fibroblast growth factor receptor 1 (FGFR1) - coding DNA reference sequence

(used for variant description)

(last modified October 11, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_023110.2 in the FGFR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007729.1, covering FGFR1 transcript NM_023110.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   agatgcaggggcgcaaacgccaaaggagaccaggctgtagga       c.-901

 .         .         .         .         .         .                g.5102
 agagaagggcagagcgccggacagctcggcccgctccccgtcctttggggccgcggctgg       c.-841

 .         .         .         .         .         .                g.5162
 ggaactacaaggcccagcaggcagctgcagggggcggaggcggaggagggaccagcgcgg       c.-781

 .         .         .         .         .         .                g.5222
 gtgggagtgagagagcgagccctcgcgccccgccggcgcatagcgctcggagcgctcttg       c.-721

 .         .         .         .         .         .                g.5282
 cggccacaggcgcggcgtcctcggcggcgggcggcagctagcgggagccgggacgccggt       c.-661

 .         .         .         .         .         .                g.5342
 gcagccgcagcgcgcggaggaacccgggtgtgccgggagctgggcggccacgtccggacg       c.-601

 .         .         .         .         .         .                g.5402
 ggaccgagacccctcgtagcgcattgcggcgacctcgccttccccggccgcgagcgcgcc       c.-541

 .         .         .         .         .         .                g.5462
 gctgcttgaaaagccgcggaacccaaggacttttctccggtccgagctcggggcgccccg       c.-481

 .         .         .         .         .         .                g.5522
 cagggcgcacggtacccgtgctgcagtcgggcacgccgcggcgccggggcctccgcaggg       c.-421

 .         .         .         .         .         .                g.5582
 cgatggagcccggtctgcaaggaaagtgaggcgccgccgctgcgttctggaggagggggg       c.-361

 .         .         .         .         .         .                g.5642
 cacaaggtctggagaccccgggtggcggacgggagccctccccccgccccgcctccgggg       c.-301

 .         .         .         .         .         .                g.5702
 caccagctccggctccattgttcccgcccgggctggaggcgccgagcaccgagcgccgcc       c.-241

 .         .         .         .         .         .                g.5762
 gggagtcgagcgccggccgcggagctcttgcgaccccgccaggacccgaacagagcccgg       c.-181

 .         .         .         .         .         .                g.5822
 gggcggcgggccggagccggggacgcgggcacacgcccgctcgcacaagccacggcggac       c.-121

 .         .         .         .  | 02      .         .             g.16328
 tctcccgaggcggaacctccacgccgagcgag | ggtcagtttgaaaaggaggatcgagctc    c.-61

 .         .         .         .         .         .                g.16388
 actgtggagtatccatggagatgtggagccttgtcaccaacctctaactgcagaactggg       c.-1

          .         .         .         .         .         .       g.16448
 ATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACC       c.60
 M  W  S  W  K  C  L  L  F  W  A  V  L  V  T  A  T  L  C  T         p.20

          .         .         .  | 03      .         .         .    g.43915
 GCTAGGCCGTCCCCGACCTTGCCTGAACAAG | CCCAGCCCTGGGGAGCCCCTGTGGAAGTG    c.120
 A  R  P  S  P  T  L  P  E  Q  A |   Q  P  W  G  A  P  V  E  V      p.40

          .         .         .         .         .         .       g.43975
 GAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGAT       c.180
 E  S  F  L  V  H  P  G  D  L  L  Q  L  R  C  R  L  R  D  D         p.60

          .         .         .         .         .         .       g.44035
 GTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGC       c.240
 V  Q  S  I  N  W  L  R  D  G  V  Q  L  A  E  S  N  R  T  R         p.80

          .         .         .         .         .         .       g.44095
 ATCACAGGGGAGGAGGTGGAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCT       c.300
 I  T  G  E  E  V  E  V  Q  D  S  V  P  A  D  S  G  L  Y  A         p.100

          .         .         .         .         .         | 04    g.45401
 TGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTCAATGTTTCAG | AT    c.360
 C  V  T  S  S  P  S  G  S  D  T  T  Y  F  S  V  N  V  S  D |       p.120

          .         .         .         .         .         .       g.45461
 GCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAA       c.420
 A  L  P  S  S  E  D  D  D  D  D  D  D  S  S  S  E  E  K  E         p.140

          .         .         | 05         .         .         .    g.45773
 ACAGATAACACCAAACCAAACCGTATGC | CCGTAGCTCCATATTGGACATCCCCAGAAAAG    c.480
 T  D  N  T  K  P  N  R  M  P |   V  A  P  Y  W  T  S  P  E  K      p.160

          .         .         .         .         .         .       g.45833
 ATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTCC       c.540
 M  E  K  K  L  H  A  V  P  A  A  K  T  V  K  F  K  C  P  S         p.180

