filaggrin (FLG) - coding DNA reference sequence

(used for variant description)

(last modified May 2, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_002016.1 in the FLG gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016190.1, covering FLG transcript NM_002016.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         | 02         .             g.14747
                         cttttggtgaacaag | gttcacatttattgccaaaag    c.-1

          .         .         .         .         .         .       g.14807
 ATGTCTACTCTCCTGGAAAACATCTTTGCCATAATTAATCTTTTCAAGCAATATTCAAAA       c.60
 M  S  T  L  L  E  N  I  F  A  I  I  N  L  F  K  Q  Y  S  K         p.20

          .         .         .         .         .         .       g.14867
 AAAGATAAAAACACTGACACATTGAGTAAAAAAGAGCTGAAGGAACTTCTGGAAAAGGAA       c.120
 K  D  K  N  T  D  T  L  S  K  K  E  L  K  E  L  L  E  K  E         p.40

          .         | 03         .         .         .         .    g.15498
 TTTCGGCAAATCCTGAAG | AATCCAGATGACCCAGATATGGTTGATGTCTTCATGGATCAC    c.180
 F  R  Q  I  L  K   | N  P  D  D  P  D  M  V  D  V  F  M  D  H      p.60

          .         .         .         .         .         .       g.15558
 TTGGATATAGACCACAACAAGAAAATTGACTTCACTGAGTTTCTTCTGATGGTATTCAAG       c.240
 L  D  I  D  H  N  K  K  I  D  F  T  E  F  L  L  M  V  F  K         p.80

          .         .         .         .         .         .       g.15618
 TTGGCTCAAGCATATTATGAGTCTACCAGAAAAGAGAATTTACCGATATCAGGACACAAG       c.300
 L  A  Q  A  Y  Y  E  S  T  R  K  E  N  L  P  I  S  G  H  K         p.100

          .         .         .         .         .         .       g.15678
 CACAGAAAGCACAGTCATCATGATAAACATGAAGATAATAAACAGGAAGAAAACAAAGAA       c.360
 H  R  K  H  S  H  H  D  K  H  E  D  N  K  Q  E  E  N  K  E         p.120

          .         .         .         .         .         .       g.15738
 AACAGAAAAAGACCCTCAAGTCTGGAAAGAAGAAACAATAGAAAAGGGAATAAGGGAAGA       c.420
 N  R  K  R  P  S  S  L  E  R  R  N  N  R  K  G  N  K  G  R         p.140

          .         .         .         .         .         .       g.15798
 TCCAAGAGCCCAAGAGAAACAGGGGGGAAAAGGCATGAATCTAGTTCTGAAAAAAAAGAA       c.480
 S  K  S  P  R  E  T  G  G  K  R  H  E  S  S  S  E  K  K  E         p.160

          .         .         .         .         .         .       g.15858
 AGAAAAGGATATTCACCTACTCATAGAGAAGAAGAATATGGAAAAAACCATCATAACTCA       c.540
 R  K  G  Y  S  P  T  H  R  E  E  E  Y  G  K  N  H  H  N  S         p.180

          .         .         .         .         .         .       g.15918
 AGTAAAAAAGAGAAAAACAAGACTGAAAATACTAGATTAGGAGACAATAGGAAGAGGCTA       c.600
 S  K  K  E  K  N  K  T  E  N  T  R  L  G  D  N  R  K  R  L         p.200

          .         .         .         .         .         .       g.15978
 AGTGAAAGACTTGAAGAGAAAGAAGACAATGAAGAAGGAGTATATGATTATGAAAATACA       c.660
 S  E  R  L  E  E  K  E  D  N  E  E  G  V  Y  D  Y  E  N  T         p.220

          .         .         .         .         .         .       g.16038
 GGAAGAATGACTCAAAAATGGATACAATCAGGCCATATTGCCACATATTACACAATCCAG       c.720
 G  R  M  T  Q  K  W  I  Q  S  G  H  I  A  T  Y  Y  T  I  Q         p.240

          .         .         .         .         .         .       g.16098
 GATGAAGCCTATGACACCACTGATAGTCTATTAGAAGAAAACAAAATATATGAAAGATCA       c.780
 D  E  A  Y  D  T  T  D  S  L  L  E  E  N  K  I  Y  E  R  S         p.260

          .         .         .         .         .         .       g.16158
 AGGTCATCTGATGGCAAATCATCATCTCAAGTGAACAGGTCAAGACATGAAAATACAAGC       c.840
 R  S  S  D  G  K  S  S  S  Q  V  N  R  S  R  H  E  N  T  S         p.280

          .         .         .         .         .         .       g.16218
 CAGGTACCATTGCAGGAGTCCAGGACAAGAAAGCGTAGGGGATCCAGAGTTAGCCAGGAC       c.900
 Q  V  P  L  Q  E  S  R  T  R  K  R  R  G  S  R  V  S  Q  D         p.300

          .         .         .         .         .         .       g.16278
 AGGGACAGTGAGGGACACTCAGAAGACTCTGAGAGGCACTCTGGGTCGGCTTCCAGAAAC       c.960
 R  D  S  E  G  H  S  E  D  S  E  R  H  S  G  S  A  S  R  N         p.320

          .         .         .         .         .         .       g.16338
 CATCATGGATCTGCGTGGGAGCAGTCAAGAGATGGCTCCAGACACCCCAGGTCCCATGAT       c.1020
 H  H  G  S  A  W  E  Q  S  R  D  G  S  R  H  P  R  S  H  D         p.340

          .         .         .         .         .         .       g.16398
 GAAGACAGAGCCAGTCATGGGCACTCTGCAGACAGCTCCAGACAATCAGGCACTCGTCAC       c.1080
 E  D  R  A  S  H  G  H  S  A  D  S  S  R  Q  S  G  T  R  H         p.360

          .         .         .         .         .         .       g.16458
 GCAGAGACTTCCTCTCGTGGACAGACTGCATCATCCCATGAACAGGCAAGATCAAGTCCA       c.1140
 A  E  T  S  S  R  G  Q  T  A  S  S  H  E  Q  A  R  S  S  P         p.380

          .         .         .         .         .         .       g.16518
 GGAGAAAGACATGGATCCGGCCACCAGCAGTCAGCAGACAGCTCCAGACACTCAGCCACT       c.1200
 G  E  R  H  G  S  G  H  Q  Q  S  A  D  S  S  R  H  S  A  T         p.400

          .         .         .         .         .         .       g.16578
 GGGCGCGGGCAAGCTTCATCTGCAGTCAGCGATCGTGGACACCGGGGGTCTAGCGGTAGT       c.1260
 G  R  G  Q  A  S  S  A  V  S  D  R  G  H  R  G  S  S  G  S         p.420

          .         .         .         .         .         .       g.16638
 CAGGCCAGTGACAGTGAGGGACATTCAGAAAACTCAGACACACAATCAGTGTCAGGCCAC       c.1320
 Q  A  S  D  S  E  G  H  S  E  N  S  D  T  Q  S  V  S  G  H         p.440

          .         .         .         .         .         .       g.16698
 GGAAAGGCTGGGCTGAGACAGCAGAGCCACCAAGAGTCCACACGTGGCCGGTCAGGGGAA       c.1380
 G  K  A  G  L  R  Q  Q  S  H  Q  E  S  T  R  G  R  S  G  E         p.460

          .         .         .         .         .         .       g.16758
 CGGTCTGGACGTTCAGGGTCTTCCCTCTACCAGGTGAGCACTCATGAACAGCCTGACTCT       c.1440
 R  S  G  R  S  G  S  S  L  Y  Q  V  S  T  H  E  Q  P  D  S         p.480

          .         .         .         .         .         .       g.16818
 GCCCATGGACGGACCGGGACCAGCACTGGAGGAAGACAAGGATCGCACCACGAGCAGGCA       c.1500
 A  H  G  R  T  G  T  S  T  G  G  R  Q  G  S  H  H  E  Q  A         p.500

          .         .         .         .         .         .       g.16878
 CGAGACAGCTCCAGGCATTCAGCGTCCCAAGAGGGTCAGGACACCATTCGTGGACACCCG       c.1560
 R  D  S  S  R  H  S  A  S  Q  E  G  Q  D  T  I  R  G  H  P         p.520

