fibrinogen alpha chain (FGA) - coding DNA reference sequence

(used for variant description)

(last modified July 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000508.3 in the FGA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008832.1, covering FGA transcript NM_000508.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   agcaatcctttctttcagctggagtgctcctcaggagccagccccacccttagaaaag       c.-1

          .         .         .         .         .     | 02   .    g.6189
 ATGTTTTCCATGAGGATCGTCTGCCTGGTCCTAAGTGTGGTGGGCACAGCATGG | ACTGCA    c.60
 M  F  S  M  R  I  V  C  L  V  L  S  V  V  G  T  A  W   | T  A      p.20

          .         .         .         .         .         .       g.6249
 GATAGTGGTGAAGGTGACTTTCTAGCTGAAGGAGGAGGCGTGCGTGGCCCAAGGGTTGTG       c.120
 D  S  G  E  G  D  F  L  A  E  G  G  G  V  R  G  P  R  V  V         p.40

          .         .         .         .         .         .       g.6309
 GAAAGACATCAATCTGCCTGCAAAGATTCAGACTGGCCCTTCTGCTCTGATGAAGACTGG       c.180
 E  R  H  Q  S  A  C  K  D  S  D  W  P  F  C  S  D  E  D  W         p.60

  | 03       .         .         .         .         .         .    g.6829
  | AACTACAAATGCCCTTCTGGCTGCAGGATGAAAGGGTTGATTGATGAAGTCAATCAAGAT    c.240
  | N  Y  K  C  P  S  G  C  R  M  K  G  L  I  D  E  V  N  Q  D      p.80

          .         .         .         .         .         .       g.6889
 TTTACAAACAGAATAAATAAGCTCAAAAATTCACTATTTGAATATCAGAAGAACAATAAG       c.300
 F  T  N  R  I  N  K  L  K  N  S  L  F  E  Y  Q  K  N  N  K         p.100

          .         .         .         .         .         .       g.6949
 GATTCTCATTCGTTGACCACTAATATAATGGAAATTTTGAGAGGCGATTTTTCCTCAGCC       c.360
 D  S  H  S  L  T  T  N  I  M  E  I  L  R  G  D  F  S  S  A         p.120

      | 04   .         .         .         .         .         .    g.8144
 AATA | ACCGTGATAATACCTACAACCGAGTGTCAGAGGATCTGAGAAGCAGAATTGAAGTC    c.420
 N  N |   R  D  N  T  Y  N  R  V  S  E  D  L  R  S  R  I  E  V      p.140

          .         .         .         .         .         .       g.8204
 CTGAAGCGCAAAGTCATAGAAAAAGTACAGCATATCCAGCTTCTGCAGAAAAATGTTAGA       c.480
 L  K  R  K  V  I  E  K  V  Q  H  I  Q  L  L  Q  K  N  V  R         p.160

          .         .         . | 05       .         .         .    g.8857
 GCTCAGTTGGTTGATATGAAACGACTGGAG | GTGGACATTGATATTAAGATCCGATCTTGT    c.540
 A  Q  L  V  D  M  K  R  L  E   | V  D  I  D  I  K  I  R  S  C      p.180

          .         .         .         .         .         .       g.8917
 CGAGGGTCATGCAGTAGGGCTTTAGCTCGTGAAGTAGATCTGAAGGACTATGAAGATCAG       c.600
 R  G  S  C  S  R  A  L  A  R  E  V  D  L  K  D  Y  E  D  Q         p.200

          .         .         .         .         .         .       g.8977
 CAGAAGCAACTTGAACAGGTCATTGCCAAAGACTTACTTCCCTCTAGAGATAGGCAACAC       c.660
 Q  K  Q  L  E  Q  V  I  A  K  D  L  L  P  S  R  D  R  Q  H         p.220

          .         .         .         .         .         .       g.9037
 TTACCACTGATAAAAATGAAACCAGTTCCAGACTTGGTTCCCGGAAATTTTAAGAGCCAG       c.720
 L  P  L  I  K  M  K  P  V  P  D  L  V  P  G  N  F  K  S  Q         p.240

