flightless I homolog (Drosophila) (FLII) - coding DNA reference sequence

(used for variant description)

(last modified September 28, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_002018.3 in the FLII gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering FLII transcript NM_002018.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5046
               aactccagcacagggggggcccgcactccttggtgcctccgcagtc       c.-181

 .         .         .         .         .         .                g.5106
 ttcgaacagacggggaaactgaggccctaagaggcctaaagcctacacttccccgcggaa       c.-121

 .         .         .         .         .         .                g.5166
 tgcggcgggcgcgggcgggttaaaggggcggggccggcgctggcccagcccgcggctccc       c.-61

 .         .         .         .         .         .                g.5226
 cccagcgccctcgccccggcgctccctagcccggcgcggcccggcagcgagagcggcgcc       c.-1

          .         .         .         .         .         .       g.5286
 ATGGAGGCCACCGGGGTGCTGCCGTTCGTGCGTGGCGTGGACCTCAGCGGCAACGACTTC       c.60
 M  E  A  T  G  V  L  P  F  V  R  G  V  D  L  S  G  N  D  F         p.20

     | 02    .         .         .         .         .         .    g.6954
 AAG | GGCGGCTACTTCCCTGAGAATGTCAAGGCCATGACCAGCCTGCGGTGGCTGAAGCTG    c.120
 K   | G  G  Y  F  P  E  N  V  K  A  M  T  S  L  R  W  L  K  L      p.40

          .         .         .         .         .     | 03   .    g.7325
 AACCGCACTGGCCTCTGCTACCTGCCCGAGGAGCTGGCCGCCCTGCAGAAGCTG | GAACAC    c.180
 N  R  T  G  L  C  Y  L  P  E  E  L  A  A  L  Q  K  L   | E  H      p.60

          .         .         .         .         .         .       g.7385
 TTGTCTGTGAGCCACAACAACCTGACCACGCTTCATGGGGAGCTGTCCAGCCTGCCATCG       c.240
 L  S  V  S  H  N  N  L  T  T  L  H  G  E  L  S  S  L  P  S         p.80

        | 04 .         .         .         .         .         .    g.8707
 CTGCGC | GCCATCGTGGCCCGAGCCAACAGTCTGAAGAATTCCGGAGTCCCCGATGACATC    c.300
 L  R   | A  I  V  A  R  A  N  S  L  K  N  S  G  V  P  D  D  I      p.100

          .         .        | 05.         .         .         .    g.9095
 TTCAAGCTAGATGATCTCTCAGTCCTG | GACTTGAGCCACAACCAGCTGACAGAGTGCCCG    c.360
 F  K  L  D  D  L  S  V  L   | D  L  S  H  N  Q  L  T  E  C  P      p.120

          .         .         .         .         .    | 06    .    g.9241
 CGGGAGCTGGAGAACGCCAAGAACATGCTGGTGCTGAACCTCAGCCACAACAG | CATCGAC    c.420
 R  E  L  E  N  A  K  N  M  L  V  L  N  L  S  H  N  S  |  I  D      p.140

          .         .         .         .         .         .       g.9301
 ACCATCCCCAACCAGCTCTTCATCAACCTCACTGACCTACTATACCTGGACCTCAGCGAG       c.480
 T  I  P  N  Q  L  F  I  N  L  T  D  L  L  Y  L  D  L  S  E         p.160

          .         .         .         .         .         .       g.9361
 AACCGCCTGGAGAGCCTGCCCCCGCAGATGCGCCGCCTGGTGCACCTGCAGACGCTCGTG       c.540
 N  R  L  E  S  L  P  P  Q  M  R  R  L  V  H  L  Q  T  L  V         p.180

          .         .         .      | 07  .         .         .    g.9759
 CTCAATGGAAACCCCCTGCTGCATGCACAGCTCCG | GCAGCTCCCAGCGATGACGGCCCTG    c.600
 L  N  G  N  P  L  L  H  A  Q  L  R  |  Q  L  P  A  M  T  A  L      p.200

          .         .         .         .         .         .       g.9819
 CAGACCCTGCACCTGCGGAGCACCCAGCGCACCCAGAGCAACCTGCCCACCAGCCTGGAG       c.660
 Q  T  L  H  L  R  S  T  Q  R  T  Q  S  N  L  P  T  S  L  E         p.220

