flavin containing monooxygenase 2 (non-functional) (FMO2) - coding DNA reference sequence

(used for variant description)

(last modified October 27, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001460.3 in the FMO2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering FMO2 transcript NM_001460.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    tttctcacagccacctccaactcttaaaaacgcttccaactgcctcccagcacacaa       c.-61

 .         .         .         .         .         .    | 02        g.5465
 ccaagggagaaaactattctgtcaaagagacggtgccaaaaggcaaaaacaaag | gagctg    c.-1

          .         .         .         .         .         .       g.5525
 ATGGCAAAGAAGGTAGCTGTGATTGGAGCTGGGGTCAGTGGCCTAATTTCTCTGAAGTGC       c.60
 M  A  K  K  V  A  V  I  G  A  G  V  S  G  L  I  S  L  K  C         p.20

          .         .         .         .         .         .       g.5585
 TGTGTGGATGAGGGACTTGAGCCCACTTGCTTTGAGAGAACTGAAGATATTGGAGGAGTG       c.120
 C  V  D  E  G  L  E  P  T  C  F  E  R  T  E  D  I  G  G  V         p.40

          .   | 03     .         .         .         .         .    g.13134
 TGGAGGTTCAAA | GAGAATGTGGAAGATGGCCGAGCAAGTATCTATCAATCTGTCGTTACC    c.180
 W  R  F  K   | E  N  V  E  D  G  R  A  S  I  Y  Q  S  V  V  T      p.60

          .         .         .         .         .         .       g.13194
 AACACCAGCAAAGAAATGTCCTGTTTCAGTGACTTTCCAATGCCTGAAGATTTTCCAAAC       c.240
 N  T  S  K  E  M  S  C  F  S  D  F  P  M  P  E  D  F  P  N         p.80

          .         .         .         .         .         .       g.13254
 TTCCTGCATAATTCTAAACTTCTGGAATATTTCAGGATTTTTGCTAAAAAATTTGATCTG       c.300
 F  L  H  N  S  K  L  L  E  Y  F  R  I  F  A  K  K  F  D  L         p.100

          .         .  | 04      .         .         .         .    g.16439
 CTAAAATATATTCAGTTCCAG | ACAACTGTCCTTAGTGTGAGAAAATGTCCAGATTTCTCA    c.360
 L  K  Y  I  Q  F  Q   | T  T  V  L  S  V  R  K  C  P  D  F  S      p.120

          .         .         .         .         .         .       g.16499
 TCCTCTGGCCAATGGAAGGTTGTCACTCAGAGCAACGGCAAGGAGCAGAGTGCTGTCTTT       c.420
 S  S  G  Q  W  K  V  V  T  Q  S  N  G  K  E  Q  S  A  V  F         p.140

          .         .         .         .         .         .       g.16559
 GACGCAGTTATGGTTTGCAGTGGCCACCACATTCTACCTCATATCCCACTGAAGTCATTT       c.480
 D  A  V  M  V  C  S  G  H  H  I  L  P  H  I  P  L  K  S  F         p.160

      | 05   .         .         .         .         .         .    g.19153
 CCAG | GTATGGAGAGGTTCAAAGGCCAATATTTCCATAGCCGCCAATACAAGCATCCAGAT    c.540
 P  G |   M  E  R  F  K  G  Q  Y  F  H  S  R  Q  Y  K  H  P  D      p.180

          .         .         .         .         .         .       g.19213
 GGATTTGAGGGAAAACGCATCCTGGTGATTGGAATGGGAAACTCAGGCTCAGATATTGCT       c.600
 G  F  E  G  K  R  I  L  V  I  G  M  G  N  S  G  S  D  I  A         p.200

          .         .        | 06.         .         .         .    g.23649
 GTTGAGCTGAGTAAGAATGCTGCTCAG | GTTTTTATCAGCACCAGGCATGGCACCTGGGTC    c.660
 V  E  L  S  K  N  A  A  Q   | V  F  I  S  T  R  H  G  T  W  V      p.220

          .         .         .         .         .         .       g.23709
 ATGAGCCGTATCTCTGAAGATGGCTATCCTTGGGACTCAGTGTTCCACACCCGGTTTCGT       c.720
 M  S  R  I  S  E  D  G  Y  P  W  D  S  V  F  H  T  R  F  R         p.240

          .         .         .         .         .         .       g.23769
 TCTATGCTCCGCAATGTACTGCCACGAACAGCTGTAAAATGGATGATAGAACAACAGATG       c.780
 S  M  L  R  N  V  L  P  R  T  A  V  K  W  M  I  E  Q  Q  M         p.260

