forkhead box C2 (MFH-1, mesenchyme forkhead 1) (FOXC2) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_005251.2 in the FOXC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012025.1, covering FOXC2 transcript NM_005251.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5025
                                    cgcgctctctcgctctcagggcccc       c.-61

 .         .         .         .         .         .                g.5085
 cctcgctcccccggccgcagtccgtgcgcgagggcgccggcgagccgtctcggaagcagc       c.-1

          .         .         .         .         .         .       g.5145
 ATGCAGGCGCGCTACTCCGTGTCCGACCCCAACGCCCTGGGAGTGGTGCCCTACCTGAGC       c.60
 M  Q  A  R  Y  S  V  S  D  P  N  A  L  G  V  V  P  Y  L  S         p.20

          .         .         .         .         .         .       g.5205
 GAGCAGAATTACTACCGGGCTGCGGGCAGCTACGGCGGCATGGCCAGCCCCATGGGCGTC       c.120
 E  Q  N  Y  Y  R  A  A  G  S  Y  G  G  M  A  S  P  M  G  V         p.40

          .         .         .         .         .         .       g.5265
 TATTCCGGCCACCCGGAGCAGTACAGCGCGGGGATGGGCCGCTCCTACGCGCCCTACCAC       c.180
 Y  S  G  H  P  E  Q  Y  S  A  G  M  G  R  S  Y  A  P  Y  H         p.60

          .         .         .         .         .         .       g.5325
 CACCACCAGCCCGCGGCGCCTAAGGACCTGGTGAAGCCGCCCTACAGCTACATCGCGCTC       c.240
 H  H  Q  P  A  A  P  K  D  L  V  K  P  P  Y  S  Y  I  A  L         p.80

          .         .         .         .         .         .       g.5385
 ATCACCATGGCCATCCAGAACGCGCCCGAGAAGAAGATCACCTTGAACGGCATCTACCAG       c.300
 I  T  M  A  I  Q  N  A  P  E  K  K  I  T  L  N  G  I  Y  Q         p.100

          .         .         .         .         .         .       g.5445
 TTCATCATGGACCGCTTCCCCTTCTACCGGGAGAACAAGCAGGGCTGGCAGAACAGCATC       c.360
 F  I  M  D  R  F  P  F  Y  R  E  N  K  Q  G  W  Q  N  S  I         p.120

          .         .         .         .         .         .       g.5505
 CGCCACAACCTCTCGCTCAACGAGTGCTTCGTCAAGGTGCCCCGCGACGACAAGAAGCCC       c.420
 R  H  N  L  S  L  N  E  C  F  V  K  V  P  R  D  D  K  K  P         p.140

          .         .         .         .         .         .       g.5565
 GGCAAGGGCAGTTACTGGACCCTGGACCCGGACTCCTACAACATGTTCGAGAACGGCAGC       c.480
 G  K  G  S  Y  W  T  L  D  P  D  S  Y  N  M  F  E  N  G  S         p.160

          .         .         .         .         .         .       g.5625
 TTCCTGCGGCGCCGGCGGCGCTTCAAAAAGAAGGACGTGTCCAAGGAGAAGGAGGAGCGG       c.540
 F  L  R  R  R  R  R  F  K  K  K  D  V  S  K  E  K  E  E  R         p.180

          .         .         .         .         .         .       g.5685
 GCCCACCTCAAGGAGCCGCCCCCGGCGGCGTCCAAGGGCGCCCCGGCCACCCCCCACCTA       c.600
 A  H  L  K  E  P  P  P  A  A  S  K  G  A  P  A  T  P  H  L         p.200

          .         .         .         .         .         .       g.5745
 GCGGACGCCCCCAAGGAGGCCGAGAAGAAGGTGGTGATCAAGAGCGAGGCGGCGTCCCCG       c.660
 A  D  A  P  K  E  A  E  K  K  V  V  I  K  S  E  A  A  S  P         p.220

          .         .         .         .         .         .       g.5805
 GCGCTGCCGGTCATCACCAAGGTGGAGACGCTGAGCCCCGAGAGCGCGCTGCAGGGCAGC       c.720
 A  L  P  V  I  T  K  V  E  T  L  S  P  E  S  A  L  Q  G  S         p.240

          .         .         .         .         .         .       g.5865
 CCGCGCAGCGCGGCCTCCACGCCCGCCGGCTCCCCCGACGGCTCGCTGCCGGAGCACCAC       c.780
 P  R  S  A  A  S  T  P  A  G  S  P  D  G  S  L  P  E  H  H         p.260

