fermitin family member 1 (FERMT1) - coding DNA reference sequence

(used for variant description)

(last modified August 3, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_017671.4 in the FERMT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016213.1, covering FERMT1 transcript NM_017671.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    ctggagtct       c.-781

 .         .         .         .         .         .                g.5069
 cccctggtcgggagcctcagccttctggagactgacaccaccctcttactcagagacgaa       c.-721

 .         .         .         .         .         .                g.5129
 tcgttttgtcgttgccttcacctccctgaccacaagtgctccggggctctttctgaggga       c.-661

 .         .         .         .         .         .                g.5189
 ggcagctgttctaggcgggaggctggagtctcctgggcctggacgcaccccggggtgtga       c.-601

 .         .         .         .         .         .                g.5249
 gtgatgggtatgcctgaaaggaggggaagtggcgcggctttaatcatctgggctagtccc       c.-541

 .         .         .         .         .         .                g.5309
 cggcgggcctgggggaacagggaaactggaggcggccttaaagcgtcaggatgagacatc       c.-481

 .         .         .         .         .         .                g.5369
 gcaagaggagctgcagatactgagcgtgcgccccgggttctcgccgccttctctccgccg       c.-421

 .         .         .         .         .         .                g.5429
 agcagcccttcggccaccctttgcccttaaaaatctgcagactgcgcctcctctccgcgg       c.-361

 .         .         .         .         .         .                g.5489
 gagcgagacctagcaggcccggggctgggcgtgccctcgcctgccacgctgcgcgctgcc       c.-301

 .         .         .         .         .         .                g.5549
 ctcagccgggccgctggggccgtgcagtgcaccgggcacgccgcgccaggctgggggcag       c.-241

 .         .         .         .         .         .                g.5609
 gcaccgagcctccgtgggaggtcccgaggcagcttcgcctgctcgccctggctccagccc       c.-181

 .         .         .         .         .         .                g.5669
 tcacctgccgcagccttagctgagcagccgccgccactgggcgccccccgctccccactt       c.-121

 .         .         .         .         .         .                g.5729
 cgccagcgcccgctcctcggctcggcccggggtagtttgtagggacgcagctctccacgt       c.-61

 .         .         .         .         .  | 02      .             g.8990
 gcgcgactgcgaggctggacgctacgggctcctggaaaggag | acaccagcatttgccaca    c.-1

          .         .         .         .         .         .       g.9050
 ATGCTGTCATCCACTGACTTTACATTTGCTTCCTGGGAGCTTGTGGTCCGCGTTGACCAT       c.60
 M  L  S  S  T  D  F  T  F  A  S  W  E  L  V  V  R  V  D  H         p.20

          .         .         .         .         .         .       g.9110
 CCCAATGAAGAGCAGCAGAAAGACGTCACACTGAGAGTATCTGGAGACCTTCATGTTGGA       c.120
 P  N  E  E  Q  Q  K  D  V  T  L  R  V  S  G  D  L  H  V  G         p.40

          .         .         .  | 03      .         .         .    g.12529
 GGAGTGATGCTCAAGTTAGTAGAACAGATCA | ATATATCCCAAGACTGGTCAGACTTTGCT    c.180
 G  V  M  L  K  L  V  E  Q  I  N |   I  S  Q  D  W  S  D  F  A      p.60

          .         .         .         .         .         .       g.12589
 CTTTGGTGGGAACAGAAGCATTGCTGGCTTCTGAAAACCCACTGGACCCTGGACAAATAT       c.240
 L  W  W  E  Q  K  H  C  W  L  L  K  T  H  W  T  L  D  K  Y         p.80

          .         .         .         .         .         .       g.12649
 GGGGTCCAGGCAGATGCAAAGCTTCTCTTCACCCCTCAGCATAAAATGCTGCGCCTTCGT       c.300
 G  V  Q  A  D  A  K  L  L  F  T  P  Q  H  K  M  L  R  L  R         p.100