          .         .         .         .        | 07.         .    g.25043
 AATCGGTGGTTCAACCATGAAAATTATGGCCTTGAGCCTCAAAACAA | ATACATTATGAAG    c.840
 N  R  W  F  N  H  E  N  Y  G  L  E  P  Q  N  K  |  Y  I  M  K      p.280

          .         .         .         .         .         .       g.25103
 GAACCTGTACTAAATGATGATGTCCCAAGTCGTCTACTCTGTGGAGCCATCAAGGTGAAA       c.900
 E  P  V  L  N  D  D  V  P  S  R  L  L  C  G  A  I  K  V  K         p.300

          .         .         .         .         .         .       g.25163
 TCTACAGTGAAAGAGCTCACAGAAACTTCTGCCATCTTTGAGGATGGAACAGTGGAGGAG       c.960
 S  T  V  K  E  L  T  E  T  S  A  I  F  E  D  G  T  V  E  E         p.320

          .         .         .         .         .         .       g.25223
 AACATTGATGTCATCATTTTTGCAACAGGATATAGTTTCTCTTTTCCCTTCCTTGAAGAT       c.1020
 N  I  D  V  I  I  F  A  T  G  Y  S  F  S  F  P  F  L  E  D         p.340

          .         .         .         .         .         .       g.25283
 TCACTCGTTAAAGTAGAGAATAATATGGTCTCACTGTATAAATACATATTCCCCGCTCAC       c.1080
 S  L  V  K  V  E  N  N  M  V  S  L  Y  K  Y  I  F  P  A  H         p.360

          .         .         .         .         .         .       g.25343
 CTGGACAAGTCAACCCTCGCGTGCATTGGTCTCATCCAGCCCCTAGGTTCCATTTTCCCA       c.1140
 L  D  K  S  T  L  A  C  I  G  L  I  Q  P  L  G  S  I  F  P         p.380

          .         .         .         .    | 08    .         .    g.27486
 ACTGCTGAACTTCAAGCTCGTTGGGTGACAAGAGTTTTCAAAG | GCTTGTGTAGCCTGCCC    c.1200
 T  A  E  L  Q  A  R  W  V  T  R  V  F  K  G |   L  C  S  L  P      p.400

          .         .         .         .         .       | 09 .    g.28549
 TCAGAGAGAACTATGATGATGGACATTATCAAAAGGAATGAAAAAAGAATTGACCT | GTTT    c.1260
 S  E  R  T  M  M  M  D  I  I  K  R  N  E  K  R  I  D  L  |  F      p.420

          .         .         .         .         .         .       g.28609
 GGAGAAAGCCAGAGCCAGACGTTGCAGACCAATTATGTTGACTACTTGGACGAGCTCGCC       c.1320
 G  E  S  Q  S  Q  T  L  Q  T  N  Y  V  D  Y  L  D  E  L  A         p.440

          .         .         .         .         .         .       g.28669
 TTAGAGATAGGTGCGAAGCCAGATTTCTGCTCTCTCTTGTTCAAAGATCCTAAACTGGCT       c.1380
 L  E  I  G  A  K  P  D  F  C  S  L  L  F  K  D  P  K  L  A         p.460

          .         .         .                                     g.28705
 GTGAGACTCTATTTCGGACCCTGCAACTCCTATTAG                               c.1416
 V  R  L  Y  F  G  P  C  N  S  Y  X                                 p.471

          .         .         .         .         .         .       g.28765
 tatcgcctggttgggcctgggcaatgggaaggagccagaaatgccatcttcacccagaaa       c.*60

          .         .         .         .         .         .       g.28825
 caaagaatactgaagccactcaagactcgggccctgaaggattcatctaatttctcagtt       c.*120

          .         .         .         .         .         .       g.28885
 tcttttctgttgaaaatcctgggccttcttgctgttgttgtggcctttttttgccaactt       c.*180

          .         .         .         .         .         .       g.28945
 caatggtcctagtcagcataatgctttgggctttattatcttgtcagtcactacctccta       c.*240

          .         .         .         .         .         .       g.29005
 aagaaaaaaaaaaaggctagaagaaaaaacattacattcatgttctaattatagatttta       c.*300

          .         .         .         .         .         .       g.29065
 gagttaggtagtacaggtaagggggaaattgtaaagaattagcagaattaggcatatgta       c.*360

