frizzled family receptor 5 (FZD5) - coding DNA reference sequence

(used for variant description)

(last modified December 23, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_003468.3 in the FZD5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering FZD5 transcript NM_003468.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           tgctgccatgtgccgctgccacgggtacccagcctgtcgctaaactttcc       c.-361

 .         .         .         .         .         .                g.5110
 gggcgccagcccggctctgagtcgcgcttctcagcggagtgacccagggacggaggaccc       c.-301

 .         .         .         .         .     | 02   .             g.5440
 aggctggctggggactgtctgctcttctcggcgggatccgtggag | agtcctttccctgga    c.-241

 .         .         .         .         .         .                g.5500
 atccgagccctaaccgtctctccccagccctatccggcgaggagcggagcgctgccagcg       c.-181

 .         .         .         .         .         .                g.5560
 gaggcagcgccttcccgaagcagtttatctttggacggttttctttaaaggaaaaagcaa       c.-121

 .         .         .         .         .         .                g.5620
 ccaacaggttgccagccccggcgccacacacgagacgccggagggagaagccccggcccg       c.-61

 .         .         .         .         .         .                g.5680
 gattcctctgcctgtgtgcgtccctcgcgggctgctggaggcgaggggagggagggggcg       c.-1

          .         .         .         .         .         .       g.5740
 ATGGCTCGGCCTGACCCATCCGCGCCGCCCTCGCTGTTGCTGCTGCTCCTAGCGCAGCTG       c.60
 M  A  R  P  D  P  S  A  P  P  S  L  L  L  L  L  L  A  Q  L         p.20

          .         .         .         .         .         .       g.5800
 GTGGGCCGGGCGGCCGCCGCGTCCAAGGCCCCGGTGTGCCAGGAAATCACGGTGCCCATG       c.120
 V  G  R  A  A  A  A  S  K  A  P  V  C  Q  E  I  T  V  P  M         p.40

          .         .         .         .         .         .       g.5860
 TGCCGCGGCATCGGCTACAACCTGACGCACATGCCCAACCAGTTCAACCACGACACGCAG       c.180
 C  R  G  I  G  Y  N  L  T  H  M  P  N  Q  F  N  H  D  T  Q         p.60

          .         .         .         .         .         .       g.5920
 GACGAGGCGGGCCTGGAGGTGCACCAGTTCTGGCCGCTGGTGGAGATCCAATGCTCGCCG       c.240
 D  E  A  G  L  E  V  H  Q  F  W  P  L  V  E  I  Q  C  S  P         p.80

          .         .         .         .         .         .       g.5980
 GACCTGCGCTTCTTCCTATGCTCTATGTACACGCCCATCTGTCTGCCCGACTACCACAAG       c.300
 D  L  R  F  F  L  C  S  M  Y  T  P  I  C  L  P  D  Y  H  K         p.100

          .         .         .         .         .         .       g.6040
 CCGCTGCCGCCCTGCCGCTCGGTGTGCGAGCGCGCCAAGGCCGGCTGCTCGCCGCTGATG       c.360
 P  L  P  P  C  R  S  V  C  E  R  A  K  A  G  C  S  P  L  M         p.120

          .         .         .         .         .         .       g.6100
 CGCCAGTACGGCTTCGCCTGGCCCGAGCGCATGAGCTGCGACCGCCTCCCGGTGCTGGGC       c.420
 R  Q  Y  G  F  A  W  P  E  R  M  S  C  D  R  L  P  V  L  G         p.140

          .         .         .         .         .         .       g.6160
 CGCGACGCCGAGGTCCTCTGCATGGATTACAACCGCAGCGAGGCCACCACGGCGCCCCCC       c.480
 R  D  A  E  V  L  C  M  D  Y  N  R  S  E  A  T  T  A  P  P         p.160

          .         .         .         .         .         .       g.6220
 AGGCCTTTCCCAGCCAAGCCCACCCTTCCAGGCCCGCCAGGGGCGCCGGCCTCGGGGGGC       c.540
 R  P  F  P  A  K  P  T  L  P  G  P  P  G  A  P  A  S  G  G         p.180

          .         .         .         .         .         .       g.6280
 GAATGCCCCGCTGGGGGCCCGTTCGTGTGCAAGTGTCGCGAGCCCTTCGTGCCCATTCTG       c.600
 E  C  P  A  G  G  P  F  V  C  K  C  R  E  P  F  V  P  I  L         p.200

