forkhead box F1 (FOXF1) - coding DNA reference sequence

(used for variant description)

(last modified October 22, 2018)

This file was created to facilitate the description of sequence variants on transcript NM_001451.2 in the FOXF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016273.1, covering FOXF1 transcript NM_001451.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5043
                  gcagagcagcggcggcagcggcggcggcggcagcagccacccg       c.-1

          .         .         .         .         .         .       g.5103
 ATGTCTTCGGCGCCCGAGAAGCAGCAGCCACCGCACGGCGGCGGCGGCGGCGGCGGCGGG       c.60
 M  S  S  A  P  E  K  Q  Q  P  P  H  G  G  G  G  G  G  G  G         p.20

          .         .         .         .         .         .       g.5163
 GGAGGCGGCGCGGCCATGGACCCCGCGTCGTCCGGCCCGTCCAAGGCCAAGAAGACCAAC       c.120
 G  G  G  A  A  M  D  P  A  S  S  G  P  S  K  A  K  K  T  N         p.40

          .         .         .         .         .         .       g.5223
 GCCGGCATCCGGCGCCCGGAGAAGCCGCCCTATTCCTACATCGCGCTCATCGTCATGGCC       c.180
 A  G  I  R  R  P  E  K  P  P  Y  S  Y  I  A  L  I  V  M  A         p.60

          .         .         .         .         .         .       g.5283
 ATCCAGAGTTCACCCACCAAGCGCCTGACGCTGAGCGAGATCTACCAGTTCCTGCAGAGC       c.240
 I  Q  S  S  P  T  K  R  L  T  L  S  E  I  Y  Q  F  L  Q  S         p.80

          .         .         .         .         .         .       g.5343
 CGCTTCCCCTTCTTCCGGGGCTCCTACCAGGGCTGGAAGAACTCCGTGCGCCACAACCTC       c.300
 R  F  P  F  F  R  G  S  Y  Q  G  W  K  N  S  V  R  H  N  L         p.100

          .         .         .         .         .         .       g.5403
 TCGCTCAACGAGTGCTTCATCAAGCTACCCAAGGGCCTTGGGCGGCCCGGCAAGGGCCAC       c.360
 S  L  N  E  C  F  I  K  L  P  K  G  L  G  R  P  G  K  G  H         p.120

          .         .         .         .         .         .       g.5463
 TACTGGACCATCGACCCGGCCAGCGAGTTCATGTTCGAGGAGGGCTCCTTTCGGCGGCGG       c.420
 Y  W  T  I  D  P  A  S  E  F  M  F  E  E  G  S  F  R  R  R         p.140

          .         .         .         .         .         .       g.5523
 CCGCGCGGCTTCCGAAGGAAATGCCAGGCGCTCAAGCCCATGTACAGCATGATGAACGGG       c.480
 P  R  G  F  R  R  K  C  Q  A  L  K  P  M  Y  S  M  M  N  G         p.160

          .         .         .         .         .         .       g.5583
 CTCGGCTTCAACCACCTCCCGGACACCTACGGCTTCCAGGGCTCGGCCGGCGGCCTCTCG       c.540
 L  G  F  N  H  L  P  D  T  Y  G  F  Q  G  S  A  G  G  L  S         p.180

          .         .         .         .         .         .       g.5643
 TGCCCGCCCAACAGCCTGGCGCTGGAGGGCGGCCTGGGCATGATGAACGGCCACTTGCCG       c.600
 C  P  P  N  S  L  A  L  E  G  G  L  G  M  M  N  G  H  L  P         p.200

          .         .         .         .         .         .       g.5703
 GGCAACGTGGACGGCATGGCCCTGCCCAGCCACTCGGTGCCCCACCTGCCTTCCAACGGC       c.660
 G  N  V  D  G  M  A  L  P  S  H  S  V  P  H  L  P  S  N  G         p.220

          .         .         .         .         .         .       g.5763
 GGCCACTCGTACATGGGCGGCTGCGGCGGCGCGGCGGCCGGCGAGTACCCGCACCACGAC       c.720
 G  H  S  Y  M  G  G  C  G  G  A  A  A  G  E  Y  P  H  H  D         p.240

          .         .         .         .         .         .       g.5823
 AGCTCGGTGCCCGCCTCCCCGCTGCTGCCCACCGGCGCCGGTGGGGTCATGGAGCCGCAC       c.780
 S  S  V  P  A  S  P  L  L  P  T  G  A  G  G  V  M  E  P  H         p.260

          .         .         .         .         .         .       g.5883
 GCCGTCTACTCGGGCTCGGCGGCGGCCTGGCCGCCCTCGGCGTCCGCGGCGCTCAACAGC       c.840
 A  V  Y  S  G  S  A  A  A  W  P  P  S  A  S  A  A  L  N  S         p.280

          .         .         .         .         .         .       g.5943
 GGCGCCTCTTATATCAAGCAGCAGCCCCTGTCCCCCTGTAACCCCGCGGCCAACCCCCTG       c.900
 G  A  S  Y  I  K  Q  Q  P  L  S  P  C  N  P  A  A  N  P  L         p.300