          .         .         .         .         .         .       g.9097
 CTTCAGAAGGTACCCCCAGAGTGGAAGGCATTAACAGACATGCCGCAGATGAGAATGGAG       c.780
 L  Q  K  V  P  P  E  W  K  A  L  T  D  M  P  Q  M  R  M  E         p.260

          .         .         .         .         .         .       g.9157
 TTAGAGAGACCTGGTGGAAATGAGATTACTCGAGGAGGCTCCACCTCTTATGGAACCGGA       c.840
 L  E  R  P  G  G  N  E  I  T  R  G  G  S  T  S  Y  G  T  G         p.280

          .         .         .         .         .         .       g.9217
 TCAGAGACGGAAAGCCCCAGGAACCCTAGCAGTGCTGGAAGCTGGAACTCTGGGAGCTCT       c.900
 S  E  T  E  S  P  R  N  P  S  S  A  G  S  W  N  S  G  S  S         p.300

          .         .         .         .         .         .       g.9277
 GGACCTGGAAGTACTGGAAACCGAAACCCTGGGAGCTCTGGGACTGGAGGGACTGCAACC       c.960
 G  P  G  S  T  G  N  R  N  P  G  S  S  G  T  G  G  T  A  T         p.320

          .         .         .         .         .         .       g.9337
 TGGAAACCTGGGAGCTCTGGACCTGGAAGTACTGGAAGCTGGAACTCTGGGAGCTCTGGA       c.1020
 W  K  P  G  S  S  G  P  G  S  T  G  S  W  N  S  G  S  S  G         p.340

          .         .         .         .         .         .       g.9397
 ACTGGAAGTACTGGAAACCAAAACCCTGGGAGCCCTAGACCTGGTAGTACCGGAACCTGG       c.1080
 T  G  S  T  G  N  Q  N  P  G  S  P  R  P  G  S  T  G  T  W         p.360

          .         .         .         .         .         .       g.9457
 AATCCTGGCAGCTCTGAACGCGGAAGTGCTGGGCACTGGACCTCTGAGAGCTCTGTATCT       c.1140
 N  P  G  S  S  E  R  G  S  A  G  H  W  T  S  E  S  S  V  S         p.380

          .         .         .         .         .         .       g.9517
 GGTAGTACTGGACAATGGCACTCTGAATCTGGAAGTTTTAGGCCAGATAGCCCAGGCTCT       c.1200
 G  S  T  G  Q  W  H  S  E  S  G  S  F  R  P  D  S  P  G  S         p.400

          .         .         .         .         .         .       g.9577
 GGGAACGCGAGGCCTAACAACCCAGACTGGGGCACATTTGAAGAGGTGTCAGGAAATGTA       c.1260
 G  N  A  R  P  N  N  P  D  W  G  T  F  E  E  V  S  G  N  V         p.420

          .         .         .         .         .         .       g.9637
 AGTCCAGGGACAAGGAGAGAGTACCACACAGAAAAACTGGTCACTTCTAAAGGAGATAAA       c.1320
 S  P  G  T  R  R  E  Y  H  T  E  K  L  V  T  S  K  G  D  K         p.440

          .         .         .         .         .         .       g.9697
 GAGCTCAGGACTGGTAAAGAGAAGGTCACCTCTGGTAGCACAACCACCACGCGTCGTTCA       c.1380
 E  L  R  T  G  K  E  K  V  T  S  G  S  T  T  T  T  R  R  S         p.460

          .         .         .         .         .         .       g.9757
 TGCTCTAAAACCGTTACTAAGACTGTTATTGGTCCTGATGGTCACAAAGAAGTTACCAAA       c.1440
 C  S  K  T  V  T  K  T  V  I  G  P  D  G  H  K  E  V  T  K         p.480

          .         .         .         .         .         .       g.9817
 GAAGTGGTGACCTCCGAAGATGGTTCTGACTGTCCCGAGGCAATGGATTTAGGCACATTG       c.1500
 E  V  V  T  S  E  D  G  S  D  C  P  E  A  M  D  L  G  T  L         p.500

          .         .         .         .         .         .       g.9877
 TCTGGCATAGGTACTCTGGATGGGTTCCGCCATAGGCACCCTGATGAAGCTGCCTTCTTC       c.1560
 S  G  I  G  T  L  D  G  F  R  H  R  H  P  D  E  A  A  F  F         p.520

