frizzled family receptor 4 (FZD4) - coding DNA reference sequence

(used for variant description)

(last modified January 10, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_012193.3 in the FZD4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011752.1, covering FZD4 transcript NM_012193.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5006
                                                ggtgagagctgcg       c.-301

 .         .         .         .         .         .                g.5066
 cagcgctggctgctggctggcctcgcggagacgccgaacggacgcggccggcgccggctt       c.-241

 .         .         .         .         .         .                g.5126
 gtgggctcgccgcctgcagccatgaccctcgcagcctgtccctcggcctcggcccgggac       c.-181

 .         .         .         .         .         .                g.5186
 gtctaaaatcccacacagtcgcgcgcagctgctggagagccggccgctgccccctcgtcg       c.-121

 .         .         .         .         .         .                g.5246
 ccgcatcacactcccgtcccgggagctgggagcagcgcgggcagccggcgcccccgtgca       c.-61

 .         .         .         .         .         .                g.5306
 aactgggggtgtctgccagagcagccccagccgctgccgctgctacccccgatgctggcc       c.-1

          .         .         .         .         .         .       g.5366
 ATGGCCTGGCGGGGCGCAGGGCCGAGCGTCCCGGGGGCGCCCGGGGGCGTCGGTCTCAGT       c.60
 M  A  W  R  G  A  G  P  S  V  P  G  A  P  G  G  V  G  L  S         p.20

          .         .         .         .         .         .       g.5426
 CTGGGGTTGCTCCTGCAGTTGCTGCTGCTCCTGGGGCCGGCGCGGGGCTTCGGGGACGAG       c.120
 L  G  L  L  L  Q  L  L  L  L  L  G  P  A  R  G  F  G  D  E         p.40

          .         .         .         .         .         .       g.5486
 GAAGAGCGGCGCTGCGACCCCATCCGCATCTCCATGTGCCAGAACCTCGGCTACAACGTG       c.180
 E  E  R  R  C  D  P  I  R  I  S  M  C  Q  N  L  G  Y  N  V         p.60

          .         .         .         .         .         .       g.5546
 ACCAAGATGCCCAACCTGGTTGGGCACGAGCTGCAGACGGACGCCGAGCTGCAGCTGACA       c.240
 T  K  M  P  N  L  V  G  H  E  L  Q  T  D  A  E  L  Q  L  T         p.80

          .         .         .         .      | 02  .         .    g.7936
 ACTTTCACACCGCTCATCCAGTACGGCTGCTCCAGCCAGCTGCAG | TTCTTCCTTTGTTCT    c.300
 T  F  T  P  L  I  Q  Y  G  C  S  S  Q  L  Q   | F  F  L  C  S      p.100

          .         .         .         .         .         .       g.7996
 GTTTATGTGCCAATGTGCACAGAGAAGATCAACATCCCCATTGGCCCATGCGGCGGCATG       c.360
 V  Y  V  P  M  C  T  E  K  I  N  I  P  I  G  P  C  G  G  M         p.120

          .         .         .         .         .         .       g.8056
 TGTCTTTCAGTCAAGAGACGCTGTGAACCCGTCCTGAAGGAATTTGGATTTGCCTGGCCA       c.420
 C  L  S  V  K  R  R  C  E  P  V  L  K  E  F  G  F  A  W  P         p.140

          .         .         .         .         .         .       g.8116
 GAGAGTCTGAACTGCAGCAAATTCCCACCACAGAACGACCACAACCACATGTGCATGGAA       c.480
 E  S  L  N  C  S  K  F  P  P  Q  N  D  H  N  H  M  C  M  E         p.160

          .         .         .         .         .         .       g.8176
 GGGCCAGGTGATGAAGAGGTGCCCTTACCTCACAAAACCCCCATCCAGCCTGGGGAAGAG       c.540
 G  P  G  D  E  E  V  P  L  P  H  K  T  P  I  Q  P  G  E  E         p.180

