FERM domain containing 7 (FRMD7) - coding DNA reference sequence

(used for variant description)

(last modified November 24, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_194277.2 in the FRMD7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012347.1, covering FRMD7 transcript NM_194277.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   acaaatgcccttgggtgtgcattacttcaagcaaacggaagtgtgccccgctgacagt       c.-121

 .         .         .         .         .         .                g.5118
 gggaatgcctggctgggggtgggggggcccgagtgcaccacatccagctgggagtgaaat       c.-61

 .         .         .         .         .         .                g.5178
 tcctggagaaagcacccacagcactctgagcctgcttgcagcccaacggcctcgctgaga       c.-1

          .         .         .         .         .        | 02.    g.32309
 ATGCTACATTTAAAAGTGCAGTTTTTGGATGATTCCCAGAAGATTTTTGTGGTTGAT | CAA    c.60
 M  L  H  L  K  V  Q  F  L  D  D  S  Q  K  I  F  V  V  D   | Q      p.20

          .         .         .         .         .         .       g.32369
 AAGTCATCCGGGAAGGCATTGTTTAACCTGAGTTGCAGCCATCTAAATCTTGCTGAAAAG       c.120
 K  S  S  G  K  A  L  F  N  L  S  C  S  H  L  N  L  A  E  K         p.40

          .         .         .         .   | 03     .         .    g.33530
 GAATATTTTGGATTAGAATTCTGCAGCCATTCTGGAAATAAT | GTTTGGCTGGAGCTTTTG    c.180
 E  Y  F  G  L  E  F  C  S  H  S  G  N  N   | V  W  L  E  L  L      p.60

          .         .      | 04  .         .         .         .    g.35713
 AAGCCCATAACAAAGCAGGTAAAAA | ATCCTAAGGAGATTGTTTTCAAATTTATGGTGAAA    c.240
 K  P  I  T  K  Q  V  K  N |   P  K  E  I  V  F  K  F  M  V  K      p.80

          .         .         .         .     | 05   .         .    g.38899
 TTTTTCCCAGTGGACCCTGGACATCTGCGGGAAGAACTTACAAG | GTATCTTTTTACTCTT    c.300
 F  F  P  V  D  P  G  H  L  R  E  E  L  T  R  |  Y  L  F  T  L      p.100

          .         .         .         .         .         .       g.38959
 CAAATAAAGAAGGATTTGGCTCTAGGAAGGCTTCCATGCAGTGACAACTGTACAGCGTTG       c.360
 Q  I  K  K  D  L  A  L  G  R  L  P  C  S  D  N  C  T  A  L         p.120

          .         .   | 06     .         .         .         .    g.47026
 ATGGTATCTCACATCTTACAAT | CAGAACTTGGAGACTTTCATGAAGAAACAGATAGGAAG    c.420
 M  V  S  H  I  L  Q  S |   E  L  G  D  F  H  E  E  T  D  R  K      p.140

          .         .         .         .         .         .       g.47086
 CATCTGGCACAAACTCGGTACTTACCAAACCAAGACTGTTTAGAGGGCAAGATCATGCAC       c.480
 H  L  A  Q  T  R  Y  L  P  N  Q  D  C  L  E  G  K  I  M  H         p.160

          .        | 07.         .         .         .         .    g.47337
 TTTCATCAGAAGCACAT | TGGCAGGAGCCCAGCTGAATCTGACATTCTGCTACTGGACATA    c.540
 F  H  Q  K  H  I  |  G  R  S  P  A  E  S  D  I  L  L  L  D  I      p.180

          .         .         .         .         .         .       g.47397
 GCAAGGAAGCTGGATATGTATGGCATCAGGCCTCACCCCGCCAGTGATGGTGAAGGGATG       c.600
 A  R  K  L  D  M  Y  G  I  R  P  H  P  A  S  D  G  E  G  M         p.200

          .         .         .         .      | 08  .         .    g.48452
 CAGATTCACCTGGCTGTTGCTCACATGGGAGTACTGGTGTTACGG | GGAAATACAAAGATC    c.660
 Q  I  H  L  A  V  A  H  M  G  V  L  V  L  R   | G  N  T  K  I      p.220

          .         .         .         .         .         .       g.48512
 AATACTTTTAACTGGGCTAAAATCCGCAAGTTGAGTTTTAAGAGAAAGCATTTTCTCATC       c.720
 N  T  F  N  W  A  K  I  R  K  L  S  F  K  R  K  H  F  L  I         p.240

          .         .  | 09      .         .         .         .    g.50535
 AAACTTCATGCCAATATCTTG | GTGTTGTGCAAGGATACCTTGGAGTTCACCATGGCCAGC    c.780
 K  L  H  A  N  I  L   | V  L  C  K  D  T  L  E  F  T  M  A  S      p.260