          .         .         .         .         .         .       g.6340
 AAGGAGTCACACCCGCTCTACAACAAGGTGCGGACGGGCCAGGTGCCCAACTGCGCGGTA       c.660
 K  E  S  H  P  L  Y  N  K  V  R  T  G  Q  V  P  N  C  A  V         p.220

          .         .         .         .         .         .       g.6400
 CCCTGCTACCAGCCGTCCTTCAGTGCCGACGAGCGCACGTTCGCCACCTTCTGGATAGGC       c.720
 P  C  Y  Q  P  S  F  S  A  D  E  R  T  F  A  T  F  W  I  G         p.240

          .         .         .         .         .         .       g.6460
 CTGTGGTCGGTGCTGTGCTTCATCTCCACGTCCACCACAGTGGCCACCTTCCTCATCGAC       c.780
 L  W  S  V  L  C  F  I  S  T  S  T  T  V  A  T  F  L  I  D         p.260

          .         .         .         .         .         .       g.6520
 ATGGAACGCTTCCGCTATCCTGAGCGCCCCATCATCTTCCTGTCAGCCTGCTACCTGTGC       c.840
 M  E  R  F  R  Y  P  E  R  P  I  I  F  L  S  A  C  Y  L  C         p.280

          .         .         .         .         .         .       g.6580
 GTGTCGCTGGGCTTCCTGGTGCGTCTGGTCGTGGGCCATGCCAGCGTGGCCTGCAGCCGC       c.900
 V  S  L  G  F  L  V  R  L  V  V  G  H  A  S  V  A  C  S  R         p.300

          .         .         .         .         .         .       g.6640
 GAGCACAACCACATCCACTACGAGACCACGGGCCCTGCACTGTGCACCATCGTCTTCCTC       c.960
 E  H  N  H  I  H  Y  E  T  T  G  P  A  L  C  T  I  V  F  L         p.320

          .         .         .         .         .         .       g.6700
 CTGGTCTACTTCTTCGGCATGGCCAGCTCCATCTGGTGGGTCATCCTGTCGCTCACCTGG       c.1020
 L  V  Y  F  F  G  M  A  S  S  I  W  W  V  I  L  S  L  T  W         p.340

          .         .         .         .         .         .       g.6760
 TTCCTGGCCGCCGGCATGAAGTGGGGCAACGAGGCCATCGCGGGCTACGCGCAGTACTTC       c.1080
 F  L  A  A  G  M  K  W  G  N  E  A  I  A  G  Y  A  Q  Y  F         p.360

          .         .         .         .         .         .       g.6820
 CACCTGGCTGCGTGGCTCATCCCCAGCGTCAAGTCCATCACGGCACTGGCGCTGAGCTCC       c.1140
 H  L  A  A  W  L  I  P  S  V  K  S  I  T  A  L  A  L  S  S         p.380

          .         .         .         .         .         .       g.6880
 GTGGACGGGGACCCAGTGGCCGGCATCTGCTACGTGGGCAACCAGAACCTGAACTCGCTG       c.1200
 V  D  G  D  P  V  A  G  I  C  Y  V  G  N  Q  N  L  N  S  L         p.400

          .         .         .         .         .         .       g.6940
 CGCGGCTTCGTGCTGGGCCCGCTGGTGCTCTACCTGCTGGTGGGCACGCTCTTCCTGCTG       c.1260
 R  G  F  V  L  G  P  L  V  L  Y  L  L  V  G  T  L  F  L  L         p.420

          .         .         .         .         .         .       g.7000
 GCGGGCTTCGTGTCGCTCTTCCGCATCCGCAGCGTCATCAAGCAGGGCGGCACCAAGACG       c.1320
 A  G  F  V  S  L  F  R  I  R  S  V  I  K  Q  G  G  T  K  T         p.440

          .         .         .         .         .         .       g.7060
 GACAAGCTGGAGAAGCTCATGATCCGCATCGGCATCTTCACGCTGCTCTACACGGTCCCC       c.1380
 D  K  L  E  K  L  M  I  R  I  G  I  F  T  L  L  Y  T  V  P         p.460

          .         .         .         .         .         .       g.7120
 GCCAGCATTGTGGTGGCCTGCTACCTGTACGAGCAGCACTACCGCGAGAGCTGGGAGGCG       c.1440
 A  S  I  V  V  A  C  Y  L  Y  E  Q  H  Y  R  E  S  W  E  A         p.480

