fms-related tyrosine kinase 3 (FLT3) - coding DNA reference sequence

(used for variant description)

(last modified August 28, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_004119.2 in the FLT3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007066.1, covering FLT3 transcript NM_004119.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.4998
                                       acctgcagcgcgaggcgcgccg       c.-61

 .         .         .         .         .         .                g.5058
 ctccaggcggcatcgcagggctgggccggcgcggcctggggaccccgggctccggaggcc       c.-1

          .         .         .         .    | 02    .         .    g.34973
 ATGCCGGCGTTGGCGCGCGACGGCGGCCAGCTGCCGCTGCTCG | TTGTTTTTTCTGCAATG    c.60
 M  P  A  L  A  R  D  G  G  Q  L  P  L  L  V |   V  F  S  A  M      p.20

          .         .         .         .         .         .       g.35033
 ATATTTGGGACTATTACAAATCAAGATCTGCCTGTGATCAAGTGTGTTTTAATCAATCAT       c.120
 I  F  G  T  I  T  N  Q  D  L  P  V  I  K  C  V  L  I  N  H         p.40

          .         .         .         .      | 03  .         .    g.43514
 AAGAACAATGATTCATCAGTGGGGAAGTCATCATCATATCCCATG | GTATCAGAATCCCCG    c.180
 K  N  N  D  S  S  V  G  K  S  S  S  Y  P  M   | V  S  E  S  P      p.60

          .         .         .         .         .         .       g.43574
 GAAGACCTCGGGTGTGCGTTGAGACCCCAGAGCTCAGGGACAGTGTACGAAGCTGCCGCT       c.240
 E  D  L  G  C  A  L  R  P  Q  S  S  G  T  V  Y  E  A  A  A         p.80

          .         .         .         .         .         .       g.43634
 GTGGAAGTGGATGTATCTGCTTCCATCACACTGCAAGTGCTGGTCGACGCCCCAGGGAAC       c.300
 V  E  V  D  V  S  A  S  I  T  L  Q  V  L  V  D  A  P  G  N         p.100

          .         .         .         .         .         .       g.43694
 ATTTCCTGTCTCTGGGTCTTTAAGCACAGCTCCCTGAATTGCCAGCCACATTTTGATTTA       c.360
 I  S  C  L  W  V  F  K  H  S  S  L  N  C  Q  P  H  F  D  L         p.120

          | 04         .         .         .         .         .    g.48158
 CAAAACAG | AGGAGTTGTTTCCATGGTCATTTTGAAAATGACAGAAACCCAAGCTGGAGAA    c.420
 Q  N  R  |  G  V  V  S  M  V  I  L  K  M  T  E  T  Q  A  G  E      p.140

          .         .         .         .         .         .       g.48218
 TACCTACTTTTTATTCAGAGTGAAGCTACCAATTACACAATATTGTTTACAGTGAGTATA       c.480
 Y  L  L  F  I  Q  S  E  A  T  N  Y  T  I  L  F  T  V  S  I         p.160

      | 05   .         .         .         .         .         .    g.52950
 AGAA | ATACCCTGCTTTACACATTAAGAAGACCTTACTTTAGAAAAATGGAAAACCAGGAC    c.540
 R  N |   T  L  L  Y  T  L  R  R  P  Y  F  R  K  M  E  N  Q  D      p.180

          .         .         .         .         .         .       g.53010
 GCCCTGGTCTGCATATCTGAGAGCGTTCCAGAGCCGATCGTGGAATGGGTGCTTTGCGAT       c.600
 A  L  V  C  I  S  E  S  V  P  E  P  I  V  E  W  V  L  C  D         p.200

          .     | 06   .         .         .         .         .    g.55392
 TCACAGGGGGAAAG | CTGTAAAGAAGAAAGTCCAGCTGTTGTTAAAAAGGAGGAAAAAGTG    c.660
 S  Q  G  E  S  |  C  K  E  E  S  P  A  V  V  K  K  E  E  K  V      p.220

          .         .         .         .         .         .       g.55452
 CTTCATGAATTATTTGGGACGGACATAAGGTGCTGTGCCAGAAATGAACTGGGCAGGGAA       c.720
 L  H  E  L  F  G  T  D  I  R  C  C  A  R  N  E  L  G  R  E         p.240

          .         .   | 07     .         .         .         .    g.55832
 TGCACCAGGCTGTTCACAATAG | ATCTAAATCAAACTCCTCAGACCACATTGCCACAATTA    c.780
 C  T  R  L  F  T  I  D |   L  N  Q  T  P  Q  T  T  L  P  Q  L      p.260

