glucosidase, alpha; acid (GAA) - coding DNA reference sequence

(used for variant description)

(last modified March 17, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000152.3 in the GAA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009822.1, covering GAA transcript NM_000152.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      acccgcc       c.-361

 .         .         .         .         .         .                g.5067
 tctgcgcgcccccgggcacgaccccggagtctccgcgggcggccagggcgcgcgtgcgcg       c.-301

 .         .         .         .         .         .                g.5127
 gaggtgagccgggccggggctgcggggcttccctgagcgcgggccgggtcggtggggcgg       c.-241

 .         .         .         .         .         .                g.5187
 tcggctgcccgcgcggcctctcagttgggaaagctgaggttgtcgccggggccgcgggtg       c.-181

 .         .         .         .         .         .                g.5247
 gaggtcggggatgaggcagcaggtaggacagtgacctcggtgacgcgaaggaccccggcc       c.-121

 .         .         .         .         .         .                g.5307
 acctctaggttctcctcgtccgcccgttgttcagcgagggaggctctgcgcgtgccgcag       c.-61

 .         .         .        | 02.         .         .             g.8031
 ctgacggggaaactgaggcacggagcgg | gcctgtaggagctgtccaggccatctccaacc    c.-1

          .         .         .         .         .         .       g.8091
 ATGGGAGTGAGGCACCCGCCCTGCTCCCACCGGCTCCTGGCCGTCTGCGCCCTCGTGTCC       c.60
 M  G  V  R  H  P  P  C  S  H  R  L  L  A  V  C  A  L  V  S         p.20

          .         .         .         .         .         .       g.8151
 TTGGCAACCGCTGCACTCCTGGGGCACATCCTACTCCATGATTTCCTGCTGGTTCCCCGA       c.120
 L  A  T  A  A  L  L  G  H  I  L  L  H  D  F  L  L  V  P  R         p.40

          .         .         .         .         .         .       g.8211
 GAGCTGAGTGGCTCCTCCCCAGTCCTGGAGGAGACTCACCCAGCTCACCAGCAGGGAGCC       c.180
 E  L  S  G  S  S  P  V  L  E  E  T  H  P  A  H  Q  Q  G  A         p.60

          .         .         .         .         .         .       g.8271
 AGCAGACCAGGGCCCCGGGATGCCCAGGCACACCCCGGCCGTCCCAGAGCAGTGCCCACA       c.240
 S  R  P  G  P  R  D  A  Q  A  H  P  G  R  P  R  A  V  P  T         p.80

          .         .         .         .         .         .       g.8331
 CAGTGCGACGTCCCCCCCAACAGCCGCTTCGATTGCGCCCCTGACAAGGCCATCACCCAG       c.300
 Q  C  D  V  P  P  N  S  R  F  D  C  A  P  D  K  A  I  T  Q         p.100

          .         .         .         .         .         .       g.8391
 GAACAGTGCGAGGCCCGCGGCTGTTGCTACATCCCTGCAAAGCAGGGGCTGCAGGGAGCC       c.360
 E  Q  C  E  A  R  G  C  C  Y  I  P  A  K  Q  G  L  Q  G  A         p.120

          .         .         .         .         .         .       g.8451
 CAGATGGGGCAGCCCTGGTGCTTCTTCCCACCCAGCTACCCCAGCTACAAGCTGGAGAAC       c.420
 Q  M  G  Q  P  W  C  F  F  P  P  S  Y  P  S  Y  K  L  E  N         p.140

          .         .         .         .         .         .       g.8511
 CTGAGCTCCTCTGAAATGGGCTACACGGCCACCCTGACCCGTACCACCCCCACCTTCTTC       c.480
 L  S  S  S  E  M  G  Y  T  A  T  L  T  R  T  T  P  T  F  F         p.160

          .         .         .         .         .         .       g.8571
 CCCAAGGACATCCTGACCCTGCGGCTGGACGTGATGATGGAGACTGAGAACCGCCTCCAC       c.540
 P  K  D  I  L  T  L  R  L  D  V  M  M  E  T  E  N  R  L  H         p.180

        | 03 .         .         .         .         .         .    g.9247
 TTCACG | ATCAAAGATCCAGCTAACAGGCGCTACGAGGTGCCCTTGGAGACCCCGCATGTC    c.600
 F  T   | I  K  D  P  A  N  R  R  Y  E  V  P  L  E  T  P  H  V      p.200