          .         .         .         .         .         .       g.16938
 GGGTCAAGCAGAGGAGGAAGGCAGGGATCCCACCACGAGCAATCGGTAAATAGGTCTGGA       c.1620
 G  S  S  R  G  G  R  Q  G  S  H  H  E  Q  S  V  N  R  S  G         p.540

          .         .         .         .         .         .       g.16998
 CACTCAGGTTCCCATCACAGCCACACCACATCCCAGGGAAGGTCTGATGCCTCCCATGGG       c.1680
 H  S  G  S  H  H  S  H  T  T  S  Q  G  R  S  D  A  S  H  G         p.560

          .         .         .         .         .         .       g.17058
 CAGTCAGGATCCAGAAGTGCAAGCAGACAAACACGAAATGAGGAACAATCAGGAGACGGC       c.1740
 Q  S  G  S  R  S  A  S  R  Q  T  R  N  E  E  Q  S  G  D  G         p.580

          .         .         .         .         .         .       g.17118
 ACCAGGCACTCAGGGTCACGTCATCATGAAGCTTCCTCTCAGGCTGACAGCTCTAGACAC       c.1800
 T  R  H  S  G  S  R  H  H  E  A  S  S  Q  A  D  S  S  R  H         p.600

          .         .         .         .         .         .       g.17178
 TCACAGGTGGGCCAGGGACAATCATCGGGGCCCAGGACAAGTAGGAACCAGGGATCCAGT       c.1860
 S  Q  V  G  Q  G  Q  S  S  G  P  R  T  S  R  N  Q  G  S  S         p.620

          .         .         .         .         .         .       g.17238
 GTTAGCCAGGACAGTGACAGTCAGGGACACTCAGAAGACTCTGAGAGGTGGTCTGGGTCT       c.1920
 V  S  Q  D  S  D  S  Q  G  H  S  E  D  S  E  R  W  S  G  S         p.640

          .         .         .         .         .         .       g.17298
 GCTTCCAGAAACCATCATGGATCTGCTCAGGAGCAGTCAAGAGATGGCTCCAGACACCCC       c.1980
 A  S  R  N  H  H  G  S  A  Q  E  Q  S  R  D  G  S  R  H  P         p.660

          .         .         .         .         .         .       g.17358
 AGGTCCCATCACGAAGACAGAGCTGGTCATGGGCACTCTGCAGACAGCTCCAGAAAATCA       c.2040
 R  S  H  H  E  D  R  A  G  H  G  H  S  A  D  S  S  R  K  S         p.680

          .         .         .         .         .         .       g.17418
 GGCACTCGTCACACACAGAATTCCTCTAGTGGACAGGCTGCGTCATCCCATGAACAGGCA       c.2100
 G  T  R  H  T  Q  N  S  S  S  G  Q  A  A  S  S  H  E  Q  A         p.700

          .         .         .         .         .         .       g.17478
 AGATCAAGTGCAGGAGAAAGACATGGATCCCGCCACCAGCTCCAGTCAGCAGACAGCTCC       c.2160
 R  S  S  A  G  E  R  H  G  S  R  H  Q  L  Q  S  A  D  S  S         p.720

          .         .         .         .         .         .       g.17538
 AGACACTCAGGCACTGGGCACGGACAAGCTTCATCTGCAGTCAGAGACAGTGGACACCGA       c.2220
 R  H  S  G  T  G  H  G  Q  A  S  S  A  V  R  D  S  G  H  R         p.740

          .         .         .         .         .         .       g.17598
 GGGTCCAGTGGTAGTCAGGCCACTGACAGTGAGGGACATTCAGAAGACTCAGACACACAG       c.2280
 G  S  S  G  S  Q  A  T  D  S  E  G  H  S  E  D  S  D  T  Q         p.760

          .         .         .         .         .         .       g.17658
 TCAGTGTCAGGCCATGGACAGGCTGGTCACCATCAGCAGAGCCACCAAGAGTCCGCACGT       c.2340
 S  V  S  G  H  G  Q  A  G  H  H  Q  Q  S  H  Q  E  S  A  R         p.780

          .         .         .         .         .         .       g.17718
 GACCGGTCAGGGGAAAGGTCTCGACGTTCAGGGTCTTTCCTCTACCAGGTGAGCACTCAT       c.2400
 D  R  S  G  E  R  S  R  R  S  G  S  F  L  Y  Q  V  S  T  H         p.800

          .         .         .         .         .         .       g.17778
 AAACAGTCTGAGTCCTCCCATGGATGGACAGGGCCCAGCACTGGAGTAAGACAAGGATCC       c.2460
 K  Q  S  E  S  S  H  G  W  T  G  P  S  T  G  V  R  Q  G  S         p.820

          .         .         .         .         .         .       g.17838
 CACCATGAGCAGGCACGAGACAACTCCAGGCACTCAGCATCCCAAGATGGTCAGGACACC       c.2520
 H  H  E  Q  A  R  D  N  S  R  H  S  A  S  Q  D  G  Q  D  T         p.840

          .         .         .         .         .         .       g.17898
 ATTCGTGGACACCCGGGGTCAAGCAGAAGAGGAAGGCAGGGGTCCCACCACGAGCAATCG       c.2580
 I  R  G  H  P  G  S  S  R  R  G  R  Q  G  S  H  H  E  Q  S         p.860

          .         .         .         .         .         .       g.17958
 GTAGATAGGTCTGGACACTCAGGGTCCCATCACAGCCACACCACATCCCAGGGAAGGTCT       c.2640
 V  D  R  S  G  H  S  G  S  H  H  S  H  T  T  S  Q  G  R  S         p.880

          .         .         .         .         .         .       g.18018
 GATGCCTCCCGTGGGCAGTCAGGATCCAGAAGTGCAAGCAGAACAACACGTAATGAGGAA       c.2700
 D  A  S  R  G  Q  S  G  S  R  S  A  S  R  T  T  R  N  E  E         p.900

          .         .         .         .         .         .       g.18078
 CAATCAAGAGACGGCTCCAGGCACTCAGGGTCACGTCACCATGAAGCTTCCTCTCATGCC       c.2760
 Q  S  R  D  G  S  R  H  S  G  S  R  H  H  E  A  S  S  H  A         p.920

          .         .         .         .         .         .       g.18138
 GACATCTCTAGACACTCACAGGCAGGCCAGGGACAATCAGAGGGGTCCAGGACAAGCAGG       c.2820
 D  I  S  R  H  S  Q  A  G  Q  G  Q  S  E  G  S  R  T  S  R         p.940

          .         .         .         .         .         .       g.18198
 CGCCAGGGATCCAGTGTTAGCCAGGACAGTGACAGTGAGGGACATTCAGAAGACTCTGAG       c.2880
 R  Q  G  S  S  V  S  Q  D  S  D  S  E  G  H  S  E  D  S  E         p.960

          .         .         .         .         .         .       g.18258
 AGGTGGTCTGGGTCTGCTTCCAGAAACCATCGTGGATCTGCTCAGGAGCAGTCAAGACAT       c.2940
 R  W  S  G  S  A  S  R  N  H  R  G  S  A  Q  E  Q  S  R  H         p.980

          .         .         .         .         .         .       g.18318
 GGCTCCAGACACCCCAGGTCCCATCACGAAGACAGAGCCGGTCACGGGCACTCTGCAGAC       c.3000
 G  S  R  H  P  R  S  H  H  E  D  R  A  G  H  G  H  S  A  D         p.1000

          .         .         .         .         .         .       g.18378
 AGCTCCAGACAATCAGGAACTCCTCACGCAGAGACTTCCTCTGGTGGACAGGCTGCGTCA       c.3060
 S  S  R  Q  S  G  T  P  H  A  E  T  S  S  G  G  Q  A  A  S         p.1020

          .         .         .         .         .         .       g.18438
 TCCCATGAACAGGCAAGATCAAGTCCAGGAGAAAGACACGGATCCCGCCACCAGCAGTCA       c.3120
 S  H  E  Q  A  R  S  S  P  G  E  R  H  G  S  R  H  Q  Q  S         p.1040

