forkhead box D2 (FOXD2) - coding DNA reference sequence

(used for variant description)

(last modified June 12, 2020)
This file was created to facilitate the description of sequence variants on transcript NM_004474.3 in the FOXD2 gene based on a coding DNA reference sequence following the HGVS recommendations.
The sequence was taken from NC_000001.10, covering FOXD2 transcript NM_004474.3.
Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          cccttggtcagaggtccca       c.-2101

 .         .         .         .         .         .                g.5079
 gagggggcccaggcgacttcctctcaaaggacatgagtagtcagacctgccttccatttt       c.-2041

 .         .         .         .         .         .                g.5139
 tttctgcccttaccttggggggatgaagaactctattttgaggattctgtgaaaagggtt       c.-1981

 .         .         .         .         .         .                g.5199
 gcaacccaactctgttctatttctttgcaggagcctgggtgagttctttctccctatcct       c.-1921

 .         .         .         .         .         .                g.5259
 gggcctctgtagctccatctgtggaatgggagagttggattaacaccaggctatcccgta       c.-1861

 .         .         .         .         .         .                g.5319
 gattggaggctgctgttagatgaaactgcaaagtgttctcagtaccctttcctaaatggc       c.-1801

 .         .         .         .         .         .                g.5379
 ctagaatatggctacacttatacatcagttctgaggtaggtgttactagcctcattttta       c.-1741

 .         .         .         .         .         .                g.5439
 caaaggcagaaacaaagcgcaaagaaccttgcccaaggtgacagatagggtaagtagtga       c.-1681

 .         .         .         .         .         .                g.5499
 aggcaggattggaaccccaggagcctgacttaaggtcgctgctcttaactactatgcaga       c.-1621

 .         .         .         .         .         .                g.5559
 ccaggaaactgaggctccgaagcggggaagtcacctaatgagggtcacacagccttgcta       c.-1561

 .         .         .         .         .         .                g.5619
 cagcggaggcagctgggattccggcctcgcacgcccgagctttagccactgtgcggcgct       c.-1501

 .         .         .         .         .         .                g.5679
 gtcggggcagcagcccaggcatccgctcagttcctgctcacgtccagcgcccatctcccc       c.-1441

 .         .         .         .         .         .                g.5739
 ttccgtgccccagaggctgaaatgggcccaatctgtgttgaagctgcttgtttctgggtc       c.-1381

 .         .         .         .         .         .                g.5799
 ctggagggaggccgggggagaaagaggtctaataggatgggcaggaacccggctagcgag       c.-1321

 .         .         .         .         .         .                g.5859
 aaacaaggcacagggccaaccttagttgcacaagacttttgagagatgaaggcaacactt       c.-1261

 .         .         .         .         .         .                g.5919
 ggtggaggtcagggttcactgagggggtgtcgggcagggggcggaggaggtcctgccgcc       c.-1201

 .         .         .         .         .         .                g.5979
 tgtcggtggggcccagaaccctgggagccaggaaggtggggggtgtccagtcctcagggc       c.-1141

 .         .         .         .         .         .                g.6039
 aactggggccagggagaggggagggagaaattaagcggattcccagacccatgaacagac       c.-1081

 .         .         .         .         .         .                g.6099
 atccagacaaatgccgtttccacagagactcacggagagtgagatagtcacagagactga       c.-1021

 .         .         .         .         .         .                g.6159
 gacaaacggatgccgagatccagagggtcggagaacaggcaaactcggagcagtagaccg       c.-961

 .         .         .         .         .         .                g.6219
 gcccgcgccccgggaacgcggccacagcggccggcgctctgcccggcctctccgcgcgga       c.-901

 .         .         .         .         .         .                g.6279
 gaggggtggcgggcccgacagcggagggaggagagggcgccgccgcaatctcacctctcc       c.-841

 .         .         .         .         .         .                g.6339
 caggcccaaggctgcgggcgccaagttcgctcctggtgatcactcgaatgcgtctcccct       c.-781

 .         .         .         .         .         .                g.6399
 cgggctggaagccgtgcgggctcgggtgggcgccggcgggccgcgctggggcggcgtggg       c.-721

 .         .         .         .         .         .                g.6459
 tcccggcgtctcagcctcgcgctcccactgcgcttcggcccggtggcccgggcgccgcct       c.-661

