glucose-6-phosphatase, catalytic subunit (G6PC) - coding DNA reference sequence

(used for variant description)

(last modified March 2, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000151.3 in the G6PC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011808.1, covering G6PC transcript NM_000151.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         atagcagagcaatcaccacc       c.-61

 .         .         .         .         .         .                g.5080
 aagcctggaataactgcaagggctctgctgacatcttcctgaggtgccaaggaaatgagg       c.-1

          .         .         .         .         .         .       g.5140
 ATGGAGGAAGGAATGAATGTTCTCCATGACTTTGGGATCCAGTCAACACATTACCTCCAG       c.60
 M  E  E  G  M  N  V  L  H  D  F  G  I  Q  S  T  H  Y  L  Q         p.20

          .         .         .         .         .         .       g.5200
 GTGAATTACCAAGACTCCCAGGACTGGTTCATCTTGGTGTCCGTGATCGCAGACCTCAGG       c.120
 V  N  Y  Q  D  S  Q  D  W  F  I  L  V  S  V  I  A  D  L  R         p.40

          .         .         .         .         .         .       g.5260
 AATGCCTTCTACGTCCTCTTCCCCATCTGGTTCCATCTTCAGGAAGCTGTGGGCATTAAA       c.180
 N  A  F  Y  V  L  F  P  I  W  F  H  L  Q  E  A  V  G  I  K         p.60

          .         .         .         .         . | 02       .    g.8144
 CTCCTTTGGGTAGCTGTGATTGGAGACTGGCTCAACCTCGTCTTTAAGTG | GATTCTCTTT    c.240
 L  L  W  V  A  V  I  G  D  W  L  N  L  V  F  K  W  |  I  L  F      p.80

          .         .         .         .         .         .       g.8204
 GGACAGCGTCCATACTGGTGGGTTTTGGATACTGACTACTACAGCAACACTTCCGTGCCC       c.300
 G  Q  R  P  Y  W  W  V  L  D  T  D  Y  Y  S  N  T  S  V  P         p.100

          .         .         .         . | 03       .         .    g.11746
 CTGATAAAGCAGTTCCCTGTAACCTGTGAGACTGGACCAG | GGAGCCCCTCTGGCCATGCC    c.360
 L  I  K  Q  F  P  V  T  C  E  T  G  P  G |   S  P  S  G  H  A      p.120

          .         .         .         .         .         .       g.11806
 ATGGGCACAGCAGGTGTATACTACGTGATGGTCACATCTACTCTTTCCATCTTTCAGGGA       c.420
 M  G  T  A  G  V  Y  Y  V  M  V  T  S  T  L  S  I  F  Q  G         p.140

          .         .       | 04 .         .         .         .    g.13540
 AAGATAAAGCCGACCTACAGATTTCG | GTGCTTGAATGTCATTTTGTGGTTGGGATTCTGG    c.480
 K  I  K  P  T  Y  R  F  R  |  C  L  N  V  I  L  W  L  G  F  W      p.160

          .         .         .         .         .         .       g.13600
 GCTGTGCAGCTGAATGTCTGTCTGTCACGAATCTACCTTGCTGCTCATTTTCCTCATCAA       c.540
 A  V  Q  L  N  V  C  L  S  R  I  Y  L  A  A  H  F  P  H  Q         p.180

          .         .   | 05     .         .         .         .    g.15156
 GTTGTTGCTGGAGTCCTGTCAG | GCATTGCTGTTGCAGAAACTTTCAGCCACATCCACAGC    c.600
 V  V  A  G  V  L  S  G |   I  A  V  A  E  T  F  S  H  I  H  S      p.200

          .         .         .         .         .         .       g.15216
 ATCTATAATGCCAGCCTCAAGAAATATTTTCTCATTACCTTCTTCCTGTTCAGCTTCGCC       c.660
 I  Y  N  A  S  L  K  K  Y  F  L  I  T  F  F  L  F  S  F  A         p.220

          .         .         .         .         .         .       g.15276
 ATCGGATTTTATCTGCTGCTCAAGGGACTGGGTGTAGACCTCCTGTGGACTCTGGAGAAA       c.720
 I  G  F  Y  L  L  L  K  G  L  G  V  D  L  L  W  T  L  E  K         p.240

          .         .         .         .         .         .       g.15336
 GCCCAGAGGTGGTGCGAGCAGCCAGAATGGGTCCACATTGACACCACACCCTTTGCCAGC       c.780
 A  Q  R  W  C  E  Q  P  E  W  V  H  I  D  T  T  P  F  A  S         p.260

          .         .         .         .         .         .       g.15396
 CTCCTCAAGAACCTGGGCACGCTCTTTGGCCTGGGGCTGGCTCTCAACTCCAGCATGTAC       c.840
 L  L  K  N  L  G  T  L  F  G  L  G  L  A  L  N  S  S  M  Y         p.280