          .         .         .         .         .         .       g.18498
 GCAGACAGCTCCAGACACTCAGGCATTCCGCGCAGACAAGCTTCATCTGCAGTCAGAGAC       c.3180
 A  D  S  S  R  H  S  G  I  P  R  R  Q  A  S  S  A  V  R  D         p.1060

          .         .         .         .         .         .       g.18558
 AGTGGACACTGGGGGTCCAGTGGTAGTCAGGCCAGTGATAGTGAGGGACATTCAGAGGAG       c.3240
 S  G  H  W  G  S  S  G  S  Q  A  S  D  S  E  G  H  S  E  E         p.1080

          .         .         .         .         .         .       g.18618
 TCAGACACACAGTCAGTGTCAGGCCATGGACAGGATGGGCCCCATCAGCAGAGCCACCAA       c.3300
 S  D  T  Q  S  V  S  G  H  G  Q  D  G  P  H  Q  Q  S  H  Q         p.1100

          .         .         .         .         .         .       g.18678
 GAGTCCGCACGTGACTGGTCAGGGGGAAGGTCTGGACGTTCAGGGTCTTTCATCTACCAG       c.3360
 E  S  A  R  D  W  S  G  G  R  S  G  R  S  G  S  F  I  Y  Q         p.1120

          .         .         .         .         .         .       g.18738
 GTGAGCACTCATGAACAGTCTGAGTCTGCCCATGGGCGGACCAGGACCAGCACTGGACGA       c.3420
 V  S  T  H  E  Q  S  E  S  A  H  G  R  T  R  T  S  T  G  R         p.1140

          .         .         .         .         .         .       g.18798
 AGACAAGGATCCCACCACGAGCAGGCACGAGACAGCTCCAGGCACTCAGCGTCCCAAGAG       c.3480
 R  Q  G  S  H  H  E  Q  A  R  D  S  S  R  H  S  A  S  Q  E         p.1160

          .         .         .         .         .         .       g.18858
 GGTCAGGACACCATTCGTGCACACCCGGGGTCAAGGAGAGGAGGAAGGCAGGGATCCCAC       c.3540
 G  Q  D  T  I  R  A  H  P  G  S  R  R  G  G  R  Q  G  S  H         p.1180

          .         .         .         .         .         .       g.18918
 CATGAGCAATCGGTAGATAGATCTGGACACTCAGGGTCCCATCACAGCCACACCACATCC       c.3600
 H  E  Q  S  V  D  R  S  G  H  S  G  S  H  H  S  H  T  T  S         p.1200

          .         .         .         .         .         .       g.18978
 CAGGGAAGGTCTGATGCCTCCCATGGGCAGTCAGGATCCAGAAGTGCAAGCAGACAAACT       c.3660
 Q  G  R  S  D  A  S  H  G  Q  S  G  S  R  S  A  S  R  Q  T         p.1220

          .         .         .         .         .         .       g.19038
 CGTAAGGACAAACAATCAGGAGACGGCTCCAGGCACTCAGGGTCACGTCACCATGAAGCT       c.3720
 R  K  D  K  Q  S  G  D  G  S  R  H  S  G  S  R  H  H  E  A         p.1240

          .         .         .         .         .         .       g.19098
 GCCTCTTGGGCTGACAGCTCTAGACACTCACAGGTGGGACAGGAACAATCATCGGGGTCC       c.3780
 A  S  W  A  D  S  S  R  H  S  Q  V  G  Q  E  Q  S  S  G  S         p.1260

          .         .         .         .         .         .       g.19158
 AGGACAAGCAGGCACCAGGGATCCAGTGTTAGCCAGGACAGTGACAGTGAGAGACACTCA       c.3840
 R  T  S  R  H  Q  G  S  S  V  S  Q  D  S  D  S  E  R  H  S         p.1280

          .         .         .         .         .         .       g.19218
 GACGACTCCGAGAGGTTGTCTGGGTCTGCTTCCAGAAACCATCATGGATCTTCTCGGGAG       c.3900
 D  D  S  E  R  L  S  G  S  A  S  R  N  H  H  G  S  S  R  E         p.1300

          .         .         .         .         .         .       g.19278
 CAGTCAAGAGATGGCTCCAGACACCCTGGGTTCCATCAAGAAGACAGAGCCAGTCACGGG       c.3960
 Q  S  R  D  G  S  R  H  P  G  F  H  Q  E  D  R  A  S  H  G         p.1320

          .         .         .         .         .         .       g.19338
 CACTCTGCAGACAGCTCCAGACAATCAGGCACTCATCACACAGAGTCTTCCTCTCATGGA       c.4020
 H  S  A  D  S  S  R  Q  S  G  T  H  H  T  E  S  S  S  H  G         p.1340

          .         .         .         .         .         .       g.19398
 CAGGCTGTGTCATCCCATGAACAGGCAAGATCAAGTCCAGGAGAAAGACATGGATCCCGC       c.4080
 Q  A  V  S  S  H  E  Q  A  R  S  S  P  G  E  R  H  G  S  R         p.1360

          .         .         .         .         .         .       g.19458
 CACCAGCAGTCAGCAGACAGCTCCAGACACTCAGGCATTGGGCACAGACAAGCTTCATCT       c.4140
 H  Q  Q  S  A  D  S  S  R  H  S  G  I  G  H  R  Q  A  S  S         p.1380

          .         .         .         .         .         .       g.19518
 GCAGTCAGAGACAGTGGACACCGAGGGTCCAGTGGTAGTCAGGTCACTAACAGTGAGGGA       c.4200
 A  V  R  D  S  G  H  R  G  S  S  G  S  Q  V  T  N  S  E  G         p.1400

          .         .         .         .         .         .       g.19578
 CATTCAGAAGACTCAGACACACAGTCAGTGTCAGCCCACGGACAAGCTGGGCCCCATCAG       c.4260
 H  S  E  D  S  D  T  Q  S  V  S  A  H  G  Q  A  G  P  H  Q         p.1420

          .         .         .         .         .         .       g.19638
 CAGAGCCACAAAGAGTCCGCACGTGGCCAGTCAGGGGAAAGCTCTGGACGTTCAAGGTCT       c.4320
 Q  S  H  K  E  S  A  R  G  Q  S  G  E  S  S  G  R  S  R  S         p.1440

          .         .         .         .         .         .       g.19698
 TTCCTCTACCAGGTGAGCTCTCATGAACAGTCTGAGTCCACACACGGACAGACTGCACCC       c.4380
 F  L  Y  Q  V  S  S  H  E  Q  S  E  S  T  H  G  Q  T  A  P         p.1460

          .         .         .         .         .         .       g.19758
 AGCACTGGAGGAAGACAAGGATCCCGCCATGAGCAGGCACGAAACAGCTCTAGGCACTCA       c.4440
 S  T  G  G  R  Q  G  S  R  H  E  Q  A  R  N  S  S  R  H  S         p.1480

          .         .         .         .         .         .       g.19818
 GCATCCCAAGACGGTCAGGACACCATTCGTGGACACCCGGGGTCAAGCAGAGGAGGAAGG       c.4500
 A  S  Q  D  G  Q  D  T  I  R  G  H  P  G  S  S  R  G  G  R         p.1500

          .         .         .         .         .         .       g.19878
 CAGGGATCCTACCACGAGCAATCAGTAGATAGGTCTGGACACTCAGGGTACCATCACAGC       c.4560
 Q  G  S  Y  H  E  Q  S  V  D  R  S  G  H  S  G  Y  H  H  S         p.1520

          .         .         .         .         .         .       g.19938
 CACACCACACCCCAGGGAAGGTCTGATGCCTCCCATGGGCAGTCAGGACCCAGAAGTGCA       c.4620
 H  T  T  P  Q  G  R  S  D  A  S  H  G  Q  S  G  P  R  S  A         p.1540

          .         .         .         .         .         .       g.19998
 AGCAGGCAAACAAGAAATGAGGAACAATCAGGAGACGGCTCCAGGCACTCAGGGTCACGT       c.4680
 S  R  Q  T  R  N  E  E  Q  S  G  D  G  S  R  H  S  G  S  R         p.1560

