formiminotransferase cyclodeaminase (FTCD) - coding DNA reference sequence

(used for variant description)

(last modified May 27, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_006657.2 in the FTCD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016191.1, covering FTCD transcript NM_006657.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 cttccatctgcccagagaggagcatctggatcaaggtgctggcc       c.-1

          .         .         .         .         .     | 02   .    g.6241
 ATGTCCCAGCTGGTGGAATGCGTCCCCAACTTTTCGGAGGGGAAGAACCAGGAG | GTGATC    c.60
 M  S  Q  L  V  E  C  V  P  N  F  S  E  G  K  N  Q  E   | V  I      p.20

          .         .         .         .         .         .       g.6301
 GACGCCATCTCTGGAGCCATCACACAGACCCCGGGCTGCGTGCTGCTGGATGTGGACGCA       c.120
 D  A  I  S  G  A  I  T  Q  T  P  G  C  V  L  L  D  V  D  A         p.40

          .         .         .         .         .         .       g.6361
 GGCCCTTCCACCAACCGCACCGTGTACACCTTCGTGGGGCCGCCGGAGTGCGTGGTGGAG       c.180
 G  P  S  T  N  R  T  V  Y  T  F  V  G  P  P  E  C  V  V  E         p.60

          .         .         .         .         .         | 03    g.7534
 GGGGCCCTCAACGCTGCCCGGGTAGCTTCCCGACTTATCGACATGAGCAGGCACCAAG | GA    c.240
 G  A  L  N  A  A  R  V  A  S  R  L  I  D  M  S  R  H  Q  G |       p.80

          .         .         .         .         .         .       g.7594
 GAGCACCCCCGCATGGGGGCCCTAGACGTCTGCCCCTTCATCCCCGTGAGGGGCGTCAGC       c.300
 E  H  P  R  M  G  A  L  D  V  C  P  F  I  P  V  R  G  V  S         p.100

          .         .         .         .         .         .       g.7654
 GTGGATGAGTGTGTGCTCTGCGCCCAGGCCTTTGGCCAGAGGCTGGCAGAGGAGCTGGAC       c.360
 V  D  E  C  V  L  C  A  Q  A  F  G  Q  R  L  A  E  E  L  D         p.120

         | 04.         .         .         .         .         .    g.8640
 GTGCCAG | TTTACCTGTACGGCGAGGCAGCCAGGATGGACAGTCGCCGGACCCTGCCGGCC    c.420
 V  P  V |   Y  L  Y  G  E  A  A  R  M  D  S  R  R  T  L  P  A      p.140

          .         .         .       | 05 .         .         .    g.8854
 ATCCGGGCCGGGGAGTACGAGGCCCTCCCTAAGAAG | CTCCAGCAGGCCGACTGGGCGCCC    c.480
 I  R  A  G  E  Y  E  A  L  P  K  K   | L  Q  Q  A  D  W  A  P      p.160

          .         .         .         .         .         .       g.8914
 GACTTTGGTCCCAGCTCCTTTGTCCCCAGTTGGGGGGCCACGGCCACGGGGGCGAGGAAG       c.540
 D  F  G  P  S  S  F  V  P  S  W  G  A  T  A  T  G  A  R  K         p.180

          .         .         .         .         .         .       g.8974
 TTCCTCATTGCTTTTAACATCAACCTGCTCGGCACAAAGGAGCAAGCCCACCGCATCGCG       c.600
 F  L  I  A  F  N  I  N  L  L  G  T  K  E  Q  A  H  R  I  A         p.200

          .         .         .       | 06 .         .         .    g.10066
 CTCAACCTGCGGGAGCAGGGCCGCGGGAAGGACCAG | CCAGGACGTCTGAAGAAAGTTCAG    c.660
 L  N  L  R  E  Q  G  R  G  K  D  Q   | P  G  R  L  K  K  V  Q      p.220

          .         .         .         .         .         .       g.10126
 GGCATTGGCTGGTACCTGGATGAGAAGAACCTGGCTCAGGTGTCCACCAATCTTCTGGAC       c.720
 G  I  G  W  Y  L  D  E  K  N  L  A  Q  V  S  T  N  L  L  D         p.240

          .         .         .         .         .     | 07   .    g.10323
 TTTGAGGTCACGGCACTGCACACGGTCTACGAGGAGACCTGCCGAGAAGCACAG | GAGCTG    c.780
 F  E  V  T  A  L  H  T  V  Y  E  E  T  C  R  E  A  Q   | E  L      p.260

          .         .         .         .         .         .       g.10383
 AGCCTCCCAGTGGTGGGCTCACAGCTGGTGGGCCTGGTGCCCCTGAAGGCTCTGCTGGAT       c.840
 S  L  P  V  V  G  S  Q  L  V  G  L  V  P  L  K  A  L  L  D         p.280