          .          | 08        .         .         .         .    g.10238
 GGTCTGAGCAACCTCGCAG | ACGTGGATCTGTCCTGCAATGACCTGACACGGGTGCCCGAG    c.720
 G  L  S  N  L  A  D |   V  D  L  S  C  N  D  L  T  R  V  P  E      p.240

          .         .         .         .         .         .       g.10298
 TGTCTGTACACCCTCCCCAGCCTGCGCCGCCTCAACCTCAGCAGCAACCAGATCACGGAG       c.780
 C  L  Y  T  L  P  S  L  R  R  L  N  L  S  S  N  Q  I  T  E         p.260

          .         .         .         .         .         .       g.10358
 CTGTCCCTGTGCATAGACCAGTGGGTGCACGTGGAAACTCTGAACCTGTCCCGAAATCAG       c.840
 L  S  L  C  I  D  Q  W  V  H  V  E  T  L  N  L  S  R  N  Q         p.280

          .      | 09  .         .         .         .         .    g.10503
 CTCACCTCACTGCCC | TCAGCCATTTGCAAGCTGAGCAAGCTGAAGAAGCTGTACCTGAAT    c.900
 L  T  S  L  P   | S  A  I  C  K  L  S  K  L  K  K  L  Y  L  N      p.300

          .         .         .         .         .         .       g.10563
 TCCAACAAGCTGGACTTTGACGGGCTGCCCTCAGGCATTGGCAAGCTCACCAACCTGGAA       c.960
 S  N  K  L  D  F  D  G  L  P  S  G  I  G  K  L  T  N  L  E         p.320

          .         .         .         .         .    | 10    .    g.11367
 GAGTTCATGGCTGCCAACAACAACCTGGAGCTGGTCCCTGAAAGTCTCTGCAG | GTGCCCA    c.1020
 E  F  M  A  A  N  N  N  L  E  L  V  P  E  S  L  C  R  |  C  P      p.340

          .         .         .         .         .         .       g.11427
 AAGCTGAGGAAACTTGTCCTGAACAAGAACCACCTGGTGACCCTCCCAGAAGCCATCCAT       c.1080
 K  L  R  K  L  V  L  N  K  N  H  L  V  T  L  P  E  A  I  H         p.360

          .         | 11         .         .         .         .    g.11812
 TTCCTGACGGAGATCGAG | GTCCTGGATGTGCGGGAGAACCCCAACCTGGTCATGCCGCCC    c.1140
 F  L  T  E  I  E   | V  L  D  V  R  E  N  P  N  L  V  M  P  P      p.380

          .         .         .         .         .         .       g.11872
 AAGCCCGCAGACCGTGCCGCTGAGTGGTACAACATCGACTTCTCGCTGCAGAACCAGCTG       c.1200
 K  P  A  D  R  A  A  E  W  Y  N  I  D  F  S  L  Q  N  Q  L         p.400

          .         .         .         .       | 12 .         .    g.12114
 CGGCTAGCGGGTGCCTCTCCTGCTACCGTGGCTGCAGCTGCAGCTG | CAGGGAGTGGGCCC    c.1260
 R  L  A  G  A  S  P  A  T  V  A  A  A  A  A  A |   G  S  G  P      p.420

          .         .         .         .         .         .       g.12174
 AAGGACCCTATGGCTCGCAAGATGCGACTGCGGAGGCGCAAGGATTCAGCCCAGGATGAC       c.1320
 K  D  P  M  A  R  K  M  R  L  R  R  R  K  D  S  A  Q  D  D         p.440

          .         .         .         .         .         .       g.12234
 CAGGCCAAGCAGGTGCTGAAGGGCATGTCAGATGTTGCCCAGGAGAAGAACAAAAAGCAG       c.1380
 Q  A  K  Q  V  L  K  G  M  S  D  V  A  Q  E  K  N  K  K  Q         p.460

     | 13    .         .         .         .         .         .    g.12496
 GAG | GAGAGCGCAGATGCCCGGGCCCCCAGCGGGAAGGTGCGGCGTTGGGACCAGGGCCTG    c.1440
 E   | E  S  A  D  A  R  A  P  S  G  K  V  R  R  W  D  Q  G  L      p.480

          .         .         .         .         .         .       g.12556
 GAGAAGCCCCGCCTTGACTACTCCGAGTTCTTCACGGAGGACGTGGGCCAGCTGCCCGGA       c.1500
 E  K  P  R  L  D  Y  S  E  F  F  T  E  D  V  G  Q  L  P  G         p.500