          .         .         .         .         .         .       g.8236
 TGTCACTCTGTGGGAACCAATTCTGATCAGTACATCTGGGTGAAAAGGAGCCTGAACTGT       c.600
 C  H  S  V  G  T  N  S  D  Q  Y  I  W  V  K  R  S  L  N  C         p.200

          .         .         .         .         .         .       g.8296
 GTGCTCAAGTGTGGCTATGATGCTGGCTTATACAGCCGCTCAGCCAAGGAGTTCACTGAT       c.660
 V  L  K  C  G  Y  D  A  G  L  Y  S  R  S  A  K  E  F  T  D         p.220

          .         .         .         .         .         .       g.8356
 ATCTGGATGGCTGTGTGGGCCAGCCTGTGTTTCATCTCCACTGCCTTCACAGTACTGACC       c.720
 I  W  M  A  V  W  A  S  L  C  F  I  S  T  A  F  T  V  L  T         p.240

          .         .         .         .         .         .       g.8416
 TTCCTGATCGATTCTTCTAGGTTTTCCTACCCTGAGCGCCCCATCATATTTCTCAGTATG       c.780
 F  L  I  D  S  S  R  F  S  Y  P  E  R  P  I  I  F  L  S  M         p.260

          .         .         .         .         .         .       g.8476
 TGCTATAATATTTATAGCATTGCTTATATTGTCAGGCTGACTGTAGGCCGGGAAAGGATA       c.840
 C  Y  N  I  Y  S  I  A  Y  I  V  R  L  T  V  G  R  E  R  I         p.280

          .         .         .         .         .         .       g.8536
 TCCTGTGATTTTGAAGAGGCAGCAGAACCTGTTCTCATCCAAGAAGGACTTAAGAACACA       c.900
 S  C  D  F  E  E  A  A  E  P  V  L  I  Q  E  G  L  K  N  T         p.300

          .         .         .         .         .         .       g.8596
 GGATGTGCAATAATTTTCTTGCTGATGTACTTTTTTGGAATGGCCAGCTCCATTTGGTGG       c.960
 G  C  A  I  I  F  L  L  M  Y  F  F  G  M  A  S  S  I  W  W         p.320

          .         .         .         .         .         .       g.8656
 GTTATTCTGACACTCACTTGGTTTTTGGCAGCAGGACTCAAATGGGGTCATGAAGCCATT       c.1020
 V  I  L  T  L  T  W  F  L  A  A  G  L  K  W  G  H  E  A  I         p.340

          .         .         .         .         .         .       g.8716
 GAAATGCACAGCTCTTATTTCCACATTGCAGCCTGGGCCATCCCCGCAGTGAAAACCATT       c.1080
 E  M  H  S  S  Y  F  H  I  A  A  W  A  I  P  A  V  K  T  I         p.360

          .         .         .         .         .         .       g.8776
 GTCATCTTGATTATGAGACTGGTGGATGCAGATGAACTGACTGGCTTGTGCTATGTTGGA       c.1140
 V  I  L  I  M  R  L  V  D  A  D  E  L  T  G  L  C  Y  V  G         p.380

          .         .         .         .         .         .       g.8836
 AACCAAAATCTCGATGCCCTCACCGGGTTCGTGGTGGCTCCCCTCTTTACTTATTTGGTC       c.1200
 N  Q  N  L  D  A  L  T  G  F  V  V  A  P  L  F  T  Y  L  V         p.400

          .         .         .         .         .         .       g.8896
 ATTGGAACTTTGTTCATTGCTGCAGGTTTGGTGGCCTTGTTCAAAATTCGGTCAAATCTT       c.1260
 I  G  T  L  F  I  A  A  G  L  V  A  L  F  K  I  R  S  N  L         p.420

          .         .         .         .         .         .       g.8956
 CAAAAGGATGGGACAAAGACAGACAAGTTAGAAAGACTGATGGTCAAGATTGGGGTGTTC       c.1320
 Q  K  D  G  T  K  T  D  K  L  E  R  L  M  V  K  I  G  V  F         p.440

