fibroblast growth factor receptor 2 (FGFR2) - coding DNA reference sequence

(used for variant description)

(last modified September 16, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000141.4 in the FGFR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012449.1, covering FGFR2 transcript NM_000141.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              ggcggcggctggaggagagcgcggtggagagccgagcgggcgggcgg       c.-601

 .         .         .         .         .         .                g.5107
 cgggtgcggagcgggcgagggagcgcgcgcggccgccacaaagctcgggcgccgcggggc       c.-541

 .         .         .         .         .         .                g.5167
 tgcatgcggcgtacctggcccggcgcggcgactgctctccgggctggcgggggccggccg       c.-481

 .         .         .         .         .         .                g.5227
 cgagccccgggggccccgaggccgcagcttgcctgcgcgctctgagccttcgcaactcgc       c.-421

 .         .         .         .         .         .                g.5287
 gagcaaagtttggtggaggcaacgccaagcctgagtcctttcttcctctcgttccccaaa       c.-361

 .         .         .         .         .         .                g.5347
 tccgagggcagcccgcgggcgtcatgcccgcgctcctccgcagcctggggtacgcgtgaa       c.-301

 .         .         .         .         .         .                g.5407
 gcccgggaggcttggcgccggcgaagacccaaggaccactcttctgcgtttggagttgct       c.-241

 .         .         .         .         .         .                g.5467
 ccccgcaaccccgggctcgtcgctttctccatcccgacccacgcggggcgcggggacaac       c.-181

 .         .         .          | 02        .         .             g.9521
 acaggtcgcggaggagcgttgccattcaag | tgactgcagcagcagcggcagcgcctcggt    c.-121

 .         .         .         .         .         .                g.9581
 tcctgagcccaccgcaggctgaaggcattgcgcgtagtccatgcccgtagaggaagtgtg       c.-61

 .         .         .         .         .         .                g.9641
 cagatgggattaacgtccacatggagatatggaagaggaccggggattggtaccgtaacc       c.-1

          .         .         .         .         .         .       g.9701
 ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTG       c.60
 M  V  S  W  G  R  F  I  C  L  V  V  V  T  M  A  T  L  S  L         p.20

          .         .         .         .          | 03        .    g.37765
 GCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAG | AGCCACCAACC    c.120
 A  R  P  S  F  S  L  V  E  D  T  T  L  E  P  E  E |   P  P  T      p.40

          .         .         .         .         .         .       g.37825
 AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG       c.180
 K  Y  Q  I  S  Q  P  E  V  Y  V  A  A  P  G  E  S  L  E  V         p.60

          .         .         .         .         .         .       g.37885
 CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGG       c.240
 R  C  L  L  K  D  A  A  V  I  S  W  T  K  D  G  V  H  L  G         p.80

          .         .         .         .         .         .       g.37945
 CCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA       c.300
 P  N  N  R  T  V  L  I  G  E  Y  L  Q  I  K  G  A  T  P  R         p.100

          .         .         .         .         .         .       g.38005
 GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC       c.360
 D  S  G  L  Y  A  C  T  A  S  R  T  V  D  S  E  T  W  Y  F         p.120

          .       | 04 .         .         .         .         .    g.38923
 ATGGTGAATGTCACAG | ATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCG    c.420
 M  V  N  V  T  D |   A  I  S  S  G  D  D  E  D  D  T  D  G  A      p.140

          .         .         .     | 05   .         .         .    g.52025
 GAAGATTTTGTCAGTGAGAACAGTAACAACAAGA | GAGCACCATACTGGACCAACACAGAA    c.480
 E  D  F  V  S  E  N  S  N  N  K  R |   A  P  Y  W  T  N  T  E      p.160

          .         .         .         .         .         .       g.52085
 AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA       c.540
 K  M  E  K  R  L  H  A  V  P  A  A  N  T  V  K  F  R  C  P         p.180

          .         .         .         .         .         .       g.52145
 GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAG       c.600
 A  G  G  N  P  M  P  T  M  R  W  L  K  N  G  K  E  F  K  Q         p.200

          .         .     | 06   .         .         .         .    g.64779
 GAGCATCGCATTGGAGGCTACAAG | GTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT    c.660
 E  H  R  I  G  G  Y  K   | V  R  N  Q  H  W  S  L  I  M  E  S      p.220

          .         .         .         .         .         .       g.64839
 GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC       c.720
 V  V  P  S  D  K  G  N  Y  T  C  V  V  E  N  E  Y  G  S  I         p.240

          .         .         | 07         .         .         .    g.83321
 AATCACACGTACCACCTGGATGTTGTGG | AGCGATCGCCTCACCGGCCCATCCTCCAAGCC    c.780
 N  H  T  Y  H  L  D  V  V  E |   R  S  P  H  R  P  I  L  Q  A      p.260

          .         .         .         .         .         .       g.83381
 GGACTGCCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTT       c.840
 G  L  P  A  N  A  S  T  V  V  G  G  D  V  E  F  V  C  K  V         p.280