          .         .         .         .         .         .       g.55892
 TTTCTTAAAGTAGGGGAACCCTTATGGATAAGGTGCAAAGCTGTTCATGTGAACCATGGA       c.840
 F  L  K  V  G  E  P  L  W  I  R  C  K  A  V  H  V  N  H  G         p.280

          .         .         .         .   | 08     .         .    g.56049
 TTCGGGCTCACCTGGGAATTAGAAAACAAAGCACTCGAGGAG | GGCAACTACTTTGAGATG    c.900
 F  G  L  T  W  E  L  E  N  K  A  L  E  E   | G  N  Y  F  E  M      p.300

          .         .         .         .         .         .       g.56109
 AGTACCTATTCAACAAACAGAACTATGATACGGATTCTGTTTGCTTTTGTATCATCAGTG       c.960
 S  T  Y  S  T  N  R  T  M  I  R  I  L  F  A  F  V  S  S  V         p.320

          .         .         .         .         .         .       g.56169
 GCAAGAAACGACACCGGATACTACACTTGTTCCTCTTCAAAGCATCCCAGTCAATCAGCT       c.1020
 A  R  N  D  T  G  Y  Y  T  C  S  S  S  K  H  P  S  Q  S  A         p.340

          .       | 09 .         .         .         .         .    g.57169
 TTGGTTACCATCGTAG | AAAAGGGATTTATAAATGCTACCAATTCAAGTGAAGATTATGAA    c.1080
 L  V  T  I  V  E |   K  G  F  I  N  A  T  N  S  S  E  D  Y  E      p.360

          .         .         .         .         .         .       g.57229
 ATTGACCAATATGAAGAGTTTTGTTTTTCTGTCAGGTTTAAAGCCTACCCACAAATCAGA       c.1140
 I  D  Q  Y  E  E  F  C  F  S  V  R  F  K  A  Y  P  Q  I  R         p.380

          .         .         .         .         .         .       g.57289
 TGTACGTGGACCTTCTCTCGAAAATCATTTCCTTGTGAGCAAAAGGGTCTTGATAACGGA       c.1200
 C  T  W  T  F  S  R  K  S  F  P  C  E  Q  K  G  L  D  N  G         p.400

       | 10  .         .         .         .         .         .    g.68335
 TACAG | CATATCCAAGTTTTGCAATCATAAGCACCAGCCAGGAGAATATATATTCCATGCA    c.1260
 Y  S  |  I  S  K  F  C  N  H  K  H  Q  P  G  E  Y  I  F  H  A      p.420

          .         .         .         .          | 11        .    g.69536
 GAAAATGATGATGCCCAATTTACCAAAATGTTCACGCTGAATATAAGAA | GGAAACCTCAA    c.1320
 E  N  D  D  A  Q  F  T  K  M  F  T  L  N  I  R  R |   K  P  Q      p.440

          .         .         .         .         .         .       g.69596
 GTGCTCGCAGAAGCATCGGCAAGTCAGGCGTCCTGTTTCTCGGATGGATACCCATTACCA       c.1380
 V  L  A  E  A  S  A  S  Q  A  S  C  F  S  D  G  Y  P  L  P         p.460

          .         .         .         | 12         .         .    g.69917
 TCTTGGACCTGGAAGAAGTGTTCAGACAAGTCTCCCAA | CTGCACAGAAGAGATCACAGAA    c.1440
 S  W  T  W  K  K  C  S  D  K  S  P  N  |  C  T  E  E  I  T  E      p.480

          .         .         .         .         .         .       g.69977
 GGAGTCTGGAATAGAAAGGCTAACAGAAAAGTGTTTGGACAGTGGGTGTCGAGCAGTACT       c.1500
 G  V  W  N  R  K  A  N  R  K  V  F  G  Q  W  V  S  S  S  T         p.500

          .         .         .         .         .         .       g.70037
 CTAAACATGAGTGAAGCCATAAAAGGGTTCCTGGTCAAGTGCTGTGCATACAATTCCCTT       c.1560
 L  N  M  S  E  A  I  K  G  F  L  V  K  C  C  A  Y  N  S  L         p.520

          .         .         .        | 13.         .         .    g.71184
 GGCACATCTTGTGAGACGATCCTTTTAAACTCTCCAG | GCCCCTTCCCTTTCATCCAAGAC    c.1620
 G  T  S  C  E  T  I  L  L  N  S  P  G |   P  F  P  F  I  Q  D      p.540

