ferrochelatase (FECH) - coding DNA reference sequence

(used for variant description)

(last modified October 21, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001012515.2 in the FECH gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008175.1, covering FECH transcript NM_001012515.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    aggtcagggggctggggacgcgcgtggggatcgctacccggctcggccactgctggg       c.-61

 .         .         .         .         .         .                g.5117
 cggacacctgggcgcgccgccgcgggaggagcccggactcgggccgaggctgcccaggca       c.-1

          .         .         .         .         .         .       g.5177
 ATGCGTTCACTCGGCGCAAACATGGCTGCGGCCCTGCGCGCCGCGGGCGTCCTGCTCCGC       c.60
 M  R  S  L  G  A  N  M  A  A  A  L  R  A  A  G  V  L  L  R         p.20

         | 02.         .         .         .         .         .    g.11591
 GATCCGC | TGGCATCCAGCAGCTGGAGGGTCTGTCAGCCATGGAGGTGGAAGTCAGGTGCA    c.120
 D  P  L |   A  S  S  S  W  R  V  C  Q  P  W  R  W  K  S  G  A      p.40

          .         .         .         .         .         .       g.11651
 GCTGCAGCGGCCGTCACCACAGAAACAGCCCAGCATGCCCAGGGTGCAAAACCTCAAGTT       c.180
 A  A  A  A  V  T  T  E  T  A  Q  H  A  Q  G  A  K  P  Q  V         p.60

          .         .         .   | 03     .         .         .    g.18400
 CAACCGCAGAAGAGGTATGAGTCTAACATCAG | GAAGCCGAAAACTGGAATATTAATGCTA    c.240
 Q  P  Q  K  R  Y  E  S  N  I  R  |  K  P  K  T  G  I  L  M  L      p.80

          .         .         .         .         .         .       g.18460
 AACATGGGAGGCCCTGAAACTCTTGGAGATGTTCACGACTTCCTTCTGAGACTCTTCTTG       c.300
 N  M  G  G  P  E  T  L  G  D  V  H  D  F  L  L  R  L  F  L         p.100

          .         .         .   | 04     .         .         .    g.20225
 GACCGAGACCTCATGACACTTCCTATTCAGAA | TAAGCTGGCACCATTCATCGCCAAACGC    c.360
 D  R  D  L  M  T  L  P  I  Q  N  |  K  L  A  P  F  I  A  K  R      p.120

          .         .         .         .         .         .       g.20285
 CGAACCCCCAAGATTCAAGAGCAGTACCGCAGGATTGGAGGCGGATCCCCCATCAAGATA       c.420
 R  T  P  K  I  Q  E  Q  Y  R  R  I  G  G  G  S  P  I  K  I         p.140

          .         .         .         .         .         .       g.20345
 TGGACTTCCAAGCAGGGAGAGGGCATGGTGAAGCTGCTGGATGAATTGTCCCCCAACACA       c.480
 W  T  S  K  Q  G  E  G  M  V  K  L  L  D  E  L  S  P  N  T         p.160

   | 05      .         .         .         .         .         .    g.25215
 G | CCCCTCACAAATACTATATTGGATTTCGGTACGTCCATCCTTTAACAGAAGAAGCAATT    c.540
 A |   P  H  K  Y  Y  I  G  F  R  Y  V  H  P  L  T  E  E  A  I      p.180

          .         .         .         .         .         .       g.25275
 GAAGAGATGGAGAGAGATGGCCTAGAAAGGGCTATTGCTTTCACACAGTATCCACAGTAC       c.600
 E  E  M  E  R  D  G  L  E  R  A  I  A  F  T  Q  Y  P  Q  Y         p.200

          .       | 06 .         .         .         .         .    g.28801
 AGCTGCTCCACCACAG | GCAGCAGCTTAAATGCCATTTACAGATACTATAATCAAGTGGGA    c.660
 S  C  S  T  T  G |   S  S  L  N  A  I  Y  R  Y  Y  N  Q  V  G      p.220

          .         .         .         .         .         .       g.28861
 CGGAAGCCCACGATGAAGTGGAGCACTATTGACAGGTGGCCCACACATCACCTCCTCATC       c.720
 R  K  P  T  M  K  W  S  T  I  D  R  W  P  T  H  H  L  L  I         p.240

     | 07    .         .         .         .         .         .    g.32551
 CAG | TGCTTTGCAGATCATATTCTAAAGGAACTGGACCATTTTCCACTTGAGAAGAGAAGC    c.780
 Q   | C  F  A  D  H  I  L  K  E  L  D  H  F  P  L  E  K  R  S      p.260