          .         .         .         .         .         .       g.20058
 CACCATGAACCTTCCACTCGGGCCGGCAGCTCTAGACACTCACAGGTGGGCCAGGGAGAA       c.4740
 H  H  E  P  S  T  R  A  G  S  S  R  H  S  Q  V  G  Q  G  E         p.1580

          .         .         .         .         .         .       g.20118
 TCAGCGGGGTCCAAGACAAGCAGGCGCCAGGGATCCAGTGTTAGTCAGGACAGGGACAGT       c.4800
 S  A  G  S  K  T  S  R  R  Q  G  S  S  V  S  Q  D  R  D  S         p.1600

          .         .         .         .         .         .       g.20178
 GAGGGACACTCAGAAGACTCTGAGAGGCGGTCTGAGTCGGCTTCCAGAAACCATTATGGA       c.4860
 E  G  H  S  E  D  S  E  R  R  S  E  S  A  S  R  N  H  Y  G         p.1620

          .         .         .         .         .         .       g.20238
 TCTGCTCGGGAGCAGTCAAGACATGGCTCCAGGAACCCCAGGTCCCATCAAGAAGATAGA       c.4920
 S  A  R  E  Q  S  R  H  G  S  R  N  P  R  S  H  Q  E  D  R         p.1640

          .         .         .         .         .         .       g.20298
 GCCAGTCATGGGCACTCTGCAGAGAGCTCCAGACAATCAGGCACTCGTCATGCAGAGACT       c.4980
 A  S  H  G  H  S  A  E  S  S  R  Q  S  G  T  R  H  A  E  T         p.1660

          .         .         .         .         .         .       g.20358
 TCCTCTGGTGGACAGGCTGCATCATCCCAGGAACAGGCAAGGTCAAGTCCAGGAGAAAGA       c.5040
 S  S  G  G  Q  A  A  S  S  Q  E  Q  A  R  S  S  P  G  E  R         p.1680

          .         .         .         .         .         .       g.20418
 CATGGATCCCGCCACCAGCAGTCAGCAGACAGCTCCACAGACTCAGGCACTGGGCGCAGA       c.5100
 H  G  S  R  H  Q  Q  S  A  D  S  S  T  D  S  G  T  G  R  R         p.1700

          .         .         .         .         .         .       g.20478
 CAAGATTCATCTGTAGTCGGAGACAGTGGAAACCGAGGGTCCAGTGGTAGCCAGGCCAGT       c.5160
 Q  D  S  S  V  V  G  D  S  G  N  R  G  S  S  G  S  Q  A  S         p.1720

          .         .         .         .         .         .       g.20538
 GACAGCGAGGGACACTCAGAAGAGTCAGACACACAGTCAGTGTCAGCCCACGGACAGGCT       c.5220
 D  S  E  G  H  S  E  E  S  D  T  Q  S  V  S  A  H  G  Q  A         p.1740

          .         .         .         .         .         .       g.20598
 GGGCCCCATCAGCAGAGCCACCAAGAGTCCACACGTGGCCAGTCAGGGGAAAGGTCTGGA       c.5280
 G  P  H  Q  Q  S  H  Q  E  S  T  R  G  Q  S  G  E  R  S  G         p.1760

          .         .         .         .         .         .       g.20658
 CGTTCAGGGTCTTTCCTCTACCAGGTGAGCACTCATGAACAGTCTGAGTCCGCCCATGGA       c.5340
 R  S  G  S  F  L  Y  Q  V  S  T  H  E  Q  S  E  S  A  H  G         p.1780

          .         .         .         .         .         .       g.20718
 CGCACAGGGCCCAGCACTGGAGGAAGACAAAGATCCCGCCACGAGCAGGCACGAGACAGC       c.5400
 R  T  G  P  S  T  G  G  R  Q  R  S  R  H  E  Q  A  R  D  S         p.1800

          .         .         .         .         .         .       g.20778
 TCCAGGCACTCAGCGTCCCAAGAGGGTCAGGACACCATTCGTGGACACCCAGGGTCAAGC       c.5460
 S  R  H  S  A  S  Q  E  G  Q  D  T  I  R  G  H  P  G  S  S         p.1820

          .         .         .         .         .         .       g.20838
 AGAGGAGGAAGGCAGGGATCCCACTATGAGCAATCGGTAGATAGTTCTGGACACTCAGGG       c.5520
 R  G  G  R  Q  G  S  H  Y  E  Q  S  V  D  S  S  G  H  S  G         p.1840

          .         .         .         .         .         .       g.20898
 TCTCATCACAGCCACACCACGTCCCAGGAAAGGTCTGATGTCTCCCGTGGGCAGTCAGGA       c.5580
 S  H  H  S  H  T  T  S  Q  E  R  S  D  V  S  R  G  Q  S  G         p.1860

          .         .         .         .         .         .       g.20958
 TCCAGAAGTGTCAGCAGACAAACACGTAATGAGAAACAATCAGGAGACGGCTCCAGGCAC       c.5640
 S  R  S  V  S  R  Q  T  R  N  E  K  Q  S  G  D  G  S  R  H         p.1880

          .         .         .         .         .         .       g.21018
 TCAGGGTCGCGTCACCATGAAGCTTCCTCTCGGGCCGACAGCTCTAGACACTCGCAGGTG       c.5700
 S  G  S  R  H  H  E  A  S  S  R  A  D  S  S  R  H  S  Q  V         p.1900

          .         .         .         .         .         .       g.21078
 GGCCAGGGACAATCATCAGGGCCCAGGACAAGCAGGAACCAGGGATCCAGTGTTAGCCAG       c.5760
 G  Q  G  Q  S  S  G  P  R  T  S  R  N  Q  G  S  S  V  S  Q         p.1920

          .         .         .         .         .         .       g.21138
 GACAGTGACAGTCAGGGACACTCAGAAGACTCTGAGAGGTGGTCTGGGTCTGCTTCCAGA       c.5820
 D  S  D  S  Q  G  H  S  E  D  S  E  R  W  S  G  S  A  S  R         p.1940

          .         .         .         .         .         .       g.21198
 AACCATCTTGGATCTGCTTGGGAGCAGTCAAGAGATGGCTCCAGACACCCTGGGTCCCAT       c.5880
 N  H  L  G  S  A  W  E  Q  S  R  D  G  S  R  H  P  G  S  H         p.1960

          .         .         .         .         .         .       g.21258
 CACGAAGACAGAGCCGGTCACGGGCACTCTGCAGACAGCTCCAGACAATCAGGCACTCGT       c.5940
 H  E  D  R  A  G  H  G  H  S  A  D  S  S  R  Q  S  G  T  R         p.1980

          .         .         .         .         .         .       g.21318
 CACACAGAGTCTTCCTCTCGTGGACAGGCTGCGTCATCCCATGAACAGGCAAGATCAAGT       c.6000
 H  T  E  S  S  S  R  G  Q  A  A  S  S  H  E  Q  A  R  S  S         p.2000

          .         .         .         .         .         .       g.21378
 GCAGGAGAAAGACATGGATCCCACCACCAGCTCCAGTCAGCAGACAGCTCCAGACACTCA       c.6060
 A  G  E  R  H  G  S  H  H  Q  L  Q  S  A  D  S  S  R  H  S         p.2020

          .         .         .         .         .         .       g.21438
 GGCATTGGGCATGGACAAGCTTCATCTGCAGTCAGAGACAGTGGACACCGAGGGTACAGT       c.6120
 G  I  G  H  G  Q  A  S  S  A  V  R  D  S  G  H  R  G  Y  S         p.2040

          .         .         .         .         .         .       g.21498
 GGTAGTCAGGCCAGTGACAGTGAGGGACATTCAGAAGACTCAGACACACAGTCAGTGTCA       c.6180
 G  S  Q  A  S  D  S  E  G  H  S  E  D  S  D  T  Q  S  V  S         p.2060

          .         .         .         .         .         .       g.21558
 GCACAGGGAAAAGCTGGGCCCCATCAGCAGAGCCACAAAGAGTCCGCACGTGGCCAGTCA       c.6240
 A  Q  G  K  A  G  P  H  Q  Q  S  H  K  E  S  A  R  G  Q  S         p.2080

