fibroblast growth factor 8 (androgen-induced) (FGF8) - coding DNA reference sequence

(used for variant description)

(last modified October 5, 2021)

This file was created to facilitate the description of sequence variants on transcript NM_033163.3 in the FGF8 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering FGF8 transcript NM_033163.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.9409
                   acccgcaccctctccgctcgcgccctgctcagcgcgtcctcc       c.-61

 .         .         .         .         .         .                g.9469
 cgcggcggcccgcgggacggcgtgacccgccgggctctcggtgccccggggccgcgcgcc       c.-1

          .         .         .   | 02     .         .         .    g.9621
 ATGGGCAGCCCCCGCTCCGCGCTGAGCTGCCT | GCTGTTGCACTTGCTGGTCCTCTGCCTC    c.60
 M  G  S  P  R  S  A  L  S  C  L  |  L  L  H  L  L  V  L  C  L      p.20

           | 03        .         .         .         .         .    g.10204
 CAAGCCCAG | GAAGGCCCGGGCAGGGGCCCTGCGCTGGGCAGGGAGCTCGCTTCCCTGTTC    c.120
 Q  A  Q   | E  G  P  G  R  G  P  A  L  G  R  E  L  A  S  L  F      p.40

          .         .         .       | 04 .         .         .    g.10481
 CGGGCTGGCCGGGAGCCCCAGGGTGTCTCCCAACAG | GTAACTGTTCAGTCCTCACCTAAT    c.180
 R  A  G  R  E  P  Q  G  V  S  Q  Q   | V  T  V  Q  S  S  P  N      p.60

          .         .         .         .         .         .       g.10541
 TTTACACAGCATGTGAGGGAGCAGAGCCTGGTGACGGATCAGCTCAGCCGCCGCCTCATC       c.240
 F  T  Q  H  V  R  E  Q  S  L  V  T  D  Q  L  S  R  R  L  I         p.80

          .         .         .         .         .         .       g.10601
 CGGACCTACCAACTCTACAGCCGCACCAGCGGGAAGCACGTGCAGGTCCTGGCCAACAAG       c.300
 R  T  Y  Q  L  Y  S  R  T  S  G  K  H  V  Q  V  L  A  N  K         p.100

          .         .         .        | 05.         .         .    g.13823
 CGCATCAACGCCATGGCAGAGGACGGCGACCCCTTCG | CAAAGCTCATCGTGGAGACGGAC    c.360
 R  I  N  A  M  A  E  D  G  D  P  F  A |   K  L  I  V  E  T  D      p.120

          .         .         .         .         .         .       g.13883
 ACCTTTGGAAGCAGAGTTCGAGTCCGAGGAGCCGAGACGGGCCTCTACATCTGCATGAAC       c.420
 T  F  G  S  R  V  R  V  R  G  A  E  T  G  L  Y  I  C  M  N         p.140

          .         .     | 06   .         .         .         .    g.14786
 AAGAAGGGGAAGCTGATCGCCAAG | AGCAACGGCAAAGGCAAGGACTGCGTCTTCACGGAG    c.480
 K  K  G  K  L  I  A  K   | S  N  G  K  G  K  D  C  V  F  T  E      p.160

          .         .         .         .         .         .       g.14846
 ATTGTGCTGGAGAACAACTACACAGCGCTGCAGAATGCCAAGTACGAGGGCTGGTACATG       c.540
 I  V  L  E  N  N  Y  T  A  L  Q  N  A  K  Y  E  G  W  Y  M         p.180

          .         .         .         .         .         .       g.14906
 GCCTTCACCCGCAAGGGCCGGCCCCGCAAGGGCTCCAAGACGCGGCAGCACCAGCGTGAG       c.600
 A  F  T  R  K  G  R  P  R  K  G  S  K  T  R  Q  H  Q  R  E         p.200

          .         .         .         .         .         .       g.14966
 GTCCACTTCATGAAGCGGCTGCCCCGGGGCCACCACACCACCGAGCAGAGCCTGCGCTTC       c.660
 V  H  F  M  K  R  L  P  R  G  H  H  T  T  E  Q  S  L  R  F         p.220

          .         .         .         .         .         .       g.15026
 GAGTTCCTCAACTACCCGCCCTTCACGCGCAGCCTGCGCGGCAGCCAGAGGACTTGGGCC       c.720
 E  F  L  N  Y  P  P  F  T  R  S  L  R  G  S  Q  R  T  W  A         p.240

          .                                                         g.15041
 CCCGAGCCCCGATAG                                                    c.735
 P  E  P  R  X                                                      p.244

          .         .         .         .         .         .       g.15101
 gtgctgcctggccctccccacaatgccagaccgcagagaggctcatcctgtagggcaccc       c.*60

          .         .         .         .         .         .       g.15161
 aaaactcaagcaagatgagctgtgcgctgctctgcaggctggggaggtgctgggggagcc       c.*120

          .         .         .         .         .         .       g.15221
 ctgggttccggttgttgatattgtttgctgttgggtttttgctgtttttttttttttttt       c.*180

          .                                                         g.15240
 tttttttaaaacaaaagag                                                c.*199

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Fibroblast growth factor 8 (androgen-induced) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.