          .         .         .         .         .         .       g.12709
 CTGCCGAATTTGAAGATGGTGAGGTTGCGAGTCAGCTTCTCAGCTGTGGTTTTTAAAGCT       c.360
 L  P  N  L  K  M  V  R  L  R  V  S  F  S  A  V  V  F  K  A         p.120

          .         .      | 04  .         .         .         .    g.15956
 GTCAGTGATATCTGCAAAATCCTGA | ATATTAGAAGATCAGAAGAGCTTTCCTTGTTAAAG    c.420
 V  S  D  I  C  K  I  L  N |   I  R  R  S  E  E  L  S  L  L  K      p.140

          .         .         .         .         .         .       g.16016
 CCGTCTGGTGACTATTTTAAGAAGAAGAAGAAAAAAGACAAAAATAATAAGGAACCCATA       c.480
 P  S  G  D  Y  F  K  K  K  K  K  K  D  K  N  N  K  E  P  I         p.160

          .         .         .         .         .   | 05     .    g.18041
 ATTGAAGATATTCTAAACCTGGAGAGTTCTCCAACAGCTTCAGGTTCATCAG | TAAGTCCT    c.540
 I  E  D  I  L  N  L  E  S  S  P  T  A  S  G  S  S  V |   S  P      p.180

          .         .         .         .         .         .       g.18101
 GGTTTATACAGTAAAACCATGACCCCTATATATGACCCCATCAATGGAACACCAGCATCA       c.600
 G  L  Y  S  K  T  M  T  P  I  Y  D  P  I  N  G  T  P  A  S         p.200

          .         .         .         .         .         .       g.18161
 TCCACCATGACTTGGTTCAGTGACAGCCCTTTGACGGAACAAAACTGCAGCATCCTCGCA       c.660
 S  T  M  T  W  F  S  D  S  P  L  T  E  Q  N  C  S  I  L  A         p.220

          .         .         .         .         .         .       g.18221
 TTCAGCCAACCCCCCCAGTCCCCAGAAGCACTTGCGGATATGTACCAGCCTCGGTCTCTG       c.720
 F  S  Q  P  P  Q  S  P  E  A  L  A  D  M  Y  Q  P  R  S  L         p.240

          .         .       | 06 .         .         .         .    g.20944
 GTTGATAAAGCCAAGCTCAATGCAGG | TTGGCTAGACTCCTCACGCTCCCTTATGGAACAA    c.780
 V  D  K  A  K  L  N  A  G  |  W  L  D  S  S  R  S  L  M  E  Q      p.260

          .         .         .         .         .         .       g.21004
 GGCATCCAAGAGGATGAGCAGCTGCTCTTACGATTTAAATATTATTCTTTCTTCGACTTG       c.840
 G  I  Q  E  D  E  Q  L  L  L  R  F  K  Y  Y  S  F  F  D  L         p.280

           | 07        .         .         .         .         .    g.30964
 AATCCTAAA | TATGATGCTGTCCGAATAAACCAACTCTATGAGCAAGCCAGGTGGGCCATT    c.900
 N  P  K   | Y  D  A  V  R  I  N  Q  L  Y  E  Q  A  R  W  A  I      p.300

          .         .         .         .         .        | 08.    g.31514
 CTCTTAGAAGAAATTGATTGCACAGAGGAAGAAATGTTGATCTTTGCAGCTCTACAG | TAC    c.960
 L  L  E  E  I  D  C  T  E  E  E  M  L  I  F  A  A  L  Q   | Y      p.320

          .         .         .         .         .         .       g.31574
 CACATTAGCAAACTGTCGTTGTCTGCTGAAACACAGGATTTTGCAGGCGAGTCCGAGGTT       c.1020
 H  I  S  K  L  S  L  S  A  E  T  Q  D  F  A  G  E  S  E  V         p.340