          .         .         .         .         .         .       g.83441
 TACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA       c.900
 Y  S  D  A  Q  P  H  I  Q  W  I  K  H  V  E  K  N  G  S  K         p.300

          .         .         .          | 08        .         .    g.86016
 TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAG | GCCGCCGGTGTTAACACCACG    c.960
 Y  G  P  D  G  L  P  Y  L  K  V  L  K   | A  A  G  V  N  T  T      p.320

          .         .         .         .         .         .       g.86076
 GACAAAGAGATTGAGGTTCTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATAT       c.1020
 D  K  E  I  E  V  L  Y  I  R  N  V  T  F  E  D  A  G  E  Y         p.340

          .         .         .         .         .         .       g.86136
 ACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGGTTGACAGTTCTG       c.1080
 T  C  L  A  G  N  S  I  G  I  S  F  H  S  A  W  L  T  V  L         p.360

      | 09   .         .         .         .         .         .    g.88195
 CCAG | CGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATT    c.1140
 P  A |   P  G  R  E  K  E  I  T  A  S  P  D  Y  L  E  I  A  I      p.380

          .         .         .         .         .         .       g.88255
 TACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATG       c.1200
 Y  C  I  G  V  F  L  I  A  C  M  V  V  T  V  I  L  C  R  M         p.400

          .         .         .         .         .         .       g.88315
 AAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAA       c.1260
 K  N  T  T  K  K  P  D  F  S  S  Q  P  A  V  H  K  L  T  K         p.420

          .         .        | 10.         .         .         .    g.99550
 CGTATCCCCCTGCGGAGACAGGTAACA | GTTTCGGCTGAGTCCAGCTCCTCCATGAACTCC    c.1320
 R  I  P  L  R  R  Q  V  T   | V  S  A  E  S  S  S  S  M  N  S      p.440

          .         .         .         .         .         .       g.99610
 AACACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTG       c.1380
 N  T  P  L  V  R  I  T  T  R  L  S  S  T  A  D  T  P  M  L         p.460

          .         .         .         .         .          | 11    g.102512
 GCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAA | G    c.1440
 A  G  V  S  E  Y  E  L  P  E  D  P  K  W  E  F  P  R  D  K  |      p.480

          .         .         .         .         .         .       g.102572
 CTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCA       c.1500
 L  T  L  G  K  P  L  G  E  G  C  F  G  Q  V  V  M  A  E  A         p.500

          .         .         .         .         .         .       g.102632
 GTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAA       c.1560
 V  G  I  D  K  D  K  P  K  E  A  V  T  V  A  V  K  M  L  K         p.520

   | 12      .         .         .         .         .         .    g.104912
 G | ATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATG    c.1620
 D |   D  A  T  E  K  D  L  S  D  L  V  S  E  M  E  M  M  K  M      p.540

          .         .         .         .         .   | 13     .    g.106744
 ATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATG | GGCCTCTC    c.1680
 I  G  K  H  K  N  I  I  N  L  L  G  A  C  T  Q  D  G |   P  L      p.560

          .         .         .         .         .         .       g.106804
 TATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGG       c.1740
 Y  V  I  V  E  Y  A  S  K  G  N  L  R  E  Y  L  R  A  R  R         p.580

          .         .         .         .         .         .       g.106864
 CCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTC       c.1800
 P  P  G  M  E  Y  S  Y  D  I  N  R  V  P  E  E  Q  M  T  F         p.600

          .         .         .         .         .         .       g.106924
 AAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAA       c.1860
 K  D  L  V  S  C  T  Y  Q  L  A  R  G  M  E  Y  L  A  S  Q         p.620

     | 14    .         .         .         .         .         .    g.115402
 AAA | TGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATG    c.1920
 K   | C  I  H  R  D  L  A  A  R  N  V  L  V  T  E  N  N  V  M      p.640

          .         .         .         .         .         .       g.115462
 AAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACC       c.1980
 K  I  A  D  F  G  L  A  R  D  I  N  N  I  D  Y  Y  K  K  T         p.660

        | 15 .         .         .         .         .         .    g.116088
 ACCAAT | GGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATAC    c.2040
 T  N   | G  R  L  P  V  K  W  M  A  P  E  A  L  F  D  R  V  Y      p.680

          .        | 16.         .         .         .         .    g.117969
 ACTCATCAGAGTGATGT | CTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGG    c.2100
 T  H  Q  S  D  V  |  W  S  F  G  V  L  M  W  E  I  F  T  L  G      p.700

          .         .         .         .         .         .       g.118029
 GGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACAC       c.2160
 G  S  P  Y  P  G  I  P  V  E  E  L  F  K  L  L  K  E  G  H         p.720

          .         .         .      | 17  .         .         .    g.119680
 AGAATGGATAAGCCAGCCAACTGCACCAACGAACT | GTACATGATGATGAGGGACTGTTGG    c.2220
 R  M  D  K  P  A  N  C  T  N  E  L  |  Y  M  M  M  R  D  C  W      p.740

          .         .         .         .         .         .       g.119740
 CATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATT       c.2280
 H  A  V  P  S  Q  R  P  T  F  K  Q  L  V  E  D  L  D  R  I         p.760