          .         .         .         .         .         .       g.21618
 GGGGAAAGCTCTGGACGTTCAGGGTCTTTCCTCTACCAGGTGAGCACTCATGAACAGTCT       c.6300
 G  E  S  S  G  R  S  G  S  F  L  Y  Q  V  S  T  H  E  Q  S         p.2100

          .         .         .         .         .         .       g.21678
 GAGTCCACCCATGGACAGTCTGCGCCCAGCACTGGAGGAAGACAAGGATCCCATTATGAT       c.6360
 E  S  T  H  G  Q  S  A  P  S  T  G  G  R  Q  G  S  H  Y  D         p.2120

          .         .         .         .         .         .       g.21738
 CAGGCACAAGACAGCTCCAGGCACTCAGCATCCCAAGAGGGTCAGGACACCATTCGTGGA       c.6420
 Q  A  Q  D  S  S  R  H  S  A  S  Q  E  G  Q  D  T  I  R  G         p.2140

          .         .         .         .         .         .       g.21798
 CACCCGGGGCCAAGCAGAGGAGGAAGACAGGGGTCCCACCAAGAGCAATCGGTAGATAGG       c.6480
 H  P  G  P  S  R  G  G  R  Q  G  S  H  Q  E  Q  S  V  D  R         p.2160

          .         .         .         .         .         .       g.21858
 TCTGGACACTCAGGGTCTCATCACAGCCACACCACATCCCAGGGAAGGTCTGATGCCTCC       c.6540
 S  G  H  S  G  S  H  H  S  H  T  T  S  Q  G  R  S  D  A  S         p.2180

          .         .         .         .         .         .       g.21918
 CGTGGGCAGTCAGGATCCAGAAGTGCAAGCAGAAAAACATATGACAAGGAACAATCAGGA       c.6600
 R  G  Q  S  G  S  R  S  A  S  R  K  T  Y  D  K  E  Q  S  G         p.2200

          .         .         .         .         .         .       g.21978
 GATGGCTCTAGGCACTCAGGGTCGCATCATCATGAAGCTTCCTCTTGGGCCGACAGCTCT       c.6660
 D  G  S  R  H  S  G  S  H  H  H  E  A  S  S  W  A  D  S  S         p.2220

          .         .         .         .         .         .       g.22038
 AGACACTCACTGGTGGGCCAGGGACAATCATCAGGGCCCAGGACAAGCAGGCCCCGGGGA       c.6720
 R  H  S  L  V  G  Q  G  Q  S  S  G  P  R  T  S  R  P  R  G         p.2240

          .         .         .         .         .         .       g.22098
 TCCAGTGTTAGCCAGGACAGTGACAGTGAGGGACACTCAGAAGATTCTGAGAGGCGGTCT       c.6780
 S  S  V  S  Q  D  S  D  S  E  G  H  S  E  D  S  E  R  R  S         p.2260

          .         .         .         .         .         .       g.22158
 GGGTCTGCGTCCAGAAACCATCATGGATCTGCTCAGGAGCAGTCAAGAGATGGCTCCAGA       c.6840
 G  S  A  S  R  N  H  H  G  S  A  Q  E  Q  S  R  D  G  S  R         p.2280

          .         .         .         .         .         .       g.22218
 CACCCCAGGTCCCATCACGAAGACAGAGCCGGTCATGGGCACTCTGCAGAGAGCTCCAGA       c.6900
 H  P  R  S  H  H  E  D  R  A  G  H  G  H  S  A  E  S  S  R         p.2300

          .         .         .         .         .         .       g.22278
 CAATCAGGCACTCATCATGCAGAGAATTCCTCTGGTGGACAGGCTGCATCATCCCATGAA       c.6960
 Q  S  G  T  H  H  A  E  N  S  S  G  G  Q  A  A  S  S  H  E         p.2320

          .         .         .         .         .         .       g.22338
 CAGGCAAGATCAAGTGCAGGAGAGAGACACGGATCCCACCACCAGCAGTCAGCAGACAGC       c.7020
 Q  A  R  S  S  A  G  E  R  H  G  S  H  H  Q  Q  S  A  D  S         p.2340

          .         .         .         .         .         .       g.22398
 TCCAGACACTCAGGCATTGGGCACGGACAAGCTTCATCTGCAGTCAGAGACAGTGGACAC       c.7080
 S  R  H  S  G  I  G  H  G  Q  A  S  S  A  V  R  D  S  G  H         p.2360

          .         .         .         .         .         .       g.22458
 CGAGGGTCCAGTGGTAGTCAGGCCAGTGACAGTGAGGGACATTCAGAAGACTCAGACACA       c.7140
 R  G  S  S  G  S  Q  A  S  D  S  E  G  H  S  E  D  S  D  T         p.2380

          .         .         .         .         .         .       g.22518
 CAGTCAGTGTCAGCCCACGGACAGGCTGGGCCCCATCAGCAGAGCCACCAAGAGTCCACA       c.7200
 Q  S  V  S  A  H  G  Q  A  G  P  H  Q  Q  S  H  Q  E  S  T         p.2400

          .         .         .         .         .         .       g.22578
 CGTGGCCGGTCAGCAGGAAGGTCTGGACGTTCAGGGTCTTTCCTCTACCAGGTGAGCACT       c.7260
 R  G  R  S  A  G  R  S  G  R  S  G  S  F  L  Y  Q  V  S  T         p.2420

          .         .         .         .         .         .       g.22638
 CATGAACAGTCTGAGTCCGCCCATGGACGGACCGGGACCAGCACTGGAGGAAGACAAGGA       c.7320
 H  E  Q  S  E  S  A  H  G  R  T  G  T  S  T  G  G  R  Q  G         p.2440

          .         .         .         .         .         .       g.22698
 TCCCACCACAAGCAGGCACGAGACAGCTCCAGGCACTCAACGTCCCAAGAGGGTCAGGAC       c.7380
 S  H  H  K  Q  A  R  D  S  S  R  H  S  T  S  Q  E  G  Q  D         p.2460

          .         .         .         .         .         .       g.22758
 ACCATTCATGGACACCCGGGGTCAAGCAGTGGAGGAAGGCAGGGATCCCACTACGAGCAA       c.7440
 T  I  H  G  H  P  G  S  S  S  G  G  R  Q  G  S  H  Y  E  Q         p.2480

          .         .         .         .         .         .       g.22818
 TTGGTAGATAGATCTGGACACTCAGGGTCTCATCACAGCCACACCACATCCCAGGGAAGG       c.7500
 L  V  D  R  S  G  H  S  G  S  H  H  S  H  T  T  S  Q  G  R         p.2500

          .         .         .         .         .         .       g.22878
 TCTGATGCCTCCCATGGGCACTCAGGATCCAGAAGTGCAAGCAGACAAACTCGTAACGAT       c.7560
 S  D  A  S  H  G  H  S  G  S  R  S  A  S  R  Q  T  R  N  D         p.2520

          .         .         .         .         .         .       g.22938
 GAACAATCAGGAGACGGCTCCAGGCACTCAGGGTCGCGTCACCATGAAGCTTCCTCTCGG       c.7620
 E  Q  S  G  D  G  S  R  H  S  G  S  R  H  H  E  A  S  S  R         p.2540

          .         .         .         .         .         .       g.22998
 GCCGACAGCTCTGGACACTCGCAGGTGGGCCAGGGACAATCAGAGGGGCCCAGGACAAGC       c.7680
 A  D  S  S  G  H  S  Q  V  G  Q  G  Q  S  E  G  P  R  T  S         p.2560

          .         .         .         .         .         .       g.23058
 AGGAACTGGGGATCCAGTTTTAGCCAGGACAGTGACAGTCAGGGACACTCAGAAGACTCT       c.7740
 R  N  W  G  S  S  F  S  Q  D  S  D  S  Q  G  H  S  E  D  S         p.2580

          .         .         .         .         .         .       g.23118
 GAGAGGTGGTCTGGGTCTGCTTCCAGAAACCATCATGGATCTGCTCAGGAGCAGCTAAGA       c.7800
 E  R  W  S  G  S  A  S  R  N  H  H  G  S  A  Q  E  Q  L  R         p.2600