          .         .         .         .         .         .       g.29125
 caaaaccaaaattttgtcatgaaattttgcctttccacgcttccctcagttcaccaaagt       c.*420

          .         .         .         .         .         .       g.29185
 taccaaaatgtaaaataaaataagactggctcaggtaagtagtgctgccaaccctgatat       c.*480

          .         .         .         .         .         .       g.29245
 aggggagttgtatggaaaaatagtagaattacacagcatgaaaagcagcccatggtttaa       c.*540

          .         .         .         .         .         .       g.29305
 attattggacaatttaaattgtgggtaaatatttaaaactcctgaacaatgtttctgatg       c.*600

          .         .         .         .         .         .       g.29365
 gtcttctatccaccctacttggtaacaaagttctcagatgttaggtcatgtttcatttgc       c.*660

          .         .         .         .         .         .       g.29425
 tcagtcggggatcactcaaaactactagacaaaaaagtgagaggatagatttagaaaaca       c.*720

          .         .         .         .         .         .       g.29485
 tcagtgatgctcagataaacttttaggacctcatattaagagctaagcaaatggccacat       c.*780

          .         .         .         .         .         .       g.29545
 ttcctatattttgacagagatactgctggaaaaattaaaattaaaatgccataatagcta       c.*840

          .         .         .         .         .         .       g.29605
 cctaacaaatatatatgtttaatgtttatcataggccagacattgtgctatgtgcatatc       c.*900

          .         .         .         .         .         .       g.29665
 atatgtattatttcatttaattctcacaacaattctgtgaaatggttacagctattatag       c.*960

          .         .         .         .         .         .       g.29725
 tcatttcacagatgatgaaactaagattcagagcagctgatcttgtgaggcagctggaat       c.*1020

          .         .         .         .         .         .       g.29785
 tggaactcagatttgttgaactctagaactaaagatcataatgttgtcttgtaatatatt       c.*1080

          .         .         .         .         .         .       g.29845
 tatttacaaaacacttcattatttataaagaatttactaacagtttatcttatttatacc       c.*1140

          .         .         .         .         .         .       g.29905
 catacatctgctactttgggaggccctttacatagaaaacagcattctttttgccaaata       c.*1200

          .         .         .         .         .         .       g.29965
 tgaccaaattacttttatttataatttttgatttatatttcagctagatctaaaaagcat       c.*1260

          .         .         .         .         .         .       g.30025
 ctgaaggaatttacaatgaaagatacctatgcaataacatttaggataatctttgacatt       c.*1320

          .         .         .         .         .         .       g.30085
 ttggaaaaataagaattgaggaaaaaaagtgtatctttcaagtagatgcaaagcattata       c.*1380

          .         .         .         .         .         .       g.30145
 atgactgacacttgtatctaactccagtcttacagataactaaggcaaaaagctaaataa       c.*1440

          .         .         .         .         .         .       g.30205
 acaatatgtaacctctaacatttggtaaaaggaagtatactggtctgttagcagagacaa       c.*1500

          .         .         .         .         .         .       g.30265
 actttttttagaattgaagtctgaaacaaacaaaagcaattcaatgtcaatagacattaa       c.*1560

          .         .         .         .         .         .       g.30325
 gcaacataatagacaaacatctcctaagggaacatttgttacagctgctccttccctgaa       c.*1620

          .         .         .         .         .         .       g.30385
 ctgtgctttggaagataagctctgtcctgagtccaaaccaagcccttccaagagagaaca       c.*1680

          .         .         .         .         .         .       g.30445
 aaggtcagagatgttgaagattccagcaaatttctcctcttatttctaccaagcctttgt       c.*1740

          .         .         .         .         .         .       g.30505
 gaacattgctcttcattttggcctgtacttctccctcagggacgtagaacaatggaatgt       c.*1800

          .         .         .         .         .         .       g.30565
 cagtcagtctctgtagttaaaactttttctttaaaattcaattaaggtacttctccctca       c.*1860

          .         .         .         .         .         .       g.30625
 gggacgtagaacaatggaatgtcagtcagtctctgtagttaaaactttttctttaaaatt       c.*1920

          .         .         .         .         .         .       g.30685
 caattaaggtacttctccctcagggacgtagaacaatggaatgtcagtcagtctctgtag       c.*1980

          .         .         .         .         .         .       g.30745
 ttaaaactttttctttaaaattcaattaagttacaccagaatttacaggcaagatttttt       c.*2040

