GTPase activating protein (SH3 domain) binding protein 2 (G3BP2) - coding DNA reference sequence

(used for variant description)

(last modified December 1, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_203505.2 in the G3BP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering G3BP2 transcript NM_203505.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 gtgctcgggggttccctggccctttcggcaggggtaaaacaataagagggggcggtggca       c.-241

 .         .         .         .         .         .                g.5120
 aagggggcgggacgtccgtggtccttgtcgcacgtcgcagcgcctggcgcccgggaagag       c.-181

 .         .         .         .         .         .                g.5180
 gtggttgtgaggcagacgaactcgcggctctccggcttccgaggcttccgagttgtcgga       c.-121

 .         .         .         .         .         .                g.5240
 ggaagggggcggcgagcaataagaacccgccgcacccggtcctcagcgactcttctgacc       c.-61

 .         .         .         .      | 02  .         .             g.16458
 tccgcgcgacgtacccgccgccgccgttggctggag | catttgacattgtgcagcaaagaa    c.-1

          .         .         .         .         .         .       g.16518
 ATGGTTATGGAGAAGCCCAGTCCGCTGCTTGTAGGGCGGGAGTTTGTGAGGCAATATTAT       c.60
 M  V  M  E  K  P  S  P  L  L  V  G  R  E  F  V  R  Q  Y  Y         p.20

          .         .         .      | 03  .         .         .    g.19584
 ACTTTGCTGAATAAAGCTCCGGAATATTTACACAG | GTTTTATGGCAGGAATTCTTCCTAT    c.120
 T  L  L  N  K  A  P  E  Y  L  H  R  |  F  Y  G  R  N  S  S  Y      p.40

          .         .         .         .         .        | 04.    g.20756
 GTTCATGGTGGAGTAGATGCTAGTGGAAAGCCCCAGGAAGCTGTTTATGGCCAAAAT | GAT    c.180
 V  H  G  G  V  D  A  S  G  K  P  Q  E  A  V  Y  G  Q  N   | D      p.60

          .         .         .         .         .         .       g.20816
 ATACACCACAAAGTATTATCTCTGAACTTCAGTGAATGTCATACTAAAATTCGTCATGTG       c.240
 I  H  H  K  V  L  S  L  N  F  S  E  C  H  T  K  I  R  H  V         p.80

          .         .         .         .         .         .       g.20876
 GATGCTCATGCAACCTTGAGTGATGGAGTAGTTGTCCAGGTCATGGGTTTGCTGTCTAAC       c.300
 D  A  H  A  T  L  S  D  G  V  V  V  Q  V  M  G  L  L  S  N         p.100

          .         .         .         .         .  | 05      .    g.21478
 AGTGGACAACCAGAAAGAAAGTTTATGCAAACCTTTGTTCTGGCTCCTGAA | GGATCTGTT    c.360
 S  G  Q  P  E  R  K  F  M  Q  T  F  V  L  A  P  E   | G  S  V      p.120

          .         .         .         .         .         .       g.21538
 CCAAATAAATTTTATGTTCACAATGATATGTTTCGTTATGAAGATGAAGTGTTTGGTGAT       c.420
 P  N  K  F  Y  V  H  N  D  M  F  R  Y  E  D  E  V  F  G  D         p.140

          .         .   | 06     .         .         .         .    g.22651
 TCTGAGCCTGAACTTGATGAAG | AATCAGAAGATGAAGTAGAAGAGGAACAAGAAGAAAGA    c.480
 S  E  P  E  L  D  E  E |   S  E  D  E  V  E  E  E  Q  E  E  R      p.160

          .         .         .         .         .         .       g.22711
 CAACCATCTCCTGAACCTGTGCAAGAAAATGCTAACAGTGGTTACTATGAAGCTCACCCT       c.540
 Q  P  S  P  E  P  V  Q  E  N  A  N  S  G  Y  Y  E  A  H  P         p.180

       | 07  .         .         .         .         .         .    g.23292
 GTGAC | TAATGGCATAGAGGAGCCTTTGGAAGAATCCTCTCATGAACCTGAACCTGAGCCA    c.600
 V  T  |  N  G  I  E  E  P  L  E  E  S  S  H  E  P  E  P  E  P      p.200