          .         .         .         .         .         .       g.9016
 TCAGTACTGTACACAGTTCCTGCAACGTGTGTGATTGCCTGTTATTTTTATGAAATCTCC       c.1380
 S  V  L  Y  T  V  P  A  T  C  V  I  A  C  Y  F  Y  E  I  S         p.460

          .         .         .         .         .         .       g.9076
 AACTGGGCACTTTTTCGGTATTCTGCAGATGATTCCAACATGGCTGTTGAAATGTTGAAA       c.1440
 N  W  A  L  F  R  Y  S  A  D  D  S  N  M  A  V  E  M  L  K         p.480

          .         .         .         .         .         .       g.9136
 ATTTTTATGTCTTTGTTGGTGGGCATCACTTCAGGCATGTGGATTTGGTCTGCCAAAACT       c.1500
 I  F  M  S  L  L  V  G  I  T  S  G  M  W  I  W  S  A  K  T         p.500

          .         .         .         .         .         .       g.9196
 CTTCACACGTGGCAGAAGTGTTCCAACAGATTGGTGAATTCTGGAAAGGTAAAGAGAGAG       c.1560
 L  H  T  W  Q  K  C  S  N  R  L  V  N  S  G  K  V  K  R  E         p.520

          .         .         .         .         .                 g.9250
 AAGAGAGGAAATGGTTGGGTGAAGCCTGGAAAAGGCAGTGAGACTGTGGTATAA             c.1614
 K  R  G  N  G  W  V  K  P  G  K  G  S  E  T  V  V  X               p.537

          .         .         .         .         .         .       g.9310
 ggctagtcagcctccatgctttcttcattttgaaggggggaatgccagcattttggagga       c.*60

          .         .         .         .         .         .       g.9370
 aattctactaaaagttttatgcagtgaatctcagtttgaacaaactagcaacaattaagt       c.*120

          .         .         .         .         .         .       g.9430
 gacccccgtcaacccactgcctcccaccccgaccccagcatcaaaaaaccaatgattttg       c.*180

          .         .         .         .         .         .       g.9490
 ctgcagactttggaatgatccaaaatggaaaagccagttagaggctttcaaagctgtgaa       c.*240

          .         .         .         .         .         .       g.9550
 aaatcaaaacgttgatcactttagcaggttgcagcttggagcgtggaggtcctgcctaga       c.*300

          .         .         .         .         .         .       g.9610
 ttccaggaagtccagggcgatactgttttcccctgcagggtgggatttgagctgtgagtt       c.*360

          .         .         .         .         .         .       g.9670
 ggtaactagcagggagaaatattaacttttttaaccctttaccattttaaatactaactg       c.*420

          .         .         .         .         .         .       g.9730
 ggtctttcagatagcaaagcaatctataaacactggaaacgctgggttcagaaaagtgtt       c.*480

          .         .         .         .         .         .       g.9790
 acaagagttttatagtttggctgatgtaacataaacatcttctgtggtgcgctgtctgct       c.*540

          .         .         .         .         .         .       g.9850
 gtttagaactttgtggactgcactcccaagaagtggtgttagaatctttcagtgcctttg       c.*600

          .         .         .         .         .         .       g.9910
 tcataaaacagttatttgaacaaacaaaagtactgtactcacacacataaggtatccagt       c.*660

          .         .         .         .         .         .       g.9970
 ggatttttcttctctgtcttcctctcttaaatttcaacatctctcttcttggctgctgct       c.*720

          .         .         .         .         .         .       g.10030
 gttttcttcattttatgttaatgactcaaaaaaggtatttttatagaatttttgtactgc       c.*780

          .         .         .         .         .         .       g.10090
 agcatgcttaaagaggggaaaaggaagggtgattcactttctgacaatcacttaattcag       c.*840

          .         .         .         .         .         .       g.10150
 aggaaaatgagatttactaagttgacttacctgacggaccccagagacctattgcattga       c.*900

          .         .         .         .         .         .       g.10210
 gcagtggggacttaatatattttacttgtgtgattgcatctatgcagacgccagtctgga       c.*960

