FYVE, RhoGEF and PH domain containing 1 (FGD1) - coding DNA reference sequence

(used for variant description)

(last modified February 4, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_004463.2 in the FGD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008054.1, covering FGD1 transcript NM_004463.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               cagggctccttccc       c.-721

 .         .         .         .         .         .                g.5074
 gcccgccgccgccgagacccaggctgaagctggggaggacggtggagcccggcccaggcc       c.-661

 .         .         .         .         .         .                g.5134
 gttctcctgcccccgcggctggagcatcgtctgggactactggctgaaggcgagccccgc       c.-601

 .         .         .         .         .         .                g.5194
 agcccaagcgcagcgcacacgcgcgcccccggccaccgccgttctctcttccctcccctc       c.-541

 .         .         .         .         .         .                g.5254
 ctctcccctcccctctcctccgcccccggcctcggctgcggcgggaggaagaacgcttcc       c.-481

 .         .         .         .         .         .                g.5314
 caaccagccaggagagcccagatctattcccattcggggagaaagaagagaccccgcact       c.-421

 .         .         .         .         .         .                g.5374
 tggatccgaccgacttctcgccccggggccacggaagtggctcgccgtccaccggagagt       c.-361

 .         .         .         .         .         .                g.5434
 ccccgccgagcgtagccctccaaccctcgcccaaccgcagccgcatagacagcgctcccc       c.-301

 .         .         .         .         .         .                g.5494
 agcgggcccccggccccgccgagcccactccccgcgcggggccggggccggggccggcga       c.-241

 .         .         .         .         .         .                g.5554
 tgcctggcacggcagcggcggtggccgcggctgctgctgctgctactgccaccgctgcca       c.-181

 .         .         .         .         .         .                g.5614
 cggctgctggcccgggcccgggctgggggcttgagtctctgcagtggggctgagcccgca       c.-121

 .         .         .         .         .         .                g.5674
 gtcccgccccccgatcctgaggccgctgctccgccgggcgccgggcctcctccgcccgcg       c.-61

 .         .         .         .         .         .                g.5734
 cctccgccccaggagctggagccaagcggggagctcgggccccgcgcccaggcccggacc       c.-1

          .         .         .         .         .         .       g.5794
 ATGCATGGCCACCGAGCCCCGGGGGGCGCCGGGCCTTCGGAGCCCGAACACCCGGCCACG       c.60
 M  H  G  H  R  A  P  G  G  A  G  P  S  E  P  E  H  P  A  T         p.20

          .         .         .         .         .         .       g.5854
 AACCCGCCGGGCGCCGCTCCGCCGGCCTGTGCCGACTCGGACCCTGGAGCCTCGGAACCC       c.120
 N  P  P  G  A  A  P  P  A  C  A  D  S  D  P  G  A  S  E  P         p.40

          .         .         .         .         .         .       g.5914
 GGACTGCTGGCGCGCAGGGGCTCAGGTTCGGCTCTTGGCGGCCCACTGGATCCCCAGTTT       c.180
 G  L  L  A  R  R  G  S  G  S  A  L  G  G  P  L  D  P  Q  F         p.60

          .         .         .         .         .         .       g.5974
 GTCGGACCCTCGGACACCAGCCTGGGCGCTGCTCCAGGCCACCGGGTCTTGCCCTGCGGT       c.240
 V  G  P  S  D  T  S  L  G  A  A  P  G  H  R  V  L  P  C  G         p.80

          .         .         .         .         .         .       g.6034
 CCCAGTCCACAGCACCACCGGGCCCTGCGCTTCTCTTACCACCTGGAGGGCTCGCAGCCT       c.300
 P  S  P  Q  H  H  R  A  L  R  F  S  Y  H  L  E  G  S  Q  P         p.100

         | 02.         .         .         .         .         .    g.29732
 CGGCCTG | GGCTGCACCAGGGAAACCGGATCCTGGTTAAAAGTTTGTCCCTTGACCCTGGC    c.360
 R  P  G |   L  H  Q  G  N  R  I  L  V  K  S  L  S  L  D  P  G      p.120