          .         .         .         .         .         .       g.23352
 GAATCTGAAACAAAGACTGAAGAGCTGAAACCACAAGTGGAGGAGAAGAACTTAGAAGAA       c.660
 E  S  E  T  K  T  E  E  L  K  P  Q  V  E  E  K  N  L  E  E         p.220

          .         .         .         .         .         .       g.23412
 CTAGAGGAGAAATCTACTACTCCTCCTCCGGCAGAACCTGTTTCTCTGCCACAAGAACCA       c.720
 L  E  E  K  S  T  T  P  P  P  A  E  P  V  S  L  P  Q  E  P         p.240

        | 08 .         .         .         .         .         .    g.24456
 CCAAAG | GCTTTCTCCTGGGCTTCAGTGACCAGTAAAAACCTGCCTCCTAGTGGTACTGTT    c.780
 P  K   | A  F  S  W  A  S  V  T  S  K  N  L  P  P  S  G  T  V      p.260

          .         .         .         .      | 09  .         .    g.29757
 TCTTCCTCTGGAATTCCACCCCATGTTAAAGCACCAGTCTCACAG | CCAAGAGTCGAAGCT    c.840
 S  S  S  G  I  P  P  H  V  K  A  P  V  S  Q   | P  R  V  E  A      p.280

          .         .         .         .         .         .       g.29817
 AAACCAGAAGTTCAATCTCAGCCACCTCGTGTGCGTGAACAACGACCTAGAGAACGACCT       c.900
 K  P  E  V  Q  S  Q  P  P  R  V  R  E  Q  R  P  R  E  R  P         p.300

          .         .         | 10         .         .         .    g.31358
 GGTTTTCCTCCTAGAGGACCAAGACCAG | GCAGAGGAGATATGGAACAGAATGACTCTGAC    c.960
 G  F  P  P  R  G  P  R  P  G |   R  G  D  M  E  Q  N  D  S  D      p.320

          .         .         .         .         .         .       g.31418
 AACCGTAGAATAATTCGCTATCCAGATAGTCATCAACTTTTTGTTGGTAACTTGCCACAT       c.1020
 N  R  R  I  I  R  Y  P  D  S  H  Q  L  F  V  G  N  L  P  H         p.340

          .         .         .        | 11.         .         .    g.32050
 GATATTGATGAAAATGAGCTAAAGGAATTCTTCATGA | GTTTTGGAAACGTTGTGGAACTT    c.1080
 D  I  D  E  N  E  L  K  E  F  F  M  S |   F  G  N  V  V  E  L      p.360

          .         .         .         .         .         .       g.32110
 CGCATCAATACCAAGGGTGTTGGGGGAAAGCTTCCAAATTTTGGTTTTGTGGTTTTTGAT       c.1140
 R  I  N  T  K  G  V  G  G  K  L  P  N  F  G  F  V  V  F  D         p.380

          .         .         .       | 12 .         .         .    g.32805
 GACTCTGAACCAGTTCAGAGAATCTTAATTGCAAAA | CCGATTATGTTTCGAGGGGAAGTA    c.1200
 D  S  E  P  V  Q  R  I  L  I  A  K   | P  I  M  F  R  G  E  V      p.400

          .         .         .         .         .         .       g.32865
 CGTTTAAATGTGGAAGAGAAAAAAACAAGAGCTGCAAGAGAGCGAGAAACCAGAGGTGGT       c.1260
 R  L  N  V  E  E  K  K  T  R  A  A  R  E  R  E  T  R  G  G         p.420

          .         .         .         .         .         .       g.32925
 GGTGATGATCGCAGGGATATTAGGCGCAATGATCGAGGTCCCGGTGGTCCACGTGGAATT       c.1320
 G  D  D  R  R  D  I  R  R  N  D  R  G  P  G  G  P  R  G  I         p.440

