fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 (FRA10AC1) - coding DNA reference sequence

(used for variant description)

(last modified December 18, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_145246.4 in the FRA10AC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering FRA10AC1 transcript NM_145246.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           acccgtagggagaggcgg       c.-181

 .         .         .         .         .         .                g.5078
 gttgcgggcggcggcggcggcggcggcggcggtggtggttgtggcgaggctgtgcggcag       c.-121

 .         .         .         .         .         .                g.5138
 ggcgcacgggacctgtgctgcagcggctctctcaggccgtgggtcgtcgctgcagctgcc       c.-61

 .         .         .         .         .         .                g.5198
 gggaaagaaggaaacgacgactccgggggcgaacttggcacacagggaggaagggaaagg       c.-1

  | 02       .         .         .         .         .         .    g.7526
  | ATGCATGGTCATGGAGGCTATGATTCTGATTTTAGTGATGATGAACGCTGTGGAGAATCC    c.60
  | M  H  G  H  G  G  Y  D  S  D  F  S  D  D  E  R  C  G  E  S      p.20

          .        | 03.         .         .         .         .    g.9219
 AGCAAAAGGAAAAAAAG | GACAGTTGAAGATGACTTACTGCTCCAAAAACCATTTCAGAAA    c.120
 S  K  R  K  K  R  |  T  V  E  D  D  L  L  L  Q  K  P  F  Q  K      p.40

          .         .         .         .         .    | 04    .    g.9398
 GAAAAACATGGAAAGGTGGCCCATAAACAAGTTGCAGCAGAATTGCTGGATAG | GGAAGAA    c.180
 E  K  H  G  K  V  A  H  K  Q  V  A  A  E  L  L  D  R  |  E  E      p.60

          .         .         .          | 05        .         .    g.12656
 GCAAGAAATAGAAGGTTTCATCTCATAGCTATGGATGCT | TATCAAAGACATACAAAGTTC    c.240
 A  R  N  R  R  F  H  L  I  A  M  D  A   | Y  Q  R  H  T  K  F      p.80

          .         .         .         .         .       | 06 .    g.14847
 GTAAATGACTATATTTTATACTATGGTGGCAAAAAAGAAGACTTCAAGCGTTTGGG | GGAA    c.300
 V  N  D  Y  I  L  Y  Y  G  G  K  K  E  D  F  K  R  L  G  |  E      p.100

          .         .         .         .         .         .       g.14907
 AATGACAAGACAGACTTGGATGTTATACGAGAAAATCATAGATTCCTATGGAATGAGGAG       c.360
 N  D  K  T  D  L  D  V  I  R  E  N  H  R  F  L  W  N  E  E         p.120

          .         . | 07       .         .         .         .    g.15519
 GACGAAATGGACATGACTTG | GGAGAAGAGACTTGCTAAGAAATACTATGATAAATTATTT    c.420
 D  E  M  D  M  T  W  |  E  K  R  L  A  K  K  Y  Y  D  K  L  F      p.140

          .         .         .         .      | 08  .         .    g.20138
 AAGGAATACTGCATAGCAGATCTCAGTAAATATAAAGAAAATAAG | TTTGGATTTAGGTGG    c.480
 K  E  Y  C  I  A  D  L  S  K  Y  K  E  N  K   | F  G  F  R  W      p.160

          .         .         .  | 09      .         .         .    g.22242
 CGAGTAGAAAAAGAAGTAATTTCAGGAAAAG | GTCAATTTTTCTGTGGAAATAAATATTGT    c.540
 R  V  E  K  E  V  I  S  G  K  G |   Q  F  F  C  G  N  K  Y  C      p.180

          .         .         .         .         .         .       g.22302
 GATAAAAAAGAAGGCTTAAAGAGTTGGGAAGTTAATTTTGGTTATATTGAGCATGGTGAG       c.600
 D  K  K  E  G  L  K  S  W  E  V  N  F  G  Y  I  E  H  G  E         p.200

          .         .      | 10  .         .         .         .    g.23509
 AAGAGAAATGCACTTGTTAAATTAA | GGTTATGCCAAGAATGTTCCATTAAATTAAATTTC    c.660
 K  R  N  A  L  V  K  L  R |   L  C  Q  E  C  S  I  K  L  N  F      p.220

          | 11         .         .         .         .         .    g.26026
 CATCACAG | GAGAAAAGAAATCAAGTCAAAAAAAAGAAAAGATAAAACCAAAAAAGACTGT    c.720
 H  H  R  |  R  K  E  I  K  S  K  K  R  K  D  K  T  K  K  D  C      p.240

          .         .         .         .         .         .       g.26086
 GAAGAGTCATCACATAAAAAATCCAGATTATCTTCTGCAGAAGAGGCCTCCAAGAAAAAA       c.780
 E  E  S  S  H  K  K  S  R  L  S  S  A  E  E  A  S  K  K  K         p.260

         | 12.         .         .         .       | 13 .         . g.36738
 GATAAAG | GACATTCATCTTCAAAGAAATCTGAAGATTCTCTACTTA | GAAACTCTGATGAG c.840
 D  K  G |   H  S  S  S  K  K  S  E  D  S  L  L  R |   N  S  D  E   p.280