          .         .         .         .         .         .       g.45893
 AGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGAC       c.600
 S  G  T  P  N  P  T  L  R  W  L  K  N  G  K  E  F  K  P  D         p.200

          .         .  | 06      .         .         .         .    g.47628
 CACAGAATTGGAGGCTACAAG | GTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTG    c.660
 H  R  I  G  G  Y  K   | V  R  Y  A  T  W  S  I  I  M  D  S  V      p.220

          .         .         .         .         .         .       g.47688
 GTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAAC       c.720
 V  P  S  D  K  G  N  Y  T  C  I  V  E  N  E  Y  G  S  I  N         p.240

          .         .      | 07  .         .         .         .    g.49170
 CACACATACCAGCTGGATGTCGTGG | AGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGG    c.780
 H  T  Y  Q  L  D  V  V  E |   R  S  P  H  R  P  I  L  Q  A  G      p.260

          .         .         .         .         .         .       g.49230
 TTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTAC       c.840
 L  P  A  N  K  T  V  A  L  G  S  N  V  E  F  M  C  K  V  Y         p.280

          .         .         .         .         .         .       g.49290
 AGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATT       c.900
 S  D  P  Q  P  H  I  Q  W  L  K  H  I  E  V  N  G  S  K  I         p.300

          .         .         .       | 08 .         .         .    g.51917
 GGCCCAGACAACCTGCCTTATGTCCAGATCTTGAAG | ACTGCTGGAGTTAATACCACCGAC    c.960
 G  P  D  N  L  P  Y  V  Q  I  L  K   | T  A  G  V  N  T  T  D      p.320

          .         .         .         .         .         .       g.51977
 AAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACG       c.1020
 K  E  M  E  V  L  H  L  R  N  V  S  F  E  D  A  G  E  Y  T         p.340

          .         .         .         .         .         .       g.52037
 TGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAA       c.1080
 C  L  A  G  N  S  I  G  L  S  H  H  S  A  W  L  T  V  L  E         p.360

   | 09      .         .         .         .         .         .    g.54158
 G | CCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACCTGGAGATCATCATCTAT    c.1140
 A |   L  E  E  R  P  A  V  M  T  S  P  L  Y  L  E  I  I  I  Y      p.380

          .         .         .         .         .         .       g.54218
 TGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACAAGATGAAG       c.1200
 C  T  G  A  F  L  I  S  C  M  V  G  S  V  I  V  Y  K  M  K         p.400

          .         .         .         .         .         .       g.54278
 AGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGC       c.1260
 S  G  T  K  K  S  D  F  H  S  Q  M  A  V  H  K  L  A  K  S         p.420

          .         .     | 10   .         .         .         .    g.55497
 ATCCCTCTGCGCAGACAGGTAACA | GTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGG    c.1320
 I  P  L  R  R  Q  V  T   | V  S  A  D  S  S  A  S  M  N  S  G      p.440

          .         .         .         .         .         .       g.55557
 GTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTC       c.1380
 V  L  L  V  R  P  S  R  L  S  S  S  G  T  P  M  L  A  G  V         p.460

          .         .         .         .         . | 11       .    g.55853
 TCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAG | ACTGGTCTTA    c.1440
 S  E  Y  E  L  P  E  D  P  R  W  E  L  P  R  D  R  |  L  V  L      p.480

          .         .         .         .         .         .       g.55913
 GGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTG       c.1500
 G  K  P  L  G  E  G  C  F  G  Q  V  V  L  A  E  A  I  G  L         p.500

          .         .         .         .         .   | 12     .    g.56426
 GACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTGAAGATGTTGAAGT | CGGACGCA    c.1560
 D  K  D  K  P  N  R  V  T  K  V  A  V  K  M  L  K  S |   D  A      p.520

          .         .         .         .         .         .       g.56486
 ACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGGGAAG       c.1620
 T  E  K  D  L  S  D  L  I  S  E  M  E  M  M  K  M  I  G  K         p.540

          .         .         .         .    | 13    .         .    g.57791
 CATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATG | GTCCCTTGTATGTCATC    c.1680
 H  K  N  I  I  N  L  L  G  A  C  T  Q  D  G |   P  L  Y  V  I      p.560

          .         .         .         .         .         .       g.57851
 GTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGG       c.1740
 V  E  Y  A  S  K  G  N  L  R  E  Y  L  Q  A  R  R  P  P  G         p.580

          .         .         .         .         .         .       g.57911
 CTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTG       c.1800
 L  E  Y  C  Y  N  P  S  H  N  P  E  E  Q  L  S  S  K  D  L         p.600

