glucose-6-phosphate dehydrogenase (G6PD) - coding DNA reference sequence

(used for variant description)

(last modified August 5, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000402.3 in the G6PD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009015.2, covering G6PD transcript NM_000402.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5582
                                 agaggcaggggctggcctgggatgcgcg       c.-121

 .         .         .         .         .         .                g.5642
 cgcacctgccctcgccccgccccgcccgcacgaggggtggtggccgaggccccgccccgc       c.-61

 .         .         .         .         .         .                g.5702
 acgcctcgcctgaggcgggtccgctcagcccaggcgcccgcccccgcccccgccgattaa       c.-1

          .         .         .         .         .         .       g.5762
 ATGGGCCGGCGGGGCTCAGCCCCCGGAAACGGTCGTACACTTCGGGGCTGCGAGCGCGGA       c.60
 M  G  R  R  G  S  A  P  G  N  G  R  T  L  R  G  C  E  R  G         p.20

          .         .   | 02     .         .         .         .    g.6447
 GGGCGACGACGACGAAGCGCAG | ACAGCGTCATGGCAGAGCAGGTGGCCCTGAGCCGGACC    c.120
 G  R  R  R  R  S  A  D |   S  V  M  A  E  Q  V  A  L  S  R  T      p.40

          .         .         .         .         .         .       g.6507
 CAGGTGTGCGGGATCCTGCGGGAAGAGCTTTTCCAGGGCGATGCCTTCCATCAGTCGGAT       c.180
 Q  V  C  G  I  L  R  E  E  L  F  Q  G  D  A  F  H  Q  S  D         p.60

          .         .         . | 03       .         .         .    g.16424
 ACACACATATTCATCATCATGGGTGCATCG | GGTGACCTGGCCAAGAAGAAGATCTACCCC    c.240
 T  H  I  F  I  I  M  G  A  S   | G  D  L  A  K  K  K  I  Y  P      p.80

          | 04         .         .         .         .         .    g.16579
 ACCATCTG | GTGGCTGTTCCGGGATGGCCTTCTGCCCGAAAACACCTTCATCGTGGGCTAT    c.300
 T  I  W  |  W  L  F  R  D  G  L  L  P  E  N  T  F  I  V  G  Y      p.100

          .         .         .         .         .        | 05.    g.17190
 GCCCGTTCCCGCCTCACAGTGGCTGACATCCGCAAACAGAGTGAGCCCTTCTTCAAG | GCC    c.360
 A  R  S  R  L  T  V  A  D  I  R  K  Q  S  E  P  F  F  K   | A      p.120

          .         .         .         .         .         .       g.17250
 ACCCCAGAGGAGAAGCTCAAGCTGGAGGACTTCTTTGCCCGCAACTCCTATGTGGCTGGC       c.420
 T  P  E  E  K  L  K  L  E  D  F  F  A  R  N  S  Y  V  A  G         p.140

          .         .         .         .         .         .       g.17310
 CAGTACGATGATGCAGCCTCCTACCAGCGCCTCAACAGCCACATGAATGCCCTCCACCTG       c.480
 Q  Y  D  D  A  A  S  Y  Q  R  L  N  S  H  M  N  A  L  H  L         p.160

          .         .         .         .         .         .       g.17370
 GGGTCACAGGCCAACCGCCTCTTCTACCTGGCCTTGCCCCCGACCGTCTACGAGGCCGTC       c.540
 G  S  Q  A  N  R  L  F  Y  L  A  L  P  P  T  V  Y  E  A  V         p.180

          .         .         .      | 06  .         .         .    g.18101
 ACCAAGAACATTCACGAGTCCTGCATGAGCCAGAT | AGGCTGGAACCGCATCATCGTGGAG    c.600
 T  K  N  I  H  E  S  C  M  S  Q  I  |  G  W  N  R  I  I  V  E      p.200

          .         .         .         .         .         .       g.18161
 AAGCCCTTCGGGAGGGACCTGCAGAGCTCTGACCGGCTGTCCAACCACATCTCCTCCCTG       c.660
 K  P  F  G  R  D  L  Q  S  S  D  R  L  S  N  H  I  S  S  L         p.220

          .         .         .         .         .         .       g.18221
 TTCCGTGAGGACCAGATCTACCGCATCGACCACTACCTGGGCAAGGAGATGGTGCAGAAC       c.720
 F  R  E  D  Q  I  Y  R  I  D  H  Y  L  G  K  E  M  V  Q  N         p.240

          .     | 07   .         .         .         .         .    g.18458
 CTCATGGTGCTGAG | ATTTGCCAACAGGATCTTCGGCCCCATCTGGAACCGGGACAACATC    c.780
 L  M  V  L  R  |  F  A  N  R  I  F  G  P  I  W  N  R  D  N  I      p.260

          .         .         .         .         .         .       g.18518
 GCCTGCGTTATCCTCACCTTCAAGGAGCCCTTTGGCACTGAGGGTCGCGGGGGCTATTTC       c.840
 A  C  V  I  L  T  F  K  E  P  F  G  T  E  G  R  G  G  Y  F         p.280

          .         . | 08       .         .         .         .    g.18943
 GATGAATTTGGGATCATCCG | GGACGTGATGCAGAACCACCTACTGCAGATGCTGTGTCTG    c.900
 D  E  F  G  I  I  R  |  D  V  M  Q  N  H  L  L  Q  M  L  C  L      p.300