          .         .         .         .         .         .       g.12616
 CTGACCATCTGGCAGATAGAGAACTTCGTGCCTGTGCTGGTGGAGGAAGCCTTCCACGGC       c.1560
 L  T  I  W  Q  I  E  N  F  V  P  V  L  V  E  E  A  F  H  G         p.520

          .         .         .       | 14 .         .         .    g.12923
 AAGTTCTACGAGGCTGACTGCTACATTGTGCTCAAG | ACCTTTCTGGATGACAGCGGCTCC    c.1620
 K  F  Y  E  A  D  C  Y  I  V  L  K   | T  F  L  D  D  S  G  S      p.540

          .         .         .         .         .         .       g.12983
 CTCAACTGGGAGATCTACTACTGGATTGGCGGGGAGGCCACACTCGACAAGAAAGCTTGC       c.1680
 L  N  W  E  I  Y  Y  W  I  G  G  E  A  T  L  D  K  K  A  C         p.560

          .         .         .         .         .         .       g.13043
 TCTGCCATCCACGCTGTCAACTTGCGCAACTACCTGGGTGCTGAGTGCCGCACTGTCCGG       c.1740
 S  A  I  H  A  V  N  L  R  N  Y  L  G  A  E  C  R  T  V  R         p.580

          .         .         .       | 15 .         .         .    g.14532
 GAGGAGATGGGCGATGAGAGCGAGGAGTTCCTGCAG | GTGTTTGACAACGACATCTCCTAC    c.1800
 E  E  M  G  D  E  S  E  E  F  L  Q   | V  F  D  N  D  I  S  Y      p.600

          .         .         .         .         .          | 16    g.14716
 ATTGAGGGTGGAACAGCCAGTGGCTTCTACACTGTGGAAGACACACACTATGTCACCAG | G    c.1860
 I  E  G  G  T  A  S  G  F  Y  T  V  E  D  T  H  Y  V  T  R  |      p.620

          .         .         .         .         .         .       g.14776
 ATGTATCGTGTGTATGGGAAAAAGAACATCAAGTTGGAGCCTGTGCCCCTCAAGGGGACC       c.1920
 M  Y  R  V  Y  G  K  K  N  I  K  L  E  P  V  P  L  K  G  T         p.640

          .     | 17   .         .         .         .         .    g.15079
 TCTCTGGACCCAAG | GTTTGTTTTCCTGCTGGACCGAGGGCTAGACATCTACGTATGGCGG    c.1980
 S  L  D  P  R  |  F  V  F  L  L  D  R  G  L  D  I  Y  V  W  R      p.660

          .         .         .         | 18         .         .    g.15217
 GGGGCCCAGGCCACACTGAGCAGCACCACCAAGGCCAG | GCTCTTTGCAGAGAAAATTAAC    c.2040
 G  A  Q  A  T  L  S  S  T  T  K  A  R  |  L  F  A  E  K  I  N      p.680

          .         .         .         .         .         .       g.15277
 AAGAATGAGCGGAAAGGGAAGGCTGAGATCACACTGCTGGTGCAGGGCCAGGAGCTCCCA       c.2100
 K  N  E  R  K  G  K  A  E  I  T  L  L  V  Q  G  Q  E  L  P         p.700

          .         .         .         .         .         .       g.15337
 GAGTTCTGGGAGGCACTGGGTGGGGAGCCCTCTGAGATCAAGAAGCACGTGCCTGAAGAC       c.2160
 E  F  W  E  A  L  G  G  E  P  S  E  I  K  K  H  V  P  E  D         p.720

          .         .         . | 19       .         .         .    g.15913
 TTCTGGCCGCCGCAGCCCAAGCTGTACAAG | GTGGGCCTGGGCTTGGGCTACCTGGAGCTG    c.2220
 F  W  P  P  Q  P  K  L  Y  K   | V  G  L  G  L  G  Y  L  E  L      p.740

          .         .         .         .         .         .       g.15973
 CCACAGATCAACTACAAGCTCTCCGTGGAACATAAGCAGCGTCCCAAGGTGGAGCTGATG       c.2280
 P  Q  I  N  Y  K  L  S  V  E  H  K  Q  R  P  K  V  E  L  M         p.760

          .      | 20  .         .         .         .         .    g.16113
 CCAAGAATGCGGCTG | CTGCAGAGTCTGCTGGACACGCGCTGCGTGTACATTCTGGACTGT    c.2340
 P  R  M  R  L   | L  Q  S  L  L  D  T  R  C  V  Y  I  L  D  C      p.780

