gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1) - coding DNA reference sequence

(used for variant description)

(last modified September 18, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_001470.2 in the GABBR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering GABBR1 transcript NM_001470.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         ccctctcttccccccgccctgccttcccttgcaccc       c.-301

 .         .         .         .         .         .                g.5096
 tccttcttccctccgcccgggagctctccctggtccccggcgccgcctccttccctcccg       c.-241

 .         .         .         .         .         .                g.5156
 gctccccgctccccgctcccgtggctgccgccgccccggggaagaagagacaggggtggg       c.-181

 .         .         .         .         .         .                g.5216
 gtttgggggaagcgagagaggaggggagagaccctggccaggctggagcctggattcgag       c.-121

 .         .         .         .         .         .                g.5276
 gggaggagggacgggaggaggagaaaggtggaggagaagggaggggggagcggggaggag       c.-61

 .         .         .         .         .         .                g.5336
 cggccgggcctggggccttgaggcccggggagagccggggagccgggcccgcgcgccgag       c.-1

  | 02       .         .         .         .         .         .    g.5860
  | ATGTTGCTGCTGCTGCTACTGGCGCCACTCTTCCTCCGCCCCCCGGGCGCGGGCGGGGCG    c.60
  | M  L  L  L  L  L  L  A  P  L  F  L  R  P  P  G  A  G  G  A      p.20

          .         .      | 03  .         .         .         .    g.6621
 CAGACCCCCAACGCCACCTCAGAAG | GTTGCCAGATCATACACCCGCCCTGGGAAGGGGGC    c.120
 Q  T  P  N  A  T  S  E  G |   C  Q  I  I  H  P  P  W  E  G  G      p.40

          .         .         .         .         .         .       g.6681
 ATCAGGTACCGGGGCCTGACTCGGGACCAGGTGAAGGCTATCAACTTCCTGCCAGTGGAC       c.180
 I  R  Y  R  G  L  T  R  D  Q  V  K  A  I  N  F  L  P  V  D         p.60

          .         .         .         .         .         .       g.6741
 TATGAGATTGAGTATGTGTGCCGGGGGGAGCGCGAGGTGGTGGGGCCCAAGGTCCGCAAG       c.240
 Y  E  I  E  Y  V  C  R  G  E  R  E  V  V  G  P  K  V  R  K         p.80

          .         .         .         .          | 04        .    g.7553
 TGCCTGGCCAACGGCTCCTGGACAGATATGGACACACCCAGCCGCTGTG | TCCGAATCTGC    c.300
 C  L  A  N  G  S  W  T  D  M  D  T  P  S  R  C  V |   R  I  C      p.100

          .         .         .         .         .         .       g.7613
 TCCAAGTCTTATTTGACCCTGGAAAATGGGAAGGTTTTCCTGACGGGTGGGGACCTCCCA       c.360
 S  K  S  Y  L  T  L  E  N  G  K  V  F  L  T  G  G  D  L  P         p.120

          .         .         .         .         .         .       g.7673
 GCTCTGGACGGAGCCCGGGTGGATTTCCGGTGTGACCCCGACTTCCATCTGGTGGGCAGC       c.420
 A  L  D  G  A  R  V  D  F  R  C  D  P  D  F  H  L  V  G  S         p.140

          .         .         .         .         .      | 05  .    g.9083
 TCCCGGAGCATCTGTAGTCAGGGCCAGTGGAGCACCCCCAAGCCCCACTGCCAGG | TGAAT    c.480
 S  R  S  I  C  S  Q  G  Q  W  S  T  P  K  P  H  C  Q  V |   N      p.160

          .       | 06 .         .         .         .         .    g.10583
 CGAACGCCACACTCAG | AACGGCGCGCAGTGTACATCGGGGCACTGTTTCCCATGAGCGGG    c.540
 R  T  P  H  S  E |   R  R  A  V  Y  I  G  A  L  F  P  M  S  G      p.180