          .         .  | 18      .         .         .         .    g.123476
 CTCACTCTCACAACCAATGAG | GAATACTTGGACCTCAGCCAACCTCTCGAACAGTATTCA    c.2340
 L  T  L  T  T  N  E   | E  Y  L  D  L  S  Q  P  L  E  Q  Y  S      p.780

          .         .         .         .         .         .       g.123536
 CCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCA       c.2400
 P  S  Y  P  D  T  R  S  S  C  S  S  G  D  D  S  V  F  S  P         p.800

          .         .         .         .         .         .       g.123596
 GACCCCATGCCTTACGAACCATGCCTTCCTCAGTATCCACACATAAACGGCAGTGTTAAA       c.2460
 D  P  M  P  Y  E  P  C  L  P  Q  Y  P  H  I  N  G  S  V  K         p.820

                                                                    g.123602
 ACATGA                                                             c.2466
 T  X                                                               p.821

          .         .         .         .         .         .       g.123662
 atgactgtgtctgcctgtccccaaacaggacagcactgggaacctagctacactgagcag       c.*60

          .         .         .         .         .         .       g.123722
 ggagaccatgcctcccagagcttgttgtctccacttgtatatatggatcagaggagtaaa       c.*120

          .         .         .         .         .         .       g.123782
 taattggaaaagtaatcagcatatgtgtaaagatttatacagttgaaaacttgtaatctt       c.*180

          .         .         .         .         .         .       g.123842
 ccccaggaggagaagaaggtttctggagcagtggactgccacaagccaccatgtaacccc       c.*240

          .         .         .         .         .         .       g.123902
 tctcacctgccgtgcgtactggctgtggaccagtaggactcaaggtggacgtgcgttctg       c.*300

          .         .         .         .         .         .       g.123962
 ccttccttgttaattttgtaataattggagaagatttatgtcagcacacacttacagagc       c.*360

          .         .         .         .         .         .       g.124022
 acaaatgcagtatataggtgctggatgtatgtaaatatattcaaattatgtataaatata       c.*420

          .         .         .         .         .         .       g.124082
 tattatatatttacaaggagttattttttgtattgattttaaatggatgtcccaatgcac       c.*480

          .         .         .         .         .         .       g.124142
 ctagaaaattggtctctctttttttaatagctatttgctaaatgctgttcttacacataa       c.*540

          .         .         .         .         .         .       g.124202
 tttcttaattttcaccgagcagaggtggaaaaatacttttgctttcagggaaaatggtat       c.*600

          .         .         .         .         .         .       g.124262
 aacgttaatttattaataaattggtaatatacaaaacaattaatcatttatagttttttt       c.*660

          .         .         .         .         .         .       g.124322
 tgtaatttaagtggcatttctatgcaggcagcacagcagactagttaatctattgcttgg       c.*720

          .         .         .         .         .         .       g.124382
 acttaactagttatcagatcctttgaaaagagaatatttacaatatatgactaatttggg       c.*780

          .         .         .         .         .         .       g.124442
 gaaaatgaagttttgatttatttgtgtttaaatgctgctgtcagacgattgttcttagac       c.*840

          .         .         .         .         .         .       g.124502
 ctcctaaatgccccatattaaaagaactcattcataggaaggtgtttcattttggtgtgc       c.*900

          .         .         .         .         .         .       g.124562
 aaccctgtcattacgtcaacgcaacgtctaactggacttcccaagataaatggtaccagc       c.*960

          .         .         .         .         .         .       g.124622
 gtcctcttaaaagatgccttaatccattccttgaggacagaccttagttgaaatgatagc       c.*1020

          .         .         .         .         .         .       g.124682
 agaatgtgcttctctctggcagctggccttctgcttctgagttgcacattaatcagatta       c.*1080

          .         .         .         .         .         .       g.124742
 gcctgtattctcttcagtgaattttgataatggcttccagactctttggcgttggagacg       c.*1140

          .         .         .         .         .         .       g.124802
 cctgttaggatcttcaagtcccatcatagaaaattgaaacacagagttgttctgctgata       c.*1200

          .         .         .         .         .         .       g.124862
 gttttggggatacgtccatctttttaagggattgctttcatctaattctggcaggacctc       c.*1260

          .         .         .         .         .         .       g.124922
 accaaaagatccagcctcatacctacatcagacaaaatatcgccgttgttccttctgtac       c.*1320

          .         .         .         .         .         .       g.124982
 taaagtattgtgttttgctttggaaacacccactcactttgcaatagccgtgcaagatga       c.*1380

          .         .         .         .         .         .       g.125042
 atgcagattacactgatcttatgtgttacaaaattggagaaagtatttaataaaacctgt       c.*1440

          .         .         .         .         .         .       g.125102
 taatttttatactgacaataaaaatgtttctacagatattaatgttaacaagacaaaata       c.*1500

          .         .                                               g.125129
 aatgtcacgcaacttatttttttaata                                        c.*1527

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fibroblast growth factor receptor 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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