          .         .         .         .         .         .       g.9937
 GACACTGCCTCAACTGGAAAAACATTCCCAGGTTTCTTCTCACCTATGTTAGGAGAGTTT       c.1620
 D  T  A  S  T  G  K  T  F  P  G  F  F  S  P  M  L  G  E  F         p.540

          .         .         .         .         .         .       g.9997
 GTCAGTGAGACTGAGTCTAGGGGCTCAGAATCTGGCATCTTCACAAATACAAAGGAATCC       c.1680
 V  S  E  T  E  S  R  G  S  E  S  G  I  F  T  N  T  K  E  S         p.560

          .         .         .         .         .         .       g.10057
 AGTTCTCATCACCCTGGGATAGCTGAATTCCCTTCCCGTGGTAAATCTTCAAGTTACAGC       c.1740
 S  S  H  H  P  G  I  A  E  F  P  S  R  G  K  S  S  S  Y  S         p.580

          .         .         .         .         .         .       g.10117
 AAACAATTTACTAGTAGCACGAGTTACAACAGAGGAGACTCCACATTTGAAAGCAAGAGC       c.1800
 K  Q  F  T  S  S  T  S  Y  N  R  G  D  S  T  F  E  S  K  S         p.600

          .         .         .         .         .         .       g.10177
 TATAAAATGGCAGATGAGGCCGGAAGTGAAGCCGATCATGAAGGAACACATAGCACCAAG       c.1860
 Y  K  M  A  D  E  A  G  S  E  A  D  H  E  G  T  H  S  T  K         p.620

          .         .         .  | 06      .         .         .    g.10941
 AGAGGCCATGCTAAATCTCGCCCTGTCAGAG | ACTGTGATGATGTCCTCCAAACACATCCT    c.1920
 R  G  H  A  K  S  R  P  V  R  D |   C  D  D  V  L  Q  T  H  P      p.640

          .         .         .         .         .         .       g.11001
 TCAGGTACCCAAAGTGGCATTTTCAATATCAAGCTACCGGGATCCAGTAAGATTTTTTCT       c.1980
 S  G  T  Q  S  G  I  F  N  I  K  L  P  G  S  S  K  I  F  S         p.660

          .         .         .         .         .         .       g.11061
 GTTTATTGCGATCAAGAGACCAGTTTGGGAGGATGGCTTTTGATCCAGCAAAGAATGGAT       c.2040
 V  Y  C  D  Q  E  T  S  L  G  G  W  L  L  I  Q  Q  R  M  D         p.680

          .         .         .         .         .         .       g.11121
 GGATCACTGAATTTTAACCGGACCTGGCAAGACTACAAGAGAGGTTTCGGCAGCCTGAAT       c.2100
 G  S  L  N  F  N  R  T  W  Q  D  Y  K  R  G  F  G  S  L  N         p.700

          .         .         .         .         .         .       g.11181
 GACGAGGGGGAAGGAGAATTCTGGCTAGGCAATGACTACCTCCACTTACTAACCCAAAGG       c.2160
 D  E  G  E  G  E  F  W  L  G  N  D  Y  L  H  L  L  T  Q  R         p.720

          .         .         .         .         .         .       g.11241
 GGCTCTGTTCTTAGGGTTGAATTAGAGGACTGGGCTGGGAATGAAGCTTATGCAGAATAT       c.2220
 G  S  V  L  R  V  E  L  E  D  W  A  G  N  E  A  Y  A  E  Y         p.740

          .         .         .         .         .         .       g.11301
 CACTTCCGGGTAGGCTCTGAGGCTGAAGGCTATGCCCTCCAAGTCTCCTCCTATGAAGGC       c.2280
 H  F  R  V  G  S  E  A  E  G  Y  A  L  Q  V  S  S  Y  E  G         p.760

          .         .         .         .         .         .       g.11361
 ACTGCGGGTGATGCTCTGATTGAGGGTTCCGTAGAGGAAGGGGCAGAGTACACCTCTCAC       c.2340
 T  A  G  D  A  L  I  E  G  S  V  E  E  G  A  E  Y  T  S  H         p.780