          .         .         .         .         .         .       g.10270
 agagctgaaatgttaagtttcttggcaactttgcattcacacagattagctgtgtaattt       c.*1020

          .         .         .         .         .         .       g.10330
 ttgtgtgtcaattacaattaaaagcacattgttggaccatgacatagtatactcaactga       c.*1080

          .         .         .         .         .         .       g.10390
 ctttaaaactatggtcaacttcaacttgcattctcagaatgatagtgcctttaaaaattt       c.*1140

          .         .         .         .         .         .       g.10450
 ttttattttttaaagcataagaatgttatcagaatctggtctacttaggacaatggagac       c.*1200

          .         .         .         .         .         .       g.10510
 tttttcagttttataaagggaactgaggacagctaatccaactacttggtgcgtaattgt       c.*1260

          .         .         .         .         .         .       g.10570
 ttcctagtaattggcaaaggctccttgtaagatttcactggaggcagtgtggcctggagt       c.*1320

          .         .         .         .         .         .       g.10630
 atttatatggtgcttaatgaatctccagaatgccagccagaagcctgattggttagtagg       c.*1380

          .         .         .         .         .         .       g.10690
 gaataaagtgtagaccatatgaaatgaactgcaaactctaatagcccaggtcttaattgc       c.*1440

          .         .         .         .         .         .       g.10750
 ctttagcagaggtatccaaagcttttaaaatttatgcatacgttcttcacaagggggtac       c.*1500

          .         .         .         .         .         .       g.10810
 ccccagcagcctctcgaaaattgcacttctcttaaaactgtaactggcctttctcttacc       c.*1560

          .         .         .         .         .         .       g.10870
 ttgccttaggccttctaatcatgagatcttggggacaaattgactatgtcacaggttgct       c.*1620

          .         .         .         .         .         .       g.10930
 ctccttgtaactcatacctgtctgcttcagcaactgctttgcaatgacatttatttatta       c.*1680

          .         .         .         .         .         .       g.10990
 attcatgccttaaaaaaataggaagggaagcttttttttttctttttttttttttcaatc       c.*1740

          .         .         .         .         .         .       g.11050
 acactttgtggaaaaacatttccagggactcaaaattccaaaaaggtggtcaaattctgg       c.*1800

          .         .         .         .         .         .       g.11110
 aagtaagcatttcctcttttttaaaaatttggtttgagccttatgcccatagtttgacat       c.*1860

          .         .         .         .         .         .       g.11170
 ttccctttcttctttcctttttgtttttgtgtggttcttgagctctctgacatcaagatg       c.*1920

          .         .         .         .         .         .       g.11230
 catgtaaagtcgattgtatgttttggaaggcaaagtcttggcttttgagactgaagttaa       c.*1980

          .         .         .         .         .         .       g.11290
 gtgggcacaggtggcccctgctgctgtgcccagtctgagtaccttggctagactctaggt       c.*2040

          .         .         .         .         .         .       g.11350
 caggctccaggagcatgagaattgatccccagaagaaccattttaactccatctgatact       c.*2100

          .         .         .         .         .         .       g.11410
 ccattgcctatgaaatgtaaaatgtgaactccctgtgctgcttgtagacagttcccataa       c.*2160

          .         .         .         .         .         .       g.11470
 ctgtccacggccctggagcacgcacccaggggcagagcctgcccttactcacgctctgct       c.*2220

          .         .         .         .         .         .       g.11530
 ctggtgtcttgggagttgtgcagggactctggcccaggcaggggaaggaagaccaggcgg       c.*2280

          .         .         .         .         .         .       g.11590
 taggggactggtcttgctgttagagtatagaggtttgtaatgcagttttcttcataatgt       c.*2340

          .         .         .         .         .         .       g.11650
 gtcagtgattgtgtgaccaaggcagcatctagcagaaagccaggcatggagtaggtgatc       c.*2400

          .         .         .         .         .         .       g.11710
 gatacttgtcaatgactaaataataacaataaaagagcacttgggtgaatctgggcacct       c.*2460