          .         .         .         .         .         .       g.15456
 AGGGAGAGCTGCAAGGGGAAACTCAGCAAGTGGCTCCCATTCCGCCTCAGCTCTATTGTA       c.900
 R  E  S  C  K  G  K  L  S  K  W  L  P  F  R  L  S  S  I  V         p.300

          .         .         .         .         .         .       g.15516
 GCCTCCCTCGTCCTCCTGCACGTCTTTGACTCCTTGAAACCCCCATCCCAAGTCGAGCTG       c.960
 A  S  L  V  L  L  H  V  F  D  S  L  K  P  P  S  Q  V  E  L         p.320

          .         .         .         .         .         .       g.15576
 GTCTTCTACGTCTTGTCCTTCTGCAAGAGTGCGGTAGTGCCCCTGGCATCCGTCAGTGTC       c.1020
 V  F  Y  V  L  S  F  C  K  S  A  V  V  P  L  A  S  V  S  V         p.340

          .         .         .         .         .                 g.15630
 ATCCCCTACTGCCTCGCCCAGGTCCTGGGCCAGCCGCACAAGAAGTCGTTGTAA             c.1074
 I  P  Y  C  L  A  Q  V  L  G  Q  P  H  K  K  S  L  X               p.357

          .         .         .         .         .         .       g.15690
 gagatgtggagtcttcggtgtttaaagtcaacaaccatgccagggattgaggaggactac       c.*60

          .         .         .         .         .         .       g.15750
 tatttgaagcaatgggcactggtatttggagcaagtgacatgccatccattctgccgtcg       c.*120

          .         .         .         .         .         .       g.15810
 tggaattaaatcacggatggcagattggagggtcgcctggcttattcccatgtgtgactc       c.*180

          .         .         .         .         .         .       g.15870
 cagcctgccctcagcacagactctttcagatggaggtgccatatcacgtacaccatatgc       c.*240

          .         .         .         .         .         .       g.15930
 aagtttcccgccaggaggtcctcctctctctacttgaatactctcacaagtagggagctc       c.*300

          .         .         .         .         .         .       g.15990
 actcccactggaacagcccattttatctttgaatggtcttctgccagcccattttgaggc       c.*360

          .         .         .         .         .         .       g.16050
 cagaggtgctgtcagctcaggtggtcctcttttacaatcctaatcatattgggtaatgtt       c.*420

          .         .         .         .         .         .       g.16110
 tttgaaaagctaatgaagctattgagaaagacctgttgctagaagttgggttgttctgga       c.*480

          .         .         .         .         .         .       g.16170
 ttttcccctgaagacttacttattcttccgtcacatatacaaaagcaagacttccaggta       c.*540

          .         .         .         .         .         .       g.16230
 gggccagctcacaagcccaggctggagatcctaactgagaattttctacctgtgttcatt       c.*600

          .         .         .         .         .         .       g.16290
 cttaccgagaaaaggagaaaggagctctgaatctgataggaaaagaaggctgcctaagga       c.*660

          .         .         .         .         .         .       g.16350
 ggagtttttagtatgtggcgtatcatgcaagtgctatgccaagccatgtctaaatggctt       c.*720

          .         .         .         .         .         .       g.16410
 taattatatagtaatgcactctcagtaatgggggaccagcttaagtataattaatagatg       c.*780

          .         .         .         .         .         .       g.16470
 gttagtggggtaattctgcttctagtattttttttactgtgcatacatgttcatcgtatt       c.*840

          .         .         .         .         .         .       g.16530
 tccttggatttctgaatggctgcagtgacccagatattgcactaggtcaaaacattcagg       c.*900

          .         .         .         .         .         .       g.16590
 tatagctgacatctcctctatcacattacatcatcctccttataagcccagctctgcttt       c.*960

          .         .         .         .         .         .       g.16650
 ttccagattcttccactggctccacatccaccccactggatcttcagaaggctagagggc       c.*1020

          .         .         .         .         .         .       g.16710
 gactctggtggtgcttttgtatgtttcaattaggctctgaaatcttgggcaaaatgacaa       c.*1080

          .         .         .         .         .         .       g.16770
 ggggagggccaggattcctctctcaggtcactccagtgttacttttaattcctagagggt       c.*1140

          .         .         .         .         .         .       g.16830
 aaatatgactcctttctctatcccaagccaaccaagagcacattcttaaaggaaaagtca       c.*1200

          .         .         .         .         .         .       g.16890
 acatcttctctctttttttttttttttgagacagggtctcactatgttgcccaggctgct       c.*1260