          .         .         .         .         .         .       g.30805
 ttttcattgctcccataagcaaatttgttttaaaataattgtaaatgaggtatatactta       c.*2100

          .         .         .         .         .         .       g.30865
 gttcttggttaaaaaatatattgctttgttaagtattaaagattatttgtaagtcattgt       c.*2160

          .         .         .         .         .         .       g.30925
 attaataatactaataaaatttatcaagcctttatagcaagggtcagtgaattaccactg       c.*2220

          .         .         .         .         .         .       g.30985
 cctgtgggccaaatctagctcactatctgtttttgtaaataaaattttataatagtacac       c.*2280

          .         .         .         .         .         .       g.31045
 agccacactcattcatttattttctgtggttgctttcaagctacaattgtagagttgggt       c.*2340

          .         .         .         .         .         .       g.31105
 agtcgcaacagaatctctgtggcccacaaggctaaaatatttacattctcacccattaca       c.*2400

          .         .         .         .         .         .       g.31165
 gaaaaagtttgataattcctgctttataatatgtaaggcattgtcccattttgcataact       c.*2460

          .         .         .         .         .         .       g.31225
 tgccttatttcatcattatcactacccatttagtagctatggttgttatcttacttctac       c.*2520

          .         .         .         .         .         .       g.31285
 agtggaagagattgaaaagcatttgtcaggttaatgctaaatcagtgcggaaatatagct       c.*2580

          .         .         .         .         .         .       g.31345
 ccactaggaaaatattattaaatttatatccctaaaatttttagaaatctctcaaaatct       c.*2640

          .         .         .         .         .         .       g.31405
 ttccaaatgttctggtatctttgaaaaatgtaaatagtttatttatagagaaccctacct       c.*2700

          .         .         .         .         .         .       g.31465
 ctgaggttgactcaaaggttaaagaaggctcatcagtctatccttctgcctccatatatc       c.*2760

          .         .         .         .         .         .       g.31525
 ctgaacatcaaactatcccaggaaaaccatctagagtagtttgtttcaaaatattagcca       c.*2820

          .         .         .         .         .         .       g.31585
 cagaccacctacatcacaataactcagggagcttatagaagtgaagattcctgaatataa       c.*2880

          .         .         .         .         .         .       g.31645
 acatagtaataattcaacctactgaatggaaatctctgctgaaatccacagttttcataa       c.*2940

          .         .         .         .         .         .       g.31705
 gctccccagatgattcctgtgtacattaaatctagaaaccattagtttgagatctctcaa       c.*3000

          .         .         .         .         .         .       g.31765
 aaataaaaataaaaattgctttcagagagtagcccatgaaatttcccattcttcaaggac       c.*3060

          .         .         .         .         .         .       g.31825
 aaattccttctgttcagccttggtcctccaactgcagtttacaatttttgttcttctcct       c.*3120

          .         .         .         .         .         .       g.31885
 gtaaagaatgtcaatggttatcaccttcaatagtttcaatatgtcccccaaagttatgtg       c.*3180

          .         .         .         .         .         .       g.31945
 tttgaaacttgcaatagtattgggagatggggcctaatgaggtgattaggtgaagtctct       c.*3240

          .         .         .         .         .         .       g.32005
 gccctcatgaaaagattaatcccattatctcaggagtgtgttggttataaaagcaagttt       c.*3300

          .         .         .         .         .         .       g.32065
 ggctccctcttttcctcacacactctttttcccttctgccttcacctttgccgtgggtgg       c.*3360

          .         .         .         .         .         .       g.32125
 acacagcaagaaggccctcatcagatgctggccccttggtcttgaatttcctagcctcta       c.*3420

          .         .         .         .         .         .       g.32185
 caactaagccaaataaatttctgtttattataaataacccagtctcagatattctgttac       c.*3480

          .         .         .         .         .         .       g.32245
 agaaacacaaaatggactaagacaccacccttttccaaaatctctccttgtgatggctcc       c.*3540

          .         .         .         .         .         .       g.32305
 ctttactaacctttcttttagctattccctttatgatagtttcttaattttttctatcaa       c.*3600

          .         .         .         .         .         .       g.32365
 aagctaaatatggcacacttgttctttacagaaaaataaagatattttaaacaaaatact       c.*3660

          .         .         .         .         .         .       g.32425
 agggccatggtatgtaataaaatttgaaacaataatttcaaataataaagattgaaaatg       c.*3720

          .                                                         g.32435
 cttaacccag                                                         c.*3730

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Flavin containing monooxygenase 2 (non-functional) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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