          .         .         .         .         .         .       g.11770
 gatttctgagttttgagttctggagctagtgttttgacaatgctttgggttttgacatgc       c.*2520

          .         .         .         .         .         .       g.11830
 cttttccacaaatctcttgccttttcagggcaaagtgtatttgatcagaagtggccattt       c.*2580

          .         .         .         .         .         .       g.11890
 ggattagtagccttagcaatgctacagggttataggcctctcctttcacattccagacaa       c.*2640

          .         .         .         .         .         .       g.11950
 tggagagtgtttatggtttcaggaaaagaactttgtggctgaggggtcagttaccagtga       c.*2700

          .         .         .         .         .         .       g.12010
 ccttcaatcaactccatcacttcttaaatcggtatttgttaaaaaaatcagttattttat       c.*2760

          .         .         .         .         .         .       g.12070
 ttattgagtgccgactgtagtaaagccctgaaatagataatctctgttcttctaactgat       c.*2820

          .         .         .         .         .         .       g.12130
 ctaggatggggacgcacccaggtctgctgaactttactgttcctctgggaaaggagcagg       c.*2880

          .         .         .         .         .         .       g.12190
 gacctctggaattcccatctgtttcactgtctccattccataaatctcttcctgtgtgag       c.*2940

          .         .         .         .         .         .       g.12250
 ccaccacacccagcctgggtctctctacttttaacacatctctcatccctttcccaggat       c.*3000

          .         .         .         .         .         .       g.12310
 tccttccaagtcagttacaggtggttttaacagaaagcatcagctctgcttcgtgacagt       c.*3060

          .         .         .         .         .         .       g.12370
 ctctggagaaatcccttaggaagactatgagagtaggccacaaggacatgggcccacaca       c.*3120

          .         .         .         .         .         .       g.12430
 tctgctttggctttgccggcaattcagggcttggggtattccatgtgacttgtataggta       c.*3180

          .         .         .         .         .         .       g.12490
 tatttgaggacagcatcttgctagagaaaaggtgagggttgtttttctttctctgaaacc       c.*3240

          .         .         .         .         .         .       g.12550
 tacagtaaatgggtatgattgtagcttcctcagaaatcccttggcctccagagattaaac       c.*3300

          .         .         .         .         .         .       g.12610
 atggtgcaatggcacctctgtccaacctcctttctggtagattcctttctcctgcttcat       c.*3360

          .         .         .         .         .         .       g.12670
 ataggccaaacctcagggcaagggaacatgggggtagagtggtgctggccagaaccatct       c.*3420

          .         .         .         .         .         .       g.12730
 gcttgagctacttggttgattcatatcctctttcctttatggagacccatttcctgatct       c.*3480

          .         .         .         .         .         .       g.12790
 ctgagactgttgctgaactggcaacttacttgggcctgaaactggagaaggggtgacatt       c.*3540

          .         .         .         .         .         .       g.12850
 tttttaatttcagagatgctttctgattttcctctcccaggtcactgtctcacctgcact       c.*3600

          .         .         .         .         .         .       g.12910
 ctccaaactcaggttccgggaagcttgtgtgtctagatactgaattgagattctgttcag       c.*3660

          .         .         .         .         .         .       g.12970
 caccttttagctctatactctctggctcccctcatcctcatggtcactgaattaaatgct       c.*3720

          .         .         .         .         .         .       g.13030
 tattgtattgagaaccaagatgggacctgaggacacaaagatgagctcaacagtctcagc       c.*3780

          .         .         .         .         .         .       g.13090
 cctagaggaatagactcagggatttcaccaggtcggtgcagtatttgatttctggtgagg       c.*3840

          .         .         .         .         .         .       g.13150
 tgaccacagctgcagttagggaagggagccattgagcacagactttggaaggaacctttt       c.*3900

          .         .         .         .         .         .       g.13210
 ttttgttgtttgtttgtttgtttgtttgtttgtttgtttgagacagggtcttgctctgtc       c.*3960

          .         .         .         .         .         .       g.13270
 acccaggctggggcgcaatggcacgatcttggctcactgcaacctctgcctcctgggttc       c.*4020