          .         .         .         .   | 08     .         .    g.36803
 GAGGTGGTCATTCTGTTTTCTGCTCACTCACTGCCCATGTCT | GTGGTCAACAGAGGCGAC    c.840
 E  V  V  I  L  F  S  A  H  S  L  P  M  S   | V  V  N  R  G  D      p.280

          .         .         .         .         .         .       g.36863
 CCATATCCTCAGGAGGTAAGCGCCACTGTCCAAAAAGTCATGGAAAGGCTGGAGTACTGC       c.900
 P  Y  P  Q  E  V  S  A  T  V  Q  K  V  M  E  R  L  E  Y  C         p.300

          .         .         . | 09       .         .         .    g.37343
 AACCCCTACCGACTGGTGTGGCAATCCAAG | GTTGGTCCAATGCCCTGGTTGGGTCCTCAA    c.960
 N  P  Y  R  L  V  W  Q  S  K   | V  G  P  M  P  W  L  G  P  Q      p.320

          .         .         .         .         .         .       g.37403
 ACAGACGAATCTATCAAAGGGCTTTGTGAGAGGGGGAGGAAGAATATCCTCTTGGTTCCG       c.1020
 T  D  E  S  I  K  G  L  C  E  R  G  R  K  N  I  L  L  V  P         p.340

          .         .         .         .         .         .       g.37463
 ATAGCATTTACCAGTGACCATATTGAAACGCTGTATGAGCTGGACATCGAGTACTCTCAA       c.1080
 I  A  F  T  S  D  H  I  E  T  L  Y  E  L  D  I  E  Y  S  Q         p.360

          .      | 10  .         .         .         .         .    g.40408
 GTTTTAGCCAAGGAG | TGTGGAGTTGAAAACATCAGAAGAGCTGAGTCTCTTAATGGAAAT    c.1140
 V  L  A  K  E   | C  G  V  E  N  I  R  R  A  E  S  L  N  G  N      p.380

          .      | 11  .         .         .         .         .    g.40936
 CCATTGTTCTCTAAG | GCCCTGGCCGACTTGGTGCATTCACACATCCAGTCAAACGAGCTG    c.1200
 P  L  F  S  K   | A  L  A  D  L  V  H  S  H  I  Q  S  N  E  L      p.400

          .         .         .         .         .         .       g.40996
 TGTTCCAAGCAGCTGACCCTGAGCTGTCCGCTCTGTGTCAATCCTGTCTGCAGGGAGACT       c.1260
 C  S  K  Q  L  T  L  S  C  P  L  C  V  N  P  V  C  R  E  T         p.420

          .         .         .                                     g.41026
 AAATCCTTCTTCACCAGCCAGCAGCTGTGA                                     c.1290
 K  S  F  F  T  S  Q  Q  L  X                                       p.429

          .         .         .         .         .         .       g.41086
 cccccgccggtggaccccgtggcgttaggcaaatgcccaacctccagatacctccgatgt       c.*60

          .         .         .         .         .         .       g.41146
 ggagagggtgttatttagagatcaaggaaggaagtcatccttccttgatatatatacagc       c.*120

          .         .         .         .         .         .       g.41206
 ctttgggtacaaattgtgtggtttcttgaggattggactcttgatggatttctattttta       c.*180

          .         .         .         .         .         .       g.41266
 tataactatacagtaagcatttgtattttctctctctaggtataagttactagtttggaa       c.*240

          .         .         .         .         .         .       g.41326
 tgtccatcaggacctttaataaatgagttaaaaatttgtcttatgagacacacctattta       c.*300

          .         .         .         .         .         .       g.41386
 agtacagattttggctttattgcccaaaaccctcctgaaagggtacggagagtcccctct       c.*360

          .         .         .         .         .         .       g.41446
 gtgggctggcagtgtgaatgagatctgtttagtctcgtgcatatagttgctgttttttaa       c.*420

          .         .         .         .         .         .       g.41506
 atgaacacagttgagtatttgaagtgaatttgaaaaagaaatgttacttaatctttccct       c.*480

          .         .         .         .         .         .       g.41566
 aagcccatgggttacagaatgctagggaggcaatttggttacctgcaatggctgcttttg       c.*540

          .         .         .         .         .         .       g.41626
 ccagcgaggccaccattcattggtcatcttggtatttgtgtgtgaatctcactttcctca       c.*600

          .         .         .         .         .         .       g.41686
 atgtaaaaaggaatcaagtatggatttcagaggtgctcttagattccccatacacccaag       c.*660

          .         .         .         .         .         .       g.41746
 ggtaataaacgtgtacaagtacagtgttcatgatacgtgccttggtgggagtccgtggtg       c.*720

