forkhead box D3 (FOXD3) - coding DNA reference sequence

(used for variant description)

(last modified November 18, 2021)

This file was created to facilitate the description of sequence variants on transcript NM_012183.2 in the FOXD3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering FOXD3 transcript NM_012183.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGACCCTCTCCGGCGGCGGCAGCGCCAGCGACATGTCCGGCCAGACGGTGCTGACGGCC       c.60
 M  T  L  S  G  G  G  S  A  S  D  M  S  G  Q  T  V  L  T  A         p.20

          .         .         .         .         .         .       g.120
 GAGGACGTGGACATCGATGTGGTGGGCGAGGGCGACGACGGGCTGGAAGAGAAGGACAGC       c.120
 E  D  V  D  I  D  V  V  G  E  G  D  D  G  L  E  E  K  D  S         p.40

          .         .         .         .         .         .       g.180
 GACGCAGGTTGCGATAGCCCCGCGGGGCCGCCGGAGCTGCGCCTGGACGAGGCGGACGAG       c.180
 D  A  G  C  D  S  P  A  G  P  P  E  L  R  L  D  E  A  D  E         p.60

          .         .         .         .         .         .       g.240
 GTGCCCCCGGCGGCACCCCATCACGGACAGCCTCAGCCGCCCCACCAGCAGCCCCTGACA       c.240
 V  P  P  A  A  P  H  H  G  Q  P  Q  P  P  H  Q  Q  P  L  T         p.80

          .         .         .         .         .         .       g.300
 TTGCCCAAGGAGGCGGCCGGAGCCGGGGCCGGACCGGGGGGCGACGTGGGCGCGCCGGAG       c.300
 L  P  K  E  A  A  G  A  G  A  G  P  G  G  D  V  G  A  P  E         p.100

          .         .         .         .         .         .       g.360
 GCGGACGGCTGCAAGGGCGGTGTTGGCGGCGAGGAGGGCGGCGCGAGCGGCGGCGGGCCT       c.360
 A  D  G  C  K  G  G  V  G  G  E  E  G  G  A  S  G  G  G  P         p.120

          .         .         .         .         .         .       g.420
 GGCGCGGGCAGCGGTTCGGCGGGAGGCCTGGCCCCGAGCAAGCCCAAGAACAGCCTAGTG       c.420
 G  A  G  S  G  S  A  G  G  L  A  P  S  K  P  K  N  S  L  V         p.140

          .         .         .         .         .         .       g.480
 AAGCCGCCTTACTCGTACATCGCGCTCATCACCATGGCCATCCTGCAGAGCCCGCAGAAG       c.480
 K  P  P  Y  S  Y  I  A  L  I  T  M  A  I  L  Q  S  P  Q  K         p.160

          .         .         .         .         .         .       g.540
 AAGCTGACCCTGAGCGGCATCTGCGAGTTCATCAGCAACCGCTTCCCCTACTACAGGGAG       c.540
 K  L  T  L  S  G  I  C  E  F  I  S  N  R  F  P  Y  Y  R  E         p.180

          .         .         .         .         .         .       g.600
 AAGTTCCCCGCCTGGCAGAACAGCATCCGCCACAACCTCTCACTCAACGACTGCTTCGTC       c.600
 K  F  P  A  W  Q  N  S  I  R  H  N  L  S  L  N  D  C  F  V         p.200

          .         .         .         .         .         .       g.660
 AAGATCCCCCGCGAGCCGGGCAACCCGGGCAAGGGCAACTACTGGACCCTGGACCCGCAG       c.660
 K  I  P  R  E  P  G  N  P  G  K  G  N  Y  W  T  L  D  P  Q         p.220

          .         .         .         .         .         .       g.720
 TCCGAGGACATGTTCGACAACGGCAGCTTCCTGCGGCGCCGGAAACGCTTCAAGCGCCAC       c.720
 S  E  D  M  F  D  N  G  S  F  L  R  R  R  K  R  F  K  R  H         p.240

          .         .         .         .         .         .       g.780
 CAGCAGGAGCACCTGCGCGAGCAGACGGCGCTCATGATGCAGAGCTTCGGCGCTTACAGC       c.780
 Q  Q  E  H  L  R  E  Q  T  A  L  M  M  Q  S  F  G  A  Y  S         p.260

          .         .         .         .         .         .       g.840
 CTGGCGGCGGCGGCCGGCGCCGCGGGACCCTACGGCCGCCCCTACGGCCTGCACCCTGCG       c.840
 L  A  A  A  A  G  A  A  G  P  Y  G  R  P  Y  G  L  H  P  A         p.280

          .         .         .         .         .         .       g.900
 GCGGCGGCCGGTGCCTATTCGCACCCGGCAGCGGCGGCGGCCGCGGCTGCTGCGGCGGCG       c.900
 A  A  A  G  A  Y  S  H  P  A  A  A  A  A  A  A  A  A  A  A         p.300