          .         .         .         .         .         .       g.32985
 GTGGGTGGTGGAATGATGCGTGATCGTGATGGAAGAGGACCTCCTCCAAGGGGTGGCATG       c.1380
 V  G  G  G  M  M  R  D  R  D  G  R  G  P  P  P  R  G  G  M         p.460

          .         .         .         .         .         .       g.33045
 GCACAGAAACTTGGCTCTGGAAGAGGAACCGGGCAAATGGAGGGCCGCTTCACAGGACAG       c.1440
 A  Q  K  L  G  S  G  R  G  T  G  Q  M  E  G  R  F  T  G  Q         p.480

                                                                    g.33054
 CGTCGCTGA                                                          c.1449
 R  R  X                                                            p.482

          .         .         .         .         .         .       g.33114
 agctccactgttggcaaagtcttggcagtggtacattattcatcgtgtttgcattcttgt       c.*60

          .         .         .         .         .         .       g.33174
 taattttttttttggctttggaatgtgacacagcctttttgatcatttctttgatgtgaa       c.*120

          .         .         .         .         .         .       g.33234
 aagcatctttggttatcagttaaattgaggtggacattatttccccaatttcacaacagg       c.*180

          .         .         .         .         .         .       g.33294
 attcacattgttaatttataaatctagacttggagaattaaggactgagaaatgaccata       c.*240

          .         .         .         .         .         .       g.33354
 tcttaaactatctacgacaaagtgaacttaaaaggacatgcccactgaattcaggtcctt       c.*300

          .         .         .         .         .         .       g.33414
 tgagtaaaaaaaaaatcttctgctgcacattttgtttaagtgttactgtttctgcctgtt       c.*360

          .         .         .         .         .         .       g.33474
 aatgctgggaacacaaatagtgcaatttgtgcaattggagaatcttgccttttttcttgg       c.*420

          .         .         .         .         .         .       g.33534
 ctccccccaaaaatacaaaccaacagaaacttgttatgcactcatcaaaatgtactaatg       c.*480

          .         .         .         .         .         .       g.33594
 ggtactctgaactcattaacattgacatctgcaacaggaggcaacagggaaaaaatctca       c.*540

          .         .         .         .         .         .       g.33654
 tcttcttttccagtagaaaatagtttgtgaaatgatgagggcattttatctgcttgctgt       c.*600

          .         .         .         .         .         .       g.33714
 gaccagcgtgtgtacacataaaccttaacaagactacaagtatattccagaaggaaatca       c.*660

          .         .         .         .         .         .       g.33774
 ttttagttatgaactaaataataaaaattagaacttcaaatgcgatggtcttgactatta       c.*720

          .         .         .         .         .         .       g.33834
 gaccagatttagtagctccatatctaagatttttctacctgcccctcttcagtacaggga       c.*780

          .         .         .         .         .         .       g.33894
 tggctggctgctcaacacactcctcctccccttttttcctttctttaagctgtgtacagt       c.*840

          .         .         .         .         .         .       g.33954
 gaaaattgtctttactgtatttttgttctctggtaatgtaataagcatgatggtgccttc       c.*900

          .         .         .         .         .         .       g.34014
 tattaatacatcattccagtcttgctggtaattttgtacagtatagtgtatgaattgctg       c.*960

          .         .         .         .         .         .       g.34074
 tgctgcaaagccaaacagctgcaaaatgttgaaaaatcatcgaaatgtataaaaattgca       c.*1020

          .         .         .         .         .         .       g.34134
 gtatctttaaaatcagtaaaatggactagcatattatttatcttgttcttcagttaacaa       c.*1080

          .         .         .         .         .         .       g.34194
 ctttgtgttctctgtgggagggagggagtcctgtgtgtttgtggggagagggaaggagga       c.*1140

          .         .         .         .         .         .       g.34254
 agtcagttatttgagtaagcctctagttgacttttctcttagcctgaatgtggacgttga       c.*1200

