forkhead box L2 (FOXL2) - coding DNA reference sequence

(used for variant description)

(last modified April 20, 2020)

This file was created to facilitate the description of sequence variants on transcript NM_023067.3 in the FOXL2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012454.1, covering FOXL2 transcript NM_023067.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
           .         .         .         .         .                g.5058
   atcagaacagagcgaggctcctggcgcactagggactccaggaggcagctccgccaga       c.-361

 .         .         .         .         .         .                g.5118
 gacgcgggtcgtgcttcgggaaaccggggggcggggggaggggaagagcgcagaaaagaa       c.-301

 .         .         .         .         .         .                g.5178
 aacccaccaaggcggggactggcctgagcggggaggggcggcgaggccggagcccctctc       c.-241

 .         .         .         .         .         .                g.5238
 tgttgggcggactccccatggccagaggctgagctccactcccgccggccgctccctagg       c.-181

 .         .         .         .         .         .                g.5298
 ggaaggggaaggagaggggagagcagcgacaggcctccagcaagcaagcgcgggcggcat       c.-121

 .         .         .         .         .         .                g.5358
 ccgcagtctccagaagtttgagacttggccgtaagcggactcgtgcgccccaactctttg       c.-61

 .         .         .         .         .         .                g.5418
 ccgcgccagcgcctggagcggagagcagaggcggcccggccgcggcgcgccggctttgtc       c.-1

          .         .         .         .         .         .       g.5478
 ATGATGGCCAGCTACCCCGAGCCCGAGGACGCGGCGGGGGCCCTGCTGGCCCCAGAGACC       c.60
 M  M  A  S  Y  P  E  P  E  D  A  A  G  A  L  L  A  P  E  T         p.20

          .         .         .         .         .         .       g.5538
 GGTCGCACAGTCAAGGAGCCAGAAGGGCCGCCGCCGAGCCCAGGCAAGGGCGGTGGGGGT       c.120
 G  R  T  V  K  E  P  E  G  P  P  P  S  P  G  K  G  G  G  G         p.40

          .         .         .         .         .         .       g.5598
 GGCGGCGGGACAGCCCCGGAGAAGCCGGACCCGGCGCAGAAGCCCCCGTACTCGTACGTG       c.180
 G  G  G  T  A  P  E  K  P  D  P  A  Q  K  P  P  Y  S  Y  V         p.60

          .         .         .         .         .         .       g.5658
 GCGCTCATCGCCATGGCGATCCGCGAGAGCGCGGAGAAGAGGCTCACGCTGTCCGGCATC       c.240
 A  L  I  A  M  A  I  R  E  S  A  E  K  R  L  T  L  S  G  I         p.80

          .         .         .         .         .         .       g.5718
 TACCAGTACATCATCGCGAAGTTCCCGTTCTACGAGAAGAATAAGAAGGGCTGGCAAAAT       c.300
 Y  Q  Y  I  I  A  K  F  P  F  Y  E  K  N  K  K  G  W  Q  N         p.100

          .         .         .         .         .         .       g.5778
 AGCATCCGCCACAACCTCAGCCTCAACGAGTGCTTCATCAAGGTGCCGCGCGAGGGCGGC       c.360
 S  I  R  H  N  L  S  L  N  E  C  F  I  K  V  P  R  E  G  G         p.120

          .         .         .         .         .         .       g.5838
 GGCGAGCGCAAGGGCAACTACTGGACGCTGGACCCGGCCTGCGAAGACATGTTCGAGAAG       c.420
 G  E  R  K  G  N  Y  W  T  L  D  P  A  C  E  D  M  F  E  K         p.140

          .         .         .         .         .         .       g.5898
 GGCAACTACCGGCGCCGCCGCCGCATGAAGAGGCCCTTCCGGCCGCCGCCCGCGCACTTC       c.480
 G  N  Y  R  R  R  R  R  M  K  R  P  F  R  P  P  P  A  H  F         p.160

          .         .         .         .         .         .       g.5958
 CAGCCCGGCAAGGGGCTCTTCGGGGCCGGAGGCGCCGCAGGCGGGTGCGGCGTGGCGGGC       c.540
 Q  P  G  K  G  L  F  G  A  G  G  A  A  G  G  C  G  V  A  G         p.180

          .         .         .         .         .         .       g.6018
 GCCGGGGCCGACGGCTACGGCTACCTGGCGCCCCCCAAGTACCTGCAGTCTGGCTTCCTC       c.600
 A  G  A  D  G  Y  G  Y  L  A  P  P  K  Y  L  Q  S  G  F  L         p.200

          .         .         .         .         .         .       g.6078
 AACAACTCGTGGCCGCTACCGCAGCCTCCCTCACCCATGCCCTATGCCTCCTGCCAGATG       c.660
 N  N  S  W  P  L  P  Q  P  P  S  P  M  P  Y  A  S  C  Q  M         p.220

          .         .         .         .         .         .       g.6138
 GCGGCAGCCGCAGCGGCTGCAGCAGCTGCGGCTGCAGCCGCGGGCCCCGGTAGCCCTGGC       c.720
 A  A  A  A  A  A  A  A  A  A  A  A  A  A  G  P  G  S  P  G         p.240

          .         .         .         .         .         .       g.6198
 GCGGCCGCTGTGGTCAAGGGGCTGGCGGGCCCGGCCGCCTCGTACGGGCCGTACACACGC       c.780
 A  A  A  V  V  K  G  L  A  G  P  A  A  S  Y  G  P  Y  T  R         p.260