          .         .         .         .         .         .       g.9307
 CACAGCCGGGCACCGTCCCCACTCTACAGCGTGGAGTTCTCCGAGGAGCCCTTCGGGGTG       c.660
 H  S  R  A  P  S  P  L  Y  S  V  E  F  S  E  E  P  F  G  V         p.220

          .         .         .   | 04     .         .         .    g.11029
 ATCGTGCGCCGGCAGCTGGACGGCCGCGTGCT | GCTGAACACGACGGTGGCGCCCCTGTTC    c.720
 I  V  R  R  Q  L  D  G  R  V  L  |  L  N  T  T  V  A  P  L  F      p.240

          .         .         .         .         .         .       g.11089
 TTTGCGGACCAGTTCCTTCAGCTGTCCACCTCGCTGCCCTCGCAGTATATCACAGGCCTC       c.780
 F  A  D  Q  F  L  Q  L  S  T  S  L  P  S  Q  Y  I  T  G  L         p.260

          .         .         .         .         .         .       g.11149
 GCCGAGCACCTCAGTCCCCTGATGCTCAGCACCAGCTGGACCAGGATCACCCTGTGGAAC       c.840
 A  E  H  L  S  P  L  M  L  S  T  S  W  T  R  I  T  L  W  N         p.280

          .         | 05         .         .         .         .    g.11286
 CGGGACCTTGCGCCCACG | CCCGGTGCGAACCTCTACGGGTCTCACCCTTTCTACCTGGCG    c.900
 R  D  L  A  P  T   | P  G  A  N  L  Y  G  S  H  P  F  Y  L  A      p.300

          .         .         .         .         .      | 06  .    g.11739
 CTGGAGGACGGCGGGTCGGCACACGGGGTGTTCCTGCTAAACAGCAATGCCATGG | ATGTG    c.960
 L  E  D  G  G  S  A  H  G  V  F  L  L  N  S  N  A  M  D |   V      p.320

          .         .         .         .         .         .       g.11799
 GTCCTGCAGCCGAGCCCTGCCCTTAGCTGGAGGTCGACAGGTGGGATCCTGGATGTCTAC       c.1020
 V  L  Q  P  S  P  A  L  S  W  R  S  T  G  G  I  L  D  V  Y         p.340

          .         .         .         .         .      | 07  .    g.11938
 ATCTTCCTGGGCCCAGAGCCCAAGAGCGTGGTGCAGCAGTACCTGGACGTTGTGG | GATAC    c.1080
 I  F  L  G  P  E  P  K  S  V  V  Q  Q  Y  L  D  V  V  G |   Y      p.360

          .         .         .         .         .         .       g.11998
 CCGTTCATGCCGCCATACTGGGGCCTGGGCTTCCACCTGTGCCGCTGGGGCTACTCCTCC       c.1140
 P  F  M  P  P  Y  W  G  L  G  F  H  L  C  R  W  G  Y  S  S         p.380

          .         .         .         .         .     | 08   .    g.12147
 ACCGCTATCACCCGCCAGGTGGTGGAGAACATGACCAGGGCCCACTTCCCCCTG | GACGTC    c.1200
 T  A  I  T  R  Q  V  V  E  N  M  T  R  A  H  F  P  L   | D  V      p.400

          .         .         .         .         .         .       g.12207
 CAGTGGAACGACCTGGACTACATGGACTCCCGGAGGGACTTCACGTTCAACAAGGATGGC       c.1260
 Q  W  N  D  L  D  Y  M  D  S  R  R  D  F  T  F  N  K  D  G         p.420

          .         .         .         .         .         .       g.12267
 TTCCGGGACTTCCCGGCCATGGTGCAGGAGCTGCACCAGGGCGGCCGGCGCTACATGATG       c.1320
 F  R  D  F  P  A  M  V  Q  E  L  H  Q  G  G  R  R  Y  M  M         p.440

        | 09 .         .         .         .         .         .    g.13443
 ATCGTG | GATCCTGCCATCAGCAGCTCGGGCCCTGCCGGGAGCTACAGGCCCTACGACGAG    c.1380
 I  V   | D  P  A  I  S  S  S  G  P  A  G  S  Y  R  P  Y  D  E      p.460

          .         .         .         .         .        | 10.    g.14174
 GGTCTGCGGAGGGGGGTTTTCATCACCAACGAGACCGGCCAGCCGCTGATTGGGAAG | GTA    c.1440
 G  L  R  R  G  V  F  I  T  N  E  T  G  Q  P  L  I  G  K   | V      p.480