          .         .         .         .         .     | 14   .    g.58939
 GTGTCCTGCGCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAG | TGCATA    c.1860
 V  S  C  A  Y  Q  V  A  R  G  M  E  Y  L  A  S  K  K   | C  I      p.620

          .         .         .         .         .         .       g.58999
 CACCGAGACCTGGCAGCCAGGAATGTCCTGGTGACAGAGGACAATGTGATGAAGATAGCA       c.1920
 H  R  D  L  A  A  R  N  V  L  V  T  E  D  N  V  M  K  I  A         p.640

          .         .         .         .         .        | 15.    g.59208
 GACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAAAGACAACCAAC | GGC    c.1980
 D  F  G  L  A  R  D  I  H  H  I  D  Y  Y  K  K  T  T  N   | G      p.660

          .         .         .         .         .         .       g.59268
 CGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCACCAG       c.2040
 R  L  P  V  K  W  M  A  P  E  A  L  F  D  R  I  Y  T  H  Q         p.680

          | 16         .         .         .         .         .    g.59597
 AGTGATGT | GTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCA    c.2100
 S  D  V  |  W  S  F  G  V  L  L  W  E  I  F  T  L  G  G  S  P      p.700

          .         .         .         .         .         .       g.59657
 TACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGAC       c.2160
 Y  P  G  V  P  V  E  E  L  F  K  L  L  K  E  G  H  R  M  D         p.720

          .         .       | 17 .         .         .         .    g.59845
 AAGCCCAGTAACTGCACCAACGAGCT | GTACATGATGATGCGGGACTGCTGGCATGCAGTG    c.2220
 K  P  S  N  C  T  N  E  L  |  Y  M  M  M  R  D  C  W  H  A  V      p.740

          .         .         .         .         .         .       g.59905
 CCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGGCCTTG       c.2280
 P  S  Q  R  P  T  F  K  Q  L  V  E  D  L  D  R  I  V  A  L         p.760

          .   | 18     .         .         .         .         .    g.60078
 ACCTCCAACCAG | GAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCCAGCTTT    c.2340
 T  S  N  Q   | E  Y  L  D  L  S  M  P  L  D  Q  Y  S  P  S  F      p.780

          .         .         .         .         .         .       g.60138
 CCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCG       c.2400
 P  D  T  R  S  S  T  C  S  S  G  E  D  S  V  F  S  H  E  P         p.800

          .         .         .         .         .         .       g.60198
 CTGCCCGAGGAGCCCTGCCTGCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAA       c.2460
 L  P  E  E  P  C  L  P  R  H  P  A  Q  L  A  N  G  G  L  K         p.820

                                                                    g.60207
 CGCCGCTGA                                                          c.2469
 R  R  X                                                            p.822

          .         .         .         .         .         .       g.60267
 ctgccacccacacgccctccccagactccaccgtcagctgtaaccctcacccacagcccc       c.*60

          .         .         .         .         .         .       g.60327
 tgctgggcccaccacctgtccgtccctgtcccctttcctgctggcaggagccggctgcct       c.*120

          .         .         .         .         .         .       g.60387
 accaggggccttcctgtgtggcctgccttcaccccactcagctcacctctccctccacct       c.*180

          .         .         .         .         .         .       g.60447
 cctctccacctgctggtgagaggtgcaaagaggcagatctttgctgccagccacttcatc       c.*240

          .         .         .         .         .         .       g.60507
 ccctcccagatgttggaccaacacccctccctgccaccaggcactgcctggagggcaggg       c.*300

          .         .         .         .         .         .       g.60567
 agtgggagccaatgaacaggcatgcaagtgagagcttcctgagctttctcctgtcggttt       c.*360

          .         .         .         .         .         .       g.60627
 ggtctgttttgccttcacccataagcccctcgcactctggtggcaggtgccttgtcctca       c.*420

          .         .         .         .         .         .       g.60687
 gggctacagcagtagggaggtcagtgcttcgtgcctcgattgaaggtgacctctgcccca       c.*480

          .         .         .         .         .         .       g.60747
 gataggtggtgccagtggcttattaattccgatactagtttgctttgctgaccaaatgcc       c.*540

          .         .         .         .         .         .       g.60807
 tggtaccagaggatggtgaggcgaaggccaggttgggggcagtgttgtggccctggggcc       c.*600

          .         .         .         .         .         .       g.60867
 cagccccaaactgggggctctgtatatagctatgaagaaaacacaaagtgtataaatctg       c.*660

          .         .         .         .         .         .       g.60927
 agtatatatttacatgtctttttaaaagggtcgttaccagagatttacccatcgggtaag       c.*720

          .         .         .         .         .         .       g.60987
 atgctcctggtggctgggaggcatcagttgctatatattaaaaacaaaaaagaaaaaaaa       c.*780

