FERM domain containing 5 (FRMD5) - coding DNA reference sequence

(used for variant description)

(last modified October 13, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_032892.3 in the FRMD5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering FRMD5 transcript NM_032892.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    ggctgagggaaggaggaggataaggaggaggaacgaggccagcaggaggcaacggca       c.-121

 .         .         .         .         .         .                g.5117
 gcgacggggccggggtgatggtgcaggtgcctggggtcggtgcggagctgccgggctgag       c.-61

 .         .         .         .         .         .                g.5177
 ggacgcctggtccagggtccgcagcgccgccgcgtcgctcccgggcgggcgggcgggaag       c.-1

          .         .         .         .         .         .       g.5237
 ATGCTGAGCAGGTTGATGAGCGGCAGCAGCAGGAGCCTGGAGCGCGAGTACAGCTGCACC       c.60
 M  L  S  R  L  M  S  G  S  S  R  S  L  E  R  E  Y  S  C  T         p.20

          .         .         .         .   | 02     .         .    g.275940
 GTGCGGCTGCTGGACGACAGCGAGTACACCTGCACCATCCAG | AGAGATGCCAAAGGCCAG    c.120
 V  R  L  L  D  D  S  E  Y  T  C  T  I  Q   | R  D  A  K  G  Q      p.40

          .         .         .         .         .         .       g.276000
 TACCTGTTTGACCTTCTTTGCCACCATCTGAACCTACTTGAGAAAGACTATTTTGGTATC       c.180
 Y  L  F  D  L  L  C  H  H  L  N  L  L  E  K  D  Y  F  G  I         p.60

          .         .        | 03.         .         .         .    g.280455
 CGCTTTGTAGACCCAGATAAGCAGCGG | CATTGGCTGGAATTTACAAAGTCTGTGGTGAAA    c.240
 R  F  V  D  P  D  K  Q  R   | H  W  L  E  F  T  K  S  V  V  K      p.80

          . | 04       .         .         .         .         .    g.280744
 CAATTGAGAT | CCCAGCCTCCATTCACCATGTGCTTCCGTGTGAAGTTTTATCCTGCAGAC    c.300
 Q  L  R  S |   Q  P  P  F  T  M  C  F  R  V  K  F  Y  P  A  D      p.100

          .         .          | 05        .         .         .    g.290283
 CCTGCTGCTCTGAAAGAAGAAATAACCAG | GTATTTAGTCTTCCTGCAGATCAAAAGGGAT    c.360
 P  A  A  L  K  E  E  I  T  R  |  Y  L  V  F  L  Q  I  K  R  D      p.120

          .         .         .         .         .         .       g.290343
 CTCTACCATGGCCGACTCCTCTGTAAAACATCGGATGCTGCCTTGTTAGCAGCTTACATC       c.420
 L  Y  H  G  R  L  L  C  K  T  S  D  A  A  L  L  A  A  Y  I         p.140

         | 06.         .         .         .         .         .    g.294333
 CTTCAAG | CGGAGATTGGGGATTATGACTCAGGGAAACACCCTGAAGGCTACAGCTCCAAG    c.480
 L  Q  A |   E  I  G  D  Y  D  S  G  K  H  P  E  G  Y  S  S  K      p.160

          .         .         .         .         .         .       g.294393
 TTCCAGTTTTTCCCTAAACATTCAGAGAAGCTGGAAAGGAAAATTGCTGAGATTCACAAG       c.540
 F  Q  F  F  P  K  H  S  E  K  L  E  R  K  I  A  E  I  H  K         p.180

          .  | 07      .         .         .         .         .    g.298018
 ACGGAACTGAG | TGGTCAAACACCAGCAACATCAGAGCTGAACTTCTTAAGAAAAGCACAG    c.600
 T  E  L  S  |  G  Q  T  P  A  T  S  E  L  N  F  L  R  K  A  Q      p.200

          .         .         .          | 08        .         .    g.308183
 ACATTGGAAACATATGGAGTGGATCCTCACCCATGTAAG | GACGTGTCAGGAAATGCTGCA    c.660
 T  L  E  T  Y  G  V  D  P  H  P  C  K   | D  V  S  G  N  A  A      p.220

          .         .         .         .         .         .       g.308243
 TTTCTGGCCTTCACTCCTTTTGGGTTTGTTGTTCTTCAAGGAAACAAGAGGGTCCACTTC       c.720
 F  L  A  F  T  P  F  G  F  V  V  L  Q  G  N  K  R  V  H  F         p.240

          | 09         .         .         .         .         .    g.311411
 ATTAAATG | GAATGAGGTGACCAAGCTGAAATTTGAAGGAAAGACTTTCTATTTATACGTA    c.780
 I  K  W  |  N  E  V  T  K  L  K  F  E  G  K  T  F  Y  L  Y  V      p.260

          .   | 10     .         .         .         .         .    g.312013
 AGTCAGAAAGAG | GAAAAGAAAATTATTCTTACATATTTTGCTCCAACTCCTGAAGCGTGT    c.840
 S  Q  K  E   | E  K  K  I  I  L  T  Y  F  A  P  T  P  E  A  C      p.280

          .         .         .         .     | 11   .         .    g.314492
 AAGCACCTCTGGAAATGTGGAATCGAGAACCAAGCCTTCTACAA | GCTGGAGAAGTCAAGC    c.900
 K  H  L  W  K  C  G  I  E  N  Q  A  F  Y  K  |  L  E  K  S  S      p.300