          .         .         .         .         .         .       g.23178
 GATGGCTCCAGACACCCCAGGTCCCATCAAGAAGACAGAGCTGGTCATGGGCACTCTGCA       c.7860
 D  G  S  R  H  P  R  S  H  Q  E  D  R  A  G  H  G  H  S  A         p.2620

          .         .         .         .         .         .       g.23238
 GACAGCTCCAGACAATCAGGCACTCGTCACACACAGACTTCCTCTGGTGGACAGGCTGCA       c.7920
 D  S  S  R  Q  S  G  T  R  H  T  Q  T  S  S  G  G  Q  A  A         p.2640

          .         .         .         .         .         .       g.23298
 TCATCCCATGAACAGGCAAGATCAAGTGCAGGAGAAAGACATGGATCCCACCACCAGCAG       c.7980
 S  S  H  E  Q  A  R  S  S  A  G  E  R  H  G  S  H  H  Q  Q         p.2660

          .         .         .         .         .         .       g.23358
 TCAGCAGACAGCTCCAGACACTCAGGCATTGGGCACGGACAAGCTTCATCTGCAGTCAGA       c.8040
 S  A  D  S  S  R  H  S  G  I  G  H  G  Q  A  S  S  A  V  R         p.2680

          .         .         .         .         .         .       g.23418
 GACAGTGGACACCGAGGGTACAGTGGTAGTCAGGCCAGTGACAATGAGGGACATTCAGAA       c.8100
 D  S  G  H  R  G  Y  S  G  S  Q  A  S  D  N  E  G  H  S  E         p.2700

          .         .         .         .         .         .       g.23478
 GACTCAGACACACAGTCAGTGTCAGCCCACGGACAGGCTGGGTCCCATCAGCAGAGCCAC       c.8160
 D  S  D  T  Q  S  V  S  A  H  G  Q  A  G  S  H  Q  Q  S  H         p.2720

          .         .         .         .         .         .       g.23538
 CAAGAGTCCGCACGTGGCCGGTCAGGGGAAACGTCTGGACATTCAGGATCTTTCCTCTAC       c.8220
 Q  E  S  A  R  G  R  S  G  E  T  S  G  H  S  G  S  F  L  Y         p.2740

          .         .         .         .         .         .       g.23598
 CAGGTGAGCACTCATGAACAGTCTGAGTCCTCCCATGGATGGACGGGGCCCAGCACTAGA       c.8280
 Q  V  S  T  H  E  Q  S  E  S  S  H  G  W  T  G  P  S  T  R         p.2760

          .         .         .         .         .         .       g.23658
 GGAAGACAAGGATCCCGCCATGAGCAGGCACAAGACAGCTCCAGGCACTCAGCATCCCAA       c.8340
 G  R  Q  G  S  R  H  E  Q  A  Q  D  S  S  R  H  S  A  S  Q         p.2780

          .         .         .         .         .         .       g.23718
 GACGGTCAGGACACCATTCGTGGACACCCGGGGTCAAGCAGAGGAGGAAGGCAGGGGTAC       c.8400
 D  G  Q  D  T  I  R  G  H  P  G  S  S  R  G  G  R  Q  G  Y         p.2800

          .         .         .         .         .         .       g.23778
 CACCACGAGCATTCGGTAGATAGCTCTGGACACTCAGGGTCCCATCACAGCCACACCACA       c.8460
 H  H  E  H  S  V  D  S  S  G  H  S  G  S  H  H  S  H  T  T         p.2820

          .         .         .         .         .         .       g.23838
 TCCCAGGGAAGGTCTGATGCCTCCCGTGGGCAGTCAGGATCCAGAAGTGCAAGCAGAACA       c.8520
 S  Q  G  R  S  D  A  S  R  G  Q  S  G  S  R  S  A  S  R  T         p.2840

          .         .         .         .         .         .       g.23898
 ACACGTAATGAGGAACAATCAGGAGACGGCTCCAGGCACTCAGGGTCGCGTCACCATGAA       c.8580
 T  R  N  E  E  Q  S  G  D  G  S  R  H  S  G  S  R  H  H  E         p.2860

          .         .         .         .         .         .       g.23958
 GCTTCCACTCATGCCGACATCTCTAGACACTCACAGGCAGTCCAGGGACAATCAGAGGGG       c.8640
 A  S  T  H  A  D  I  S  R  H  S  Q  A  V  Q  G  Q  S  E  G         p.2880

          .         .         .         .         .         .       g.24018
 TCCAGGAGAAGCAGGCGCCAGGGATCCAGTGTGAGCCAGGACAGTGACAGTGAGGGACAT       c.8700
 S  R  R  S  R  R  Q  G  S  S  V  S  Q  D  S  D  S  E  G  H         p.2900

          .         .         .         .         .         .       g.24078
 TCAGAAGACTCTGAGAGGTGGTCTGGGTCTGCTTCCAGAAACCATCATGGATCTGCTCAG       c.8760
 S  E  D  S  E  R  W  S  G  S  A  S  R  N  H  H  G  S  A  Q         p.2920

          .         .         .         .         .         .       g.24138
 GAGCAGCTAAGAGATGGCTCCAGACACCCCAGGTCCCATCAAGAAGACAGAGCTGGTCAT       c.8820
 E  Q  L  R  D  G  S  R  H  P  R  S  H  Q  E  D  R  A  G  H         p.2940

          .         .         .         .         .         .       g.24198
 GGGCACTCTGCAGACAGCTCCAGACAATCAGGCACTCGTCACACACAGACTTCCTCTGGT       c.8880
 G  H  S  A  D  S  S  R  Q  S  G  T  R  H  T  Q  T  S  S  G         p.2960

          .         .         .         .         .         .       g.24258
 GGACAGGCTGCATCATCCCATGAACAGGCAAGATCAAGTGCAGGAGAAAGACATGGATCC       c.8940
 G  Q  A  A  S  S  H  E  Q  A  R  S  S  A  G  E  R  H  G  S         p.2980

          .         .         .         .         .         .       g.24318
 CACCACCAGCAGTCAGCAGACAGCTCCAGACACTCAGGCATTGGGCACGGACAAGCTTCA       c.9000
 H  H  Q  Q  S  A  D  S  S  R  H  S  G  I  G  H  G  Q  A  S         p.3000

          .         .         .         .         .         .       g.24378
 TCTGCAGTCAGAGACAGTGGACACCGAGGGTACAGTGGTAGTCAGGCCAGTGACAATGAG       c.9060
 S  A  V  R  D  S  G  H  R  G  Y  S  G  S  Q  A  S  D  N  E         p.3020

          .         .         .         .         .         .       g.24438
 GGACATTCAGAAGACTCAGACACACAGTCAGTGTCAGCCCACGGACAGGCTGGGTCCCAT       c.9120
 G  H  S  E  D  S  D  T  Q  S  V  S  A  H  G  Q  A  G  S  H         p.3040

          .         .         .         .         .         .       g.24498
 CAGCAGAGCCACCAAGAGTCCGCACGTGGCCGGTCAGGGGAAACGTCTGGACATTCAGGA       c.9180
 Q  Q  S  H  Q  E  S  A  R  G  R  S  G  E  T  S  G  H  S  G         p.3060

          .         .         .         .         .         .       g.24558
 TCTTTCCTCTACCAGGTGAGCACTCATGAACAGTCTGAGTCCTCCCATGGATGGACGGGG       c.9240
 S  F  L  Y  Q  V  S  T  H  E  Q  S  E  S  S  H  G  W  T  G         p.3080

          .         .         .         .         .         .       g.24618
 CCCAGCACTAGAGGAAGACAAGGATCCCGCCATGAGCAGGCACAAGACAGCTCCAGGCAC       c.9300
 P  S  T  R  G  R  Q  G  S  R  H  E  Q  A  Q  D  S  S  R  H         p.3100

          .         .         .         .         .         .       g.24678
 TCAGCATCCCAATACGGTCAGGACACCATTCGTGGACACCCGGGGTCAAGCAGAGGAGGA       c.9360
 S  A  S  Q  Y  G  Q  D  T  I  R  G  H  P  G  S  S  R  G  G         p.3120