          .         .         .         .         .         .       g.14234
 TGGCCCGGGTCCACTGCCTTCCCCGACTTCACCAACCCCACAGCCCTGGCCTGGTGGGAG       c.1500
 W  P  G  S  T  A  F  P  D  F  T  N  P  T  A  L  A  W  W  E         p.500

          .         .         .         .         .  | 11      .    g.14394
 GACATGGTGGCTGAGTTCCATGACCAGGTGCCCTTCGACGGCATGTGGATT | GACATGAAC    c.1560
 D  M  V  A  E  F  H  D  Q  V  P  F  D  G  M  W  I   | D  M  N      p.520

          .         .         .         .         .         .       g.14454
 GAGCCTTCCAACTTCATCAGGGGCTCTGAGGACGGCTGCCCCAACAATGAGCTGGAGAAC       c.1620
 E  P  S  N  F  I  R  G  S  E  D  G  C  P  N  N  E  L  E  N         p.540

          .       | 12 .         .         .         .         .    g.15471
 CCACCCTACGTGCCTG | GGGTGGTTGGGGGGACCCTCCAGGCGGCCACCATCTGTGCCTCC    c.1680
 P  P  Y  V  P  G |   V  V  G  G  T  L  Q  A  A  T  I  C  A  S      p.560

          .         .         .         .         .         .       g.15531
 AGCCACCAGTTTCTCTCCACACACTACAACCTGCACAACCTCTACGGCCTGACCGAAGCC       c.1740
 S  H  Q  F  L  S  T  H  Y  N  L  H  N  L  Y  G  L  T  E  A         p.580

          .     | 13   .         .         .         .         .    g.16068
 ATCGCCTCCCACAG | GGCGCTGGTGAAGGCTCGGGGGACACGCCCATTTGTGATCTCCCGC    c.1800
 I  A  S  H  R  |  A  L  V  K  A  R  G  T  R  P  F  V  I  S  R      p.600

          .         .         .         .         .         .       g.16128
 TCGACCTTTGCTGGCCACGGCCGATACGCCGGCCACTGGACGGGGGACGTGTGGAGCTCC       c.1860
 S  T  F  A  G  H  G  R  Y  A  G  H  W  T  G  D  V  W  S  S         p.620

          .         .         | 14         .         .         .    g.16352
 TGGGAGCAGCTCGCCTCCTCCGTGCCAG | AAATCCTGCAGTTTAACCTGCTGGGGGTGCCT    c.1920
 W  E  Q  L  A  S  S  V  P  E |   I  L  Q  F  N  L  L  G  V  P      p.640

          .         .         .         .         .         .       g.16412
 CTGGTCGGGGCCGACGTCTGCGGCTTCCTGGGCAACACCTCAGAGGAGCTGTGTGTGCGC       c.1980
 L  V  G  A  D  V  C  G  F  L  G  N  T  S  E  E  L  C  V  R         p.660

          .         .         .         .         .         .       g.16472
 TGGACCCAGCTGGGGGCCTTCTACCCCTTCATGCGGAACCACAACAGCCTGCTCAGTCTG       c.2040
 W  T  Q  L  G  A  F  Y  P  F  M  R  N  H  N  S  L  L  S  L         p.680

  | 15       .         .         .         .         .         .    g.16722
  | CCCCAGGAGCCGTACAGCTTCAGCGAGCCGGCCCAGCAGGCCATGAGGAAGGCCCTCACC    c.2100
  | P  Q  E  P  Y  S  F  S  E  P  A  Q  Q  A  M  R  K  A  L  T      p.700

          .         .         .         .         .         .       g.16782
 CTGCGCTACGCACTCCTCCCCCACCTCTACACACTGTTCCACCAGGCCCACGTCGCGGGG       c.2160
 L  R  Y  A  L  L  P  H  L  Y  T  L  F  H  Q  A  H  V  A  G         p.720

          .         .          | 16        .         .         .    g.20443
 GAGACCGTGGCCCGGCCCCTCTTCCTGGA | GTTCCCCAAGGACTCTAGCACCTGGACTGTG    c.2220
 E  T  V  A  R  P  L  F  L  E  |  F  P  K  D  S  S  T  W  T  V      p.740

          .         .         .         .         .         .       g.20503
 GACCACCAGCTCCTGTGGGGGGAGGCCCTGCTCATCACCCCAGTGCTCCAGGCCGGGAAG       c.2280
 D  H  Q  L  L  W  G  E  A  L  L  I  T  P  V  L  Q  A  G  K         p.760