          .         .         .         .         .         .       g.50595
 CGAGATGCCTGCAAGGCTTTCTGGAAGACTTGTGTGGAATACCATGCTTTCTTCAGGCTT       c.840
 R  D  A  C  K  A  F  W  K  T  C  V  E  Y  H  A  F  F  R  L         p.280

          .         .         .         .         .         .       g.50655
 TCGGAAGAGCCCAAATCAAAGCCCAAAACCCTACTCTGCAGCAAGGGTTCCAGTTTCCGC       c.900
 S  E  E  P  K  S  K  P  K  T  L  L  C  S  K  G  S  S  F  R         p.300

       | 10  .         .         .         .         .         .    g.52811
 TATAG | TGGACGAACCCAAAGGCAACTTTTGGAATATGGGAGAAAAGGGAGGCTGAAGAGC    c.960
 Y  S  |  G  R  T  Q  R  Q  L  L  E  Y  G  R  K  G  R  L  K  S      p.320

          .     | 11   .         .         .         .         .    g.52987
 TTGCCATTTGAAAG | GAAACATTACCCATCTCAGTACCATGAACGACAGTGCAGGTCCTCA    c.1020
 L  P  F  E  R  |  K  H  Y  P  S  Q  Y  H  E  R  Q  C  R  S  S      p.340

          .         .         . | 12       .         .         .    g.54086
 CCAGACCTCCTCTCTGATGTGTCAAAACAA | GTGGAAGATTTGAGACTAGCATATGGTGGT    c.1080
 P  D  L  L  S  D  V  S  K  Q   | V  E  D  L  R  L  A  Y  G  G      p.360

          .         .         .         .         .         .       g.54146
 GGCTACTACCAAAATGTGAATGGAGTGCACGCATCTGAGCCAGTGCTGGAGAGTAGGAGG       c.1140
 G  Y  Y  Q  N  V  N  G  V  H  A  S  E  P  V  L  E  S  R  R         p.380

          .         .         .         .         .         .       g.54206
 AGGAATTCTGCATTGGAGGTGACATTTGCAACTGAGCTGGAGCATTCCAAACCAGAGGCG       c.1200
 R  N  S  A  L  E  V  T  F  A  T  E  L  E  H  S  K  P  E  A         p.400

          .         .         .         .         .         .       g.54266
 GATCCCACATTGCTACATCAGTCCCAAAGCAGTTCCTCTTTCCCTTTTATTTATATGGAC       c.1260
 D  P  T  L  L  H  Q  S  Q  S  S  S  S  F  P  F  I  Y  M  D         p.420

          .         .         .         .         .         .       g.54326
 CCTGTCTTTAACACTGAGCCCAATCCTAACCCTGATCCCAGAGACATTTTTTCAGAGAGG       c.1320
 P  V  F  N  T  E  P  N  P  N  P  D  P  R  D  I  F  S  E  R         p.440

          .         .         .         .         .         .       g.54386
 AGTTCTCTAAGCTCCTTCCAAACAAGCTGTAAGTTTTCTGGTAATCACATGAGCATATAT       c.1380
 S  S  L  S  S  F  Q  T  S  C  K  F  S  G  N  H  M  S  I  Y         p.460

          .         .         .         .         .         .       g.54446
 TCTGGCCTCACAAGCAAAGTGCGTCCAGCAAAGCAGCTAACTTACACGGATGTGCCCTAT       c.1440
 S  G  L  T  S  K  V  R  P  A  K  Q  L  T  Y  T  D  V  P  Y         p.480

          .         .         .         .         .         .       g.54506
 ATTCCTTGTACAGGTCAGCAGGTTGGTATTATGCCTCCCCAGGTCTTTTTTTATGTGGAC       c.1500
 I  P  C  T  G  Q  Q  V  G  I  M  P  P  Q  V  F  F  Y  V  D         p.500

          .         .         .         .         .         .       g.54566
 AAGCCACCCCAGGTGCCCAGATGGTCCCCAATTAGAGCAGAGGAAAGGACAAGTCCACAT       c.1560
 K  P  P  Q  V  P  R  W  S  P  I  R  A  E  E  R  T  S  P  H         p.520

          .         .         .         .         .         .       g.54626
 AGCTATGTAGAGCCCACTGCAATGAAGCCAGCTGAAAGAAGCCCAAGGAATATCAGAATG       c.1620
 S  Y  V  E  P  T  A  M  K  P  A  E  R  S  P  R  N  I  R  M         p.540

          .         .         .         .         .         .       g.54686
 AAGAGCTTTCAGCAAGACCTGCAAGTACTCCAAGAAGCTATAGCCAGGACTAGCGGTAGG       c.1680
 K  S  F  Q  Q  D  L  Q  V  L  Q  E  A  I  A  R  T  S  G  R         p.560