          .         .         .         .         .         .       g.6258
 GTGCAGAGCATGGCGCTGCCCCCCGGCGTAGTGAACTCGTACAATGGCCTGGGAGGCCCG       c.840
 V  Q  S  M  A  L  P  P  G  V  V  N  S  Y  N  G  L  G  G  P         p.280

          .         .         .         .         .         .       g.6318
 CCGGCCGCACCCCCGCCTCCGCCGCACCCCCACCCGCATCCGCACGCACACCATCTGCAC       c.900
 P  A  A  P  P  P  P  P  H  P  H  P  H  P  H  A  H  H  L  H         p.300

          .         .         .         .         .         .       g.6378
 GCGGCCGCCGCACCGCCGCCTGCCCCACCGCACCACGGGGCCGCCGCGCCGCCGCCGGGC       c.960
 A  A  A  A  P  P  P  A  P  P  H  H  G  A  A  A  P  P  P  G         p.320

          .         .         .         .         .         .       g.6438
 CAGCTCAGCCCTGCCAGCCCAGCCACCGCCGCGCCCCCGGCGCCCGCGCCCACCAGTGCG       c.1020
 Q  L  S  P  A  S  P  A  T  A  A  P  P  A  P  A  P  T  S  A         p.340

          .         .         .         .         .         .       g.6498
 CCGGGCCTGCAGTTCGCTTGTGCCCGGCAGCCCGAGCTCGCCATGATGCATTGCTCTTAC       c.1080
 P  G  L  Q  F  A  C  A  R  Q  P  E  L  A  M  M  H  C  S  Y         p.360

          .         .         .         .         .                 g.6549
 TGGGACCACGACAGCAAGACCGGCGCGCTGCATTCGCGCCTCGATCTCTGA                c.1131
 W  D  H  D  S  K  T  G  A  L  H  S  R  L  D  L  X                  p.376

          .         .         .         .         .         .       g.6609
 gagcccaccgcatgccggtgcagacggatgcgaggatgcagggacgcgcgacgccggccc       c.*60

          .         .         .         .         .         .       g.6669
 cggtcgcagccgacgacgccgccgccagcctgacctcacaccctctgggcccgcctctgg       c.*120

          .         .         .         .         .         .       g.6729
 agccagcgcccagggtccctctgtgctttttcgctttcctaagctcctgtcgctcctctt       c.*180

          .         .         .         .         .         .       g.6789
 tgtcccctcagtttatgtcctcctgtgctcacctccctgacctctgtgaccttgcactcc       c.*240

          .         .         .         .         .         .       g.6849
 cctggcctgaagctgcctctctgcgcgctttctactgggctcgtctctttccggagcccc       c.*300

          .         .         .         .         .         .       g.6909
 agcgtctcctgcccaaattcaccgcggaaagggcccggggcggaggtgcgaccgggcgtc       c.*360

          .         .         .         .         .         .       g.6969
 ggcagcgcagacctcttggccttctctcacaggtcggtgcgctcgctctccgcgttcccc       c.*420

          .         .         .         .         .         .       g.7029
 gcccgactgccgtgcagtccatggctagacgcgccggacaggactgatggcgggaccgcg       c.*480

          .         .         .         .         .         .       g.7089
 ctgcccgagaaagggacggaccaatacgtgtgtttgctccgcgaaccctcttgaagctgt       c.*540

          .         .         .         .         .         .       g.7149
 tcagaagccgcttgccgcggggcccactaggcggggcgggggttgggacccagcgggagc       c.*600

          .         .         .         .         .         .       g.7209
 cggggcagcctggctccacggcctgtactcggtttacaccgcgggcgggcgcggagggag       c.*660

          .         .         .         .         .         .       g.7269
 gctgcgtttcctccgctatcagtcccgtcgcttcgggcacctccgggccccggcggctgg       c.*720

          .         .         .         .         .         .       g.7329
 ctaatgttttgtttgaaagatcggtggaactttttaagagagtatttaaaaaaaaaaaaa       c.*780

          .         .         .         .         .         .       g.7389
 ggaaaaaaaattcaccgggcaaccggggaagtattgtggccttggagtttgctaaatcca       c.*840

          .         .         .         .         .         .       g.7449
 aatatgaaaatcaaaagctttagtattcctcatcttctcttctggaagatttgcgttaga       c.*900

          .         .         .         .         .         .       g.7509
 gtttttgttgggccttcaaaaagctgtgttcagagttaggagaatatatccaataaaaga       c.*960

          .         .         .         .         .         .       g.7569
 tggtttcgtctaccaattggggaagtttcaccctctccctatctgaagaaaaaaatcaaa       c.*1020

          .         .         .         .         .         .       g.7629
 aacaaatgtccccggatctttcgatgcaagtcctggaggcagggagatcactgcctgcct       c.*1080

          .         .         .         .         .         .       g.7689
 ggcccacgctgctgggacggctcgtcctccctgctttttgtttttcaaacctcctgcttc       c.*1140

          .         .         .         .         .         .       g.7749
 tcccaccttgggaaggagaaatgtgaaacccggcagcggccgacctaggcggtcttgtgg       c.*1200

          .         .         .         .         .         .       g.7809
 cccggagccggcccggcccgaaaaccatagacctggttgtactgtagcttgttgtttggg       c.*1260

          .         .         .         .         .         .       g.7869
 ggaccaaattttctagagagaactagagcacttttgttgtgtttttttgttttgtttttg       c.*1320

          .         .         .         .                           g.7917
 ttttttgccttgtcgattcccgaataaattttgtgttccttcttttaa                   c.*1368

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Forkhead box L2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.