          .         .         .         .         .         .       g.5925
 GCCGCGGCGCCCAACGGGCTGCCTGGCTTCAGCGTGGAGAACATCATGACCCTGCGAACG       c.840
 A  A  A  P  N  G  L  P  G  F  S  V  E  N  I  M  T  L  R  T         p.280

          .         .         .         .         .         .       g.5985
 TCGCCGCCGGGCGGAGAGCTGAGCCCGGGGGCCGGACGCGCGGGCCTGGTGGTGCCGCCG       c.900
 S  P  P  G  G  E  L  S  P  G  A  G  R  A  G  L  V  V  P  P         p.300

          .         .         .         .         .         .       g.6045
 CTGGCGCTGCCCTACGCCGCCGCGCCGCCCGCCGCCTACGGCCAGCCGTGCGCTCAGGGC       c.960
 L  A  L  P  Y  A  A  A  P  P  A  A  Y  G  Q  P  C  A  Q  G         p.320

          .         .         .         .         .         .       g.6105
 CTGGAGGCCGGGGCCGCCGGGGGCTACCAGTGCAGCATGCGAGCGATGAGCCTGTACACC       c.1020
 L  E  A  G  A  A  G  G  Y  Q  C  S  M  R  A  M  S  L  Y  T         p.340

          .         .         .         .         .         .       g.6165
 GGGGCCGAGCGGCCGGCGCACATGTGCGTCCCGCCCGCCCTGGACGAGGCCCTCTCGGAC       c.1080
 G  A  E  R  P  A  H  M  C  V  P  P  A  L  D  E  A  L  S  D         p.360

          .         .         .         .         .         .       g.6225
 CACCCGAGCGGCCCCACGTCGCCCCTGAGCGCTCTCAACCTCGCCGCCGGCCAGGAGGGC       c.1140
 H  P  S  G  P  T  S  P  L  S  A  L  N  L  A  A  G  Q  E  G         p.380

          .         .         .         .         .         .       g.6285
 GCGCTCGCCGCCACGGGCCACCACCACCAGCACCACGGCCACCACCACCCGCAGGCGCCG       c.1200
 A  L  A  A  T  G  H  H  H  Q  H  H  G  H  H  H  P  Q  A  P         p.400

          .         .         .         .         .         .       g.6345
 CCGCCCCCGCCGGCTCCCCAGCCCCAGCCGACGCCGCAGCCCGGGGCCGCCGCGGCGCAG       c.1260
 P  P  P  P  A  P  Q  P  Q  P  T  P  Q  P  G  A  A  A  A  Q         p.420

          .         .         .         .         .         .       g.6405
 GCGGCCTCCTGGTATCTCAACCACAGCGGGGACCTGAACCACCTCCCCGGCCACACGTTC       c.1320
 A  A  S  W  Y  L  N  H  S  G  D  L  N  H  L  P  G  H  T  F         p.440

          .         .         .         .         .         .       g.6465
 GCGGCCCAGCAGCAAACTTTCCCCAACGTGCGGGAGATGTTCAACTCCCACCGGCTGGGG       c.1380
 A  A  Q  Q  Q  T  F  P  N  V  R  E  M  F  N  S  H  R  L  G         p.460

          .         .         .         .         .         .       g.6525
 ATTGAGAACTCGACCCTCGGGGAGTCCCAGGTGAGTGGCAATGCCAGCTGCCAGCTGCCC       c.1440
 I  E  N  S  T  L  G  E  S  Q  V  S  G  N  A  S  C  Q  L  P         p.480

          .         .         .         .         .         .       g.6585
 TACAGATCCACGCCGCCTCTCTATCGCCACGCAGCCCCCTACTCCTACGACTGCACGAAA       c.1500
 Y  R  S  T  P  P  L  Y  R  H  A  A  P  Y  S  Y  D  C  T  K         p.500

                                                                    g.6591
 TACTGA                                                             c.1506
 Y  X                                                               p.501

          .         .         .         .         .         .       g.6651
 cgtgtcccgggacctcccctccccggcccgctccggcttcgcttcccagccccgacccaa       c.*60

          .         .         .                                     g.6683
 ccagacaattaaggggctgcagagacgcaaaa                                   c.*92

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Forkhead box C2 (MFH-1, mesenchyme forkhead 1) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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