          .         .         .         .         .         .       g.960
 CTCCAGTACCCGTACGCGCTGCCGCCGGTGGCACCGGTGCTGCCTCCCGCTGTGCCGCTG       c.960
 L  Q  Y  P  Y  A  L  P  P  V  A  P  V  L  P  P  A  V  P  L         p.320

          .         .         .         .         .         .       g.1020
 CTGCCCTCGGGCGAGCTGGGCCGCAAAGCGGCCGCCTTCGGCTCACAGCTCGGCCCGGGC       c.1020
 L  P  S  G  E  L  G  R  K  A  A  A  F  G  S  Q  L  G  P  G         p.340

          .         .         .         .         .         .       g.1080
 CTGCAGCTGCAGCTCAATAGCCTGGGCGCCGCCGCGGCCGCTGCGGGCACAGCGGGCGCC       c.1080
 L  Q  L  Q  L  N  S  L  G  A  A  A  A  A  A  G  T  A  G  A         p.360

          .         .         .         .         .         .       g.1140
 GCGGGCACCACCGCGTCGCTCATCAAGTCCGAGCCAAGCGCGCGGCCGTCGTTCAGCATC       c.1140
 A  G  T  T  A  S  L  I  K  S  E  P  S  A  R  P  S  F  S  I         p.380

          .         .         .         .         .         .       g.1200
 GAGAACATCATAGGTGGGGGCCCCGCGGCTCCTGGGGGCTCGGCGGTGGGCGCTGGGGTC       c.1200
 E  N  I  I  G  G  G  P  A  A  P  G  G  S  A  V  G  A  G  V         p.400

          .         .         .         .         .         .       g.1260
 GCCGGCGGCACTGGGGGTTCAGGGGGCGGCAGCACGGCGCAGTCGTTTCTGCGGCCACCC       c.1260
 A  G  G  T  G  G  S  G  G  G  S  T  A  Q  S  F  L  R  P  P         p.420

          .         .         .         .         .         .       g.1320
 GGGACCGTGCAGTCGGCAGCGCTCATGGCCACCCACCAACCGCTGTCGCTGAGCCGGACG       c.1320
 G  T  V  Q  S  A  A  L  M  A  T  H  Q  P  L  S  L  S  R  T         p.440

          .         .         .         .         .         .       g.1380
 ACTGCCACCATCGCGCCCATTCTTAGCGTGCCACTCTCCGGACAGTTTCTGCAGCCCGCA       c.1380
 T  A  T  I  A  P  I  L  S  V  P  L  S  G  Q  F  L  Q  P  A         p.460

          .         .         .         .         .                 g.1437
 GCCTCGGCCGCCGCCGCTGCTGCGGCCGCCGCTCAAGCCAAATGGCCGGCGCAATAG          c.1437
 A  S  A  A  A  A  A  A  A  A  A  Q  A  K  W  P  A  Q  X            p.478

          .         .         .         .         .         .       g.1497
 ggacgcgccaatggccgggacccagggtccggcggcggcctcgagcaacaaatgcacctc       c.*60

          .         .         .         .         .         .       g.1557
 caggctgcgcgccctgtcccaagcccggtcccggtcccgctgcccaatcctggactctgc       c.*120

          .         .         .         .         .         .       g.1617
 ctctccccaatttcctttcccctgagcccccaacgcctaccttccgcggcctccatcccc       c.*180

          .         .         .         .         .         .       g.1677
 tcgcgcacacctaagctggtcgagcaaactcaccgcgcgcccgccggggatagctttcca       c.*240

          .         .         .         .         .         .       g.1737
 tacaggtaaaaccgaaaaccgaattttccaaaaatgcaccccgacggcgcctgctcttag       c.*300

          .         .         .         .         .         .       g.1797
 taccgtggggatgggagggaaattctttgtatatatttgtaaaaaaattattgactttcc       c.*360

          .         .         .         .         .         .       g.1857
 ttttggggtttttatttttttaagaaaaaacaaattccgtagatttagagctctgaactt       c.*420

          .         .         .         .         .         .       g.1917
 tcattttttttgaaggttcactctccgaagttttatctgagaaaagaatgtatagagacg       c.*480

          .         .         .         .         .         .       g.1977
 ttgggagattttaaatataaaaaattttcaaaaaggcaaaaagtgtcattctattataaa       c.*540

          .         .         .         .         .         .       g.2037
 agtctgtttatatatgaatgaatatatatggtattctaaatgttattccatcgtgttgta       c.*600

          .         .         .                                     g.2068
 cacaactttgtaaataaatttttaaaatgcc                                    c.*631

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Forkhead box D3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.