          .         .         .         .         .         .       g.24738
 AGGCAGGGGTACCACCACGAGCATTCGGTAGATAGCTCTGGACACTCAGGGTCCCATCAC       c.9420
 R  Q  G  Y  H  H  E  H  S  V  D  S  S  G  H  S  G  S  H  H         p.3140

          .         .         .         .         .         .       g.24798
 AGCCACACCACATCCCAGGGAAGGTCTGATGCCTCCCGTGGGCAGTCAGGATCCAGAAGT       c.9480
 S  H  T  T  S  Q  G  R  S  D  A  S  R  G  Q  S  G  S  R  S         p.3160

          .         .         .         .         .         .       g.24858
 GCAAGCAGAACAACACGTAATGAGGAACAATCAGGAGACAGCTCCAGGCACTCAGTGTCA       c.9540
 A  S  R  T  T  R  N  E  E  Q  S  G  D  S  S  R  H  S  V  S         p.3180

          .         .         .         .         .         .       g.24918
 CGTCACCATGAAGCTTCCACTCATGCCGACATCTCTAGACACTCACAGGCAGTCCAGGGA       c.9600
 R  H  H  E  A  S  T  H  A  D  I  S  R  H  S  Q  A  V  Q  G         p.3200

          .         .         .         .         .         .       g.24978
 CAATCAGAGGGGTCCAGGAGAAGCAGGCGCCAGGGATCCAGTGTGAGCCAGGACAGTGAC       c.9660
 Q  S  E  G  S  R  R  S  R  R  Q  G  S  S  V  S  Q  D  S  D         p.3220

          .         .         .         .         .         .       g.25038
 AGTGAGGGACATTCAGAAGACTCTGAGAGGTGGTCTGGGTCTGCTTCCAGAAACCATCGT       c.9720
 S  E  G  H  S  E  D  S  E  R  W  S  G  S  A  S  R  N  H  R         p.3240

          .         .         .         .         .         .       g.25098
 GGATCTGTTCAGGAGCAGTCAAGGCACGGCTCCAGACACCCCAGGTCCCATCACGAAGAC       c.9780
 G  S  V  Q  E  Q  S  R  H  G  S  R  H  P  R  S  H  H  E  D         p.3260

          .         .         .         .         .         .       g.25158
 AGAGCCGGTCACGGGCACTCTGCAGACCGCTCCAGACAATCAGGCACTCGTCACGCAGAG       c.9840
 R  A  G  H  G  H  S  A  D  R  S  R  Q  S  G  T  R  H  A  E         p.3280

          .         .         .         .         .         .       g.25218
 ACTTCCTCTGGTGGACAGGCTGCATCATCCCATGAACAGGCAAGATCAAGTCCAGGAGAG       c.9900
 T  S  S  G  G  Q  A  A  S  S  H  E  Q  A  R  S  S  P  G  E         p.3300

          .         .         .         .         .         .       g.25278
 AGACACGGATCCCGCCACCAGCAGTCAGCAGACAGCTCCAGACACTCAGGCATTCCGCGT       c.9960
 R  H  G  S  R  H  Q  Q  S  A  D  S  S  R  H  S  G  I  P  R         p.3320

          .         .         .         .         .         .       g.25338
 GGACAAGCTTCATCTGCAGTCAGAGACAGTAGACACTGGGGGTCCAGTGGTAGTCAGGCC       c.10020
 G  Q  A  S  S  A  V  R  D  S  R  H  W  G  S  S  G  S  Q  A         p.3340

          .         .         .         .         .         .       g.25398
 AGTGATAGTGAGGGACATTCAGAAGAGTCAGACACACAGTCAGTGTCAGGCCATGGACAG       c.10080
 S  D  S  E  G  H  S  E  E  S  D  T  Q  S  V  S  G  H  G  Q         p.3360

          .         .         .         .         .         .       g.25458
 GCTGGGCCCCATCAGCAGAGCCACCAAGAGTCCGCACGTGACCGGTCAGGGGGAAGGTCT       c.10140
 A  G  P  H  Q  Q  S  H  Q  E  S  A  R  D  R  S  G  G  R  S         p.3380

          .         .         .         .         .         .       g.25518
 GGACGTTCAGGGTCTTTCCTCTACCAGGTGAGCACTCATGAACAGTCTGAGTCTGCCCAT       c.10200
 G  R  S  G  S  F  L  Y  Q  V  S  T  H  E  Q  S  E  S  A  H         p.3400

          .         .         .         .         .         .       g.25578
 GGGCGGACCAGGACCAGCACTGGACGAAGACAAGGATCCCACCACGAGCAGGCACGAGAC       c.10260
 G  R  T  R  T  S  T  G  R  R  Q  G  S  H  H  E  Q  A  R  D         p.3420

          .         .         .         .         .         .       g.25638
 AGCTCCAGGCACTCAGCGTCCCAAGAGGGTCAGGACACCATTCGTGGACACCCGGGGTCA       c.10320
 S  S  R  H  S  A  S  Q  E  G  Q  D  T  I  R  G  H  P  G  S         p.3440

          .         .         .         .         .         .       g.25698
 AGCAGAAGAGGAAGGCAGGGATCCCACTACGAGCAATCGGTAGATAGGTCTGGACACTCA       c.10380
 S  R  R  G  R  Q  G  S  H  Y  E  Q  S  V  D  R  S  G  H  S         p.3460

          .         .         .         .         .         .       g.25758
 GGGTCCCATCACAGCCACACCACATCCCAGGGAAGGTCTGATGCCTCCCGTGGGCAGTCA       c.10440
 G  S  H  H  S  H  T  T  S  Q  G  R  S  D  A  S  R  G  Q  S         p.3480

          .         .         .         .         .         .       g.25818
 GGATCCAGAAGTGCCAGCAGACAAACTCGTAATGACGAACAATCAGGAGATGGCTCCAGG       c.10500
 G  S  R  S  A  S  R  Q  T  R  N  D  E  Q  S  G  D  G  S  R         p.3500

          .         .         .         .         .         .       g.25878
 CACTCATGGTCGCATCACCATGAAGCTTCCACTCAGGCGGACAGCTCTAGACACTCACAG       c.10560
 H  S  W  S  H  H  H  E  A  S  T  Q  A  D  S  S  R  H  S  Q         p.3520

          .         .         .         .         .         .       g.25938
 TCCGGCCAGGGACAATCAGCGGGGCCCAGGACAAGCAGGAACCAGGGATCCAGTGTTAGC       c.10620
 S  G  Q  G  Q  S  A  G  P  R  T  S  R  N  Q  G  S  S  V  S         p.3540

          .         .         .         .         .         .       g.25998
 CAGGACAGTGACAGTCAGGGACACTCAGAAGACTCTGAGAGGTGGTCTGGGTCTGCTTCC       c.10680
 Q  D  S  D  S  Q  G  H  S  E  D  S  E  R  W  S  G  S  A  S         p.3560

          .         .         .         .         .         .       g.26058
 AGAAACCATCGTGGATCTGCTCAGGAGCAGTCAAGAGATGGCTCCAGACACCCCACGTCC       c.10740
 R  N  H  R  G  S  A  Q  E  Q  S  R  D  G  S  R  H  P  T  S         p.3580

          .         .         .         .         .         .       g.26118
 CATCACGAAGACAGAGCCGGTCACGGGCACTCTGCAGAGAGCTCCAGACAATCAGGCACT       c.10800
 H  H  E  D  R  A  G  H  G  H  S  A  E  S  S  R  Q  S  G  T         p.3600

          .         .         .         .         .         .       g.26178
 CATCATGCAGAGAATTCCTCTGGTGGACAGGCTGCATCATCCCATGAACAGGCAAGATCA       c.10860
 H  H  A  E  N  S  S  G  G  Q  A  A  S  S  H  E  Q  A  R  S         p.3620

          .         .         .         .         .         .       g.26238
 AGTGCAGGAGAGAGACATGGATCCCACCACCAGCAGTCAGCAGACAGCTCCAGACACTCA       c.10920
 S  A  G  E  R  H  G  S  H  H  Q  Q  S  A  D  S  S  R  H  S         p.3640