 .         .         .         .         .         .                g.6519
 tggggagaggacgggtggggaccgccgccacttccctggctgcggctggcgcccgagtga       c.-601

 .         .         .         .         .         .                g.6579
 gccttaacatccaggggctgagcgttctgaaggcggcggcttcagggagcacagggtgca       c.-541

 .         .         .         .         .         .                g.6639
 ggagcggcggcgaagacaagggcccgcctccggccactcgagcccagctcccgccgcggc       c.-481

 .         .         .         .         .         .                g.6699
 ggcggtttgttcccgccgggtccctcagcggaggcgctacgcccgcccctgtcgcctcgc       c.-421

 .         .         .         .         .         .                g.6759
 cccaccccgcccagggagctccgccctagcccgcagctcttccgccttaggcagccgcta       c.-361

 .         .         .         .         .         .                g.6819
 ggcgggagggacaatcccccaccaccaaccactgccaccccgaggggactaggggctgag       c.-301

 .         .         .         .         .         .                g.6879
 gcccgcccaggtaagggaaagcctcagctccttccgttgcgccccagcggcgggtcccag       c.-241

 .         .         .         .         .         .                g.6939
 ctcggattcccggggtagtggcgggggccgccggcgggtcgtgccctggaaggtgagcgc       c.-181

 .         .         .         .         .         .                g.6999
 ggccgagctgggccgccagggggcgctgcggagccgggggacacccctccctgcctgcct       c.-121

 .         .         .         .         .         .                g.7059
 cagtcccccgccccctccccgcccgcgcgcaaaacgcactcgccccagaggcagcgcggc       c.-61

 .         .         .         .         .         .                g.7119
 cgagcccgagccgctgccggagcggagccggagagtggcggcggcggcggcagcggcacc       c.-1

          .         .         .         .         .         .       g.7179
 ATGACCCTGGGCAGCTGCTGCTGCGAGATCATGTCCTCCGAGAGCTCCCCGGCCGCGCTG       c.60
 M  T  L  G  S  C  C  C  E  I  M  S  S  E  S  S  P  A  A  L         p.20

          .         .         .         .         .         .       g.7239
 TCCGAGGCCGACGCAGACATAGACGTGGTGGGCGGCGGCAGCGGCGGGGGGGAGCTCCCA       c.120
 S  E  A  D  A  D  I  D  V  V  G  G  G  S  G  G  G  E  L  P         p.40

          .         .         .         .         .         .       g.7299
 GCTCGCTCCGGGCCCCGCGCCCCCCGGGACGTGCTCCCCCACGGCCACGAGCCTCCCGCG       c.180
 A  R  S  G  P  R  A  P  R  D  V  L  P  H  G  H  E  P  P  A         p.60

          .         .         .         .         .         .       g.7359
 GAGGAAGCCGAGGCAGACTTAGCCGAGGACGAGGAGGAGTCTGGTGGCTGCTCGGACGGC       c.240
 E  E  A  E  A  D  L  A  E  D  E  E  E  S  G  G  C  S  D  G         p.80

          .         .         .         .         .         .       g.7419
 GAGCCCCGCGCTCTGGCGTCCCGGGGGGCGGCGGCCGCAGCGGGGAGCCCGGGGCCAGGC       c.300
 E  P  R  A  L  A  S  R  G  A  A  A  A  A  G  S  P  G  P  G         p.100

          .         .         .         .         .         .       g.7479
 GCCGCGGCGGCCCGCGGCGCAGCGGGGCCCGGGCCGGGACCGCCGTCGGGGGGCGCGGCG       c.360
 A  A  A  A  R  G  A  A  G  P  G  P  G  P  P  S  G  G  A  A         p.120

          .         .         .         .         .         .       g.7539
 ACGCGGAGCCCGCTGGTGAAGCCGCCCTACTCGTACATCGCGCTCATCACCATGGCCATC       c.420
 T  R  S  P  L  V  K  P  P  Y  S  Y  I  A  L  I  T  M  A  I         p.140

