follicle stimulating hormone receptor (FSHR) - coding DNA reference sequence

(used for variant description)

(last modified February 8, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_000145.3 in the FSHR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering FSHR transcript NM_000145.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           agttctcaagtcagatctcttctcataagggcactgtgtggagcttctga       c.-61

 .         .         .         .         .         .                g.5110
 gatctgtggaggtttttctctgcaaatgcaggaagaaatcaggtggatggatgcataatt       c.-1

          .         .         .         .         .         .       g.5170
 ATGGCCCTGCTCCTGGTCTCTTTGCTGGCATTCCTGAGCTTGGGCTCAGGATGTCATCAT       c.60
 M  A  L  L  L  V  S  L  L  A  F  L  S  L  G  S  G  C  H  H         p.20

          .         .         .         .         .         .       g.5230
 CGGATCTGTCACTGCTCTAACAGGGTTTTTCTCTGCCAAGAGAGCAAGGTGACAGAGATT       c.120
 R  I  C  H  C  S  N  R  V  F  L  C  Q  E  S  K  V  T  E  I         p.40

          .         .         .   | 02     .         .         .    g.91265
 CCTTCTGACCTCCCGAGGAATGCCATTGAACT | GAGGTTTGTCCTCACCAAGCTTCGAGTC    c.180
 P  S  D  L  P  R  N  A  I  E  L  |  R  F  V  L  T  K  L  R  V      p.60

          .         .         .         .     | 03   .         .    g.139383
 ATCCAAAAAGGTGCATTTTCAGGATTTGGGGACCTGGAGAAAAT | AGAGATCTCTCAGAAT    c.240
 I  Q  K  G  A  F  S  G  F  G  D  L  E  K  I  |  E  I  S  Q  N      p.80

          .         .         .         .         .          | 04    g.141965
 GATGTCTTGGAGGTGATAGAGGCAGATGTGTTCTCCAACCTTCCCAAATTACATGAAAT | T    c.300
 D  V  L  E  V  I  E  A  D  V  F  S  N  L  P  K  L  H  E  I  |      p.100

          .         .         .         .         .         .       g.142025
 AGAATTGAAAAGGCCAACAACCTGCTCTACATCAACCCTGAGGCCTTCCAGAACCTTCCC       c.360
 R  I  E  K  A  N  N  L  L  Y  I  N  P  E  A  F  Q  N  L  P         p.120

          .     | 05   .         .         .         .         .    g.168936
 AACCTTCAATATCT | GTTAATATCCAACACAGGTATTAAGCACCTTCCAGATGTTCACAAG    c.420
 N  L  Q  Y  L  |  L  I  S  N  T  G  I  K  H  L  P  D  V  H  K      p.140

          .         .       | 06 .         .         .         .    g.170507
 ATTCATTCTCTCCAAAAAGTTTTACT | TGACATTCAAGATAACATAAACATCCACACAATT    c.480
 I  H  S  L  Q  K  V  L  L  |  D  I  Q  D  N  I  N  I  H  T  I      p.160

          .         .         .         .     | 07   .         .    g.176377
 GAAAGAAATTCTTTCGTGGGGCTGAGCTTTGAAAGTGTGATTCT | ATGGCTGAATAAGAAT    c.540
 E  R  N  S  F  V  G  L  S  F  E  S  V  I  L  |  W  L  N  K  N      p.180

          .         .         .         .         .    | 08    .    g.176548
 GGGATTCAAGAAATACACAACTGTGCATTCAATGGAACCCAACTAGATGAGCT | GAATCTA    c.600
 G  I  Q  E  I  H  N  C  A  F  N  G  T  Q  L  D  E  L  |  N  L      p.200

          .         .         .         .         .         .       g.176608
 AGCGATAATAATAATTTAGAAGAATTGCCTAATGATGTTTTCCACGGAGCCTCTGGACCA       c.660
 S  D  N  N  N  L  E  E  L  P  N  D  V  F  H  G  A  S  G  P         p.220

          | 09         .         .         .         .         .    g.190696
 GTCATTCT | AGATATTTCAAGAACAAGGATCCATTCCCTGCCTAGCTATGGCTTAGAAAAT    c.720
 V  I  L  |  D  I  S  R  T  R  I  H  S  L  P  S  Y  G  L  E  N      p.240