          .         .         .         .         .         .       g.29792
 CAAAGCCTAGAGCCTCATCCAGAAGGTCCCCAGCGGCTTCGCTCAGACCCAGGTCCCCCG       c.420
 Q  S  L  E  P  H  P  E  G  P  Q  R  L  R  S  D  P  G  P  P         p.140

          .         .         .         .         .         .       g.29852
 ACTGAAACCCCTAGCCAGCGTCCTTCACCACTGAAGCGGGCACCGGGCCCGAAGCCACAG       c.480
 T  E  T  P  S  Q  R  P  S  P  L  K  R  A  P  G  P  K  P  Q         p.160

   | 03      .         .         .         .         .         .    g.30465
 G | TGCCCCCAAAGCCCAGCTACCTGCAGATGCCCCGGATGCCCCCCCCACTGGAGCCCATC    c.540
 V |   P  P  K  P  S  Y  L  Q  M  P  R  M  P  P  P  L  E  P  I      p.180

          .         .         .         .         .         .       g.30525
 CCCCCTCCACCATCACGCCCACTGCCTGCCGACCCCCGAGTGGCCAAGGGCCTGGCTCCC       c.600
 P  P  P  P  S  R  P  L  P  A  D  P  R  V  A  K  G  L  A  P         p.200

          .         .         .         .         .          | 04    g.30710
 AGGGCAGAGGCCAGCCCCAGTTCTGCAGCAGTATCCTCACTGATTGAGAAGTTTGAAAG | A    c.660
 R  A  E  A  S  P  S  S  A  A  V  S  S  L  I  E  K  F  E  R  |      p.220

          .         .         .         .         .         .       g.30770
 GAGCCTGTGATTGTCGCCTCGGATAGACCAGTCCCTGGCCCCAGCCCAGGTCCCCCAGAG       c.720
 E  P  V  I  V  A  S  D  R  P  V  P  G  P  S  P  G  P  P  E         p.240

          .         .         .         .         .         .       g.30830
 CCAGTCATGTTGCCACAGCCAACCTCGCAGCCACCAGTGCCCCAGCTCCCCGAGGGTGAG       c.780
 P  V  M  L  P  Q  P  T  S  Q  P  P  V  P  Q  L  P  E  G  E         p.260

          .         .         .         .         .         .       g.30890
 GCCTCCCGCTGCCTGTTTCTGCTGGCTCCTGGGCCCCGGGACGGTGAGAAGGTGCCCAAC       c.840
 A  S  R  C  L  F  L  L  A  P  G  P  R  D  G  E  K  V  P  N         p.280

          .         .         .         .         .         .       g.30950
 CGGGACAGCGGCATTGATAGCATCAGCTCGCCATCCAACAGCGAGGAGACCTGCTTCGTC       c.900
 R  D  S  G  I  D  S  I  S  S  P  S  N  S  E  E  T  C  F  V         p.300

          .         .         .         .         .         .       g.31010
 AGTGATGACGGGCCCCCCAGCCACAGCCTCTGCCCTGGGCCCCCTGCCCTGGCTAGTGTG       c.960
 S  D  D  G  P  P  S  H  S  L  C  P  G  P  P  A  L  A  S  V         p.320

          .         .         .         .         .         .       g.31070
 CCTGTTGCCTTGGCCGACCCCCACCGGCCTGGCTCCCAAGAGGTTGACAGTGACCTGGAG       c.1020
 P  V  A  L  A  D  P  H  R  P  G  S  Q  E  V  D  S  D  L  E         p.340

          .         .         .         .         .         .       g.31130
 GAGGAGGACGACGAGGAGGAGGAGGAAGAGAAGGACAGAGAAATCCCAGTGCCCCTGATG       c.1080
 E  E  D  D  E  E  E  E  E  E  K  D  R  E  I  P  V  P  L  M         p.360