          .         .         .         .         .         .       g.13330
 aagtgattctcctgccacagcctcctgaggagctgggactacaggtgcgtgctaccacgc       c.*4080

          .         .         .         .         .         .       g.13390
 ccagctacttctgtatttttagtagagacggggtttcactgtgttggccaggctggtctc       c.*4140

          .         .         .         .         .         .       g.13450
 gaactcctgacctcatgatctgcccgcctcagcctcccaaagtgctgggattacaagtgt       c.*4200

          .         .         .         .         .         .       g.13510
 gagccaccacacctggcctggaaggaacctcttaaaatcagtttacgtcttgtattttgt       c.*4260

          .         .         .         .         .         .       g.13570
 tctgtgatggaggacactggagagagttgctattccagtcaatcatgtcgagtcactgga       c.*4320

          .         .         .         .         .         .       g.13630
 ctctgaaaatcctattggttcctttattttatttgagtttagagttcccttctgggtttg       c.*4380

          .         .         .         .         .         .       g.13690
 tattatgtctggcaaatgacctgggttatcacttttcctccagggttagatcatagatct       c.*4440

          .         .         .         .         .         .       g.13750
 tggaaactccttagagagcattttgctcctaccaaggatcagatactggagccccacata       c.*4500

          .         .         .         .         .         .       g.13810
 atagatttcatttcactctagcctacatagagctttctgttgctgtctcttgccatgcac       c.*4560

          .         .         .         .         .         .       g.13870
 ttgtgcggtgattacacacttgacagtaccaggagacaaatgacttacagatcccccgac       c.*4620

          .         .         .         .         .         .       g.13930
 atgcctcttccccttggcaagctcagttgccctgatagtagcatgtttctgtttctgatg       c.*4680

          .         .         .         .         .         .       g.13990
 taccttttttctcttcttctttgcatcagccaattcccagaatttccccaggcaatttgt       c.*4740

          .         .         .         .         .         .       g.14050
 agaggacctttttggggtcctatatgagccatgtcctcaaagcttttaaacctccttgct       c.*4800

          .         .         .         .         .         .       g.14110
 ctcctacaatattcagtacatgaccactgtcatcctagaaggcttctgaaaagaggggca       c.*4860

          .         .         .         .         .         .       g.14170
 agagccactctgcgccacaaaggttgggtccatcttctctccgaggttgtgaaagttttc       c.*4920

          .         .         .         .         .         .       g.14230
 aaattgtactaataggctggggccctgacttggctgtgggctttgggaggggtaagctgc       c.*4980

          .         .         .         .         .         .       g.14290
 tttctagatctctcccagtgaggcatggaggtgtttctgaattttgtctacctcacaggg       c.*5040

          .         .         .         .         .         .       g.14350
 atgttgtgaggcttgaaaaggtcaaaaaatgatggccccttgagctctttgtaagaaagg       c.*5100

          .         .         .         .         .         .       g.14410
 tagatgaaatatcggatgtaatctgaaaaaaagataaaatgtgacttcccctgctctgtg       c.*5160

          .         .         .         .         .         .       g.14470
 cagcagtcgggctggatgctctgtggcctttcttgggtcctcatgccaccccacagctcc       c.*5220

          .         .         .         .         .         .       g.14530
 aggaaccttgaagccaatctgggggactttcagatgtttgacaaagaggtaccaggcaaa       c.*5280

          .         .         .         .         .         .       g.14590
 cttcctgctacacatgccctgaatgaattgctaaatttcaaaggaaatggaccctgcttt       c.*5340

          .         .         .         .         .         .       g.14650
 taaggatgtacaaaagtatgtctgcatcgatgtctgtactgtaaatttctaatttatcac       c.*5400

          .         .         .         .         .         .       g.14710
 tgtacaaagaaaaccccttgctatttaattttgtattaaaggaaaataaagttttgtttg       c.*5460

                                                                    g.14717
 ttaggtt                                                            c.*5467

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Frizzled family receptor 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 22
©2004-2020 Leiden University Medical Center