          .         .         .         .         .         .       g.190756
 CTTAAGAAGCTGAGGGCCAGGTCGACTTACAACTTAAAAAAGCTGCCTACTCTGGAAAAG       c.780
 L  K  K  L  R  A  R  S  T  Y  N  L  K  K  L  P  T  L  E  K         p.260

          .         .         .         .         .         .       g.190816
 CTTGTCGCCCTCATGGAAGCCAGCCTCACCTATCCCAGCCATTGCTGTGCCTTTGCAAAC       c.840
 L  V  A  L  M  E  A  S  L  T  Y  P  S  H  C  C  A  F  A  N         p.280

          .     | 10   .         .         .         .         .    g.195607
 TGGAGACGGCAAAT | CTCTGAGCTTCATCCAATTTGCAACAAATCTATTTTAAGGCAAGAA    c.900
 W  R  R  Q  I  |  S  E  L  H  P  I  C  N  K  S  I  L  R  Q  E      p.300

          .         .         .         .         .         .       g.195667
 GTTGATTATATGACTCAGGCTAGGGGTCAGAGATCCTCTCTGGCAGAAGACAATGAGTCC       c.960
 V  D  Y  M  T  Q  A  R  G  Q  R  S  S  L  A  E  D  N  E  S         p.320

          .         .         .         .         .         .       g.195727
 AGCTACAGCAGAGGATTTGACATGACGTACACTGAGTTTGACTATGACTTATGCAATGAA       c.1020
 S  Y  S  R  G  F  D  M  T  Y  T  E  F  D  Y  D  L  C  N  E         p.340

          .         .         .         .         .         .       g.195787
 GTGGTTGACGTGACCTGCTCCCCTAAGCCAGATGCATTCAACCCATGTGAAGATATCATG       c.1080
 V  V  D  V  T  C  S  P  K  P  D  A  F  N  P  C  E  D  I  M         p.360

          .         .         .         .         .         .       g.195847
 GGGTACAACATCCTCAGAGTCCTGATATGGTTTATCAGCATCCTGGCCATCACTGGGAAC       c.1140
 G  Y  N  I  L  R  V  L  I  W  F  I  S  I  L  A  I  T  G  N         p.380

          .         .         .         .         .         .       g.195907
 ATCATAGTGCTAGTGATCCTAACTACCAGCCAATATAAACTCACAGTCCCCAGGTTCCTT       c.1200
 I  I  V  L  V  I  L  T  T  S  Q  Y  K  L  T  V  P  R  F  L         p.400

          .         .         .         .         .         .       g.195967
 ATGTGCAACCTGGCCTTTGCTGATCTCTGCATTGGAATCTACCTGCTGCTCATTGCATCA       c.1260
 M  C  N  L  A  F  A  D  L  C  I  G  I  Y  L  L  L  I  A  S         p.420

          .         .         .         .         .         .       g.196027
 GTTGATATCCATACCAAGAGCCAATATCACAACTATGCCATTGACTGGCAAACTGGGGCA       c.1320
 V  D  I  H  T  K  S  Q  Y  H  N  Y  A  I  D  W  Q  T  G  A         p.440

          .         .         .         .         .         .       g.196087
 GGCTGTGATGCTGCTGGCTTTTTCACTGTCTTTGCCAGTGAGCTGTCAGTCTACACTCTG       c.1380
 G  C  D  A  A  G  F  F  T  V  F  A  S  E  L  S  V  Y  T  L         p.460

          .         .         .         .         .         .       g.196147
 ACAGCTATCACCTTGGAAAGATGGCATACCATCACGCATGCCATGCAGCTGGACTGCAAG       c.1440
 T  A  I  T  L  E  R  W  H  T  I  T  H  A  M  Q  L  D  C  K         p.480

          .         .         .         .         .         .       g.196207
 GTGCAGCTCCGCCATGCTGCCAGTGTCATGGTGATGGGCTGGATTTTTGCTTTTGCAGCT       c.1500
 V  Q  L  R  H  A  A  S  V  M  V  M  G  W  I  F  A  F  A  A         p.500

          .         .         .         .         .         .       g.196267
 GCCCTCTTTCCCATCTTTGGCATCAGCAGCTACATGAAGGTGAGCATCTGCCTGCCCATG       c.1560
 A  L  F  P  I  F  G  I  S  S  Y  M  K  V  S  I  C  L  P  M         p.520