          .         .         .         .         .         .       g.71244
 AACATCTCATTCTATGCAACAATTGGTGTTTGTCTCCTCTTCATTGTCGTTTTAACCCTG       c.1680
 N  I  S  F  Y  A  T  I  G  V  C  L  L  F  I  V  V  L  T  L         p.560

          .         .     | 14   .         .         .         .    g.71390
 CTAATTTGTCACAAGTACAAAAAG | CAATTTAGGTATGAAAGCCAGCTACAGATGGTACAG    c.1740
 L  I  C  H  K  Y  K  K   | Q  F  R  Y  E  S  Q  L  Q  M  V  Q      p.580

          .         .         .         .         .         .       g.71450
 GTGACCGGCTCCTCAGATAATGAGTACTTCTACGTTGATTTCAGAGAATATGAATATGAT       c.1800
 V  T  G  S  S  D  N  E  Y  F  Y  V  D  F  R  E  Y  E  Y  D         p.600

          .         .         .        | 15.         .         .    g.71600
 CTCAAATGGGAGTTTCCAAGAGAAAATTTAGAGTTTG | GGAAGGTACTAGGATCAGGTGCT    c.1860
 L  K  W  E  F  P  R  E  N  L  E  F  G |   K  V  L  G  S  G  A      p.620

          .         .         .         .         .         .       g.71660
 TTTGGAAAAGTGATGAACGCAACAGCTTATGGAATTAGCAAAACAGGAGTCTCAATCCAG       c.1920
 F  G  K  V  M  N  A  T  A  Y  G  I  S  K  T  G  V  S  I  Q         p.640

          .         .   | 16     .         .         .         .    g.77318
 GTTGCCGTCAAAATGCTGAAAG | AAAAAGCAGACAGCTCTGAAAGAGAGGCACTCATGTCA    c.1980
 V  A  V  K  M  L  K  E |   K  A  D  S  S  E  R  E  A  L  M  S      p.660

          .         .         .         .         .         .       g.77378
 GAACTCAAGATGATGACCCAGCTGGGAAGCCACGAGAATATTGTGAACCTGCTGGGGGCG       c.2040
 E  L  K  M  M  T  Q  L  G  S  H  E  N  I  V  N  L  L  G  A         p.680

          .    | 17    .         .         .         .         .    g.78374
 TGCACACTGTCAG | GACCAATTTACTTGATTTTTGAATACTGTTGCTATGGTGATCTTCTC    c.2100
 C  T  L  S  G |   P  I  Y  L  I  F  E  Y  C  C  Y  G  D  L  L      p.700

          .         .         .         .         .         .       g.78434
 AACTATCTAAGAAGTAAAAGAGAAAAATTTCACAGGACTTGGACAGAGATTTTCAAGGAA       c.2160
 N  Y  L  R  S  K  R  E  K  F  H  R  T  W  T  E  I  F  K  E         p.720

          .         .         .         .        | 18.         .    g.80638
 CACAATTTCAGTTTTTACCCCACTTTCCAATCACATCCAAATTCCAG | CATGCCTGGTTCA    c.2220
 H  N  F  S  F  Y  P  T  F  Q  S  H  P  N  S  S  |  M  P  G  S      p.740

          .         .         .         .         .         .       g.80698
 AGAGAAGTTCAGATACACCCGGACTCGGATCAAATCTCAGGGCTTCATGGGAATTCATTT       c.2280
 R  E  V  Q  I  H  P  D  S  D  Q  I  S  G  L  H  G  N  S  F         p.760

          . | 19       .         .         .         .         .    g.82141
 CACTCTGAAG | ATGAAATTGAATATGAAAACCAAAAAAGGCTGGAAGAAGAGGAGGACTTG    c.2340
 H  S  E  D |   E  I  E  Y  E  N  Q  K  R  L  E  E  E  E  D  L      p.780

          .         .         .         .         .         .       g.82201
 AATGTGCTTACATTTGAAGATCTTCTTTGCTTTGCATATCAAGTTGCCAAAGGAATGGAA       c.2400
 N  V  L  T  F  E  D  L  L  C  F  A  Y  Q  V  A  K  G  M  E         p.800

          .         | 20         .         .         .         .    g.87021
 TTTCTGGAATTTAAGTCG | TGTGTTCACAGAGACCTGGCCGCCAGGAACGTGCTTGTCACC    c.2460
 F  L  E  F  K  S   | C  V  H  R  D  L  A  A  R  N  V  L  V  T      p.820

          .         .         .         .         .         .       g.87081
 CACGGGAAAGTGGTGAAGATATGTGACTTTGGATTGGCTCGAGATATCATGAGTGATTCC       c.2520
 H  G  K  V  V  K  I  C  D  F  G  L  A  R  D  I  M  S  D  S         p.840