          .         .         .         .         .         .       g.10643
 GGCTGGCCAGGGGGCCAGGCCTGCCAGCCCGCGGTGGAGATGGCGCTGGAGGACGTGAAT       c.600
 G  W  P  G  G  Q  A  C  Q  P  A  V  E  M  A  L  E  D  V  N         p.200

          .         .         .         .         .        | 07.    g.14164
 AGCCGCAGGGACATCCTGCCGGACTATGAGCTCAAGCTCATCCACCACGACAGCAAG | TGT    c.660
 S  R  R  D  I  L  P  D  Y  E  L  K  L  I  H  H  D  S  K   | C      p.220

          .         .         .         .         .         .       g.14224
 GATCCAGGCCAAGCCACCAAGTACCTATATGAGCTGCTCTACAACGACCCTATCAAGATC       c.720
 D  P  G  Q  A  T  K  Y  L  Y  E  L  L  Y  N  D  P  I  K  I         p.240

          .         .         .         .         .         .       g.14284
 ATCCTTATGCCTGGCTGCAGCTCTGTCTCCACGCTGGTGGCTGAGGCTGCTAGGATGTGG       c.780
 I  L  M  P  G  C  S  S  V  S  T  L  V  A  E  A  A  R  M  W         p.260

          .   | 08     .         .         .         .         .    g.14758
 AACCTCATTGTG | CTTTCCTATGGCTCCAGCTCACCAGCCCTGTCAAACCGGCAGCGTTTC    c.840
 N  L  I  V   | L  S  Y  G  S  S  S  P  A  L  S  N  R  Q  R  F      p.280

          .         .         .         .         .         .       g.14818
 CCCACTTTCTTCCGAACGCACCCATCAGCCACACTCCACAACCCTACCCGCGTGAAACTC       c.900
 P  T  F  F  R  T  H  P  S  A  T  L  H  N  P  T  R  V  K  L         p.300

          .         .         .         .         .         .       g.14878
 TTTGAAAAGTGGGGCTGGAAGAAGATTGCTACCATCCAGCAGACCACTGAGGTCTTCACT       c.960
 F  E  K  W  G  W  K  K  I  A  T  I  Q  Q  T  T  E  V  F  T         p.320

     | 09    .         .         .         .         .         .    g.16037
 TCG | ACTCTGGACGACCTGGAGGAACGAGTGAAGGAGGCTGGAATTGAGATTACTTTCCGC    c.1020
 S   | T  L  D  D  L  E  E  R  V  K  E  A  G  I  E  I  T  F  R      p.340

          .         .         .         .      | 10  .         .    g.16383
 CAGAGTTTCTTCTCAGATCCAGCTGTGCCCGTCAAAAACCTGAAG | CGCCAGGATGCCCGA    c.1080
 Q  S  F  F  S  D  P  A  V  P  V  K  N  L  K   | R  Q  D  A  R      p.360

          .         .         .         .         .  | 11      .    g.16902
 ATCATCGTGGGACTTTTCTATGAGACTGAAGCCCGGAAAGTTTTTTGTGAG | GTGTACAAG    c.1140
 I  I  V  G  L  F  Y  E  T  E  A  R  K  V  F  C  E   | V  Y  K      p.380

          .         .         .         .         .         .       g.16962
 GAGCGTCTCTTTGGGAAGAAGTACGTCTGGTTCCTCATTGGGTGGTATGCTGACAATTGG       c.1200
 E  R  L  F  G  K  K  Y  V  W  F  L  I  G  W  Y  A  D  N  W         p.400

          .         .         .         .         .         .       g.17022
 TTCAAGATCTACGACCCTTCTATCAACTGCACAGTGGATGAGATGACTGAGGCGGTGGAG       c.1260
 F  K  I  Y  D  P  S  I  N  C  T  V  D  E  M  T  E  A  V  E         p.420

