GTPase activating protein (SH3 domain) binding protein 1 (G3BP1) - coding DNA reference sequence

(used for variant description)

(last modified December 1, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_005754.2 in the G3BP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering G3BP1 transcript NM_005754.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          gagtggcagttatatagaccggcggcggagcacgcgtgtgtgcggacgcag       c.-121

 .         .         .         .         .         .                g.5111
 ttgcgtgaggggtttgtactatcctcggtgctgtggtgcagagctagttcctctccagct       c.-61

 .         . | 02       .         .         .         .             g.19706
 cagccgcgtag | gtttggacatatttgactcttttccccccaggttgaattgaccaaagca    c.-1

          .         .         .         .         .         .       g.19766
 ATGGTGATGGAGAAGCCTAGTCCCCTGCTGGTCGGGCGGGAATTTGTGAGACAGTATTAC       c.60
 M  V  M  E  K  P  S  P  L  L  V  G  R  E  F  V  R  Q  Y  Y         p.20

          .         .         .      | 03  .         .         .    g.23433
 ACACTGCTGAACCAGGCCCCAGACATGCTGCATAG | ATTTTATGGAAAGAACTCTTCTTAT    c.120
 T  L  L  N  Q  A  P  D  M  L  H  R  |  F  Y  G  K  N  S  S  Y      p.40

          .         .         .         .         .        | 04.    g.23977
 GTCCATGGGGGATTGGATTCAAATGGAAAGCCAGCAGATGCAGTCTACGGACAGAAA | GAA    c.180
 V  H  G  G  L  D  S  N  G  K  P  A  D  A  V  Y  G  Q  K   | E      p.60

          .         .         .         .         .         .       g.24037
 ATCCACAGGAAAGTGATGTCACAAAACTTCACCAACTGCCACACCAAGATTCGCCATGTT       c.240
 I  H  R  K  V  M  S  Q  N  F  T  N  C  H  T  K  I  R  H  V         p.80

          .         .         .         .         .         .       g.24097
 GATGCTCATGCCACGCTAAATGATGGTGTGGTAGTCCAGGTGATGGGGCTTCTCTCTAAC       c.300
 D  A  H  A  T  L  N  D  G  V  V  V  Q  V  M  G  L  L  S  N         p.100

          .         .         .         .         .  | 05      .    g.27253
 AACAACCAGGCTTTGAGGAGATTCATGCAAACGTTTGTCCTTGCTCCTGAG | GGGTCTGTT    c.360
 N  N  Q  A  L  R  R  F  M  Q  T  F  V  L  A  P  E   | G  S  V      p.120

          .         .         .         .         .         .       g.27313
 GCAAATAAATTCTATGTTCACAATGATATCTTCAGATACCAAGATGAGGTCTTTGGTGGG       c.420
 A  N  K  F  Y  V  H  N  D  I  F  R  Y  Q  D  E  V  F  G  G         p.140

          .         .   | 06     .         .         .         .    g.28602
 TTTGTCACTGAGCCTCAGGAGG | AGTCTGAAGAAGAAGTAGAGGAACCTGAAGAAAGACAG    c.480
 F  V  T  E  P  Q  E  E |   S  E  E  E  V  E  E  P  E  E  R  Q      p.160

          .         .         .         .         .          | 07    g.30313
 CAAACACCTGAGGTGGTACCTGATGATTCTGGAACTTTCTATGATCAGGCAGTTGTCAG | T    c.540
 Q  T  P  E  V  V  P  D  D  S  G  T  F  Y  D  Q  A  V  V  S  |      p.180

          .         .         .         .         .         .       g.30373
 AATGACATGGAAGAACATTTAGAGGAGCCTGTTGCTGAACCAGAGCCTGATCCTGAACCA       c.600
 N  D  M  E  E  H  L  E  E  P  V  A  E  P  E  P  D  P  E  P         p.200