          .         .  | 21      .         .         .         .    g.89906
 AACTATGTTGTCAGGGGCAAT | GCCCGTCTGCCTGTAAAATGGATGGCCCCCGAAAGCCTG    c.2580
 N  Y  V  V  R  G  N   | A  R  L  P  V  K  W  M  A  P  E  S  L      p.860

          .         .         .         .         .         .       g.89966
 TTTGAAGGCATCTACACCATTAAGAGTGATGTCTGGTCATATGGAATATTACTGTGGGAA       c.2640
 F  E  G  I  Y  T  I  K  S  D  V  W  S  Y  G  I  L  L  W  E         p.880

          .    | 22    .         .         .         .         .    g.90359
 ATCTTCTCACTTG | GTGTGAATCCTTACCCTGGCATTCCGGTTGATGCTAACTTCTACAAA    c.2700
 I  F  S  L  G |   V  N  P  Y  P  G  I  P  V  D  A  N  F  Y  K      p.900

          .         .         .         .         .    | 23    .    g.91018
 CTGATTCAAAATGGATTTAAAATGGATCAGCCATTTTATGCTACAGAAGAAAT | ATACATT    c.2760
 L  I  Q  N  G  F  K  M  D  Q  P  F  Y  A  T  E  E  I  |  Y  I      p.920

          .         .         .         .         .         .       g.91078
 ATAATGCAATCCTGCTGGGCTTTTGACTCAAGGAAACGGCCATCCTTCCCTAATTTGACT       c.2820
 I  M  Q  S  C  W  A  F  D  S  R  K  R  P  S  F  P  N  L  T         p.940

          .         .         .          | 24        .         .    g.101415
 TCGTTTTTAGGATGTCAGCTGGCAGATGCAGAAGAAGCG | ATGTATCAGAATGTGGATGGC    c.2880
 S  F  L  G  C  Q  L  A  D  A  E  E  A   | M  Y  Q  N  V  D  G      p.960

          .         .         .         .         .         .       g.101475
 CGTGTTTCGGAATGTCCTCACACCTACCAAAACAGGCGACCTTTCAGCAGAGAGATGGAT       c.2940
 R  V  S  E  C  P  H  T  Y  Q  N  R  R  P  F  S  R  E  M  D         p.980

          .         .         .         .                           g.101517
 TTGGGGCTACTCTCTCCGCAGGCTCAGGTCGAAGATTCGTAG                         c.2982
 L  G  L  L  S  P  Q  A  Q  V  E  D  S  X                           p.993

          .         .         .         .         .         .       g.101577
 aggaacaatttagttttaaggacttcatccctccacctatccctaacaggctgtagatta       c.*60

          .         .         .         .         .         .       g.101637
 ccaaaacaagattaatttcatcactaaaagaaaatctattatcaactgctgcttcaccag       c.*120

          .         .         .         .         .         .       g.101697
 acttttctctagaagctgtctgcgtttactcttgttttcaaagggacttttgtaaaatca       c.*180

          .         .         .         .         .         .       g.101757
 aatcatcctgtcacaaggcaggaggagctgataatgaactttattggagcattgatctgc       c.*240

          .         .         .         .         .         .       g.101817
 atccaaggccttctcaggctggcttgagtgaattgtgtacctgaagtacagtatattctt       c.*300

          .         .         .         .         .         .       g.101877
 gtaaatacataaaacaaaagcattttgctaaggagaagctaatatgattttttaagtcta       c.*360

          .         .         .         .         .         .       g.101937
 tgttttaaaataatatgtaaatttttcagctatttagtgatatattttatgggtgggaat       c.*420

          .         .         .         .         .         .       g.101997
 aaaatttctactacagaattgcccattattgaattatttacatggtataattagggcaag       c.*480

          .         .         .         .         .         .       g.102057
 tcttaactggagttcacgaaccccctgaaattgtgcacccatagccacctacacattcct       c.*540

          .         .         .         .         .         .       g.102117
 tccagagcacgtgtgcttttaccccaagatacaaggaatgtgtaggcagctatggttgtc       c.*600

          .         .         .         .         .         .       g.102177
 acagcctaagatttctgcaacaacaggggttgtattgggggaagtttataatgaataggt       c.*660

          .         .         .         .         .         .       g.102237
 gttctaccataaagagtaatacatcacctagacactttggcggccttcccagactcaggg       c.*720

          .         .         .         .         .                 g.102295
 ccagtcagaagtaacatggaggattagtattttcaataaagttactcttgtccccaca         c.*778

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fms-related tyrosine kinase 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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