          .         .         .         .         .         .       g.7599
 CTGCAGAGCCCCAAGAAGCGGCTGACGTTGAGCGAGATCTGCGAGTTCATCAGCGGCCGC       c.480
 L  Q  S  P  K  K  R  L  T  L  S  E  I  C  E  F  I  S  G  R         p.160

          .         .         .         .         .         .       g.7659
 TTCCCCTACTACCGGGAGAAGTTCCCCGCCTGGCAGAACAGCATCCGCCACAACCTCTCT       c.540
 F  P  Y  Y  R  E  K  F  P  A  W  Q  N  S  I  R  H  N  L  S         p.180

          .         .         .         .         .         .       g.7719
 CTCAACGACTGCTTCGTCAAGATCCCCCGCGAGCCGGGCAACCCGGGCAAGGGCAACTAC       c.600
 L  N  D  C  F  V  K  I  P  R  E  P  G  N  P  G  K  G  N  Y         p.200

          .         .         .         .         .         .       g.7779
 TGGACGCTGGACCCGGAGTCGGCCGACATGTTCGACAACGGCAGCTTCCTGCGGCGTCGC       c.660
 W  T  L  D  P  E  S  A  D  M  F  D  N  G  S  F  L  R  R  R         p.220

          .         .         .         .         .         .       g.7839
 AAGCGCTTCAAGCGGCAGCCCCTGCCGCCGCCGCACCCACACCCGCACCCTCACCCGGAG       c.720
 K  R  F  K  R  Q  P  L  P  P  P  H  P  H  P  H  P  H  P  E         p.240

          .         .         .         .         .         .       g.7899
 CTGCTGCTGCGTGGCGGGGCCGCGGCGGCGGGGGATCCCGGCGCTTTCCTGCCCGGCTTC       c.780
 L  L  L  R  G  G  A  A  A  A  G  D  P  G  A  F  L  P  G  F         p.260

          .         .         .         .         .         .       g.7959
 GCTGCCTACGGCGCCTACGGCTACGGCTACGGGCTGGCTCTCCCGGCCTACGGCGCACCC       c.840
 A  A  Y  G  A  Y  G  Y  G  Y  G  L  A  L  P  A  Y  G  A  P         p.280

          .         .         .         .         .         .       g.8019
 CCGCCGGGGCCGGCCCCGCATCCGCACCCGCACCCGCACGCCTTCGCTTTCGCCGCGGCA       c.900
 P  P  G  P  A  P  H  P  H  P  H  P  H  A  F  A  F  A  A  A         p.300

          .         .         .         .         .         .       g.8079
 GCCGCCGCCGCTCCTTGCCAGCTGTCGGTACCCCCAGGCCGCGCCGCCGCGCCTCCACCC       c.960
 A  A  A  A  P  C  Q  L  S  V  P  P  G  R  A  A  A  P  P  P         p.320

          .         .         .         .         .         .       g.8139
 GGACCTCCGACGGCCTCGGTGTTCGCAGGCGCGGGATCGGCCCCAGCTCCTGCGCCTGCC       c.1020
 G  P  P  T  A  S  V  F  A  G  A  G  S  A  P  A  P  A  P  A         p.340

          .         .         .         .         .         .       g.8199
 TCAGGCTCGGGCCCGGGCCCGGGCCCCGCAGGCCTGCCCGCCTTCCTGGGCGCGGAGCTG       c.1080
 S  G  S  G  P  G  P  G  P  A  G  L  P  A  F  L  G  A  E  L         p.360

          .         .         .         .         .         .       g.8259
 GGCTGCGCCAAAGCCTTCTACGCGGCGTCCCTGAGTCCTCCCGCAGCCGGCACCGCGGCG       c.1140
 G  C  A  K  A  F  Y  A  A  S  L  S  P  P  A  A  G  T  A  A         p.380

          .         .         .         .         .         .       g.8319
 GGTCTGCCCACCGCACTTCTGCGCCAGGGCCTCAAGACGGACGCGGGCGGTGGTGCAGGC       c.1200
 G  L  P  T  A  L  L  R  Q  G  L  K  T  D  A  G  G  G  A  G         p.400

          .         .         .         .         .         .       g.8379
 GGCGGGGGCGCCGGGGCAGGGCAGAGGCCTTCCTTCTCTATAGACCACATCATGGGCCAC       c.1260
 G  G  G  A  G  A  G  Q  R  P  S  F  S  I  D  H  I  M  G  H         p.420