          .         .         .         .         .         .       g.16950
 cttgaattcctgggctcaagcagtcctcccaccctaccacagcgtcccgcgtagctggga       c.*1320

          .         .         .         .         .         .       g.17010
 ctacaggtgcaagccactatgtccagctagccaactcctccttgcctgcttttctttttt       c.*1380

          .         .         .         .         .         .       g.17070
 tttctttttttgagacggcgcacctatcacccaggctggagtggagtggcacgatcttgg       c.*1440

          .         .         .         .         .         .       g.17130
 ctcactgcaacctcttcctcctggttcaagcgattctcatgtctcagcctcctcagtagc       c.*1500

          .         .         .         .         .         .       g.17190
 taggactaccggcgtgcaccaccatgccaggctaatttttatatttttagaattttagaa       c.*1560

          .         .         .         .         .         .       g.17250
 gagatgggatttcatcatgttggccaggctggtctcgaactcctgacctcaagtgatcca       c.*1620

          .         .         .         .         .         .       g.17310
 cctgccttggcctcccaaggtgctaggattacaggcatgagccaccgcaccgggccctcc       c.*1680

          .         .         .         .         .         .       g.17370
 ttgcctgtttttcaatctcatctgatatgcagagtatttctgccccacccacctaccccc       c.*1740

          .         .         .         .         .         .       g.17430
 caaaaaaagctgaagcctatttatttgaaagtccttgtttttgctactaattatatagta       c.*1800

          .         .         .         .         .         .       g.17490
 taccatacattatcattcaaaacaaccatcctgctcataacatctttgaaaagaaaaata       c.*1860

          .         .         .         .         .         .       g.17550
 tatatgtgcagtattttattaaagcaacattttatttaagaataaagtcttgttaattac       c.*1920

          .         .         .         .         .         .       g.17610
 tatattttagatgcaatgtgatctgaagtttctaattctggcccaactaaatttctagct       c.*1980

          .         .         .         .         .         .       g.17670
 ctgtttccctaaacaaataatttggtttctctgtgcctgcattttccctttggagaagaa       c.*2040

          .         .         .         .         .         .       g.17730
 aagtgctctctcttgagttgaccgagagtcccattagggatagggagacttaaatgcatc       c.*2100

          .         .         .         .         .         .       g.17790
 cacaggggcacaggcagagttgagcacataaacggaggcccaaaatcagcatagaaccag       c.*2160

          .         .         .         .         .         .       g.17850
 aaagattcagagttggccaagaatgaacattggctaccagaccacaagtcagcatgagtt       c.*2220

          .         .         .         .         .         .       g.17910
 gctctatggcatcaaattgcaacttgagagtagatgggcagggtcactatcaaattaagc       c.*2280

          .         .         .         .         .         .       g.17970
 aatcagggcacacaagttgcagtaacacaacaagactaggccagctctggaatccagtaa       c.*2340

          .         .         .         .         .         .       g.18030
 ctcagtgtcagcaaggttttgggttatagttcaagaaagtctaaacagagccagtcacag       c.*2400

          .         .         .         .         .         .       g.18090
 caccaaggaatgctcaagggagctattgcaggtttctctgctaagagatttatttcatcc       c.*2460

          .         .         .         .         .         .       g.18150
 tgggtgcagggttcgacctccaaaggcctcaaatcatcaccgtatcaatggatttcctga       c.*2520

          .         .         .         .         .         .       g.18210
 gggtaagctccgctatttcacacctgaactccggagtctgtatattcagggaagattgca       c.*2580

          .         .         .         .         .         .       g.18270
 ttctcctactggatttgggctctcagagggcgttgtgggaaccaggcccctcacagaatc       c.*2640

          .         .         .         .         .         .       g.18330
 aaatggtcccaaccagggagaaagaaaatagtcttttttttttttttaatagagatgggg       c.*2700

          .         .         .         .         .         .       g.18390
 gtctcactatgctgcccaggctggtcttgaactcctgggttcaagtgatcctcctgcctc       c.*2760

          .         .         .         .         .         .       g.18450
 agcctcccaaagtgctgggattacagtgtgagccactgcgcttggccagaaatggttttg       c.*2820

          .         .         .         .         .         .       g.18510
 atctgtctgaactgaaccctactgcttaggcatagccccatccttgataatctatttgct       c.*2880

          .         .         .         .         .         .       g.18570
 cccaaggaccaagtccaagatccttacaagaaaggtctgccagaaagtaaatactgcccc       c.*2940

          .         .         .         .         .         .       g.18630
 cactccctgaagtttatgaggttgataagaaaacataacagataaagtttattgagtgct       c.*3000

                                                                    g.18637
 aacttta                                                            c.*3007

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glucose-6-phosphatase, catalytic subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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