          .         .         .         .         .         .       g.6003
 TCCGGCAGCCTCTCCACGCACTCCCTGGAGCAGCCGTATCTGCACCAGAACAGCCACAAC       c.960
 S  G  S  L  S  T  H  S  L  E  Q  P  Y  L  H  Q  N  S  H  N         p.320

          .          | 02        .         .         .         .    g.7439
 GCCCCAGCCGAGCTGCAAG | GCATCCCGCGGTATCACTCGCAGTCGCCCAGCATGTGTGAC    c.1020
 A  P  A  E  L  Q  G |   I  P  R  Y  H  S  Q  S  P  S  M  C  D      p.340

          .         .         .         .         .         .       g.7499
 CGAAAGGAGTTTGTCTTCTCTTTCAACGCCATGGCGTCCTCTTCCATGCACTCGGCCGGC       c.1080
 R  K  E  F  V  F  S  F  N  A  M  A  S  S  S  M  H  S  A  G         p.360

          .         .         .         .         .         .       g.7559
 GGGGGCTCCTACTACCACCAGCAGGTCACCTACCAAGACATCAAGCCTTGCGTGATGTGA       c.1140
 G  G  S  Y  Y  H  Q  Q  V  T  Y  Q  D  I  K  P  C  V  M  X         p.379

          .         .         .         .         .         .       g.7619
 ggctgccgccgcaggccctcctggtgcaggcaggcgggtcacagggaccctggaccggca       c.*60

          .         .         .         .         .         .       g.7679
 caagaaactgctttcttctcgaggtataaccgtcggcagaagaaaagggttccacctctc       c.*120

          .         .         .         .         .         .       g.7739
 cccaaccggagtttttggcaaggagtccccaatgcaaagacacagcgctgcggttggcac       c.*180

          .         .         .         .         .         .       g.7799
 ctccttcctcactccttcaaaattgttaagaaatgttagtggtgggtctgatctgactgc       c.*240

          .         .         .         .         .         .       g.7859
 agccatcggtaaataaaagtttttgatcctgttgaacccgcctgagacggtgctgtgcag       c.*300

          .         .         .         .         .         .       g.7919
 gggaaagcccccgcacccacacaggaattctgctgaggtcccccctccttccggccaatg       c.*360

          .         .         .         .         .         .       g.7979
 gcagaagtgggggaaaatttttagaagaaaagcaaacatgtgagaccaatcattatcaaa       c.*420

          .         .         .         .         .         .       g.8039
 tacttttattttttggttgagtatttatctttttattttttattttttttttgaaagaat       c.*480

          .         .         .         .         .         .       g.8099
 gtcttggaatgcgcaagtctccctttagagccgtcttttgcagggagcgggaagtgacaa       c.*540

          .         .         .         .         .         .       g.8159
 gagctcagatctccctcccgatctccctccccacctccgaagtctcctccgtggaccaca       c.*600

          .         .         .         .         .         .       g.8219
 ggtggatctttgtgcgaacaacttgcatttcggaagccactgtccgtctttaaacagaaa       c.*660

          .         .         .         .         .         .       g.8279
 gtcaaaggagccacgaagcaagcggccgtccgggcgtccgcctccgtccccttccatgtt       c.*720

          .         .         .         .         .         .       g.8339
 cctcctcttccttcgcttcagcctcttctgttatgttttgtcttgaattttatttagact       c.*780

          .         .         .         .         .         .       g.8399
 ttttcagtgggtatttttctgtctcccaacctctactgtaaactttctggtccgagaacg       c.*840

          .         .         .         .         .         .       g.8459
 agccgaacacagcgcgacgcagggactaggacggcccggtgaccgcgcggattcaggatt       c.*900

          .         .         .         .         .         .       g.8519
 gcggggacgcagaaaggttaaggcacttttaaaaactatagcaaggctcctgtttattta       c.*960

          .         .         .         .         .         .       g.8579
 ttctactttctttccctaataatcaaaacaccgcgtaggctcctccgtttatcagtatta       c.*1020

          .         .         .         .         .         .       g.8639
 atggtgtaactttgttggcaatatttgccgtgtagaattttttttagatatccattgtaa       c.*1080

          .         .         .         .         .         .       g.8699
 atttgaaacaaagaccgatctgtgtaaaaacaaatttccatatgttttatataaatatat       c.*1140

          .         .         .         .         .         .       g.8759
 atataatatgaaggactaccctccttttttttttttgtattttggctgctagagtgcagc       c.*1200

          .         .         .         .         .         .       g.8819
 atttgtgacacgtatttgaaatttgaaatttccttctgcactgtataaaaggaccatttg       c.*1260

          .         .         .         .         .         .       g.8879
 aggatgttttgccttttgtgtattttttcctaaaaaaagaacaaaaataaaaatgtataa       c.*1320

          .         .         .         .         .                 g.8938
 catttgtacatggcctttaaaattgtatcaactagaaataaaattgcatgagtatttta        c.*1379

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Forkhead box F1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.