frizzled-related protein (FRZB) - coding DNA reference sequence

(used for variant description)

(last modified February 24, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001463.3 in the FRZB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_017197.1, covering FRZB transcript NM_001463.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       gttgggaaagagcagcctgggcggcaggggcggtggct       c.-181

 .         .         .         .         .         .                g.5098
 ggagctcggtaaagctcgtgggaccccattgggggaatttgatccaaggaagcggtgatt       c.-121

 .         .         .         .         .         .                g.5158
 gccgggggaggagaagctcccagatccttgtgtccacttgcagcgggggaggcggagacg       c.-61

 .         .         .         .         .         .                g.5218
 gcggagcgggccttttggcgtccactgcgcggctgcaccctgccccatcctgccgggatc       c.-1

          .         .         .         .         .         .       g.5278
 ATGGTCTGCGGCAGCCCGGGAGGGATGCTGCTGCTGCGGGCCGGGCTGCTTGCCCTGGCT       c.60
 M  V  C  G  S  P  G  G  M  L  L  L  R  A  G  L  L  A  L  A         p.20

          .         .         .         .         .         .       g.5338
 GCTCTCTGCCTGCTCCGGGTGCCCGGGGCTCGGGCTGCAGCCTGTGAGCCCGTCCGCATC       c.120
 A  L  C  L  L  R  V  P  G  A  R  A  A  A  C  E  P  V  R  I         p.40

          .         .         .         .         .         .       g.5398
 CCCCTGTGCAAGTCCCTGCCCTGGAACATGACTAAGATGCCCAACCACCTGCACCACAGC       c.180
 P  L  C  K  S  L  P  W  N  M  T  K  M  P  N  H  L  H  H  S         p.60

          .         .         .         .         .         .       g.5458
 ACTCAGGCCAACGCCATCCTGGCCATCGAGCAGTTCGAAGGTCTGCTGGGCACCCACTGC       c.240
 T  Q  A  N  A  I  L  A  I  E  Q  F  E  G  L  L  G  T  H  C         p.80

          .         .         .         .         .         .       g.5518
 AGCCCCGATCTGCTCTTCTTCCTCTGTGCCATGTACGCGCCCATCTGCACCATTGACTTC       c.300
 S  P  D  L  L  F  F  L  C  A  M  Y  A  P  I  C  T  I  D  F         p.100

          .         .         .         .         .         .       g.5578
 CAGCACGAGCCCATCAAGCCCTGTAAGTCTGTGTGCGAGCGGGCCCGGCAGGGCTGTGAG       c.360
 Q  H  E  P  I  K  P  C  K  S  V  C  E  R  A  R  Q  G  C  E         p.120

          .         .         .         .         .         .       g.5638
 CCCATACTCATCAAGTACCGCCACTCGTGGCCGGAGAACCTGGCCTGCGAGGAGCTGCCA       c.420
 P  I  L  I  K  Y  R  H  S  W  P  E  N  L  A  C  E  E  L  P         p.140

          .         .         .         .         .         | 02    g.12939
 GTGTACGACAGGGGCGTGTGCATCTCTCCCGAGGCCATCGTTACTGCGGACGGAGCTG | AT    c.480
 V  Y  D  R  G  V  C  I  S  P  E  A  I  V  T  A  D  G  A  D |       p.160

          .         .         .         .       | 03 .         .    g.29241
 TTTCCTATGGATTCTAGTAACGGAAACTGTAGAGGGGCAAGCAGTG | AACGCTGTAAATGT    c.540
 F  P  M  D  S  S  N  G  N  C  R  G  A  S  S  E |   R  C  K  C      p.180

          .         .         .         .         .   | 04     .    g.33165
 AAGCCTATTAGAGCTACACAGAAGACCTATTTCCGGAACAATTACAACTATG | TCATTCGG    c.600
 K  P  I  R  A  T  Q  K  T  Y  F  R  N  N  Y  N  Y  V |   I  R      p.200

          .         .         .         .         .         .       g.33225
 GCTAAAGTTAAAGAGATAAAGACTAAGTGCCATGATGTGACTGCAGTAGTGGAGGTGAAG       c.660
 A  K  V  K  E  I  K  T  K  C  H  D  V  T  A  V  V  E  V  K         p.220

          .         .         .         .         .         .       g.33285
 GAGATTCTAAAGTCCTCTCTGGTAAACATTCCACGGGACACTGTCAACCTCTATACCAGC       c.720
 E  I  L  K  S  S  L  V  N  I  P  R  D  T  V  N  L  Y  T  S         p.240

          .         .         .         .         .         .       g.33345
 TCTGGCTGCCTCTGCCCTCCACTTAATGTTAATGAGGAATATATCATCATGGGCTATGAA       c.780
 S  G  C  L  C  P  P  L  N  V  N  E  E  Y  I  I  M  G  Y  E         p.260

          .        | 05.         .         .         .         .    g.33802
 GATGAGGAACGTTCCAG | ATTACTCTTGGTGGAAGGCTCTATAGCTGAGAAGTGGAAGGAT    c.840
 D  E  E  R  S  R  |  L  L  L  V  E  G  S  I  A  E  K  W  K  D      p.280

