glucose-6-phosphate dehydrogenase (G6PD) - coding DNA reference sequence

(used for variant description)

(last modified January 22, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_001042351.1 in the G6PD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009015.2, covering G6PD transcript NM_001042351.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        cgagaactcgggaagccggcgagaagtgtgaggccgcggtagggccgcatccc       c.-61

 .         .         .         .         .         .  | 02          g.6417
 gctccggagagaagtctgagtccgccaggctctgcaggcccgcggaagctcg | acagcgtc    c.-1

          .         .         .         .         .         .       g.6477
 ATGGCAGAGCAGGTGGCCCTGAGCCGGACCCAGGTGTGCGGGATCCTGCGGGAAGAGCTT       c.60
 M  A  E  Q  V  A  L  S  R  T  Q  V  C  G  I  L  R  E  E  L         p.20

          .         .         .         .         .         .       g.6537
 TTCCAGGGCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCG       c.120
 F  Q  G  D  A  F  H  Q  S  D  T  H  I  F  I  I  M  G  A  S         p.40

  | 03       .         .         .         | 04         .         . g.16549
  | GGTGACCTGGCCAAGAAGAAGATCTACCCCACCATCTG | GTGGCTGTTCCGGGATGGCCTT c.180
  | G  D  L  A  K  K  K  I  Y  P  T  I  W  |  W  L  F  R  D  G  L   p.60

          .         .         .         .         .         .       g.16609
 CTGCCCGAAAACACCTTCATCGTGGGCTATGCCCGTTCCCGCCTCACAGTGGCTGACATC       c.240
 L  P  E  N  T  F  I  V  G  Y  A  R  S  R  L  T  V  A  D  I         p.80

          .         .        | 05.         .         .         .    g.17220
 CGCAAACAGAGTGAGCCCTTCTTCAAG | GCCACCCCAGAGGAGAAGCTCAAGCTGGAGGAC    c.300
 R  K  Q  S  E  P  F  F  K   | A  T  P  E  E  K  L  K  L  E  D      p.100

          .         .         .         .         .         .       g.17280
 TTCTTTGCCCGCAACTCCTATGTGGCTGGCCAGTACGATGATGCAGCCTCCTACCAGCGC       c.360
 F  F  A  R  N  S  Y  V  A  G  Q  Y  D  D  A  A  S  Y  Q  R         p.120

          .         .         .         .         .         .       g.17340
 CTCAACAGCCACATGAATGCCCTCCACCTGGGGTCACAGGCCAACCGCCTCTTCTACCTG       c.420
 L  N  S  H  M  N  A  L  H  L  G  S  Q  A  N  R  L  F  Y  L         p.140

          .         .         .         .         .         .       g.17400
 GCCTTGCCCCCGACCGTCTACGAGGCCGTCACCAAGAACATTCACGAGTCCTGCATGAGC       c.480
 A  L  P  P  T  V  Y  E  A  V  T  K  N  I  H  E  S  C  M  S         p.160

       | 06  .         .         .         .         .         .    g.18131
 CAGAT | AGGCTGGAACCGCATCATCGTGGAGAAGCCCTTCGGGAGGGACCTGCAGAGCTCT    c.540
 Q  I  |  G  W  N  R  I  I  V  E  K  P  F  G  R  D  L  Q  S  S      p.180

          .         .         .         .         .         .       g.18191
 GACCGGCTGTCCAACCACATCTCCTCCCTGTTCCGTGAGGACCAGATCTACCGCATCGAC       c.600
 D  R  L  S  N  H  I  S  S  L  F  R  E  D  Q  I  Y  R  I  D         p.200

          .         .         .         .     | 07   .         .    g.18428
 CACTACCTGGGCAAGGAGATGGTGCAGAACCTCATGGTGCTGAG | ATTTGCCAACAGGATC    c.660
 H  Y  L  G  K  E  M  V  Q  N  L  M  V  L  R  |  F  A  N  R  I      p.220

          .         .         .         .         .         .       g.18488
 TTCGGCCCCATCTGGAACCGGGACAACATCGCCTGCGTTATCCTCACCTTCAAGGAGCCC       c.720
 F  G  P  I  W  N  R  D  N  I  A  C  V  I  L  T  F  K  E  P         p.240

          .         .         .         .         . | 08       .    g.18913
 TTTGGCACTGAGGGTCGCGGGGGCTATTTCGATGAATTTGGGATCATCCG | GGACGTGATG    c.780
 F  G  T  E  G  R  G  G  Y  F  D  E  F  G  I  I  R  |  D  V  M      p.260

          .         .         .         .         .         .       g.18973
 CAGAACCACCTACTGCAGATGCTGTGTCTGGTGGCCATGGAGAAGCCCGCCTCCACCAAC       c.840
 Q  N  H  L  L  Q  M  L  C  L  V  A  M  E  K  P  A  S  T  N         p.280

          .         .     | 09   .         .         .         .    g.19480
 TCAGATGACGTCCGTGATGAGAAG | GTCAAGGTGTTGAAATGCATCTCAGAGGTGCAGGCC    c.900
 S  D  D  V  R  D  E  K   | V  K  V  L  K  C  I  S  E  V  Q  A      p.300