          .         .         .         .         .         .       g.31634
 GATGAAATAGAAGCGGCGCTTTCTAATTTGGAAGTAACCCTAGAAGGTGGAAAAGCGGAC       c.1080
 D  E  I  E  A  A  L  S  N  L  E  V  T  L  E  G  G  K  A  D         p.360

           | 09        .         .         .         .          | 10 g.39456
 AGCCTTTTG | GAGGACATTACTGATATCCCTAAACTTGCAGATAATCTCAAATTATTTAG | G c.1140
 S  L  L   | E  D  I  T  D  I  P  K  L  A  D  N  L  K  L  F  R  |   p.380

          .         .         .         .         .         .       g.39516
 CCCAAGAAGTTACTACCAAAAGCTTTCAAACAATATTGGTTTATCTTTAAAGACACATCC       c.1200
 P  K  K  L  L  P  K  A  F  K  Q  Y  W  F  I  F  K  D  T  S         p.400

          .         .         .         .         .         .       g.39576
 ATAGCATACTTTAAAAATAAGGAACTTGAACAAGGAGAACCACTAGAAAAACTAAATCTT       c.1260
 I  A  Y  F  K  N  K  E  L  E  Q  G  E  P  L  E  K  L  N  L         p.420

      | 11   .         .         .         .         .         .    g.40717
 AGAG | GCTGCGAAGTTGTGCCCGATGTAAATGTAGCAGGAAGAAAATTTGGAATCAAGTTA    c.1320
 R  G |   C  E  V  V  P  D  V  N  V  A  G  R  K  F  G  I  K  L      p.440

          .         .         .         .         .  | 12      .    g.43266
 CTAATCCCTGTTGCCGATGGTATGAATGAAATGTATTTGAGATGTGACCAT | GAGAATCAA    c.1380
 L  I  P  V  A  D  G  M  N  E  M  Y  L  R  C  D  H   | E  N  Q      p.460

          .         .         .         .         .         .       g.43326
 TACGCCCAATGGATGGCTGCCTGCATGTTGGCATCGAAGGGCAAAACCATGGCAGACAGC       c.1440
 Y  A  Q  W  M  A  A  C  M  L  A  S  K  G  K  T  M  A  D  S         p.480

          .         .         .         .         .         .       g.43386
 TCCTACCAGCCAGAGGTCCTCAACATCCTTTCATTTCTGAGGATGAAAAACAGGAACTCT       c.1500
 S  Y  Q  P  E  V  L  N  I  L  S  F  L  R  M  K  N  R  N  S         p.500

          .         .         .         .         .         .       g.43446
 GCATCTCAGGTGGCTTCCAGTCTCGAAAACATGGATATGAACCCAGAATGTTTTGTGTCA       c.1560
 A  S  Q  V  A  S  S  L  E  N  M  D  M  N  P  E  C  F  V  S         p.520

          .         .         .    | 13    .         .         .    g.44407
 CCACGGTGTGCAAAAAGACACAAATCCAAACAG | CTGGCCGCCCGGATCCTGGAGGCGCAC    c.1620
 P  R  C  A  K  R  H  K  S  K  Q   | L  A  A  R  I  L  E  A  H      p.540

          .         .         .         .         .         .       g.44467
 CAGAACGTGGCCCAGATGCCCCTGGTCGAAGCCAAGCTGCGGTTCATCCAGGCGTGGCAG       c.1680
 Q  N  V  A  Q  M  P  L  V  E  A  K  L  R  F  I  Q  A  W  Q         p.560

          .         .         .         | 14         .         .    g.48989
 TCACTGCCTGAGTTTGGCCTCACCTACTACCTTGTCAG | ATTTAAAGGAAGCAAAAAAGAT    c.1740
 S  L  P  E  F  G  L  T  Y  Y  L  V  R  |  F  K  G  S  K  K  D      p.580