          .         .         .         .         .         .       g.11421
 AACAACATGCAGTTCAGCACCTTTGACAGGGATGCAGACCAGTGGGAAGAGAACTGTGCA       c.2400
 N  N  M  Q  F  S  T  F  D  R  D  A  D  Q  W  E  E  N  C  A         p.800

          .         .         .         .         .         .       g.11481
 GAAGTCTATGGGGGAGGCTGGTGGTATAATAACTGCCAAGCAGCCAATCTCAATGGAATC       c.2460
 E  V  Y  G  G  G  W  W  Y  N  N  C  Q  A  A  N  L  N  G  I         p.820

          .         .         .         .         .         .       g.11541
 TACTACCCTGGGGGCTCCTATGACCCAAGGAATAACAGTCCTTATGAGATTGAGAATGGA       c.2520
 Y  Y  P  G  G  S  Y  D  P  R  N  N  S  P  Y  E  I  E  N  G         p.840

          .         .         .         .         .         .       g.11601
 GTGGTCTGGGTTTCCTTTAGAGGGGCAGATTATTCCCTCAGGGCTGTTCGCATGAAAATT       c.2580
 V  V  W  V  S  F  R  G  A  D  Y  S  L  R  A  V  R  M  K  I         p.860

          .         .                                               g.11622
 AGGCCCCTTGTGACCCAATAG                                              c.2601
 R  P  L  V  T  Q  X                                                p.866

          .         .         .         .         .         .       g.11682
 gctgaagaagtgggaatgggagcactctgtcttctttgctagagaagtggagagaaaata       c.*60

          .         .         .         .         .         .       g.11742
 caaaaggtaaagcagttgagattctctacaacctaaaaaattcctaggtgctattttctt       c.*120

          .         .         .         .         .         .       g.11802
 atcctttgtactgtagctaaatgtacctgagacatattagtctttgaaaaataaagttat       c.*180

          .         .         .         .         .         .       g.11862
 gtaaggttttttttatctttaaatagctctgtgggttttaacatttttataaagatatac       c.*240

          .         .         .         .         .         .       g.11922
 caagggccattcagtacatcaggaaagtggcagacagaagcttctctctgcaaccttgaa       c.*300

          .         .         .         .         .         .       g.11982
 gactattggtttgagaacttctcttcccataccacccaaaatcataatgccattggaaag       c.*360

          .         .         .         .         .         .       g.12042
 caaaaagttgttttatccatttgatttgaattgttttaagccaatattttaaggtaaaac       c.*420

          .         .         .         .         .         .       g.12102
 tcactgaatctaaccatagctgacctttgtagtagaatttacaacttataattacaatgc       c.*480

          .         .         .         .         .         .       g.12162
 acaatttataattacaatatgtatttatgtcttttgctatggagcaaatccaggaaggca       c.*540

          .         .         .         .         .         .       g.12222
 agagaaacattctttcctaaatataaatgaaaatctatcctttaaactcttccactagac       c.*600

          .         .         .         .         .         .       g.12282
 gttgtaatgcacacttatttttttcccaaggagtaaccaatttctttctaaaacacattt       c.*660

          .         .         .         .         .         .       g.12342
 aaaattttaaaactatttatgaatattaaaaaaagacataattcacacattaataaacaa       c.*720

          .         .         .         .         .         .       g.12402
 tctcccaagtattgatttaacttcatttttctaataatcataaactatattctgtgacat       c.*780

          .         .         .         .         .         .       g.12462
 gctaattattattaaatgtaagtcgttagttcgaaagcctctcactaagtatgatctatg       c.*840

          .         .         .         .         .         .       g.12522
 ctatattcaaaattcaacccatttactttggtcaatatttgatctaagttgcatctttaa       c.*900

          .         .         .         .         .         .       g.12582
 tcctggtggtcttgccttctgatttttaatttgtatccttttctattaagatatatttgt       c.*960

          .         .         .                                     g.12618
 cattttctcttgaatatgtattaaaatatcccaagc                               c.*996

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fibrinogen alpha chain protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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