          .         .         .         .         .         .       g.16173
 TGGTCCGACGTGTTCATCTGGCTCGGCCGCAAGTCCCCGCGCCTGGTGCGCGCTGCCGCC       c.2400
 W  S  D  V  F  I  W  L  G  R  K  S  P  R  L  V  R  A  A  A         p.800

          .         .         .         .         .         .       g.16233
 CTCAAGCTGGGTCAGGAGCTGTGCGGGATGCTGCACCGGCCACGCCATGCCACGGTCAGC       c.2460
 L  K  L  G  Q  E  L  C  G  M  L  H  R  P  R  H  A  T  V  S         p.820

          .         .        | 21.         .         .         .    g.16592
 CGCAGCCTCGAGGGCACCGAGGCGCAG | GTGTTCAAGGCCAAGTTCAAGAATTGGGACGAT    c.2520
 R  S  L  E  G  T  E  A  Q   | V  F  K  A  K  F  K  N  W  D  D      p.840

          .         .         .         .         .         .       g.16652
 GTGTTGACGGTGGACTACACACGCAATGCGGAGGCCGTGCTGCAGAGCCCGGGTCTCTCC       c.2580
 V  L  T  V  D  Y  T  R  N  A  E  A  V  L  Q  S  P  G  L  S         p.860

          .         .         .         .         .         .       g.16712
 GGGAAGGTGAAACGCGACGCCGAGAAGAAAGACCAGATGAAGGCTGACCTCACTGCGCTT       c.2640
 G  K  V  K  R  D  A  E  K  K  D  Q  M  K  A  D  L  T  A  L         p.880

          .         .         .       | 22 .         .         .    g.16888
 TTCCTGCCGCGGCAGCCGCCCATGTCGCTGGCCGAG | GCGGAGCAGCTGATGGAGGAGTGG    c.2700
 F  L  P  R  Q  P  P  M  S  L  A  E   | A  E  Q  L  M  E  E  W      p.900

          .         .         .         .         .         .       g.16948
 AACGAAGACCTAGACGGCATGGAGGGTTTCGTGCTGGAGGGCAAGAAGTTTGCGCGGCTG       c.2760
 N  E  D  L  D  G  M  E  G  F  V  L  E  G  K  K  F  A  R  L         p.920

          .         .         .         .         .       | 23 .    g.17092
 CCGGAAGAGGAGTTTGGCCACTTCTACACGCAGGACTGCTACGTCTTCCTCTGCAG | GTAC    c.2820
 P  E  E  E  F  G  H  F  Y  T  Q  D  C  Y  V  F  L  C  R  |  Y      p.940

          .         .         .         .         .         .       g.17152
 TGGGTGCCTGTGGAGTACGAGGAGGAGGAAAAGAAGGAAGACAAGGAGGAGAAGGCCGAG       c.2880
 W  V  P  V  E  Y  E  E  E  E  K  K  E  D  K  E  E  K  A  E         p.960

          .         .         .         .         .         .       g.17212
 GGCAAAGAAGGCGAGGAAGCAACCGCTGAGGCAGAGGAGAAGCAGCCAGAGGAGGACTTC       c.2940
 G  K  E  G  E  E  A  T  A  E  A  E  E  K  Q  P  E  E  D  F         p.980

          .         .         .         .         .         .       g.17272
 CAGTGCATCGTGTACTTCTGGCAGGGCCGTGAAGCCTCCAATATGGGCTGGCTCACCTTC       c.3000
 Q  C  I  V  Y  F  W  Q  G  R  E  A  S  N  M  G  W  L  T  F         p.1000

          .         .         .         .         .  | 24      .    g.17463
 ACCTTCAGCCTGCAAAAGAAGTTCGAGAGCCTCTTCCCTGGGAAGCTGGAG | GTGGTACGC    c.3060
 T  F  S  L  Q  K  K  F  E  S  L  F  P  G  K  L  E   | V  V  R      p.1020

          .         .         .         .         .         .       g.17523
 ATGACGCAGCAGCAGGAGAACCCCAAGTTCCTGTCCCATTTCAAGAGGAAGTTCATCATC       c.3120
 M  T  Q  Q  Q  E  N  P  K  F  L  S  H  F  K  R  K  F  I  I         p.1040

          .         .         .         .         .         .       g.17583
 CACCGGGGCAAGAGGAAGGCGGTCCAGGGCGCCCAACAGCCCAGCCTCTACCAGATCCGC       c.3180
 H  R  G  K  R  K  A  V  Q  G  A  Q  Q  P  S  L  Y  Q  I  R         p.1060