          .         .         .         .         .         .       g.49049
 GACATTCTGGGAGTTTCATATAACAGGTTGATTAAAATTGATGCAGCCACCGGGATTCCA       c.1800
 D  I  L  G  V  S  Y  N  R  L  I  K  I  D  A  A  T  G  I  P         p.600

          .         .         .         .         .         .       g.49109
 GTGACAACATGGAGATTCACAAATATCAAACAGTGGAATGTAAACTGGGAAACCCGGCAG       c.1860
 V  T  T  W  R  F  T  N  I  K  Q  W  N  V  N  W  E  T  R  Q         p.620

  | 15       .         .         .         .         .         .    g.51258
  | GTGGTCATCGAGTTTGACCAAAACGTCTTTACTGCTTTCACCTGCCTGAGTGCAGATTGC    c.1920
  | V  V  I  E  F  D  Q  N  V  F  T  A  F  T  C  L  S  A  D  C      p.640

          .         .         .         .         .         .       g.51318
 AAGATTGTGCACGAGTACATTGGCGGCTACATTTTCTTGTCCACCCGCTCCAAGGACCAG       c.1980
 K  I  V  H  E  Y  I  G  G  Y  I  F  L  S  T  R  S  K  D  Q         p.660

          .         .         .         .         .                 g.51372
 AATGAAACACTCGATGAGGACTTGTTCCACAAATTGACCGGCGGTCAGGATTGA             c.2034
 N  E  T  L  D  E  D  L  F  H  K  L  T  G  G  Q  D  X               p.677

          .         .         .         .         .         .       g.51432
 aacaagcacgcgtgctcggctcacaccaacaaggcaagccaaaggcgcccctccccagag       c.*60

          .         .         .         .         .         .       g.51492
 ggatccctaacgtgcccagcatgtagattctggactaacagacaacatacattcaccgct       c.*120

          .         .         .         .         .         .       g.51552
 ggtcacccagatcctcattcaaacccactgctggcacatccctttccttactttgccctg       c.*180

          .         .         .         .         .         .       g.51612
 tgctaccagccacggaaggagcctctcttgttttttctataaaatgggtaggcaggagaa       c.*240

          .         .         .         .         .         .       g.51672
 aagcaggtgccctaagattgctctaaggcccagcatgtggttacagttctctgacttgca       c.*300

          .         .         .         .         .         .       g.51732
 gaacctgccaggtgtatggctacaagttatcctcgtgctgatctgtctcattactaagtc       c.*360

          .         .         .         .         .         .       g.51792
 aatggagaagacagaaaggtaaaaatcacgtgtagcaagaacaactcttatttcacaaac       c.*420

          .         .         .         .         .         .       g.51852
 tcaggtatgaaacgaaacgcctgtccttcatggaactgcttttagctcctgtcttttcaa       c.*480

          .         .         .         .         .         .       g.51912
 aatggcagagggagttcctacacacactttttccctggaggccaaggtctaggggtagaa       c.*540

          .         .         .         .         .         .       g.51972
 aggggaggggtggggctaccaggtagcagttgacaacccaaggtcagaggagtggccctc       c.*600

          .         .         .         .         .         .       g.52032
 agtgtcatctgtccacagtgatacctgccaagatgaccactgacccacatctggtcttag       c.*660

          .         .         .         .         .         .       g.52092
 tcattggtctcctcagatttctggggccacctgcaagccccattccattcctacagatct       c.*720

          .         .         .         .         .         .       g.52152
 ctcagccacctgtaagtcctttgtgaagatgtgggtgacacagggggacaggaaaaccca       c.*780

          .         .         .         .         .         .       g.52212
 tttctcaacccagatccatgtctccactgcttctactctgggttgggattcaggaagaca       c.*840

          .         .         .         .         .         .       g.52272
 ggcacagtcctctctgttcatagaaacacctgccagtgtcaaggattccagtcaggtgtc       c.*900