          .         .         .         .         .         .       g.41806
 ccacagggaaggggctcccactgcttctggtctccagggacagtgctgctggaaaggcta       c.*780

          .         .         .         .         .         .       g.41866
 gtgatgagcttcaccctggagctcctcccgggaccttgcaagcctctccatccagcatct       c.*840

          .         .         .         .         .         .       g.41926
 tctctatcttagttgaatgccttctttctgaacatttgttttaagaattattttataaag       c.*900

          .         .         .         .         .         .       g.41986
 tcaacaatactttgcttgaattctttcttaatttacgattttttattataaaaatgtata       c.*960

          .         .         .         .         .         .       g.42046
 gtgatacaatgggacatgtgaagaatacagaaaagtaaccactttaatgcaataactgtt       c.*1020

          .         .         .         .         .         .       g.42106
 atcataatattgtatttcgtggtagtcctttcctgtagatatttttaatgccatttaatg       c.*1080

          .         .         .         .         .         .       g.42166
 ccattgtcaccttggatttatgagtgaaaagtgtttctaaaaatatagaaataatgtcag       c.*1140

          .         .         .         .         .         .       g.42226
 atcagagtctgatcttctatgtttgtatttaaatggattaaaagatccccggtggttcca       c.*1200

          .         .         .         .         .         .       g.42286
 tgaagaatttgtaaagatcactttctctttcctccaagccctgaaactttgttcttcaaa       c.*1260

          .         .         .         .         .         .       g.42346
 agagcgtttctttttttttttttttttagccagtttataaagtggaagtattaggagatt       c.*1320

          .         .         .         .         .         .       g.42406
 cataaatcttctatattgagaattggctatgttaataaatattacaacatcattaaggtt       c.*1380

          .         .         .         .         .         .       g.42466
 ttagctaagtttgattcatgctgtctgttaaatcaaaactgatctaaatcagaattatta       c.*1440

          .         .         .         .         .         .       g.42526
 aatgtgaggagcttttttaatacaggaaaagaaacatgtcatccacttgagttaatagtt       c.*1500

          .         .         .         .         .         .       g.42586
 ttcctacgttgatgacagccctcatgagtagcatccacatttttaaaatttcaaattggt       c.*1560

          .         .         .         .         .         .       g.42646
 ttttctactagtagattgtgtttctagagaaagatacaaggcataggtgattgtttagga       c.*1620

          .         .         .         .         .         .       g.42706
 ttttcctctagcctttgccattacctttttggggatgaggttcacagtagactttgagtg       c.*1680

          .         .         .         .         .         .       g.42766
 accgtcccaccgtgaagtgaattctctgagctggtggtgtggtgctggaaggaaggttat       c.*1740

          .         .         .         .         .         .       g.42826
 ttttggagccactctctccccttaaggatatttcccaagggcctgcttcaattctttgat       c.*1800

          .         .         .         .         .         .       g.42886
 gactttagaggtgaaaaaatatttttatggagatgatgcagaaaactccaattcaggagc       c.*1860

          .         .         .         .         .         .       g.42946
 ccttgcgagtatatctgaagcacttatttgctaaggaaacctgaattgatagcagtactg       c.*1920

          .         .         .         .         .         .       g.43006
 tgctgtctggaataatgtccttgatactgagttgggaccagactggcttttatagtgaca       c.*1980

          .         .         .         .         .         .       g.43066
 ggcaaagaggaatttattgagatcactgctcatggcatttgttgctgtaagaagtgttgc       c.*2040

          .         .         .         .         .         .       g.43126
 ctttgattgttactaaccacggatgggtaacggtcatacattaggctagtgtttggtagg       c.*2100

          .         .         .         .         .         .       g.43186
 acaaaatctttttagagctttgagaattgtcatcctgttggtcaactttgaaatacaaat       c.*2160

          .         .         .         .         .         .       g.43246
 gtttgccctggtaattagcaatgaactgctggcagtttcttcagctgtgtatatacggat       c.*2220

          .         .         .         .         .         .       g.43306
 ctggcttttaattgatgaatcaacttctacagaaacttttgcagggacagtgttgatgag       c.*2280

          .         .         .         .         .         .       g.43366
 gcagtttagcttgccagggtgatgataaagcccaggtccctgcatgtatagtgctcttct       c.*2340

          .         .         .         .         .         .       g.43426
 aaagaatatgcattcttgaactacttaactttttaaaaatcacaataaatttttgcactc       c.*2400

          .         .         .         .         .         .       g.43486
 aaaatttgcttcgtatcaggagaaatgaactcattgttttgttttgtttttttttttttt       c.*2460