          .         .         .         .         .         .       g.17082
 GGCCACATCACAACTGAGATTGTCATGCTGAATCCTGCCAATACCCGCAGCATTTCCAAC       c.1320
 G  H  I  T  T  E  I  V  M  L  N  P  A  N  T  R  S  I  S  N         p.440

     | 12    .         .         .         .         .         .    g.24757
 ATG | ACATCCCAGGAATTTGTGGAGAAACTAACCAAGCGACTGAAAAGACACCCTGAGGAG    c.1380
 M   | T  S  Q  E  F  V  E  K  L  T  K  R  L  K  R  H  P  E  E      p.460

          .         .         .         .         .         .       g.24817
 ACAGGAGGCTTCCAGGAGGCACCGCTGGCCTATGATGCCATCTGGGCCTTGGCACTGGCC       c.1440
 T  G  G  F  Q  E  A  P  L  A  Y  D  A  I  W  A  L  A  L  A         p.480

          .         .         .         .         .         .       g.24877
 CTGAACAAGACATCTGGAGGAGGCGGCCGTTCTGGTGTGCGCCTGGAGGACTTCAACTAC       c.1500
 L  N  K  T  S  G  G  G  G  R  S  G  V  R  L  E  D  F  N  Y         p.500

          .         .         .         .         .         .       g.24937
 AACAACCAGACCATTACCGACCAAATCTACCGGGCAATGAACTCTTCGTCCTTTGAGGGT       c.1560
 N  N  Q  T  I  T  D  Q  I  Y  R  A  M  N  S  S  S  F  E  G         p.520

        | 13 .         .         .         .         .         .    g.25625
 GTCTCT | GGCCATGTGGTGTTTGATGCCAGCGGCTCTCGGATGGCATGGACGCTTATCGAG    c.1620
 V  S   | G  H  V  V  F  D  A  S  G  S  R  M  A  W  T  L  I  E      p.540

          . | 14       .         .         .         .         .    g.27234
 CAGCTTCAGG | GTGGCAGCTACAAGAAGATTGGCTACTATGACAGCACCAAGGATGATCTT    c.1680
 Q  L  Q  G |   G  S  Y  K  K  I  G  Y  Y  D  S  T  K  D  D  L      p.560

          .         .         | 15         .         .         .    g.28838
 TCCTGGTCCAAAACAGATAAATGGATTG | GAGGGTCCCCCCCAGCTGACCAGACCCTGGTC    c.1740
 S  W  S  K  T  D  K  W  I  G |   G  S  P  P  A  D  Q  T  L  V      p.580

          .         .         .         .         .         .       g.28898
 ATCAAGACATTCCGCTTCCTGTCACAGAAACTCTTTATCTCCGTCTCAGTTCTCTCCAGC       c.1800
 I  K  T  F  R  F  L  S  Q  K  L  F  I  S  V  S  V  L  S  S         p.600

          .         .         .         .         .          | 16    g.29453
 CTGGGCATTGTCCTAGCTGTTGTCTGTCTGTCCTTTAACATCTACAACTCACATGTCCG | T    c.1860
 L  G  I  V  L  A  V  V  C  L  S  F  N  I  Y  N  S  H  V  R  |      p.620

          .         .         .         .         .         .       g.29513
 TATATCCAGAACTCACAGCCCAACCTGAACAACCTGACTGCTGTGGGCTGCTCACTGGCT       c.1920
 Y  I  Q  N  S  Q  P  N  L  N  N  L  T  A  V  G  C  S  L  A         p.640

          .         .         .         .         .         .       g.29573
 TTAGCTGCTGTCTTCCCCCTGGGGCTCGATGGTTACCACATTGGGAGGAACCAGTTTCCT       c.1980
 L  A  A  V  F  P  L  G  L  D  G  Y  H  I  G  R  N  Q  F  P         p.660

