  E  K  P  G  P  A  E  A  A  R  Q  A  S  A  S         p.300

          .         .         .         .         .         .       g.13845
 CGTGCCTGGGGCCTCCGCTTTTTCCGAAGCCCCCAGCAGGTGCTGCCCTCACCAGATGGG       c.960
 R  A  W  G  L  R  F  F  R  S  P  Q  Q  V  L  P  S  P  D  G         p.320

          .         .         .         .   | 10     .         .    g.13985
 CGGCGGGCAGCAGGTGTCCGCCTAGCAGTCACTAGACTGGAG | GGTGTCGATGAGGCCACC    c.1020
 R  R  A  A  G  V  R  L  A  V  T  R  L  E   | G  V  D  E  A  T      p.340

          .         .         .         .         .         .       g.14045
 CGTGCAGTGCCCACGGGAGACATGGAAGACCTCCCTTGTGGGCTGGTGCTCAGCAGCATT       c.1080
 R  A  V  P  T  G  D  M  E  D  L  P  C  G  L  V  L  S  S  I         p.360

          .         .         .         .         .         .       g.14105
 GGGTATAAGAGCCGCCCTGTCGACCCAAGCGTGCCCTTTGACTCCAAGCTTGGGGTCATC       c.1140
 G  Y  K  S  R  P  V  D  P  S  V  P  F  D  S  K  L  G  V  I         p.380

          .         .         .     | 11   .         .         .    g.14814
 CCCAATGTGGAGGGCCGGGTTATGGATGTGCCAG | GCCTCTACTGCAGCGGCTGGGTGAAG    c.1200
 P  N  V  E  G  R  V  M  D  V  P  G |   L  Y  C  S  G  W  V  K      p.400

          .         .         .         .         .         .       g.14874
 AGAGGACCTACAGGTGTCATAGCCACAACCATGACTGACAGCTTCCTCACCGGCCAGATG       c.1260
 R  G  P  T  G  V  I  A  T  T  M  T  D  S  F  L  T  G  Q  M         p.420

          .         .         .         .         .         .       g.14934
 CTGCTGCAGGACCTGAAGGCTGGGTTGCTCCCCTCTGGCCCCAGGCCTGGCTACGCAGCC       c.1320
 L  L  Q  D  L  K  A  G  L  L  P  S  G  P  R  P  G  Y  A  A         p.440

          .         .      | 12  .         .         .         .    g.15122
 ATCCAGGCCCTGCTCAGCAGCCGAG | GGGTCCGGCCAGTCTCTTTCTCAGACTGGGAGAAG    c.1380
 I  Q  A  L  L  S  S  R  G |   V  R  P  V  S  F  S  D  W  E  K      p.460

          .         .         .         .         .         .       g.15182
 CTGGATGCCGAGGAGGTGGCCCGGGGCCAGGGCACGGGGAAGCCCAGGGAGAAGCTGGTG       c.1440
 L  D  A  E  E  V  A  R  G  Q  G  T  G  K  P  R  E  K  L  V         p.480

          .         .         .                                     g.15218
 GATCCTCAGGAGATGCTGCGCCTCCTGGGCCACTGA                               c.1476
 D  P  Q  E  M  L  R  L  L  G  H  X                                 p.491

          .         .         .         .         .         .       g.15278
 gcccagccccagccccggcccccagcagggaagggatgagtgttgggaggggaagggctg       c.*60

          .         .         .         .         .         .       g.15338
 ggtccgtctgagtgggactttgcacctctgctgatcccggccggccctggcttggaggct       c.*120

          .         .         .         .         .         .       g.15398
 tggctgctcttccagcgtctctcctccctcctggggaaggtcgcccttgcgcgcaaggtt       c.*180

          .         .         .         .         .         .       g.15458
 ttagctttcagcaactgaggtaaccttagggacaggtggaggtgtgggccgatctaaccc       c.*240

          .         .         .         .         .         .       g.15518
 cttacccatctctctactgctggactgtggagggtcaccaggttgggaacatgctggaaa       c.*300

          .         .                                               g.15538
 taaaacagctgcaaccaaga                                               c.*320

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Ferredoxin reductase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.