          .         .         .         .         .         .       g.26298
 GGCATTGGGCACGGACAAGCTTCATCTGCAGTCAGAGACAGTGGACACCGAGGGTCCAGT       c.10980
 G  I  G  H  G  Q  A  S  S  A  V  R  D  S  G  H  R  G  S  S         p.3660

          .         .         .         .         .         .       g.26358
 GGTAGTCAGGCCAGTGACAGTGAGGGACATTCAGAAGACTCAGACACACAGTCAGTGTCA       c.11040
 G  S  Q  A  S  D  S  E  G  H  S  E  D  S  D  T  Q  S  V  S         p.3680

          .         .         .         .         .         .       g.26418
 GCCCACGGACAGGCTGGGCCCCATCAGCAGAGCCACCAAGAGTCCACACGTGGCCGGTCA       c.11100
 A  H  G  Q  A  G  P  H  Q  Q  S  H  Q  E  S  T  R  G  R  S         p.3700

          .         .         .         .         .         .       g.26478
 GCAGGAAGGTCTGGACGTTCAGGGTCTTTCCTCTACCAGGTGAGCACTCATGAACAGTCT       c.11160
 A  G  R  S  G  R  S  G  S  F  L  Y  Q  V  S  T  H  E  Q  S         p.3720

          .         .         .         .         .         .       g.26538
 GAGTCTGCCCATGGACGGGCTGGGCCCAGTACTGGAGGAAGACAAGGATCCCGCCACGAG       c.11220
 E  S  A  H  G  R  A  G  P  S  T  G  G  R  Q  G  S  R  H  E         p.3740

          .         .         .         .         .         .       g.26598
 CAGGCACGAGACAGCTCCAGGCACTCAGCGTCCCAAGAGGGTCAGGACACCATTCGTGGA       c.11280
 Q  A  R  D  S  S  R  H  S  A  S  Q  E  G  Q  D  T  I  R  G         p.3760

          .         .         .         .         .         .       g.26658
 CACCCGGGGTCAAGGAGAGGAGGAAGACAGGGATCCTACCACGAGCAATCGGTAGATAGG       c.11340
 H  P  G  S  R  R  G  G  R  Q  G  S  Y  H  E  Q  S  V  D  R         p.3780

          .         .         .         .         .         .       g.26718
 TCTGGACACTCAGGGTCCCATCACAGCCACACCACATCCCAGGGAAGGTCTGATGCCTCC       c.11400
 S  G  H  S  G  S  H  H  S  H  T  T  S  Q  G  R  S  D  A  S         p.3800

          .         .         .         .         .         .       g.26778
 CATGGGCAGTCAGGATCCAGAAGTGCAAGCAGAGAAACACGTAATGAGGAACAGTCAGGA       c.11460
 H  G  Q  S  G  S  R  S  A  S  R  E  T  R  N  E  E  Q  S  G         p.3820

          .         .         .         .         .         .       g.26838
 GACGGCTCCAGGCACTCAGGGTCGCGTCACCATGAAGCTTCCACTCAGGCTGACAGCTCT       c.11520
 D  G  S  R  H  S  G  S  R  H  H  E  A  S  T  Q  A  D  S  S         p.3840

          .         .         .         .         .         .       g.26898
 AGACACTCACAGTCCGGCCAGGGTGAATCAGCGGGGTCCAGGAGAAGCAGGCGCCAGGGA       c.11580
 R  H  S  Q  S  G  Q  G  E  S  A  G  S  R  R  S  R  R  Q  G         p.3860

          .         .         .         .         .         .       g.26958
 TCCAGTGTTAGCCAGGACAGTGACAGTGAGGCATACCCAGAGGACTCTGAGAGGCGATCT       c.11640
 S  S  V  S  Q  D  S  D  S  E  A  Y  P  E  D  S  E  R  R  S         p.3880

          .         .         .         .         .         .       g.27018
 GAGTCTGCTTCCAGAAACCATCATGGATCTTCTCGGGAGCAGTCAAGAGATGGCTCCAGA       c.11700
 E  S  A  S  R  N  H  H  G  S  S  R  E  Q  S  R  D  G  S  R         p.3900

          .         .         .         .         .         .       g.27078
 CACCCCGGATCCTCTCACCGCGATACAGCCAGTCATGTACAGTCTTCACCTGTACAGTCA       c.11760
 H  P  G  S  S  H  R  D  T  A  S  H  V  Q  S  S  P  V  Q  S         p.3920

          .         .         .         .         .         .       g.27138
 GACTCTAGTACCGCTAAGGAACATGGTCACTTTAGTAGTCTTTCACAAGATTCTGCGTAT       c.11820
 D  S  S  T  A  K  E  H  G  H  F  S  S  L  S  Q  D  S  A  Y         p.3940

          .         .         .         .         .         .       g.27198
 CACTCAGGAATACAGTCACGTGGCAGTCCTCACAGTTCTAGTTCTTATCATTATCAATCT       c.11880
 H  S  G  I  Q  S  R  G  S  P  H  S  S  S  S  Y  H  Y  Q  S         p.3960

          .         .         .         .         .         .       g.27258
 GAGGGCACTGAAAGGCAAAAAGGTCAATCAGGTTTAGTTTGGAGACATGGCAGCTATGGT       c.11940
 E  G  T  E  R  Q  K  G  Q  S  G  L  V  W  R  H  G  S  Y  G         p.3980

          .         .         .         .         .         .       g.27318
 AGTGCAGATTATGATTATGGTGAATCCGGGTTTAGACACTCTCAGCACGGAAGTGTTAGT       c.12000
 S  A  D  Y  D  Y  G  E  S  G  F  R  H  S  Q  H  G  S  V  S         p.4000

          .         .         .         .         .         .       g.27378
 TACAATTCCAATCCTGTTGTTTTCAAGGAAAGATCTGATATCTGTAAAGCAAGTGCGTTT       c.12060
 Y  N  S  N  P  V  V  F  K  E  R  S  D  I  C  K  A  S  A  F         p.4020

          .         .         .         .         .         .       g.27438
 GGTAAAGATCATCCAAGGTATTATGCAACGTATATTAATAAGGACCCAGGTTTATGTGGC       c.12120
 G  K  D  H  P  R  Y  Y  A  T  Y  I  N  K  D  P  G  L  C  G         p.4040

          .         .         .         .         .         .       g.27498
 CATTCTAGTGATATATCGAAACAACTGGGATTTAGTCAGTCACAGAGATACTATTACTAT       c.12180
 H  S  S  D  I  S  K  Q  L  G  F  S  Q  S  Q  R  Y  Y  Y  Y         p.4060

                                                                    g.27504
 GAGTAA                                                             c.12186
 E  X                                                               p.4061

          .         .         .         .         .         .       g.27564
 gaaattaatggcaaaggaattaatccaagaatagaagaatgaagcaagttcactttcaat       c.*60

          .         .         .         .         .         .       g.27624
 caagaaacttcataatactttcagggaagttatcttttcctgtcaatctgtttaaaatat       c.*120

          .         .         .         .         .         .       g.27684
 gctatagtatttcattagtttggtggtagcttatttttattgtgtaatgatctttaaacg       c.*180

          .         .         .         .         .         .       g.27744
 ctatatttcagaaatattaaatggaagaaatcaatatcatggagagctaactttagaaaa       c.*240

          .         .         .         .         .         .       g.27804
 ctagctggagtattttaggagattctgggtcaagtaatgttttatgtttttgaaagttta       c.*300

          .         .         .         .         .         .       g.27864
 agttttagacactccccaaatttctaaattaatctttttcagaaatatcgaaggagccaa       c.*360

          .         .         .         .         .         .       g.27924
 aaatataaaacagttctgtataccaaagtggctatatcaacatcagggctagcacatctt       c.*420

          .         .         .         .         .         .       g.27984
 tctctattatccttctattggaattctagtattctgtattcaaaaaatcatcttggacat       c.*480

          .         .         .         .                           g.28029
 aattaatattatagtaagctgcatctaaattaaaaataaactatt                      c.*525

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Filaggrin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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