          .   | 17     .         .         .         .         .    g.31015
 TTCGTCTGCCAG | GCCCGCCTCTGGCTCCTGGGCCTGGGCTTTAGTCTGGGCTACGGTTCC    c.2040
 F  V  C  Q   | A  R  L  W  L  L  G  L  G  F  S  L  G  Y  G  S      p.680

          .         .         .         .         .         .       g.31075
 ATGTTCACCAAGATTTGGTGGGTCCACACGGTCTTCACAAAGAAGGAAGAAAAGAAGGAG       c.2100
 M  F  T  K  I  W  W  V  H  T  V  F  T  K  K  E  E  K  K  E         p.700

           | 18        .         .         .         .         .    g.31232
 TGGAGGAAG | ACTCTGGAACCCTGGAAGCTGTATGCCACAGTGGGCCTGCTGGTGGGCATG    c.2160
 W  R  K   | T  L  E  P  W  K  L  Y  A  T  V  G  L  L  V  G  M      p.720

          .         .         .         .         .        | 19.    g.31704
 GATGTCCTCACTCTCGCCATCTGGCAGATCGTGGACCCTCTGCACCGGACCATTGAG | ACA    c.2220
 D  V  L  T  L  A  I  W  Q  I  V  D  P  L  H  R  T  I  E   | T      p.740

          .         .         .         .         .         .       g.31764
 TTTGCCAAGGAGGAACCTAAGGAAGATATTGACGTCTCTATTCTGCCCCAGCTGGAGCAT       c.2280
 F  A  K  E  E  P  K  E  D  I  D  V  S  I  L  P  Q  L  E  H         p.760

          .         .         .  | 20      .         .         .    g.32518
 TGCAGCTCCAGGAAGATGAATACATGGCTTG | GCATTTTCTATGGTTACAAGGGGCTGCTG    c.2340
 C  S  S  R  K  M  N  T  W  L  G |   I  F  Y  G  Y  K  G  L  L      p.780

          .         .         .         .         .         .       g.32578
 CTGCTGCTGGGAATCTTCCTTGCTTATGAGACCAAGAGTGTGTCCACTGAGAAGATCAAT       c.2400
 L  L  L  G  I  F  L  A  Y  E  T  K  S  V  S  T  E  K  I  N         p.800

          .         .         .          | 21        .         .    g.33218
 GATCACCGGGCTGTGGGCATGGCTATCTACAATGTGGCA | GTCCTGTGCCTCATCACTGCT    c.2460
 D  H  R  A  V  G  M  A  I  Y  N  V  A   | V  L  C  L  I  T  A      p.820

          .         .         .         .         .         .       g.33278
 CCTGTCACCATGATTCTGTCCAGCCAGCAGGATGCAGCCTTTGCCTTTGCCTCTCTTGCC       c.2520
 P  V  T  M  I  L  S  S  Q  Q  D  A  A  F  A  F  A  S  L  A         p.840

          .         .         .         .         | 22         .    g.33560
 ATAGTTTTCTCCTCCTATATCACTCTTGTTGTGCTCTTTGTGCCCAAG | ATGCGCAGGCTG    c.2580
 I  V  F  S  S  Y  I  T  L  V  V  L  F  V  P  K   | M  R  R  L      p.860

          .         .         .         .         .         .       g.33620
 ATCACCCGAGGGGAATGGCAGTCGGAGGCGCAGGACACCATGAAGACAGGGTCATCGACC       c.2640
 I  T  R  G  E  W  Q  S  E  A  Q  D  T  M  K  T  G  S  S  T         p.880

          .         .         .         .         .         .       g.33680
 AACAACAACGAGGAGGAGAAGTCCCGGCTGTTGGAGAAGGAGAACCGTGAACTGGAAAAG       c.2700
 N  N  N  E  E  E  K  S  R  L  L  E  K  E  N  R  E  L  E  K         p.900