          .         .         .         .         .         .       g.30433
 GAACCAGAACAAGAACCTGTATCTGAAATCCAAGAGGAAAAGCCTGAGCCAGTATTAGAA       c.660
 E  P  E  Q  E  P  V  S  E  I  Q  E  E  K  P  E  P  V  L  E         p.220

          .         .         .         .         .         .       g.30493
 GAAACTGCCCCTGAGGATGCTCAGAAGAGTTCTTCTCCAGCACCTGCAGACATAGCTCAG       c.720
 E  T  A  P  E  D  A  Q  K  S  S  S  P  A  P  A  D  I  A  Q         p.240

          .         .  | 08      .         .         .         .    g.32336
 ACAGTACAGGAAGACTTGAGG | ACATTTTCTTGGGCATCTGTGACCAGTAAGAATCTTCCA    c.780
 T  V  Q  E  D  L  R   | T  F  S  W  A  S  V  T  S  K  N  L  P      p.260

          .         .         .         .         .         .       g.32396
 CCCAGTGGAGCTGTTCCAGTTACTGGGATACCACCTCATGTTGTTAAAGTACCAGCTTCA       c.840
 P  S  G  A  V  P  V  T  G  I  P  P  H  V  V  K  V  P  A  S         p.280

     | 09    .         .         .         .         .         .    g.33031
 CAG | CCCCGTCCAGAGTCTAAGCCTGAATCTCAGATTCCACCACAAAGACCTCAGCGGGAT    c.900
 Q   | P  R  P  E  S  K  P  E  S  Q  I  P  P  Q  R  P  Q  R  D      p.300

          .         .         .         .         .      | 10  .    g.33308
 CAAAGAGTGCGAGAACAACGAATAAATATTCCTCCCCAAAGGGGACCCAGACCAA | TCCGT    c.960
 Q  R  V  R  E  Q  R  I  N  I  P  P  Q  R  G  P  R  P  I |   R      p.320

          .         .         .         .         .         .       g.33368
 GAGGCTGGTGAGCAAGGTGACATTGAACCCCGAAGAATGGTGAGACACCCTGACAGTCAC       c.1020
 E  A  G  E  Q  G  D  I  E  P  R  R  M  V  R  H  P  D  S  H         p.340

          .         .         .         .         .         .       g.33428
 CAACTCTTCATTGGCAACCTGCCTCATGAAGTGGACAAATCAGAGCTTAAAGATTTCTTT       c.1080
 Q  L  F  I  G  N  L  P  H  E  V  D  K  S  E  L  K  D  F  F         p.360

      | 11   .         .         .         .         .         .    g.33901
 CAAA | GTTATGGAAACGTGGTGGAGTTGCGCATTAACAGTGGTGGGAAATTACCCAATTTT    c.1140
 Q  S |   Y  G  N  V  V  E  L  R  I  N  S  G  G  K  L  P  N  F      p.380

          .         .         .         .         .     | 12   .    g.36976
 GGTTTTGTTGTGTTTGATGATTCTGAGCCTGTTCAGAAAGTCCTTAGCAACAGG | CCCATC    c.1200
 G  F  V  V  F  D  D  S  E  P  V  Q  K  V  L  S  N  R   | P  I      p.400

          .         .         .         .         .         .       g.37036
 ATGTTCAGAGGTGAGGTCCGTCTGAATGTCGAAGAGAAGAAGACTCGAGCTGCCAGGGAA       c.1260
 M  F  R  G  E  V  R  L  N  V  E  E  K  K  T  R  A  A  R  E         p.420

          .         .         .         .         .         .       g.37096
 GGCGACCGACGAGATAATCGCCTTCGGGGACCTGGAGGCCCTCGAGGTGGGCTGGGTGGT       c.1320
 G  D  R  R  D  N  R  L  R  G  P  G  G  P  R  G  G  L  G  G         p.440