          .         .         .         .         .         .       g.36798
 GAAGAAAGTGCTTCAGAATCTGAACTTTGGAAGGGTCCACTACCAGAGACAGATGAAAAA       c.900
 E  E  S  A  S  E  S  E  L  W  K  G  P  L  P  E  T  D  E  K         p.300

       | 14  .         .         .         .                        g.37759
 TCACA | GGAAGAAGAATTTGATGAGTATTTTCAGGATTTGTTTCTATGA                c.948
 S  Q  |  E  E  E  F  D  E  Y  F  Q  D  L  F  L  X                  p.315

          .         .         .         .         .         .       g.37819
 gacgagagagagaagcctccgctccttaatgtgaaacttcatgaagttttaaacttcatg       c.*60

          .         .         .         .         .         .       g.37879
 caatttgaaattccatataagtttttatctgcaagttacagcttgtgtggtttgtctttg       c.*120

          .         .         .         .         .         .       g.37939
 gaaataaaaatccaggttctctcagaatgtcagaggctttggaagttcattagttcaatt       c.*180

          .         .         .         .         .         .       g.37999
 aaagactttcctgtcctttaaatatcttttcaattgcttatctacaattctgttttattt       c.*240

          .         .         .         .         .         .       g.38059
 gtagctcctagaggatagagctggacagattccattgttcctacattttgtaggtttttt       c.*300

          .         .         .         .         .         .       g.38119
 ttcactgccttcattatgtatcttctcttgccttcattattttattttattatttcttct       c.*360

          .         .         .         .         .         .       g.38179
 ttttctcttttttagagccaccaatactggatttgtttgtttttcatttttttcttttgt       c.*420

          .         .         .         .         .         .       g.38239
 ggaaacggagtcctcctgtgttgcccaggctggtattcaaactcctggccttatgcattc       c.*480

          .         .         .         .         .         .       g.38299
 ctcccaccctggcctcccagagtgctgggattacaggtgtgagccaccatgctctgccaa       c.*540

          .         .         .         .         .         .       g.38359
 ttattttaaattactaggattaaagtatattatgtatgtctttaacttctttctttccca       c.*600

          .         .         .         .         .         .       g.38419
 ttgataaactggcacccttcttttaagtacctgctctcccattaccacctatttccagct       c.*660

          .         .         .         .         .         .       g.38479
 gctttttgaggttttttgcttgcctgtctcttgcttccttcttaacctctaccacttaag       c.*720

          .         .         .         .         .         .       g.38539
 agagtttgttataatcaaatttgacttcctagcctgtggataatttactattaagtaaat       c.*780

          .         .         .         .         .         .       g.38599
 tattaccacagggagccagtgaggtcccagtagtctaaaacagttcatgtgttcacaaaa       c.*840

          .         .         .         .         .         .       g.38659
 attgcctccccggcagagattatgcagtaagataatttaactgaataatactatgtgcat       c.*900

          .         .         .         .         .         .       g.38719
 gtatcttgcctcagatatactcatgcaaatatgaatatacctctgatatggtttggctct       c.*960

          .         .         .         .         .         .       g.38779
 gtgtccccacccaaatctcatcttgaatgtgtactcccataattcccacattttatagga       c.*1020

          .         .         .         .         .         .       g.38839
 gggatccagtgagagataatttgaatcaagggggcggtttcccccatattgttcttgtgg       c.*1080

          .         .         .         .         .         .       g.38899
 tagtgaataagtctcacaagatctgatggttttatcaggggcttctgcttttgcatcctt       c.*1140

          .         .         .         .         .         .       g.38959
 ctcattttcttttgctgctgccatgtaagaagtgccttttgcctcccaccatgattctga       c.*1200

          .         .         .         .         .         .       g.39019
 ggctttcccagccatgtggaactgtaagtccaattaaacctctttttcttccccagtctc       c.*1260

          .         .         .         .         .         .       g.39079
 tggtatgtctttatcagcagtgtgaaaatggactaatagaacttctatgcagaaatataa       c.*1320

          .         .         .         .         .         .       g.39139
 aatgtaacttcttaacataaggtcctagtcgcaagggtctatggaggtgcttcaggagat       c.*1380

          .         .         .         .         .         .       g.39199
 ccaagcctttttagaatctgtgcaaacttctgtgtatgttttttggaggaaaagtccata       c.*1440

          .         .         .         .         .         .       g.39259
 aatttcaaattttcaaaaatcagattttcaaaaggatttattgatttctgaaaactagca       c.*1500

          .         .         .         .         .         .       g.39319
 aagatctgcttttataaagagcaaatagatggatagatataggagaagatgcttgacttg       c.*1560

          .         .         .         .         .         .       g.39379
 atgaataagagaaaggacatatagaaaatgaactgaacataagcaagtattttattgaag       c.*1620

          .         .         .         .         .         .       g.39439
 atatactattttaaataacatttaaacacggaatgattggcaataaactgcaaaatgagt       c.*1680

          .         .         .         .         .         .       g.39499
 aatttggtatcattttaaaatggttattatcagagattttccttttattaaacagttatt       c.*1740

          .         .         .         .         .         .       g.39559
 cattaattccacaaatatttatcaggcttctattatatgtgaggcactgagctgggcatg       c.*1800

          .         .         .         .         .         .       g.39619
 gctgtaaaggaaccatctaggaagtaattatgcaatcatttctgaacctgtttcagaaaa       c.*1860

          .         .         .         .         .         .       g.39679
 gtaaatcagtgttgggtttatcagtgtttaacattgtttgatagtcccctcacttcttga       c.*1920

          .         .                                               g.39702
 ataaattgttttttttcacctca                                            c.*1943

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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