          .         .         .         .         .         .       g.52332
 tatcccaactggtcagggagagaagggcagacccattctcaaagaccaccatgtccaagg       c.*960

          .         .         .         .         .         .       g.52392
 tctgacagctccccactggctgcccccacaggggctttaggctggtctgggtcatgggga       c.*1020

          .         .         .         .         .         .       g.52452
 agcgtccctcttatcgctggtctgtgttctcctggatttggtatctatgttggtacgact       c.*1080

          .         .         .         .         .         .       g.52512
 cctggccttttatctaaaggactttggcttttgtaaatcacaagccaataatagactttt       c.*1140

          .         .         .         .         .         .       g.52572
 ttctccccctctgttttttgctgtgtcatctctgccttgagactgccttgagacagtgct       c.*1200

          .         .         .         .         .         .       g.52632
 tgccttgagagagtgagccaattaacagctgcctgaattgtcattttccattttggtttg       c.*1260

          .         .         .         .         .         .       g.52692
 ttagaggtgggaggggtgggttttgagaaggtcaaaagcaataccagaagtaaagggaaa       c.*1320

          .         .         .         .         .         .       g.52752
 tatcagacaatattttattattttttcatagatgttctgccacacaaagaacttggggtg       c.*1380

          .         .         .         .         .         .       g.52812
 taaggataaggcaaaagctccaatcccatttttcagttctcctaggatgcacccctcagg       c.*1440

          .         .         .         .         .         .       g.52872
 gagcctggccagagttccgaggcccgtgagcgtcagctgttgctttattttccatcaaag       c.*1500

          .         .         .         .         .         .       g.52932
 ccctctgagaagtgagacctcagcaattccgggagccacatagagacagacttggcaagg       c.*1560

          .         .         .         .         .         .       g.52992
 gaccccctggttctgagccagtagctgccatctggaaattcctcttttagcctctcctta       c.*1620

          .         .         .         .         .         .       g.53052
 gaggtgaatgtgaatgaagcctcccaggcacccgctgaatttctgaggccttgcttaaag       c.*1680

          .         .         .         .         .         .       g.53112
 ctcagaagtggtttaggcatttggaaaatctggttcacatcataaagaacttgatttgaa       c.*1740

          .         .         .         .         .         .       g.53172
 atgttttctatagaaacaagtgctaagtgtaccgtatatacttgatgttggtcatttctc       c.*1800

          .         .         .         .         .         .       g.53232
 agtcctatttctcagttctattattttagaacctagtcagttctttaagattataactgg       c.*1860

          .         .         .         .         .         .       g.53292
 tcctacattaaaataatgcttctcgatgtcagattttacctgtttgctgctgagaacatc       c.*1920

          .         .         .         .         .         .       g.53352
 tctgcctaatttaccaaagccagaccttcagttcaacatgcttccttagcttttcatagt       c.*1980

          .         .         .         .         .         .       g.53412
 tgtctgacatttccatgaaaacaaaggaaccaactttgttttaaccaaactttgtttggt       c.*2040

          .         .         .         .         .         .       g.53472
 tacagttttcaggggagcgtttcttccatgacacacagcaacatcccaaagaaataaaca       c.*2100

          .         .         .         .         .         .       g.53532
 agtgtgacaaaaaaaaaaaaaaacaaacctaaatgctactgttccaaagagcaacttgat       c.*2160

          .         .         .         .         .         .       g.53592
 ggttttttttaatactgagtgcaaaaggtcacccaaattcctatgatgaaattttaaatt       c.*2220

          .         .         .         .         .         .       g.53652
 aatgggcacctttcaacatcatttgcttccttatctacagttgattcagaaatctgcatt       c.*2280

          .         .         .         .                           g.53700
 ttttattcttttatatgacttttaagtaaaagatttatatggatttga                   c.*2328

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fermitin family member 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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