          .         .         .         .         .         .       g.7180
 GCGCTCACCTGCGCCTGCCCGGGCCACGACACCGGCCAGCCGCGCGCCAAGCCCGAGTAC       c.1500
 A  L  T  C  A  C  P  G  H  D  T  G  Q  P  R  A  K  P  E  Y         p.500

          .         .         .         .         .         .       g.7240
 TGGGTGCTCATGCTCAAGTACTTCATGTGCCTGGTGGTGGGCATCACGTCGGGCGTCTGG       c.1560
 W  V  L  M  L  K  Y  F  M  C  L  V  V  G  I  T  S  G  V  W         p.520

          .         .         .         .         .         .       g.7300
 ATCTGGTCGGGCAAGACGGTGGAGTCGTGGCGGCGTTTCACCAGCCGCTGCTGCTGCCGC       c.1620
 I  W  S  G  K  T  V  E  S  W  R  R  F  T  S  R  C  C  C  R         p.540

          .         .         .         .         .         .       g.7360
 CCGCGGCGCGGCCACAAGAGCGGGGGCGCCATGGCCGCAGGGGACTACCCCGAGGCGAGC       c.1680
 P  R  R  G  H  K  S  G  G  A  M  A  A  G  D  Y  P  E  A  S         p.560

          .         .         .         .         .         .       g.7420
 GCCGCGCTCACAGGCAGGACCGGGCCGCCGGGCCCCGCCGCCACCTACCACAAGCAGGTG       c.1740
 A  A  L  T  G  R  T  G  P  P  G  P  A  A  T  Y  H  K  Q  V         p.580

          .                                                         g.7438
 TCCCTGTCGCACGTGTAG                                                 c.1758
 S  L  S  H  V  X                                                   p.585

          .         .         .         .         .         .       g.7498
 gaggctgccgccgagggactcggccggagagctgaggggaggggggcgttttgtttggta       c.*60

          .         .         .         .         .         .       g.7558
 gttttgccaaggtcacttccgtttaccttcatggtgctgttgccccctcccgcggcgact       c.*120

          .         .         .         .         .         .       g.7618
 tggagagagggaagaggggcgttttcgaggaagaacctgtcccaggtcttctccaagggg       c.*180

          .         .         .         .         .         .       g.7678
 cccagctcacgtgtattctattttgcgtttcttactgccttctttatgggaaccctcttt       c.*240

          .         .         .         .         .         .       g.7738
 ttaatttatatgtatttttcttaatttgtaactttgttgcattttggcaacaatttacct       c.*300

          .         .         .         .         .         .       g.7798
 ttgctttgggggctttacaatcctaaggttggcgttgtaatgaagttccacttggttcag       c.*360

          .         .         .         .         .         .       g.7858
 gtttctttgaactgtgtggtctcaattgggaaaatatatttcctatacgtgtgtctttaa       c.*420

          .         .         .         .         .         .       g.7918
 aaaaaaatgtgaacagtgaacgtttcggttgctgtgactgggaagttgttgggtgtgctt       c.*480

          .         .         .         .         .         .       g.7978
 tttcagccagcttctccttccactgcttaaagtgtccatgattctttaaggtgagctgca       c.*540

          .         .         .         .         .         .       g.8038
 gtttatagccccaggtcatacctaggaggggagcataatgagctcagggcctccccaaag       c.*600

          .         .         .         .         .         .       g.8098
 tgacaaggttagggagtgcttagcggttttgtgttcagccttagctttgtttatagaggg       c.*660

          .         .         .         .         .         .       g.8158
 aggttcagtttcttttctgtagtgcttgtaataattctcactcctaacagcaccatcgtt       c.*720

          .         .         .         .         .         .       g.8218
 gtgtcttgaataagttagaggtagcattatagaggatctggcataaatatttgcagtagt       c.*780

          .         .         .         .         .         .       g.8278
 gagagcctaagcgatggtgattggtggagcttgaattttaggctggtgagatggcagctt       c.*840

          .         .         .         .         .         .       g.8338
 tgtgcctgagaggtagtgggtggttcttaagcttcagtgatccccttttttttttttttt       c.*900

          .         .         .         .         .         .       g.8398
 ttttttttttaaggaacttgtgttataattttggtaaaagtataaacccactccctctgg       c.*960

          .         .         .         .         .         .       g.8458
 acaatacttagcgacagttgctaaagggggctcctttttaaatgtaaggactgaaatgga       c.*1020

          .         .         .         .         .         .       g.8518
 tatacttctaataagtaaatttccaacacttatttgctccaccccctcccccctcccccc       c.*1080