          .         .         .         .         .         .       g.19540
 AACAATGTGGTCCTGGGCCAGTACGTGGGGAACCCCGATGGAGAGGGCGAGGCCACCAAA       c.960
 N  N  V  V  L  G  Q  Y  V  G  N  P  D  G  E  G  E  A  T  K         p.320

          .         .         .         .         .         .       g.19600
 GGGTACCTGGACGACCCCACGGTGCCCCGCGGGTCCACCACCGCCACTTTTGCAGCCGTC       c.1020
 G  Y  L  D  D  P  T  V  P  R  G  S  T  T  A  T  F  A  A  V         p.340

          .         .         .  | 10      .         .         .    g.19799
 GTCCTCTATGTGGAGAATGAGAGGTGGGATG | GGGTGCCCTTCATCCTGCGCTGCGGCAAG    c.1080
 V  L  Y  V  E  N  E  R  W  D  G |   V  P  F  I  L  R  C  G  K      p.360

          .         .         .         .         .         .       g.19859
 GCCCTGAACGAGCGCAAGGCCGAGGTGAGGCTGCAGTTCCATGATGTGGCCGGCGACATC       c.1140
 A  L  N  E  R  K  A  E  V  R  L  Q  F  H  D  V  A  G  D  I         p.380

          .         .         .         .         .         .       g.19919
 TTCCACCAGCAGTGCAAGCGCAACGAGCTGGTGATCCGCGTGCAGCCCAACGAGGCCGTG       c.1200
 F  H  Q  Q  C  K  R  N  E  L  V  I  R  V  Q  P  N  E  A  V         p.400

          .         .         .         .         .         .       g.19979
 TACACCAAGATGATGACCAAGAAGCCGGGCATGTTCTTCAACCCCGAGGAGTCGGAGCTG       c.1260
 Y  T  K  M  M  T  K  K  P  G  M  F  F  N  P  E  E  S  E  L         p.420

          .         .        | 11.         .         .         .    g.20143
 GACCTGACCTACGGCAACAGATACAAG | AACGTGAAGCTCCCTGACGCCTACGAGCGCCTC    c.1320
 D  L  T  Y  G  N  R  Y  K   | N  V  K  L  P  D  A  Y  E  R  L      p.440

          .         .         .         .     | 12   .         .    g.20308
 ATCCTGGACGTCTTCTGCGGGAGCCAGATGCACTTCGTGCGCAG | CGACGAGCTCCGTGAG    c.1380
 I  L  D  V  F  C  G  S  Q  M  H  F  V  R  S  |  D  E  L  R  E      p.460

          .         .         .         .         .         .       g.20368
 GCCTGGCGTATTTTCACCCCACTGCTGCACCAGATTGAGCTGGAGAAGCCCAAGCCCATC       c.1440
 A  W  R  I  F  T  P  L  L  H  Q  I  E  L  E  K  P  K  P  I         p.480

          .        | 13.         .         .         .         .    g.20525
 CCCTATATTTATGGCAG | CCGAGGCCCCACGGAGGCAGACGAGCTGATGAAGAGAGTGGGT    c.1500
 P  Y  I  Y  G  S  |  R  G  P  T  E  A  D  E  L  M  K  R  V  G      p.500

          .         .         .         .                           g.20573
 TTCCAGTATGAGGGCACCTACAAGTGGGTGAACCCCCACAAGCTCTGA                   c.1548
 F  Q  Y  E  G  T  Y  K  W  V  N  P  H  K  L  X                     p.515

          .         .         .         .         .         .       g.20633
 gccctgggcacccacctccacccccgccacggccaccctccttcccgccgcccgaccccg       c.*60

          .         .         .         .         .         .       g.20693
 agtcgggaggactccgggaccattgacctcagctgcacattcctggccccgggctctggc       c.*120

          .         .         .         .         .         .       g.20753
 caccctggcccgcccctcgctgctgctactacccgagcccagctacattcctcagctgcc       c.*180

          .         .         .         .         .         .       g.20813
 aagcactcgagaccatcctggcccctccagaccctgcctgagcccaggagctgagtcacc       c.*240

          .         .         .         .         .         .       g.20873
 tcctccactcactccagcccaacagaaggaaggaggagggcgcccattcgtctgtcccag       c.*300

          .         .         .         .         .         .       g.20933
 agcttattggccactgggtctcactcctgagtggggccagggtgggagggagggacaagg       c.*360

          .         .         .         .         .         .       g.20993
 gggaggaaaggggcgagcacccacgtgagagaatctgcctgtggccttgcccgccagcct       c.*420

          .         .         .         .         .         .       g.21053
 cagtgccacttgacattccttgtcaccagcaacatctcgagccccctggatgtcccctgt       c.*480

          .         .         .         .         .         .       g.21113
 cccaccaactctgcactccatggccaccccgtgccacccgtaggcagcctctctgctata       c.*540

          .         .         .         .         .         .       g.21173
 agaaaagcagacgcagcagctgggacccctcccaacctcaatgccctgccattaaatccg       c.*600

                                                                    g.21182
 caaacagcc                                                          c.*609

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glucose-6-phosphate dehydrogenase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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