FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) (FLAD1) - coding DNA reference sequence

(used for variant description)

(last modified April 19, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_025207.4 in the FLAD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_042310.1, covering FLAD1 transcript NM_025207.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    ttcaatgtcagctaggtgcaaggcgggactttaagtacgga       c.-361

 .         .         .         .         .         .                g.5101
 agctgccccgggacatgaggaaaggaacaagggaaagagccggtgaaggggcagaacagg       c.-301

 .         .         .         .         .         .                g.5161
 caggtgagagtctaagagggctcagtaatctgaagcttggtgggaagaagggattctggg       c.-241

 .         .         .         .         .         .                g.5221
 ctagaaagggtgcagaagcctgaagtagaaagagacgggattttggtccggggtggagag       c.-181

 .         .         .         .         .         .                g.5281
 cgaatgcattgaaaagggccaaggcccaggataaggtagacatttaaaggggtacggatg       c.-121

 .         .         .         .         .         .                g.5341
 cccaaggtagagcagacacttgaggagaccagctcagcaaacggaagacacttaaagtgg       c.-61

 .         .         .         .         .         .                g.5401
 taggttctcaagagagaagaagtttttaagactagagctaagcaagacatttaaaaggac       c.-1

          .         .         .         .         .         .       g.5461
 ATGGGTTGGGATTTGGGAACACGTTTATTCCAGAGGCAGGAACAAAGGAGTCGCTTGTCA       c.60
 M  G  W  D  L  G  T  R  L  F  Q  R  Q  E  Q  R  S  R  L  S         p.20

          .         .         .         .         .         .       g.5521
 AGGATCTGGTTAGAGAAGACTAGGGTCTTCCTCGAAGGAAGCACGCGCACGCCTGCTCTC       c.120
 R  I  W  L  E  K  T  R  V  F  L  E  G  S  T  R  T  P  A  L         p.40

          .         .         .         .         .         .       g.5581
 CCCCATTGTCTTTTCTGGCTTCTCCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGC       c.180
 P  H  C  L  F  W  L  L  Q  V  P  S  T  Q  D  P  L  F  P  G         p.60

          .         .         .         .         .         .       g.5641
 TATGGCCCCCAGTGCCCTGTAGACCTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGG       c.240
 Y  G  P  Q  C  P  V  D  L  A  G  P  P  C  L  R  P  L  F  G         p.80

          .         .         .         .         .         .       g.5701
 GGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGGACCATGACATCT       c.300
 G  L  G  G  Y  W  R  A  L  Q  R  G  R  E  G  R  T  M  T  S         p.100

          .         .         .         .         .         .       g.5761
 AGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGAT       c.360
 R  A  S  E  L  S  P  G  R  S  V  T  A  G  I  I  I  V  G  D         p.120

          .   | 02     .         .         .         .         .    g.9859
 GAGATCCTTAAG | GGACACACTCAGGACACCAACACCTTCTTTCTGTGCCGGACACTGCGC    c.420
 E  I  L  K   | G  H  T  Q  D  T  N  T  F  F  L  C  R  T  L  R      p.140

          .         .         .         .         .         .       g.9919
 TCCCTAGGGGTCCAGGTTTGCCGAGTCTCAGTTGTACCTGATGAGGTAGCCACCATTGCA       c.480
 S  L  G  V  Q  V  C  R  V  S  V  V  P  D  E  V  A  T  I  A         p.160

          .         .         .         .         .         .       g.9979
 GCTGAGGTCACTTCTTTCTCCAACCGCTTCACCCATGTCCTCACAGCAGGGGGCATCGGC       c.540
 A  E  V  T  S  F  S  N  R  F  T  H  V  L  T  A  G  G  I  G         p.180

          .         .         .         .         .         .       g.10039
 CCCACTCATGATGATGTGACCTTTGAGGCAGTGGCACAGGCCTTTGGAGATGAGCTGAAG       c.600
 P  T  H  D  D  V  T  F  E  A  V  A  Q  A  F  G  D  E  L  K         p.200

          .         .         .         .         .         .       g.10099
 CCACACCCCAAGTTGGAAGCAGCCACCAAAGCCCTAGGAGGGGAAGGCTGGGAGAAGCTA       c.660
 P  H  P  K  L  E  A  A  T  K  A  L  G  G  E  G  W  E  K  L         p.220

          .         .         .         .         .         .       g.10159
 TCATTGGTGCCCTCCTCTGCCCGCCTGCATTATGGCACAGATCCTTGCACTGGTCAACCT       c.720
 S  L  V  P  S  S  A  R  L  H  Y  G  T  D  P  C  T  G  Q  P         p.240

          .         .         .         .         .         .       g.10219
 TTCAGATTCCCTCTGGTCTCCGTCCGAAACGTCTACCTCTTCCCAGGCATTCCAGAGCTG       c.780
 F  R  F  P  L  V  S  V  R  N  V  Y  L  F  P  G  I  P  E  L         p.260

          .         .         .         .         .         .       g.10279
 CTGCGGCGGGTGCTGGAGGGGATGAAGGGACTATTCCAAAACCCAGCTGTTCAGTTCCAC       c.840
 L  R  R  V  L  E  G  M  K  G  L  F  Q  N  P  A  V  Q  F  H         p.280