          .         .         .         .         .         .       g.8439
 GGTGGCGGCGGGGCAGCACCCCCGGGCGCCGGCGAGGGCTCTCCGGGACCGCCATTCGCG       c.1320
 G  G  G  G  A  A  P  P  G  A  G  E  G  S  P  G  P  P  F  A         p.440

          .         .         .         .         .         .       g.8499
 GCAGCCGCGGGTCCTGGGGGCCAAGCCCAGGTCTTGGCCATGCTGACTGCTCCGGCCCTG       c.1380
 A  A  A  G  P  G  G  Q  A  Q  V  L  A  M  L  T  A  P  A  L         p.460

          .         .         .         .         .         .       g.8559
 GCTCCCGTTGCTGGCCACATTCGCCTCTCGCATCCCGGGGACGCGCTGCTGTCCTCAGGG       c.1440
 A  P  V  A  G  H  I  R  L  S  H  P  G  D  A  L  L  S  S  G         p.480

          .         .         .         .                           g.8607
 TCCCGGTTTGCCAGCAAAGTCGCCGGCCTTAGTGGCTGCCACTTCTGA                   c.1488
 S  R  F  A  S  K  V  A  G  L  S  G  C  H  F  X                     p.495

          .         .         .         .         .         .       g.8667
 ccgcagcaggcccagggccggttaggtccgcactcctcagcctctcccgggagttcctgc       c.*60

          .         .         .         .         .         .       g.8727
 ggtcccagcggaactcagggagtctatttatgaagtctccagaccttgggccggcacgcg       c.*120

          .         .         .         .         .         .       g.8787
 tgacacggcacttcaggctccacgcacagaatctcgcagatagttgggactaagcgggct       c.*180

          .         .         .         .         .         .       g.8847
 ctatcgctcagggcgacaggcccggggctacgcgaagaagtcgcaggccaagattcttta       c.*240

          .         .         .         .         .         .       g.8907
 cagtttgagaaataaaagcaggggggtgggggcttcgtttttttccctgcctctgcgcct       c.*300

          .         .         .         .         .         .       g.8967
 ctcggggaacacattccgggagagatgcctggccaggctccacggatcccgccagaaaca       c.*360

          .         .         .         .         .         .       g.9027
 ccaacagagggtctccctttctgcctttcccctctcacttcttccccaacgttgagaccc       c.*420

          .         .         .         .         .         .       g.9087
 tgcttgtccaatattataatttaaagacatctattatctgctttgtgcttaaaagaaaaa       c.*480

          .         .         .         .         .         .       g.9147
 ttcaacctttttttttttttttttttttttgctgttctccaaggaagttcgtttcctctg       c.*540

          .         .         .         .         .         .       g.9207
 aagcctaaaccagtgtctacgcaggcggagctgaacggagaggtgaagcagggggtcttt       c.*600

          .         .         .         .         .         .       g.9267
 atattccctgcagaaaccctggatcccactccactgaggaaaatcctttctcttttgtgt       c.*660

          .         .         .         .         .         .       g.9327
 ttgggtgcttttaaaggaatttctttcctttcccttggctggctgggtccagccatctcc       c.*720

          .         .         .         .         .         .       g.9387
 ggccagcaaccctgtcagtgttccaccctgtcccaggccctgtgatatttattgtggcta       c.*780

          .         .         .         .         .         .       g.9447
 aaggcaatgagattgggtggaagagaagggtctgggccagggactggagaggtgggggtg       c.*840

          .         .         .         .         .         .       g.9507
 gagtgggcaagggcacaccctgtggcagggggtcctataattttgtgtaaatatctgtac       c.*900

          .         .         .         .         .         .       g.9567
 agcgcgctgctctcggcgttctctgtccactgggtgtgcattgatttaaacttctccact       c.*960

          .         .         .         .         .         .       g.9627
 gtggggaagctctgtgaaatcgtctgatggtctgtgtggaagaaaagaaaaatctgtctg       c.*1020

          .         .         .         .                           g.9675
 ccgcctatttcccattggtgtcgattgaataaatgtatgtgaacttca                   c.*1068

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Forkhead box D2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.