          .         .         .         .         .         .       g.196327
 GATATTGACAGCCCTTTGTCACAGCTGTATGTCATGTCCCTCCTTGTGCTCAATGTCCTG       c.1620
 D  I  D  S  P  L  S  Q  L  Y  V  M  S  L  L  V  L  N  V  L         p.540

          .         .         .         .         .         .       g.196387
 GCCTTTGTGGTCATCTGTGGCTGCTATATCCACATCTACCTCACAGTGCGGAACCCCAAC       c.1680
 A  F  V  V  I  C  G  C  Y  I  H  I  Y  L  T  V  R  N  P  N         p.560

          .         .         .         .         .         .       g.196447
 ATCGTGTCCTCCTCTAGTGACACCAGGATCGCCAAGCGCATGGCCATGCTCATCTTCACT       c.1740
 I  V  S  S  S  S  D  T  R  I  A  K  R  M  A  M  L  I  F  T         p.580

          .         .         .         .         .         .       g.196507
 GACTTCCTCTGCATGGCACCCATTTCTTTCTTTGCCATTTCTGCCTCCCTCAAGGTGCCC       c.1800
 D  F  L  C  M  A  P  I  S  F  F  A  I  S  A  S  L  K  V  P         p.600

          .         .         .         .         .         .       g.196567
 CTCATCACTGTGTCCAAAGCAAAGATTCTGCTGGTTCTGTTTCACCCCATCAACTCCTGT       c.1860
 L  I  T  V  S  K  A  K  I  L  L  V  L  F  H  P  I  N  S  C         p.620

          .         .         .         .         .         .       g.196627
 GCCAACCCCTTCCTCTATGCCATCTTTACCAAAAACTTTCGCAGAGATTTCTTCATTCTG       c.1920
 A  N  P  F  L  Y  A  I  F  T  K  N  F  R  R  D  F  F  I  L         p.640

          .         .         .         .         .         .       g.196687
 CTGAGCAAGTGTGGCTGCTATGAAATGCAAGCCCAAATTTATAGGACAGAAACTTCATCC       c.1980
 L  S  K  C  G  C  Y  E  M  Q  A  Q  I  Y  R  T  E  T  S  S         p.660

          .         .         .         .         .         .       g.196747
 ACTGTCCACAACACCCATCCAAGGAATGGCCACTGCTCTTCAGCTCCCAGAGTCACCAGT       c.2040
 T  V  H  N  T  H  P  R  N  G  H  C  S  S  A  P  R  V  T  S         p.680

          .         .         .         .                           g.196795
 GGTTCCACTTACATACTTGTCCCTCTAAGTCATTTAGCCCAAAACTAA                   c.2088
 G  S  T  Y  I  L  V  P  L  S  H  L  A  Q  N  X                     p.695

          .         .         .         .         .         .       g.196855
 aacacaatgtgaaaatgtatctgagtattgaatgataattcagtcttgcctttgaagggt       c.*60

          .         .         .         .         .         .       g.196915
 atgtcacaaagagctgacagtgcttctacacatttcatctaatttaatattcctggcata       c.*120

          .         .         .         .         .         .       g.196975
 cctttaaggtaaattggtcaggaactattaattccatgtgatacattaggaagctgaatt       c.*180

          .         .         .         .         .         .       g.197035
 attagtaacaacaataataattaaagaatgcaatactgtattacatattttatccttata       c.*240

          .         .         .         .         .         .       g.197095
 tatgttatttttgcacgttatgttcaaagtgcttttgttcagatatctcaagtgatccct       c.*300

          .         .         .         .         .         .       g.197155
 gttaaataagcaggacagggattattcttggagttttacaaatgaggaaaccacgactca       c.*360

          .         .         .         .         .         .       g.197215
 aagagttaagtgacttgttcaaaattgtttagtttgtaagaggcagagccaggattaggt       c.*420

          .         .         .         .         .         .       g.197275
 attccgactcccagagaatttcccagagaagcaccatggtattcattcattcattcattc       c.*480

          .         .         .         .         .         .       g.197335
 aacaaatattaattgaacacccatctgaagcctttgtaatgcgtcagtgtggataggctg       c.*540

          .         .         .                                     g.197371
 aaatacatttcccagatttcccttcctcatgtgttt                               c.*576

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Follicle stimulating hormone receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 28d
©2004-2023 Leiden University Medical Center