          .         .         .         .         .         .       g.61047
 ggaaaatgtttttaaaaaggtcatatattttttgctacttttgctgttttatttttttaa       c.*840

          .         .         .         .         .         .       g.61107
 attatgttctaaacctattttcagtttaggtccctcaataaaaattgctgctgcttcatt       c.*900

          .         .         .         .         .         .       g.61167
 tatctatgggctgtatgaaaagggtgggaatgtccactggaaagaagggacacccacggg       c.*960

          .         .         .         .         .         .       g.61227
 ccctggggctaggtctgtcccgagggcaccgcatgctcccggcgcaggttccttgtaacc       c.*1020

          .         .         .         .         .         .       g.61287
 tcttcttcctaggtcctgcacccagacctcacgacgcacctcctgcctctccgctgcttt       c.*1080

          .         .         .         .         .         .       g.61347
 tggaaagtcagaaaaagaagatgtctgcttcgagggcaggaaccccatccatgcagtaga       c.*1140

          .         .         .         .         .         .       g.61407
 ggcgctgggcagagagtcaaggcccagcagccatcgaccatggatggtttcctccaagga       c.*1200

          .         .         .         .         .         .       g.61467
 aaccggtggggttgggctggggagggggcacctacctaggaatagccacggggtagagct       c.*1260

          .         .         .         .         .         .       g.61527
 acagtgattaagaggaaagcaagggcgcggttgctcacgcctgtaatcccagcactttgg       c.*1320

          .         .         .         .         .         .       g.61587
 gacaccgaggtgggcagatcacttcaggtcaggagtttgagaccagcctggccaacttag       c.*1380

          .         .         .         .         .         .       g.61647
 tgaaaccccatctctactaaaaatgcaaaaattatccaggcatggtggcacacgcctgta       c.*1440

          .         .         .         .         .         .       g.61707
 atcccagctccacaggaggctgaggcagaatcccttgaagctgggaggcggaggttgcag       c.*1500

          .         .         .         .         .         .       g.61767
 tgagccgagattgcgccattgcactccagcctgggcaacagagaaaacaaaaaggaaaac       c.*1560

          .         .         .         .         .         .       g.61827
 aaatgatgaaggtctgcagaaactgaaacccagacatgtgtctgccccctctatgtgggc       c.*1620

          .         .         .         .         .         .       g.61887
 atggttttgccagtgcttctaagtgcaggagaacatgtcacctgaggctagttttgcatt       c.*1680

          .         .         .         .         .         .       g.61947
 caggtccctggcttcgtttcttgttggtatgcctccccagatcgtccttcctgtatccat       c.*1740

          .         .         .         .         .         .       g.62007
 gtgaccagactgtatttgttgggactgtcgcagatcttggcttcttacagttcttcctgt       c.*1800

          .         .         .         .         .         .       g.62067
 ccaaactccatcctgtccctcaggaacggggggaaaattctccgaatgtttttggttttt       c.*1860

          .         .         .         .         .         .       g.62127
 tggctgcttggaatttacttctgccacctgctggtcatcactgtcctcactaagtggatt       c.*1920

          .         .         .         .         .         .       g.62187
 ctggctcccccgtacctcatggctcaaactaccactcctcagtcgctatattaaagctta       c.*1980

          .         .         .         .         .         .       g.62247
 tattttgctggattactgctaaatacaaaagaaagttcaatatgttttcatttctgtagg       c.*2040

          .         .         .         .         .         .       g.62307
 gaaaatgggattgctgctttaaatttctgagctagggattttttggcagctgcagtgttg       c.*2100

          .         .         .         .         .         .       g.62367
 gcgactattgtaaaattctctttgtttctctctgtaaatagcacctgctaacattacaat       c.*2160

          .         .         .         .         .         .       g.62427
 ttgtatttatgtttaaagaaggcatcatttggtgaacagaactaggaaatgaatttttag       c.*2220

          .         .         .         .         .         .       g.62487
 ctcttaaaagcatttgctttgagaccgcacaggagtgtctttccttgtaaaacagtgatg       c.*2280

          .         .         .         .         .         .       g.62547
 ataatttctgccttggccctaccttgaagcaatgttgtgtgaagggatgaagaatctaaa       c.*2340

          .         .         .         .         .         .       g.62607
 agtcttcataagtccttgggagaggtgctagaaaaatataaggcactatcataattacag       c.*2400

          .         .         .         .         .         .       g.62667
 tgatgtccttgctgttactactcaaatcacccacaaatttccccaaagactgcgctagct       c.*2460

          .         .         .                                     g.62697
 gtcaaataaaagacagtgaaattgacctga                                     c.*2490

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fibroblast growth factor receptor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 17
©2004-2016 Leiden University Medical Center