          .         .  | 05      .         .         .         .    g.32329
 GAGAGACAGGAGTCTGTGGAG | TTGACTGTGCAGCAAAAGGTGTTTCACATTGCCAATGAG    c.1140
 E  R  Q  E  S  V  E   | L  T  V  Q  Q  K  V  F  H  I  A  N  E      p.380

          .         .         .         .         .  | 06      .    g.33243
 CTCCTGCAAACTGAGAAGGCCTACGTTTCCAGGCTCCATCTCCTGGATCAG | GTGTTCTGT    c.1200
 L  L  Q  T  E  K  A  Y  V  S  R  L  H  L  L  D  Q   | V  F  C      p.400

          .         .         .         .         .         .       g.33303
 GCCCGGCTGCTGGAAGAAGCTCGGAACCGCAGTTCCTTCCCGGCCGACGTTGTCCACGGC       c.1260
 A  R  L  L  E  E  A  R  N  R  S  S  F  P  A  D  V  V  H  G         p.420

          .         .         .         .         .         .       g.33363
 ATCTTCTCTAACATCTGCTCCATCTATTGCTTCCACCAGCAGTTCCTGCTGCCTGAGCTA       c.1320
 I  F  S  N  I  C  S  I  Y  C  F  H  Q  Q  F  L  L  P  E  L         p.440

          .         . | 07       .         .         .         .    g.35354
 GAGAAGCGCATGGAGGAATG | GGACCGCTATCCACGCATTGGAGACATCCTGCAGAAACTG    c.1380
 E  K  R  M  E  E  W  |  D  R  Y  P  R  I  G  D  I  L  Q  K  L      p.460

          .         .         .         .         .         .       g.35414
 GCCCCCTTCCTCAAGATGTATGGTGAGTATGTGAAGAACTTTGACCGGGCCGTGGAGCTG       c.1440
 A  P  F  L  K  M  Y  G  E  Y  V  K  N  F  D  R  A  V  E  L         p.480

          .         .         .         .         .        | 08.    g.35580
 GTCAACACCTGGACAGAGCGCTCCACCCAGTTTAAAGTCATCATCCATGAGGTGCAG | AAG    c.1500
 V  N  T  W  T  E  R  S  T  Q  F  K  V  I  I  H  E  V  Q   | K      p.500

          .         .         .         .         .         .       g.35640
 GAGGAAGCCTGTGGCAACCTGACATTGCAGCACCACATGCTGGAGCCTGTGCAGCGCATC       c.1560
 E  E  A  C  G  N  L  T  L  Q  H  H  M  L  E  P  V  Q  R  I         p.520

          .         .         .         .         .         .       g.35700
 CCCCGCTATGAGCTTCTTCTCAAGGACTATCTGTTAAAGCTGCCCCATGGCTCCCCGGAC       c.1620
 P  R  Y  E  L  L  L  K  D  Y  L  L  K  L  P  H  G  S  P  D         p.540

          .       | 09 .         .         .         .         .    g.44643
 AGCAAGGATGCCCAAA | AGTCTCTGGAGCTGATCGCCACAGCAGCAGAGCACTCGAATGCT    c.1680
 S  K  D  A  Q  K |   S  L  E  L  I  A  T  A  A  E  H  S  N  A      p.560

          .      | 10  .         .         .         .         .    g.44845
 GCCATCCGCAAAATG | GAGCGAATGCATAAGCTGCTGAAGGTATATGAGCTGTTAGGGGGC    c.1740
 A  I  R  K  M   | E  R  M  H  K  L  L  K  V  Y  E  L  L  G  G      p.580

          .         .         .         .         .         .       g.44905
 GAGGAGGACATTGTCAGCCCCACCAAAGAGCTCATAAAAGAAGGCCACATCCTTAAGCTG       c.1800
 E  E  D  I  V  S  P  T  K  E  L  I  K  E  G  H  I  L  K  L         p.600