          .         .         .         .         .         .       g.10339
 TCAAAGGAGCTATATGTGGCTGCTGATGAAGCCTCCATCGCCCCCATTCTGGCTGAGGCC       c.900
 S  K  E  L  Y  V  A  A  D  E  A  S  I  A  P  I  L  A  E  A         p.300

          .         .         .         .         .         .       g.10399
 CAGGCCCACTTTGGACGTAGGCTTGGCCTGGGTTCCTACCCTGACTGGGGCAGCAACTAC       c.960
 Q  A  H  F  G  R  R  L  G  L  G  S  Y  P  D  W  G  S  N  Y         p.320

          .         .         .         .         .         .       g.10459
 TATCAGGTGAAGCTGACTCTAGACTCAGAGGAAGAAGGACCCCTGGAGGAATGCTTGGCC       c.1020
 Y  Q  V  K  L  T  L  D  S  E  E  E  G  P  L  E  E  C  L  A         p.340

          .         .         .         .         .         .       g.10519
 TACCTGACTGCCCGTTTGCCCCAGGGATCGCTGGTCCCCTACATGCCCAACGCTGTGGAG       c.1080
 Y  L  T  A  R  L  P  Q  G  S  L  V  P  Y  M  P  N  A  V  E         p.360

          .         .         .        | 03.         .         .    g.11289
 CAGGCCAGTGAGGCTGTATACAAACTCGCTGAATCAG | GGTCTTCTTTGGGGAAAAAGGTG    c.1140
 Q  A  S  E  A  V  Y  K  L  A  E  S  G |   S  S  L  G  K  K  V      p.380

          .         .         .         .         .         .       g.11349
 GCAGGTGCCCTACAGACCATTGAGACCTCCCTGGCTCAGTACAGCCTCACCCAGCTCTGT       c.1200
 A  G  A  L  Q  T  I  E  T  S  L  A  Q  Y  S  L  T  Q  L  C         p.400

          .         .         .         .         .         .       g.11409
 GTGGGCTTCAACGGGGGCAAAGACTGCACTGCCCTCCTGCACCTCTTCCATGCAGCTGTG       c.1260
 V  G  F  N  G  G  K  D  C  T  A  L  L  H  L  F  H  A  A  V         p.420

       | 04  .         .         .         .         .         .    g.11920
 CAGAG | GAAATTACCTGATGTTCCAAACCCCCTCCAGATCCTGTATATCCGCAGCATCTCC    c.1320
 Q  R  |  K  L  P  D  V  P  N  P  L  Q  I  L  Y  I  R  S  I  S      p.440

          .         .         .         .     | 05   .         .    g.12061
 CCTTTCCCTGAGCTGGAACAGTTTCTACAGGACACTATCAAGAG | GTATAATCTGCAGATG    c.1380
 P  F  P  E  L  E  Q  F  L  Q  D  T  I  K  R  |  Y  N  L  Q  M      p.460

          .         .         .         .         .         .       g.12121
 TTGGAAGCTGAGGGCAGCATGAAGCAGGCCCTGGGTGAACTGCAGGCACGGCACCCCCAG       c.1440
 L  E  A  E  G  S  M  K  Q  A  L  G  E  L  Q  A  R  H  P  Q         p.480

          .         .         .         .         .         .       g.12181
 CTGGAGGCTGTCCTTATGGGCACCCGCCGGACTGACCCCTACTCCTGTAGCCTCTGCCCT       c.1500
 L  E  A  V  L  M  G  T  R  R  T  D  P  Y  S  C  S  L  C  P         p.500

          .         .         .         .         .     | 06   .    g.14425
 TTCAGCCCCACTGACCCAGGCTGGCCCGCATTCATGCGCATCAACCCACTGCTG | GACTGG    c.1560
 F  S  P  T  D  P  G  W  P  A  F  M  R  I  N  P  L  L   | D  W      p.520

          .         .         .         .         .         .       g.14485
 ACCTACAGAGACATCTGGGATTTTCTGCGTCAGCTGTTTGTCCCATACTGTATCCTGTAT       c.1620
 T  Y  R  D  I  W  D  F  L  R  Q  L  F  V  P  Y  C  I  L  Y         p.540

          | 07         .         .         .         .         .    g.14660
 GACCGAGG | ATACACATCACTGGGGAGTCGGGAGAATACCGTGCGGAACCCGGCCCTGAAG    c.1680
 D  R  G  |  Y  T  S  L  G  S  R  E  N  T  V  R  N  P  A  L  K      p.560

          .         .         .         .         .         .       g.14720
 TGCCTGAGCCCAGGAGGACACCCCACATACCGTCCAGCCTATCTACTGGAGAACGAAGAA       c.1740
 C  L  S  P  G  G  H  P  T  Y  R  P  A  Y  L  L  E  N  E  E         p.580

          .         .                                               g.14744
 GAGGAGCGGAACTCCCGCACATGA                                           c.1764
 E  E  R  N  S  R  T  X                                             p.587

          .         .         .         .         .         .       g.14804
 cctcccaccctaggagggagggaaggacaccgtcctagggtataacctggcaataaaccg       c.*60

          .                                                         g.14818
 tgcctctcactgtg                                                     c.*74

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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