          .         .       | 25 .         .         .         .    g.17728
 ACCAACGGCAGCGCCCTCTGCACCCG | GTGCATCCAGATCAACACCGACTCCAGCCTCCTC    c.3240
 T  N  G  S  A  L  C  T  R  |  C  I  Q  I  N  T  D  S  S  L  L      p.1080

          .         .        | 26.         .         .         .    g.17887
 AACTCCGAGTTCTGCTTCATCCTCAAG | GTTCCCTTTGAGAGTGAGGACAACCAGGGCATC    c.3300
 N  S  E  F  C  F  I  L  K   | V  P  F  E  S  E  D  N  Q  G  I      p.1100

          .         .         .         .         .         .       g.17947
 GTGTATGCCTGGGTGGGCCGGGCATCAGACCCTGACGAAGCCAAGTTGGCAGAAGACATC       c.3360
 V  Y  A  W  V  G  R  A  S  D  P  D  E  A  K  L  A  E  D  I         p.1120

          .         .         .       | 27 .         .         .    g.18090
 CTGAACACCATGTTTGACACCTCCTACAGCAAGCAG | GTTATCAACGAAGGTGAGGAGCCT    c.3420
 L  N  T  M  F  D  T  S  Y  S  K  Q   | V  I  N  E  G  E  E  P      p.1140

          .         .         .         .         .         .       g.18150
 GAGAACTTCTTCTGGGTGGGCATTGGGGCACAGAAGCCCTATGATGACGATGCCGAGTAC       c.3480
 E  N  F  F  W  V  G  I  G  A  Q  K  P  Y  D  D  D  A  E  Y         p.1160

          .         .    | 28    .         .         .         .    g.18293
 ATGAAACACACACGTCTCTTCCG | GTGCTCCAACGAGAAGGGCTACTTTGCAGTGACTGAG    c.3540
 M  K  H  T  R  L  F  R  |  C  S  N  E  K  G  Y  F  A  V  T  E      p.1180

          .         .         .         .         .         .       g.18353
 AAATGCTCCGACTTTTGCCAAGATGACCTGGCAGATGATGACATCATGTTGCTAGACAAT       c.3600
 K  C  S  D  F  C  Q  D  D  L  A  D  D  D  I  M  L  L  D  N         p.1200

           | 29        .         .         .         .         .    g.18548
 GGCCAAGAG | GTCTACATGTGGGTGGGGACCCAGACTAGCCAGGTGGAGATCAAGCTGAGC    c.3660
 G  Q  E   | V  Y  M  W  V  G  T  Q  T  S  Q  V  E  I  K  L  S      p.1220

          .      | 30  .         .         .         .         .    g.18689
 CTGAAGGCCTGCCAG | GTATATATCCAGCACATGCGGTCCAAGGAACATGAGCGGCCGCGC    c.3720
 L  K  A  C  Q   | V  Y  I  Q  H  M  R  S  K  E  H  E  R  P  R      p.1240

          .         .         .         .         .         .       g.18749
 CGGCTGCGCCTGGTCCGCAAGGGCAATGAGCAGCACGCCTTTACCCGCTGCTTCCACGCC       c.3780
 R  L  R  L  V  R  K  G  N  E  Q  H  A  F  T  R  C  F  H  A         p.1260

          .         .         .                                     g.18779
 TGGAGCGCCTTCTGCAAGGCCCTGGCCTAA                                     c.3810
 W  S  A  F  C  K  A  L  A  X                                       p.1269

          .         .         .         .         .         .       g.18839
 gacaggctggcacagccccaggcttggtgaggaagaggaaggggcctcatccactgtctg       c.*60

          .         .         .         .         .         .       g.18899
 ctagcaaagaatgtactcaggtgacaccacctgctccagccacgtccagtgccacagtcc       c.*120

          .         .         .         .         .         .       g.18959
 ccagtagcctcaagcagcaccaatggggatgaccctgacaggtgccctcaggggtctggg       c.*180

          .         .         .         .         .         .       g.19019
 aaatccaactctctccacagtgtgagtgcacgtgtgaagccccctcactcttccgctagg       c.*240

          .         .         .         .         .         .       g.19079
 gataaagcagatgtggatgccctttaagagatattaaatgcttttattttcaatattaaa       c.*300

          .         .                                               g.19102
 aatcagtatttttaatattaaaa                                            c.*323

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Flightless I homolog (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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