          .         .  | 06      .         .         .         .    g.36845
 CGACTCGGTAAAAAAGTTAAG | CGCTGGGATATGAAGCTTCGTCATCTTGGACTCAGTAAA    c.900
 R  L  G  K  K  V  K   | R  W  D  M  K  L  R  H  L  G  L  S  K      p.300

          .         .         .         .         .         .       g.36905
 AGTGATTCTAGCAATAGTGATTCCACTCAGAGTCAGAAGTCTGGCAGGAACTCGAACCCC       c.960
 S  D  S  S  N  S  D  S  T  Q  S  Q  K  S  G  R  N  S  N  P         p.320

          .                                                         g.36923
 CGGCAAGCACGCAACTAA                                                 c.978
 R  Q  A  R  N  X                                                   p.325

          .         .         .         .         .         .       g.36983
 atcccgaaatacaaaaagtaacacagtggacttcctattaagacttacttgcattgctgg       c.*60

          .         .         .         .         .         .       g.37043
 actagcaaaggaaaattgcactattgcacatcatattctattgtttactataaaaatcat       c.*120

          .         .         .         .         .         .       g.37103
 gtgataactgattattacttctgtttctcttttggtttctgcttctctcttctctcaacc       c.*180

          .         .         .         .         .         .       g.37163
 cctttgtaatggtttgggggcagactcttaagtatattgtgagttttctatttcactaat       c.*240

          .         .         .         .         .         .       g.37223
 catgagaaaaactgttcttttgcaataataataaattaaacatgctgttaccagagcctc       c.*300

          .         .         .         .         .         .       g.37283
 tttgctggagtctccagatgttaatttactttctgcaccccaattgggaatgcaatattg       c.*360

          .         .         .         .         .         .       g.37343
 gatgaaaagagaggtttctggtattcacagaaagctagatatgccttaaaacatactctg       c.*420

          .         .         .         .         .         .       g.37403
 ccgatctaattacagccttatttttgtatgccttttgggcattctcctcatgcttagaaa       c.*480

          .         .         .         .         .         .       g.37463
 gttccaaatgtttataaaggtaaaatggcagtttgaagtcaaatgtcacataggcaaagc       c.*540

          .         .         .         .         .         .       g.37523
 aatcaagcaccaggaagtgtttatgaggaaacaacacccaagatgaattatttttgagac       c.*600

          .         .         .         .         .         .       g.37583
 tgtcaggaagtaaaataaataggagcttaagaaagaacattttgcctgattgagaagcac       c.*660

          .         .         .         .         .         .       g.37643
 aactgaaaccagtagccgctggggtgttaatggtagcattcttcttttggcaatacattt       c.*720

          .         .         .         .         .         .       g.37703
 gatttgttcatgaatatattaatcagcattagagaaatgaattataactagacatctgct       c.*780

          .         .         .         .         .         .       g.37763
 gttatcaccatagttttgtttaatttgcttccttttaaataaacccattggtgaaagtct       c.*840

          .         .         .         .         .         .       g.37823
 ttttttttctcttcttttaaaataaatcagaattgccgtattgaccaggaaaagattatg       c.*900

          .         .         .         .         .         .       g.37883
 tatgcacgtgcaccagggttagtttttaaaagtacatggctccataaaaatgctgtagat       c.*960

          .         .         .         .         .         .       g.37943
 tacagagtgataaaatatgcaggtttttttgtttttgttttttctgttgtgtgtgtgtct       c.*1020

          .         .         .         .         .         .       g.38003
 gtatttgtgtacatgtgtgtccttgcactcacacccaaggtggattaaaatacaggcctg       c.*1080

          .         .         .         .         .         .       g.38063
 caaactggcctgcactttatcatttggatttgtgctgcttaatgctcagcgaaaaatgtc       c.*1140

          .         .         .         .         .         .       g.38123
 tagtaaaatgaattatggttgtcaggagagaggttatttcgacttttgaaccaattgcac       c.*1200

          .         .         .         .         .         .       g.38183
 atttctcattacccaagctgtggtgagatcccaggggctgtggtgaacaaatgatgcttt       c.*1260

          .         .         .         .         .         .       g.38243
 tatagatggtccctagcttacaatgattcaatttacaatgcttcaatttaacaatttgtt       c.*1320

          .         .         .         .         .         .       g.38303
 gacttacaatgggtttatcaggatgtaacccaatgcatttcaacttacgatattttcagt       c.*1380

          .         .         .         .         .         .       g.38363
 ttcgaatgggtttatccagatgtaaccccatcgtaaatggcggagcatctgtacttcctt       c.*1440

          .         .         .         .         .         .       g.38423
 cctctggcagagttccttagagcctgtgccaattacttgaaagtttcattctctgccatt       c.*1500

          .         .         .         .         .         .       g.38483
 tacatgtgtgctattagtagaaccaaatttctaagctgtggcgtgctgaaaataaaatgc       c.*1560

          .                                                         g.38497
 ttatgaagcaaaaa                                                     c.*1574

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Frizzled-related protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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