          .         .         .         .         .         .       g.43546
 taagatggagtcttgctatgtcacccaggctggagggcagtggtgcgatctcggctcact       c.*2520

          .         .         .         .         .         .       g.43606
 gctacttccacctcctgggctcaagtgatcctcccacctcagcctccaagtagctgggac       c.*2580

          .         .         .         .         .         .       g.43666
 tacaggagtgcttcaccacgctgggctacttttttatattttttgtagagatggggtttt       c.*2640

          .         .         .         .         .         .       g.43726
 gccatgttgtccaggctggtcttgaactcctgggctcaagggattctcctgcctcagtct       c.*2700

          .         .         .         .         .         .       g.43786
 cccaaagtgctgggattacaaggatgagcctctgcacctggccctgaactcattattaaa       c.*2760

          .         .         .         .         .         .       g.43846
 agccctttaaatgtgaggctgggtgccgtgccttacatgtgtaattccaatactttggaa       c.*2820

          .         .         .         .         .         .       g.43906
 ggccaaggttggaggattgcttgatcccaagagttcaagaccagcctgggcaacataggg       c.*2880

          .         .         .         .         .         .       g.43966
 agaccctgactctacaaaaaataaagtaaaaattaactgggtgtagtgtcacatgcctgt       c.*2940

          .         .         .         .         .         .       g.44026
 agttccagctacttaggaggctgaggtggtaggattgcttgagcccagcagtttgaggtt       c.*3000

          .         .         .         .         .         .       g.44086
 gcagtgaggtgtgattgcaccactgcactccagcctgggtgacagaggaagaccctgtcc       c.*3060

          .         .         .         .         .         .       g.44146
 caaaaccaaaaaaaagaaaagaaatacagagactgggtcatttacaaaggaaagaggttt       c.*3120

          .         .         .         .         .         .       g.44206
 aattgactcggttcggctttctgaggaagccttaggaaattgacaatcatggcagaaggg       c.*3180

          .         .         .         .         .         .       g.44266
 gaagcagatgtcttacatggcagtgagtgagagcaagcaaaggggaagagcccccttata       c.*3240

          .         .         .         .         .         .       g.44326
 aaaccatcagatctcgtgagaactggctgtcacaagaacagcatgggggaactgtctcca       c.*3300

          .         .         .         .         .         .       g.44386
 tgttccaatctccttccaccaggtccctccctcaacacgtggggattatggggattacaa       c.*3360

          .         .         .         .         .         .       g.44446
 tttgaaatgagatttgggtggggaacagagccaaatcatatcattccaccctggcccctc       c.*3420

          .         .         .         .         .         .       g.44506
 ccaaatcacatgtcctttttacatttcaaaaccaatcatgccttcacaacagtcctccag       c.*3480

          .         .         .         .         .         .       g.44566
 agtcttaactcattccagcattaacccaaaagtccaagttcaaagtctcatccaagacaa       c.*3540

          .         .         .         .         .         .       g.44626
 ggcaagtcccttctgcctgtgagcctgtaacattaaaagcaagttagtgacttccaagat       c.*3600

          .         .         .         .         .         .       g.44686
 acaatgggagtacagacattggtaaatgttcccattccaaatgggagaaattggccaaaa       c.*3660

          .         .         .         .         .         .       g.44746
 cacaggggctacaggccccatgcaccactgcactccactgtgcaagtctgaaacccggca       c.*3720

          .         .         .         .         .         .       g.44806
 gggcactccttaaattttttttttttttttttgagatggagtctcgctctgttgcccaag       c.*3780

          .         .         .         .         .         .       g.44866
 ctggagtacagtggcacgatctcggctcactgcaacctccgcctcttgggttcaaaggat       c.*3840

          .         .         .         .         .         .       g.44926
 catcctgcctcagcctccggagtagctgggctactcaggcgtgtgccaccatgcccggct       c.*3900

          .         .         .         .         .         .       g.44986
 aatttttgtatttttagtagagatggggcctgaccatgttggtcaggctggtctctaatt       c.*3960

          .         .         .         .         .         .       g.45046
 cctgacctcgtgatccacccgcctcagcctctgaaagtgttgggattacaggcgtgagcc       c.*4020

          .         .         .         .         .         .       g.45106
 accatccccggcctactcaataaatcttaaagttccggaataatctcctttgactccatg       c.*4080

          .         .         .         .         .         .       g.45166
 tctcacctccaggtcacgctgatgcaagaggtgggctaatctttctagtaaattccatat       c.*4140