          .         .         .         .   | 11     .         .    g.45400
 TCAGCAAAGAATGGGACCACTCAAGACCGATACCTCATACTA | TTCAACGACCGCCTCCTT    c.1860
 S  A  K  N  G  T  T  Q  D  R  Y  L  I  L   | F  N  D  R  L  L      p.620

          .         .         .         .         .         .       g.45460
 TACTGCGTGCCCAGGCTGCGGCTCCTTGGCCAGAAGTTTAGCGTGCGGGCACGCATTGAT       c.1920
 Y  C  V  P  R  L  R  L  L  G  Q  K  F  S  V  R  A  R  I  D         p.640

          .      | 12  .         .         .         .         .    g.45684
 GTAGATGGCATGGAG | CTAAAGGAGAGCTCCAACCTCAATCTGCCTCGAACCTTCCTGGTG    c.1980
 V  D  G  M  E   | L  K  E  S  S  N  L  N  L  P  R  T  F  L  V      p.660

          .         .         .      | 13  .         .         .    g.50890
 TCAGGAAAGCAGCGCTCCCTCGAGCTCCAGGCCAG | GACTGAGGAGGAGAAGAAAGACTGG    c.2040
 S  G  K  Q  R  S  L  E  L  Q  A  R  |  T  E  E  E  K  K  D  W      p.680

        | 14 .         .         .         .         .         .    g.51460
 GTCCAG | GCCATCAACTCCACCCTCCTGAAGCATGAACAGACGCTGGAGACTTTCAAACTG    c.2100
 V  Q   | A  I  N  S  T  L  L  K  H  E  Q  T  L  E  T  F  K  L      p.700

          .         .         .         .         | 15         .    g.51910
 TTGAACTCAACAAACAGGGAAGATGAAGACACCCCACCCAACTCTCCA | AACGTGGATCTT    c.2160
 L  N  S  T  N  R  E  D  E  D  T  P  P  N  S  P   | N  V  D  L      p.720

          .         .         .         .         .         .       g.51970
 GGGAAGCGGGCACCTACGCCCATCCGGGAAAAGGAAGTCACCATGTGCATGCGCTGCCAG       c.2220
 G  K  R  A  P  T  P  I  R  E  K  E  V  T  M  C  M  R  C  Q         p.740

          .         .         .         .         .     | 16   .    g.52205
 GAGCCCTTCAATTCTATCACCAAACGCAGGCACCACTGCAAGGCCTGCGGGCAT | GTGGTT    c.2280
 E  P  F  N  S  I  T  K  R  R  H  H  C  K  A  C  G  H   | V  V      p.760

          .         .         .         .         .         .       g.52265
 TGTGGGAAGTGCTCCGAGTTCCGGGCCCGCCTCGTCTATGACAACAACCGCTCCAACCGT       c.2340
 C  G  K  C  S  E  F  R  A  R  L  V  Y  D  N  N  R  S  N  R         p.780

          .         .         .         .         .         .       g.52325
 GTGTGCACTGATTGCTATGTGGCCTTGCACGGGGTGCCTGGGAGCAGTCCAGCCTGCAGC       c.2400
 V  C  T  D  C  Y  V  A  L  H  G  V  P  G  S  S  P  A  C  S         p.800

          .         .         .       | 17 .         .         .    g.53736
 CAGCATACACCCCAGCGCCGGAGGTCCATCCTGGAG | AAACAGGCCTCAGTGGCTGCAGAG    c.2460
 Q  H  T  P  Q  R  R  R  S  I  L  E   | K  Q  A  S  V  A  A  E      p.820

          .         .         .         .         .         .       g.53796
 AACAGCGTCATCTGCAGCTTCCTGCACTACATGGAGAAGGGTGGCAAAGGATGGCACAAG       c.2520
 N  S  V  I  C  S  F  L  H  Y  M  E  K  G  G  K  G  W  H  K         p.840