          .         .         .         .         .         .       g.37156
 GGAATGAGAGGCCCTCCCCGTGGAGGCATGGTGCAGAAACCAGGATTTGGAGTGGGAAGG       c.1380
 G  M  R  G  P  P  R  G  G  M  V  Q  K  P  G  F  G  V  G  R         p.460

          .         .                                               g.37177
 GGGCTTGCGCCACGGCAGTGA                                              c.1401
 G  L  A  P  R  Q  X                                                p.466

          .         .         .         .         .         .       g.37237
 atcttcatggatcttcatgcagccatacaaaccctggttccaacagaatggtgaattttc       c.*60

          .         .         .         .         .         .       g.37297
 gacagcctttggtatcttggagtatgaccccagtctgttataaactgcttaagtttgtat       c.*120

          .         .         .         .         .         .       g.37357
 aattttactttttttgtgtgttaatggtgtgtgctccctctccctctcttccctttcctg       c.*180

          .         .         .         .         .         .       g.37417
 acctttagtctttcacttccaattttgtggaatgatattttaggaataacggacttttaa       c.*240

          .         .         .         .         .         .       g.37477
 agaagcaaaaaaaaagactgaatttccttgcttactttgcatatacagactggatttttt       c.*300

          .         .         .         .         .         .       g.37537
 ttttttttttacagccatttccccaaaggaatgtcttgcatattactgacatttggtatg       c.*360

          .         .         .         .         .         .       g.37597
 tttcattcattggaatatttcttattttctacgtgtttgaaaagcctgtaagaaatacag       c.*420

          .         .         .         .         .         .       g.37657
 gatttgataatattttgaaggcaggaaaaacccaaattgtttcttctttgagagtcatga       c.*480

          .         .         .         .         .         .       g.37717
 ctaccttctggtgtggagaaattgccattggaaaatttgacaattttgattctcactggt       c.*540

          .         .         .         .         .         .       g.37777
 atgtttaaaaactgaataaaaggaatagaatttttttttgataaaggatcacaaaacaat       c.*600

          .         .         .         .         .         .       g.37837
 tctaaaacctaactgtttttaccattgaaatttaaattgtgataataggttttaaatgtc       c.*660

          .         .         .         .         .         .       g.37897
 tagaatgcaactgataggcttttcttgaactgttagtttttttgaagtagttttttcatg       c.*720

          .         .         .         .         .         .       g.37957
 tttaatttgtatttgtaaaaaaacaaaaagcaaaaaaattcccaaaacccagataacaac       c.*780

          .         .         .         .         .         .       g.38017
 cagagcaaaactgttgtgccttctatttatctttgatttcagtcttggcaattgtttaaa       c.*840

          .         .         .         .         .         .       g.38077
 aaaaaaatctagatttgttttattaggttcagagtatgtggggaattatagaatccctct       c.*900

          .         .         .         .         .         .       g.38137
 ttcatcactttgtgtatgtcttttgttaacatatttgttatgccttattctaaaattgag       c.*960

          .         .         .         .         .         .       g.38197
 tctcaaactggaatgcctttgaagacagatgcttctatagaggttctttgacctaaatag       c.*1020

          .         .         .         .         .         .       g.38257
 ttcagcatttgtatttttattctggtatctaatcagattcctaatcatagcccgtaagaa       c.*1080

          .         .         .         .         .         .       g.38317
 ggaatgttactttaatattggactttgctcatgtgctcgtgtccgcatttttttttttct       c.*1140

          .         .         .         .         .         .       g.38377
 taaaatcatagccatatggtaaattttctattttgttatggttctcttttattgatgggc       c.*1200

          .         .         .         .         .         .       g.38437
 atgcagtgggtgttacttggaaatggccaatttttattaaaatatttctggaagaaaatt       c.*1260

                                                                    g.38440
 taa                                                                c.*1263

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GTPase activating protein (SH3 domain) binding protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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