          .         .         .         .         .         .       g.8578
 tccccctttatcatgttaaacagcctttttgcttttcttattcctcctctcctggagagc       c.*1140

          .         .         .         .         .         .       g.8638
 tgtgattagaaaccacacccacccttgaatgaagtgcttgaactgggggagggaggctgg       c.*1200

          .         .         .         .         .         .       g.8698
 ctacctgtgaacaaacattggcccaaataagggaaaataagtgttcctggactttggact       c.*1260

          .         .         .         .         .         .       g.8758
 agtttatagccagatattccaagagcagcaagacgttgctctctgccgtctctgaaaaca       c.*1320

          .         .         .         .         .         .       g.8818
 aaagagatgcataacatgcttgcacaaccttttaaaatatagatcagtatagtgctacct       c.*1380

          .         .         .         .         .         .       g.8878
 ctatagttttcttcctcttctgagaaagcctgtatattgatgatcacacacacacacact       c.*1440

          .         .         .         .         .         .       g.8938
 ttgcaattagagaatttggtttgctttactaatctgtttaactattccttcattcattat       c.*1500

          .         .         .         .         .         .       g.8998
 gaacgcttatattgatgaacatacacacagaggtttctttgctattagaaaattctgttt       c.*1560

          .         .         .         .         .         .       g.9058
 gctttcctaatctgtttaagcattcattcatgaagagtgtggggccattactggggaagg       c.*1620

          .         .         .         .         .         .       g.9118
 ggggtgacagtgcctcagccagcaaaataccaatgaccaggattggggactaaatttagg       c.*1680

          .         .         .         .         .         .       g.9178
 aagctaaaatggccagagcaattaacatttgagaaaatcctgtctaggaaaacaacttga       c.*1740

          .         .         .         .         .         .       g.9238
 gtgtaggcatttgtaattcacttataccaaagttggaaaagtaaaatttaagcctaggac       c.*1800

          .         .         .         .         .         .       g.9298
 aatttttacttcatggatgttaaatagacaaatgcatagttcccagggggaatttaaaca       c.*1860

          .         .         .         .         .         .       g.9358
 ctttactggtgggaagaaacctagtattaaagttgtaaggactctcaaaaacttcacatt       c.*1920

          .         .         .         .         .         .       g.9418
 tattaaaatgcactgctcttacccaatttatcctctgaattaaaatttcagtggattcta       c.*1980

          .         .         .         .         .         .       g.9478
 caaaacctcgtacaaatagctacagaactttgtgcctattttattcctctatttattctt       c.*2040

          .         .         .         .         .         .       g.9538
 ctaggaagaagcctcttcctagaatcttgaaatagatcccttgactgaatgccaattcct       c.*2100

          .         .         .         .         .         .       g.9598
 ctcctgtttttcaaatgagagaaccttttctgatcaccttgaccttttccctcatttcat       c.*2160

          .         .         .         .         .         .       g.9658
 atgtcttcccagaaagtagacagactgctctgctgccttcagtcattgtgcctcatttgg       c.*2220

          .         .         .         .         .         .       g.9718
 gttgtccctccttctttgtggagaaatctggaaatgatgcacagtgtatccaaaagttgt       c.*2280

          .         .         .         .         .         .       g.9778
 gggatgaagtggatgaaagtgatttaattcatttttagaatttttttttgttttgtttta       c.*2340

          .         .         .         .         .         .       g.9838
 gcaacatgctgaacaactaatttactttaaaaataagccagttaaaacaaaggacgctaa       c.*2400

          .         .         .         .         .         .       g.9898
 gcccaagtggggggcaatattagtcaggatctttggggtctaattccagaccaactttca       c.*2460

          .         .         .         .         .         .       g.9958
 gaagcacttctttgtctctgttctcacctctgctgtccctctcttccctcatcccctaag       c.*2520

          .         .         .         .         .         .       g.10018
 agagacaaagataaaagcccacctgcatccctaagtcttactgagatcagccaccccagg       c.*2580

          .         .         .         .         .         .       g.10078
 ggagagaaactggatctacttacagccaccccctgtttccatccatatagttacttcccc       c.*2640

          .         .         .         .         .         .       g.10138
 caatttgcatgtgattatggaaacaagtcatgctcatgaaagcaactgtaaaataaaagg       c.*2700

          .         .         .         .         .         .       g.10198
 ttatggagtagttcagcaacttcttcacagccagctttgtggagctggggaggacttagg       c.*2760