          .         .         .         .         .         .       g.10443
 GCGGCCGCCTTCTACTGCGAGAAGGAGAACCTCTTCATCCTGGAGGAGGAGCAGCGGATC       c.900
 A  A  A  F  Y  C  E  K  E  N  L  F  I  L  E  E  E  Q  R  I         p.300

        | 08 .         .         .         .         .         .    g.14294
 AGGCTG | GTGGTGAGCCGGCTGGGCCTGGACTCCCTGTGCCCCTTCAGCCCTAAGGAGCGG    c.960
 R  L   | V  V  S  R  L  G  L  D  S  L  C  P  F  S  P  K  E  R      p.320

          | 09         .         .         .         .         .    g.14672
 ATCATCGA | GTACCTGGTCCCTGAGCGCGGGCCTGAGCGAGGCCTGGGCAGCAAGTCCCTG    c.1020
 I  I  E  |  Y  L  V  P  E  R  G  P  E  R  G  L  G  S  K  S  L      p.340

          .         .         .         .         .         .       g.14732
 CGCGCCTTCGTGGGGGAGGTGGGTGCCCGCTCTGCGGCCCCCGGGGGCGGCTCGGTGGCG       c.1080
 R  A  F  V  G  E  V  G  A  R  S  A  A  P  G  G  G  S  V  A         p.360

          .         | 10         .         .         .         .    g.15031
 GCGGCCGCTGCGGCCATG | GGTGCGGCGCTGGGCTCCATGGTGGGCCTCATGACCTACGGG    c.1140
 A  A  A  A  A  M   | G  A  A  L  G  S  M  V  G  L  M  T  Y  G      p.380

          .         .         .         .         .         .       g.15091
 CGGCGCCAATTCCAGTCCCTGGACACGACGATGCGGCGCCTGATCCCGCCCTTCCGCGAG       c.1200
 R  R  Q  F  Q  S  L  D  T  T  M  R  R  L  I  P  P  F  R  E         p.400

          .         .         .         .         .         .       g.15151
 GCTTCGGCCAAGCTAACCACGCTGGTGGATGCCGACGCCGAGGCCTTCACCGCCTACCTG       c.1260
 A  S  A  K  L  T  T  L  V  D  A  D  A  E  A  F  T  A  Y  L         p.420

  | 11       .         .         .         .     | 12   .         . g.21937
  | GAAGCAATGAGGCTCCCCAAGAACACACCTGAGGAAAAGGACAG | GCGCACGGCGGCCCTA c.1320
  | E  A  M  R  L  P  K  N  T  P  E  E  K  D  R  |  R  T  A  A  L   p.440

          .         .         .         .         .         .       g.21997
 CAGGAGGGTCTGAGGCGGGCAGTCTCTGTGCCGCTGACGCTGGCGGAGACGGTGGCCTCG       c.1380
 Q  E  G  L  R  R  A  V  S  V  P  L  T  L  A  E  T  V  A  S         p.460

          .         .         .         .         .         .       g.22057
 CTGTGGCCGGCCCTGCAGGAACTGGCCCGGTGTGGGAACCTGGCCTGCCGGTCAGACCTC       c.1440
 L  W  P  A  L  Q  E  L  A  R  C  G  N  L  A  C  R  S  D  L         p.480

     | 13    .         .         .         .         .         .    g.23290
 CAG | GTGGCGGCCAAAGCCCTGGAGATGGGCGTGTTTGGCGCATATTTCAACGTGCTCATC    c.1500
 Q   | V  A  A  K  A  L  E  M  G  V  F  G  A  Y  F  N  V  L  I      p.500

          .         .         .          | 14        .         .    g.23515
 AACCTGAGGGACATCACAGACGAGGCATTTAAGGACCAG | ATCCACCATCGTGTTTCCAGC    c.1560
 N  L  R  D  I  T  D  E  A  F  K  D  Q   | I  H  H  R  V  S  S      p.520

          .         .         .         .         .         .       g.23575
 CTCCTGCAGGAAGCCAAGACCCAGGCTGCACTGGTGCTGGACTGCTTGGAGACCCGGCAG       c.1620
 L  L  Q  E  A  K  T  Q  A  A  L  V  L  D  C  L  E  T  R  Q         p.540

                                                                g.23581
 GAGTGA |                                                          c.1627
 E  X                                                            p.541

    | 15     .         .         .         .         .         .    g.24131
 cg | aaaccccagggacagcaggaccttcgacgctggaaggatagcctcgcttcccaggtgc    c.*60

          .         .         .         .         .         .       g.24191
 agctcccggcaggtctggacagttccacagagcacggtactggccctgtcctcagttccc       c.*120

          .         .         .         .         .         .       g.24251
 gtccacccttcaaccagtggctcctgggagacttttcctccctgcctcagctccctgccc       c.*180

          .         .         .         .         .                 g.24306
 agccagcctcctgtctccagagaagttctccattaaaaaataatttagcaaatca            c.*235

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Formiminotransferase cyclodeaminase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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