          .         .         .         .         .          | 12    g.315437
 CAAGTCCGCACAGTGTCCAGCAGCAATTTATTCTTTAAAGGGAGCCGGTTCCGATACAG | T    c.960
 Q  V  R  T  V  S  S  S  N  L  F  F  K  G  S  R  F  R  Y  S  |      p.320

          .         .         .         .         .         .       g.315497
 GGCCGAGTTGCAAAGGAAGTCATGGAATCAAGTGCTAAGATCAAACGGGAGCCACCGGAA       c.1020
 G  R  V  A  K  E  V  M  E  S  S  A  K  I  K  R  E  P  P  E         p.340

          | 13         .         .         .         .         .    g.316474
 ATACACAG | AGCAGGGATGGTTCCCAGCCGGAGCTGTCCCTCCATAACCCATGGCCCAAGG    c.1080
 I  H  R  |  A  G  M  V  P  S  R  S  C  P  S  I  T  H  G  P  R      p.360

          .         .         .         .         .      | 14  .    g.325774
 CTGAGCAGCGTCCCCAGGACCCGCAGAAGAGCTGTTCACATCTCCATCATGGAAG | GCCTA    c.1140
 L  S  S  V  P  R  T  R  R  R  A  V  H  I  S  I  M  E  G |   L      p.380

          .         .         .         .         .         .       g.325834
 GAGTCCTTACGGGACAGTGCCCATTCCACACCAGTGCGTTCCACTTCCCATGGGGACACC       c.1200
 E  S  L  R  D  S  A  H  S  T  P  V  R  S  T  S  H  G  D  T         p.400

          .         .         .         .         .         .       g.325894
 TTCCTGCCTCACGTGAGAAGCAGCCGGACAGATAGCAATGAGCGAGTAGCTGTGATTGCA       c.1260
 F  L  P  H  V  R  S  S  R  T  D  S  N  E  R  V  A  V  I  A         p.420

          .         .         .         .         .         .       g.325954
 GACGAGGCCTACAGCCCTGCAGACAGCGTGCTGCCCACCCCTGTGGCTGAGCACAGCCTG       c.1320
 D  E  A  Y  S  P  A  D  S  V  L  P  T  P  V  A  E  H  S  L         p.440

          .         .         .         .         .         .       g.326014
 GAGCTGATGTTGCTTTCCCGGCAGATCAATGGAGCCACCTGCAGCATTGAGGAGGAGAAG       c.1380
 E  L  M  L  L  S  R  Q  I  N  G  A  T  C  S  I  E  E  E  K         p.460

          .         .         .         .         .         .       g.326074
 GAATCTGAAGCCAGCACCCCAACTGCTACAGAGGTGGAGGCCCTTGGGGGAGAGCTGAGG       c.1440
 E  S  E  A  S  T  P  T  A  T  E  V  E  A  L  G  G  E  L  R         p.480

          .         .         .         .         .         .       g.326134
 GCCCTGTGTCAGGGGCACAGCGGGCCCGAGGAGGAACAGGTGAATAAGTTTGTTCTAAGT       c.1500
 A  L  C  Q  G  H  S  G  P  E  E  E  Q  V  N  K  F  V  L  S         p.500

          .         .         .         .         .         .       g.326194
 GTCCTCCGTTTGCTCCTTGTGACCATGGGACTCCTCTTTGTTTTGCTCCTCCTCCTGATC       c.1560
 V  L  R  L  L  L  V  T  M  G  L  L  F  V  L  L  L  L  L  I         p.520

          .         .         .         .         .         .       g.326254
 ATCCTTACCGAGTCTGACCTTGACATTGCCTTTTTCCGTGATATCCGCCAGACCCCCGAG       c.1620
 I  L  T  E  S  D  L  D  I  A  F  F  R  D  I  R  Q  T  P  E         p.540

          .         .         .         .         .         .       g.326314
 TTTGAACAATTCCACTATCAATACTTTTGTCCCCTCAGGCGATGGTTTGCCTGCAAAATC       c.1680
 F  E  Q  F  H  Y  Q  Y  F  C  P  L  R  R  W  F  A  C  K  I         p.560

          .         .         .                                     g.326347
 CGCTCAGTGGTGAGCCTGCTCATTGACACCTGA                                  c.1713
 R  S  V  V  S  L  L  I  D  T  X                                    p.570

          .         .         .         .         .         .       g.326407
 gaaggcatgactcctcccaaaaactagccaggtggaccaaggaacccggctacccattcc       c.*60

          .         .         .         .         .         .       g.326467
 cagcaatgggacccatcgcggaaccatcggcacatataccaagtcctcctctcatgactc       c.*120

          .         .         .         .         .         .       g.326527
 aaagtccactgcagcctaggagggtgtttcccagaagaagaaagggataggctcatgccc       c.*180

          .         .         .         .         .         .       g.326587
 tgtctaaacaaactgggaaaactcattttcttcagaagttatttcaagaaaggctcagcg       c.*240

          .         .         .         .         .         .       g.326647
 actctgtttctcatctttccaatttgcaggataatttttggttttgaattttgatttttc       c.*300

          .         .         .         .         .                 g.326700
 atagatgtatattattttgaagtatcaaataaaaataatttattttactatta              c.*353

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The FERM domain containing 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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