          .         .         .         .         .         .       g.10258
 gcccattggagtctcttatgtgtacagcttcagggctgtccctttcagtttgattttaag       c.*2820

          .         .         .         .         .         .       g.10318
 caatgcctcacttcatagcttagggggtaaggattccattcaggtaggttgtctaaagga       c.*2880

          .         .         .         .         .         .       g.10378
 actaatgggacctctcagtgaattagctgaccagattttaggaaatctttttaatttcta       c.*2940

          .         .         .         .         .         .       g.10438
 tgattttccttctcacattttgaaatggtaaaattgactggaaataatttttcttggtgc       c.*3000

          .         .         .         .         .         .       g.10498
 cttattggttttccttgcaaacctttctcatattttctcatgaccattgccagtgaccaa       c.*3060

          .         .         .         .         .         .       g.10558
 ggcccatgtgtgtgttgtgtgtaattgtgggcatgtacaagcttaaataacgtgccgaca       c.*3120

          .         .         .         .         .         .       g.10618
 gcactgtttcaaagttggtattcattaggctgttgcctcctgggctggagctgcgctaat       c.*3180

          .         .         .         .         .         .       g.10678
 cctgacaccggctgccaggagaaaacctcatggatcacacaccaaaccttaataacagca       c.*3240

          .         .         .         .         .         .       g.10738
 tccgtgacctgcactctccagtacagaatgggaaccccagagctaggaaatgtagttgta       c.*3300

          .         .         .         .         .         .       g.10798
 tattttaatgaactgctaccccagccaaagaagcttctttcacttttgtgctctacagaa       c.*3360

          .         .         .         .         .         .       g.10858
 agcccaaggggggtaggagggacagagctttgaataactgctttctaacactaaatgtgg       c.*3420

          .         .         .         .         .         .       g.10918
 ccaacaggacagagcacatcacacgtataggcaggtgtgagggacagtggctaagaattg       c.*3480

          .         .         .         .         .         .       g.10978
 cctgctccctctgcatgctctttcttgtttccaaagtccaatcaagtgatcctgggaaac       c.*3540

          .         .         .         .         .         .       g.11038
 aaatctgtctggattgcggagggtggttctgaaagaactgccaagacgttaaagaagggt       c.*3600

          .         .         .         .         .         .       g.11098
 gaagagtaggcagaatataagtagctaacctgagtcaagactctcaaaagctagcagcct       c.*3660

          .         .         .         .         .         .       g.11158
 gatgacaataggatttatttcagccaggatagtgtctgtctgtgagtgcatcattttaag       c.*3720

          .         .         .         .         .         .       g.11218
 acagtatgacttcatgttgttacaaactatgtatagtatgtatgttttgtgggttgtata       c.*3780

          .         .         .         .         .         .       g.11278
 tatacataatatatattatatatatatatgagagatttggtgacttttgatacgggtttg       c.*3840

          .         .         .         .         .         .       g.11338
 gtgcaggtgaatttattactgagccaaatgaggcacataccgagtcagtagttgaagtcc       c.*3900

          .         .         .         .         .         .       g.11398
 agggcattcgatactgtttatgatttccatatatgtatagtgcctatcccatgctgtagt       c.*3960

          .         .         .         .         .         .       g.11458
 cactgttatgttaaatccagaagttacactagagccagcgatactttatttgtagacaat       c.*4020

          .         .         .         .         .         .       g.11518
 caatttgaatccatatgttattactggcagatgatacatgattacagttctgaatctgta       c.*4080

          .         .         .         .         .         .       g.11578
 acacttacaaaaggaaacccagagcagcttgatgagtttttgtttctgcttcgttcctgg       c.*4140

          .         .         .         .         .         .       g.11638
 gagtcagtagaaacagcagttgtatgtggttatgttagtctcaagatacttaatttgttg       c.*4200

          .         .         .         .         .         .       g.11698
 accttacttcagaaaaattttgtatgtattatatttgtgggaaggtaaaataatcatttg       c.*4260

          .         .         .         .         .         .       g.11758
 agatttttatcaaatatgaagattagttatttatgaaaaacaaagaaatgtctatttttc       c.*4320

          .         .         .         .         .         .       g.11818
 tttgttcccaattaatgtagataaattttaaaatgcattaaagtaatggtaaagacaata       c.*4380

          .                                                         g.11834
 aaaagatgctgtagaa                                                   c.*4396

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Frizzled family receptor 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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