          .         .         .         .         .         .       g.53856
 GCATGGTTCGTGGTCCCTGAAAATGAACCCTTGGTGCTGTATATCTACGGAGCCCCTCAG       c.2580
 A  W  F  V  V  P  E  N  E  P  L  V  L  Y  I  Y  G  A  P  Q         p.860

  | 18       .         .         .         .         .         .    g.54812
  | GATGTGAAAGCCCAGCGCAGCCTGCCCCTCATTGGCTTCGAGGTGGGACCGCCCGAGGCA    c.2640
  | D  V  K  A  Q  R  S  L  P  L  I  G  F  E  V  G  P  P  E  A      p.880

          .         .         .         .         .         .       g.54872
 GGGGAGCGGCCTGACAGAAGGCATGTCTTCAAGATCACCCAGAGCCACCTCAGCTGGTAC       c.2700
 G  E  R  P  D  R  R  H  V  F  K  I  T  Q  S  H  L  S  W  Y         p.900

          .         .         .         .         .         .       g.54932
 TTCAGCCCTGAGACAGAGGAACTACAGCGACGCTGGATGGCTGTGCTTGGCCGGGCGGGC       c.2760
 F  S  P  E  T  E  E  L  Q  R  R  W  M  A  V  L  G  R  A  G         p.920

          .         .         .         .         .         .       g.54992
 CGAGGGGACACGTTCTGCCCGGGGCCCACACTGTCTGAGGACAGGGAGATGGAGGAGGCA       c.2820
 R  G  D  T  F  C  P  G  P  T  L  S  E  D  R  E  M  E  E  A         p.940

          .         .         .         .         .         .       g.55052
 CCGGTGGCTGCTTTAGGAGCCACTGCTGAACCCCCCGAATCCCCCCAGACCCGAGACAAG       c.2880
 P  V  A  A  L  G  A  T  A  E  P  P  E  S  P  Q  T  R  D  K         p.960

                                                                    g.55058
 ACCTAG                                                             c.2886
 T  X                                                               p.961

          .         .         .         .         .         .       g.55118
 agggtttgggacaaactgggagcccccaccccacactctagttgcccatgtctgattggg       c.*60

          .         .         .         .         .         .       g.55178
 ggctctagccccttccctcccagctcagtcaatacttgaactcccatcacgggcactttc       c.*120

          .         .         .         .         .         .       g.55238
 aatcccgaatgctgggtcttgggttttttaattcatcttttcacaaaacgtgggctttta       c.*180

          .         .         .         .         .         .       g.55298
 aaaaatatattcctacagtgatgtcaatttttattaatccctgtccccagggagggtggg       c.*240

          .         .         .         .         .         .       g.55358
 agccgttgccagtcctacctgaattaggtcgtttttctccctcatccctcaataccctac       c.*300

          .         .         .         .         .         .       g.55418
 cacagatcctgcctccacccagttccccacaaagcaccagaggtaggagacctggattca       c.*360

          .         .         .         .         .         .       g.55478
 agtgccagctctgccactgaccctggggccccgacccagccctgcctcctcagccagtgt       c.*420

          .         .         .         .         .         .       g.55538
 cttcacacgtacaactccacgtggggtggcaactagacctctcctgcctctcccatggct       c.*480

          .         .         .         .         .         .       g.55598
 tacagcttctacccggccccaaggctacccagtattttatcgtccagacccatggcaggg       c.*540

          .         .         .         .         .         .       g.55658
 ccagcgggcaggacagggaaacaggggggaggacaatggatactcagttttttgtgtttt       c.*600

          .         .         .         .         .                 g.55713
 tttgtgtgtttttttttttttaagaaaaatacagtttatttcaggcttacagtaa            c.*655

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The FYVE, RhoGEF and PH domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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