          .         .         .         .         .         .       g.34314
 aacatatcacttcagggcttggaaaagtcagtcaacttgacgtacatttttagtgacatt       c.*1260

          .         .         .         .         .         .       g.34374
 ttaaaagcagtcagattctataaatggcaagtaagcctgaagtgaggatactgcaatttt       c.*1320

          .         .         .         .         .         .       g.34434
 cggagaaaagaacagcagctctttaagtgtttgcattttctatttggggggcagggaact       c.*1380

          .         .         .         .         .         .       g.34494
 gtcattcattttgcacaattcttgaactgatgtcagcacccgagtggctcctgaatttaa       c.*1440

          .         .         .         .         .         .       g.34554
 gtctgggacgacatcttttatttttacatgaatctttaaacaattctgtgagcaaagttt       c.*1500

          .         .         .         .         .         .       g.34614
 gtagctgctggattattgtctgtctttatagcaagttccagtaaaccacaagtatggcaa       c.*1560

          .         .         .         .         .         .       g.34674
 agcttatccaattttatgcttggagcagtcagtacataccagtttctgatgtttcaggca       c.*1620

          .         .         .         .         .         .       g.34734
 ggagtggggtaaataagtgtgaccacttaaagctgctcgttagcatggaagacttctcca       c.*1680

          .         .         .         .         .         .       g.34794
 ttctatctttgtaaaacagacaagatatgcacttgacatagtagcaaattggttctgaat       c.*1740

          .         .         .         .         .         .       g.34854
 tatgcaactgtttgctatttagtaaactagcaaatgatgcatgtattttgtttttcatgt       c.*1800

          .         .         .         .         .         .       g.34914
 actgggcaatatgagtaaaatctgtccctttttccccctttgaatgaggtcttccatgtt       c.*1860

          .         .         .         .         .         .       g.34974
 tgagggaaagtcttgcactattgcatatattttggggacacagattttcatagtttccat       c.*1920

          .         .         .         .         .         .       g.35034
 ttttggggggcttaaggattttttttttttctgtttgaaacagttttatactttctgata       c.*1980

          .         .         .         .         .         .       g.35094
 tagtacttgaaattcttaccagaaaattactttggagttttgaagcctttattaatacta       c.*2040

          .         .         .         .         .         .       g.35154
 cttttaaagaagcagttgttttattgtcaatgttttttttcccccaagcatattttcttg       c.*2100

          .         .         .         .         .         .       g.35214
 tatttctgtttccatatatatatatatatatataatttccaattcaggatattgccctgc       c.*2160

          .         .         .         .         .         .       g.35274
 catccatgaaaactgttctggcaccaaaagtaatgacaaatgttaagtgtaataatagaa       c.*2220

          .         .         .         .         .         .       g.35334
 aagtagagcaaagagccattcagcttcagtctttacataccatgaataaaacattaaaac       c.*2280

          .         .         .         .         .         .       g.35394
 atcatatggagaagtttacatggtgattgttcacctgcagtactgtggagttttaacatt       c.*2340

          .         .         .         .         .         .       g.35454
 ttgtcctcttttcagtgaaacagagtaaaaatattcatctaccattactgttatttgctg       c.*2400

          .         .         .         .         .         .       g.35514
 attttgttttattttttgatggtaatattctatccttatgacactattgcaaccaaattg       c.*2460

          .         .         .         .         .         .       g.35574
 gctttaccatcttggctttagtaggtatagaagacaatggattaccatctttattgctgt       c.*2520

          .         .         .         .         .         .       g.35634
 aatgtgttaagcattatatgctagtagaatctagtttaattgtttcaggtggaaagtatt       c.*2580

          .         .         .         .         .         .       g.35694
 ctttgagtttccatattgaatgtgtttggactaaacaaacaataaactactgatgtctgc       c.*2640

          .         .                                               g.35715
 agcatttatctatgtccctaa                                              c.*2661

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GTPase activating protein (SH3 domain) binding protein 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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