          .         .         .         .         .     | 09   .    g.19450
 GTGGCCATGGAGAAGCCCGCCTCCACCAACTCAGATGACGTCCGTGATGAGAAG | GTCAAG    c.960
 V  A  M  E  K  P  A  S  T  N  S  D  D  V  R  D  E  K   | V  K      p.320

          .         .         .         .         .         .       g.19510
 GTGTTGAAATGCATCTCAGAGGTGCAGGCCAACAATGTGGTCCTGGGCCAGTACGTGGGG       c.1020
 V  L  K  C  I  S  E  V  Q  A  N  N  V  V  L  G  Q  Y  V  G         p.340

          .         .         .         .         .         .       g.19570
 AACCCCGATGGAGAGGGCGAGGCCACCAAAGGGTACCTGGACGACCCCACGGTGCCCCGC       c.1080
 N  P  D  G  E  G  E  A  T  K  G  Y  L  D  D  P  T  V  P  R         p.360

          .         .         .         .         .         .       g.19630
 GGGTCCACCACCGCCACTTTTGCAGCCGTCGTCCTCTATGTGGAGAATGAGAGGTGGGAT       c.1140
 G  S  T  T  A  T  F  A  A  V  V  L  Y  V  E  N  E  R  W  D         p.380

   | 10      .         .         .         .         .         .    g.19829
 G | GGGTGCCCTTCATCCTGCGCTGCGGCAAGGCCCTGAACGAGCGCAAGGCCGAGGTGAGG    c.1200
 G |   V  P  F  I  L  R  C  G  K  A  L  N  E  R  K  A  E  V  R      p.400

          .         .         .         .         .         .       g.19889
 CTGCAGTTCCATGATGTGGCCGGCGACATCTTCCACCAGCAGTGCAAGCGCAACGAGCTG       c.1260
 L  Q  F  H  D  V  A  G  D  I  F  H  Q  Q  C  K  R  N  E  L         p.420

          .         .         .         .         .         .       g.19949
 GTGATCCGCGTGCAGCCCAACGAGGCCGTGTACACCAAGATGATGACCAAGAAGCCGGGC       c.1320
 V  I  R  V  Q  P  N  E  A  V  Y  T  K  M  M  T  K  K  P  G         p.440

          .         .         .         .         .        | 11.    g.20113
 ATGTTCTTCAACCCCGAGGAGTCGGAGCTGGACCTGACCTACGGCAACAGATACAAG | AAC    c.1380
 M  F  F  N  P  E  E  S  E  L  D  L  T  Y  G  N  R  Y  K   | N      p.460

          .         .         .         .         .         .       g.20173
 GTGAAGCTCCCTGACGCCTACGAGCGCCTCATCCTGGACGTCTTCTGCGGGAGCCAGATG       c.1440
 V  K  L  P  D  A  Y  E  R  L  I  L  D  V  F  C  G  S  Q  M         p.480

          .     | 12   .         .         .         .         .    g.20338
 CACTTCGTGCGCAG | CGACGAGCTCCGTGAGGCCTGGCGTATTTTCACCCCACTGCTGCAC    c.1500
 H  F  V  R  S  |  D  E  L  R  E  A  W  R  I  F  T  P  L  L  H      p.500

          .         .         .         .        | 13.         .    g.20495
 CAGATTGAGCTGGAGAAGCCCAAGCCCATCCCCTATATTTATGGCAG | CCGAGGCCCCACG    c.1560
 Q  I  E  L  E  K  P  K  P  I  P  Y  I  Y  G  S  |  R  G  P  T      p.520

          .         .         .         .         .         .       g.20555
 GAGGCAGACGAGCTGATGAAGAGAGTGGGTTTCCAGTATGAGGGCACCTACAAGTGGGTG       c.1620
 E  A  D  E  L  M  K  R  V  G  F  Q  Y  E  G  T  Y  K  W  V         p.540

          .                                                         g.20573
 AACCCCCACAAGCTCTGA                                                 c.1638
 N  P  H  K  L  X                                                   p.545

          .         .         .         .         .         .       g.20633
 gccctgggcacccacctccacccccgccacggccaccctccttcccgccgcccgaccccg       c.*60

          .         .         .         .         .         .       g.20693
 agtcgggaggactccgggaccattgacctcagctgcacattcctggccccgggctctggc       c.*120

          .         .         .         .         .         .       g.20753
 caccctggcccgcccctcgctgctgctactacccgagcccagctacattcctcagctgcc       c.*180

          .         .         .         .         .         .       g.20813
 aagcactcgagaccatcctggcccctccagaccctgcctgagcccaggagctgagtcacc       c.*240

          .         .         .         .         .         .       g.20873
 tcctccactcactccagcccaacagaaggaaggaggagggcgcccattcgtctgtcccag       c.*300

          .         .         .         .         .         .       g.20933
 agcttattggccactgggtctcactcctgagtggggccagggtgggagggagggacaagg       c.*360

          .         .         .         .         .         .       g.20993
 gggaggaaaggggcgagcacccacgtgagagaatctgcctgtggccttgcccgccagcct       c.*420

          .         .         .         .         .         .       g.21053
 cagtgccacttgacattccttgtcaccagcaacatctcgagccccctggatgtcccctgt       c.*480

          .         .         .         .         .         .       g.21113
 cccaccaactctgcactccatggccaccccgtgccacccgtaggcagcctctctgctata       c.*540

          .         .         .         .         .         .       g.21173
 agaaaagcagacgcagcagctgggacccctcccaacctcaatgccctgccattaaatccg       c.*600

                                                                    g.21182
 caaacagcc                                                          c.*609

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glucose-6-phosphate dehydrogenase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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