          .         .         .         .         .         .       g.45226
 ttaattcaagaaaccataacttaaggcatgtaaaagagatcctttgctcaatgtgatgcc       c.*4200

          .         .         .         .         .         .       g.45286
 attgtgcttatccaaagtatattattattacccacaaagggtgagagattaggctgcagc       c.*4260

          .         .         .         .         .         .       g.45346
 cataccccaagtggagtgagcagcaagacctgccccctgctcagagtgtagatgactggg       c.*4320

          .         .         .         .         .         .       g.45406
 ggcacctgcattcctaggggctctgccgtatgagctcctgtcgatgcggcaaaggaccac       c.*4380

          .         .         .         .         .         .       g.45466
 cttgcccaacgacagcgggaaggcagaatttaaagctggcagctgtaagcgaacgtctat       c.*4440

          .         .         .         .         .         .       g.45526
 gtgtgcgcacgggggcacgtgaaggcacaggtgcatcagccaagaacctccaattcacct       c.*4500

          .         .         .         .         .         .       g.45586
 cttaaccttctcacctcacctgaaaccccttctgccagaatcctgaaggtggcccaggaa       c.*4560

          .         .         .         .         .         .       g.45646
 cagggctcctaacgttaggtggaaatgggaaattcattgagatgtcacaagctggaataa       c.*4620

          .         .         .         .         .         .       g.45706
 gaaaattctgagctcacccggaaactaatgccctaaattaagattattcagcttctcaat       c.*4680

          .         .         .         .         .         .       g.45766
 ttttaatagcaaaatggagacctgagtgtggataacttttagtatctgtgggggatcctg       c.*4740

          .         .         .         .         .         .       g.45826
 gaaccaattccctgccaatatagaaggacaactgtctacagtacttgaagtattattaac       c.*4800

          .         .         .         .         .         .       g.45886
 tacattcgccatgctgtatgttagatccccagaacatatttatcctgcatatctaaaatt       c.*4860

          .         .         .         .         .         .       g.45946
 ttgatcattttacaaactttctattttttttgtcaattttctccagctagacacttgtgc       c.*4920

          .         .         .         .         .         .       g.46006
 aatacggctattatctgatctttgccttaaatgttgtgcttcttttccatatgcacgtat       c.*4980

          .         .         .         .         .         .       g.46066
 tttgcaaaatataaagtgtgtagagctatatagcactcagccaagtggtgggtacctgca       c.*5040

          .         .         .         .         .         .       g.46126
 ggtgcttcagagaagtaaattgatgctgctaatatttgttgaatggcacgaatatgatga       c.*5100

          .         .         .         .         .         .       g.46186
 gcaatagcaggtggtgcccttcagccagaccatcgctccgtgcgtctgatgcatcttgcc       c.*5160

          .         .         .         .         .         .       g.46246
 aaagagtagttctgggaggtggttgcctctagagaacacattcctcctattctggggtcc       c.*5220

          .         .         .         .         .         .       g.46306
 cgtgagagaaagaaatgcttttgcttttgatgtgggactcttactaagcctttcttcaga       c.*5280

          .         .         .         .         .         .       g.46366
 gaaaaggaagtgaaaaatgcaccccatgataatcagtttcttacaacatactgtgatagt       c.*5340

          .         .         .         .         .         .       g.46426
 accggcttcgttgtttttagctggaatcattagcttccatttttagaataacagctattg       c.*5400

          .         .         .         .         .         .       g.46486
 gctaaattaggctacagtaggccattaagatggatgttggaattaaaaacatttttggaa       c.*5460

          .         .         .         .         .         .       g.46546
 aaaagcctgctttgagcctttgttataagcccttgggtagagatctgggtcctgtttctg       c.*5520

          .         .         .         .         .         .       g.46606
 atttcttgtgagccttcactctgacagttttgtttccagaaacacactcttagcctgctc       c.*5580

          .         .         .         .         .         .       g.46666
 ctgaaatgggaacagacaggccaacttcccctctccagtctcccctgcgggtcaaagctt       c.*5640

          .         .         .         .         .         .       g.46726
 tactttcctgtcatgttaagaaagaatagatttaaccttgataatccatgtagtattctg       c.*5700

          .         .         .         .         .         .       g.46786
 tatttttaccttttccttatctgaaaaaaagtgtatatatggcatggaattgattgcaca       c.*5760

          .         .         .         .         .         .       g.46846
 ggcacatggcatgttggcttgtgaaccaattgttaaaatttcaagttaatcattaaaata       c.*5820

          .         .         .         .         .                 g.46897
 atatctttcaaattaagttatattaaaaacaaaggtaacattctaaattca                c.*5871

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ferrochelatase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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