          .         .         .         .         .  | 17      .    g.21053
 GCCGAAGTGACTGGCTACTTCCCCTTGGGCACATGGTACGACCTGCAGACG | GTGCCAGTA    c.2340
 A  E  V  T  G  Y  F  P  L  G  T  W  Y  D  L  Q  T   | V  P  V      p.780

          .         .         .         .         .         .       g.21113
 GAGGCCCTTGGCAGCCTCCCACCCCCACCTGCAGCTCCCCGTGAGCCAGCCATCCACAGC       c.2400
 E  A  L  G  S  L  P  P  P  P  A  A  P  R  E  P  A  I  H  S         p.800

          .         .         .         .         .         .       g.21173
 GAGGGGCAGTGGGTGACGCTGCCGGCCCCCCTGGACACCATCAACGTCCACCTCCGGGCT       c.2460
 E  G  Q  W  V  T  L  P  A  P  L  D  T  I  N  V  H  L  R  A         p.820

          .         .  | 18      .         .         .         .    g.21676
 GGGTACATCATCCCCCTGCAG | GGCCCTGGCCTCACAACCACAGAGTCCCGCCAGCAGCCC    c.2520
 G  Y  I  I  P  L  Q   | G  P  G  L  T  T  T  E  S  R  Q  Q  P      p.840

          .         .         .         .         .         .       g.21736
 ATGGCCCTGGCTGTGGCCCTGACCAAGGGTGGGGAGGCCCGAGGGGAGCTGTTCTGGGAC       c.2580
 M  A  L  A  V  A  L  T  K  G  G  E  A  R  G  E  L  F  W  D         p.860

          .         .         .         .         .         .       g.21796
 GATGGAGAGAGCCTGGAAGTGCTGGAGCGAGGGGCCTACACACAGGTCATCTTCCTGGCC       c.2640
 D  G  E  S  L  E  V  L  E  R  G  A  Y  T  Q  V  I  F  L  A         p.880

        | 19 .         .         .         .         .         .    g.22151
 AGGAAT | AACACGATCGTGAATGAGCTGGTACGTGTGACCAGTGAGGGAGCTGGCCTGCAG    c.2700
 R  N   | N  T  I  V  N  E  L  V  R  V  T  S  E  G  A  G  L  Q      p.900

          .         .         .         .         .         .       g.22211
 CTGCAGAAGGTGACTGTCCTGGGCGTGGCCACGGCGCCCCAGCAGGTCCTCTCCAACGGT       c.2760
 L  Q  K  V  T  V  L  G  V  A  T  A  P  Q  Q  V  L  S  N  G         p.920

          .         .         .          | 20        .         .    g.22737
 GTCCCTGTCTCCAACTTCACCTACAGCCCCGACACCAAG | GTCCTGGACATCTGTGTCTCG    c.2820
 V  P  V  S  N  F  T  Y  S  P  D  T  K   | V  L  D  I  C  V  S      p.940

          .         .         .                                     g.22776
 CTGTTGATGGGAGAGCAGTTTCTCGTCAGCTGGTGTTAG                            c.2859
 L  L  M  G  E  Q  F  L  V  S  W  C  X                              p.952

          .         .         .         .         .         .       g.22836
 ccgggcggagtgtgttagtctctccagagggaggctggttccccagggaagcagagcctg       c.*60

          .         .         .         .         .         .       g.22896
 tgtgcgggcagcagctgtgtgcgggcctgggggttgcatgtgtcacctggagctgggcac       c.*120

          .         .         .         .         .         .       g.22956
 taaccattccaagccgccgcatcgcttgtttccacctcctgggccggggctctggccccc       c.*180

          .         .         .         .         .         .       g.23016
 aacgtgtctaggagagctttctccctagatcgcactgtgggccggggccctggagggctg       c.*240

          .         .         .         .         .         .       g.23076
 ctctgtgttaataagattgtaaggtttgccctcctcacctgttgccggcatgcgggtagt       c.*300

          .         .         .         .         .         .       g.23136
 attagccacccccctccatctgttcccagcaccggagaagggggtgctcaggtggaggtg       c.*360

          .         .         .         .         .         .       g.23196
 tggggtatgcacctgagctcctgcttcgcgcctgctgctctgccccaacgcgaccgctgc       c.*420

          .         .         .         .         .         .       g.23256
 ccggctgcccagagggctggatgcctgccggtccccgagcaagcctgggaactcaggaaa       c.*480

          .         .         .         .         .         .       g.23316
 attcacaggacttgggagattctaaatcttaagtgcaattatttttaataaaaggggcat       c.*540

                                                                    g.23325
 ttggaatca                                                          c.*549

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glucosidase, alpha; acid protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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