          .         .         .         .         .         .       g.54746
 AGCAACATCAATGTAGGTCTAGAAGAGGAAGACCCAAATTTGGAAGATGCATTTGTATGT       c.1740
 S  N  I  N  V  G  L  E  E  E  D  P  N  L  E  D  A  F  V  C         p.580

          .         .         .         .         .         .       g.54806
 AACATTCAAGAGCAAACCCCTAAAAGGTCCCAGAGCCAATCAGACATGAAAACTATTCGT       c.1800
 N  I  Q  E  Q  T  P  K  R  S  Q  S  Q  S  D  M  K  T  I  R         p.600

          .         .         .         .         .         .       g.54866
 TTTCCTTTTGGGTCAGAATTTAGACCTTTAGGGCCTTGTCCTGCTCTCAGTCATAAAGCA       c.1860
 F  P  F  G  S  E  F  R  P  L  G  P  C  P  A  L  S  H  K  A         p.620

          .         .         .         .         .         .       g.54926
 GACCTGTTTACGGATATGTTTGCAGAGCAGGAGTTGCCAGCAGTTCTAATGGATCAAAGT       c.1920
 D  L  F  T  D  M  F  A  E  Q  E  L  P  A  V  L  M  D  Q  S         p.640

          .         .         .         .         .         .       g.54986
 ACAGCAGAAAGGTATGTAGCTAGTGAATCCAGTGATTCTGAATCAGAGATTCTTAAACCA       c.1980
 T  A  E  R  Y  V  A  S  E  S  S  D  S  E  S  E  I  L  K  P         p.660

          .         .         .         .         .         .       g.55046
 GACTACTATGCTTTGTATGGCAAAGAAATAAGGTCACCCATGGCCAGAATCCGCCTGTCT       c.2040
 D  Y  Y  A  L  Y  G  K  E  I  R  S  P  M  A  R  I  R  L  S         p.680

          .         .         .         .         .         .       g.55106
 TCTGGTAGTCTACAGTTAGATGAAGAAGATGAAGATGCTTATTTCAACACACCAACTGCT       c.2100
 S  G  S  L  Q  L  D  E  E  D  E  D  A  Y  F  N  T  P  T  A         p.700

          .         .         .         .                           g.55151
 GAAGACAGGACTTCACTAAAACCATGTAATTACTTTTTAGCTTAA                      c.2145
 E  D  R  T  S  L  K  P  C  N  Y  F  L  A  X                        p.714

          .         .         .         .         .         .       g.55211
 aagtgtgaacctatggacatttctgagccagttccatgttaccgacttaggcagaaaata       c.*60

          .         .         .         .         .         .       g.55271
 atgaagttgtagaaaccattttcttggttactacatattcattggtattaaggaaatctc       c.*120

          .         .         .         .         .         .       g.55331
 attttggatgcctgccttatgaaagatccagctgttgcctcattccttgagtttcactct       c.*180

          .         .         .         .         .         .       g.55391
 tccattacctctgaagggactttagaacatgccctctcctcaccagcactgtggcaaggc       c.*240

          .         .         .         .         .         .       g.55451
 aaggtgggtatttgtcatctccactgcatacttcctcatagagacattgtgagtgaaggt       c.*300

          .         .         .         .         .         .       g.55511
 caggctcttcaatgctgaagaatggtgacagtatgggttggcatatggaattagcgtcta       c.*360

          .         .         .         .         .         .       g.55571
 atggcatttagtgatttagtagattgtgactgtgttgatctttgtgctcttaaacaacac       c.*420

          .         .         .         .         .         .       g.55631
 tgaacaaatatttcagtctttactatttgtgtggggcccagtagaaatggtcttgtaata       c.*480

          .         .         .         .         .         .       g.55691
 tgctaaatacttccatttttataacatataaaagcagagcatggccctcctacagcctca       c.*540

          .         .         .         .         .         .       g.55751
 ggaaggaggtggtggcatagatcctctcaagagaatacaggtttagaattaatctaggac       c.*600

          .         .         .         .         .         .       g.55811
 ttggcagaattctaaacctaggaaattcatgaattaaatcaatttctagagccagacata       c.*660

          .         .         .         .         .         .       g.55871
 aaccagatgaaagtatcatgttgttttacttataacttctatattcttatctactatatc       c.*720

          .         .         .         .         .         .       g.55931
 tagtaaaagagaaacattatcaggtcagtttgtttatctaatatttcctgccagaattta       c.*780

          .         .         .         .         .         .       g.55991
 ttttttgtcatagcttcttgcatgtatgcaggccaggaaatgaatgttattgtaataaag       c.*840

          .         .         .                                     g.56030
 tgtgatggaaaatccaggtaattaaaaaataaattataa                            c.*879

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The FERM domain containing 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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