          .   | 23     .         .         .         .         .    g.34517
 ATCATTGCTGAG | AAAGAGGAGCGTGTCTCTGAACTGCGCCATCAACTCCAGTCTCGGCAG    c.2760
 I  I  A  E   | K  E  E  R  V  S  E  L  R  H  Q  L  Q  S  R  Q      p.920

          .         .         .         .         .         .       g.34577
 CAGCTCCGCTCCCGGCGCCACCCACCGACACCCCCAGAACCCTCTGGGGGCCTGCCCAGG       c.2820
 Q  L  R  S  R  R  H  P  P  T  P  P  E  P  S  G  G  L  P  R         p.940

          .         .         .         .         .         .       g.34637
 GGACCCCCTGAGCCCCCCGACCGGCTTAGCTGTGATGGGAGTCGAGTGCATTTGCTTTAT       c.2880
 G  P  P  E  P  P  D  R  L  S  C  D  G  S  R  V  H  L  L  Y         p.960

                                                                    g.34643
 AAGTGA                                                             c.2886
 K  X                                                               p.961

          .         .         .         .         .         .       g.34703
 gggtagggtgagggaggacaggccagtagggggagggaaagggagaggggaagggcaggg       c.*60

          .         .         .         .         .         .       g.34763
 gactcaggaagcagggggtccccatccccagctgggaagaacatgctatccaatctcatc       c.*120

          .         .         .         .         .         .       g.34823
 tcttgtaaatacatgtccccctgtgagttctgggctgatttgggtctctcatacctctgg       c.*180

          .         .         .         .         .         .       g.34883
 gaaacagacctttttctctcttactgcttcatgtaattttgtatcacctcttcacaattt       c.*240

          .         .         .         .         .         .       g.34943
 agttcgtacctggcttgaagctgctcactgctcacacgctgcctcctcagcagcctcact       c.*300

          .         .         .         .         .         .       g.35003
 gcatctttctcttcccatgcaacaccctcttctagttaccacggcaacccctgcagctcc       c.*360

          .         .         .         .         .         .       g.35063
 tctgcctttgtgctctgttcctgtccagcaggggtctcccaacaagtgctctttccaccc       c.*420

          .         .         .         .         .         .       g.35123
 caaaggggcctctccttttctccactgtcataatctctttccatcttacttgcccttcta       c.*480

          .         .         .         .         .         .       g.35183
 tactttctcacatgtggctccccctgaattttgcttcctttgggagctcattcttttcgc       c.*540

          .         .         .         .         .         .       g.35243
 caaggctcacatgctccttgcctctgctctgtgcactcacgctcagcacacatgcatcct       c.*600

          .         .         .         .         .         .       g.35303
 cccctctcctgcgtgtgcccactgaacatgctcatgtgtacacacgcttttcccgtatgc       c.*660

          .         .         .         .         .         .       g.35363
 tttcttcatgttcagtcacatgtgctctcgggtgccctgcattcacagctacgtgtgccc       c.*720

          .         .         .         .         .         .       g.35423
 ctctcatggtcatgggtctgcccttgagcgtgtttgggtaggcatgtgcaatttgtctag       c.*780

          .         .         .         .         .         .       g.35483
 catgctgagtcatgtctttcctatttgcacacgtccatgtttatccatgtactttccctg       c.*840

          .         .         .         .         .         .       g.35543
 tgtaccctccatgtaccttgtgtactttcttcccttaaatcatggtattcttctgacaga       c.*900

          .         .         .         .         .         .       g.35603
 gccatatgtaccctaccctgcacattgttatgcacttttccccaattcatgtttggtggg       c.*960

          .         .         .         .         .         .       g.35663
 gccatccacaccctctccttgtcacagaatctccatttctgctcagattccccccatctc       c.*1020

          .         .         .         .         .         .       g.35723
 cattgcattcatgtactaccctcagtctacactcacaatcatcttctcccaagactgctc       c.*1080

          .         .         .         .         .         .       g.35783
 ccttttgttttgtgtttttttgaggggaattaaggaaaaataagtgggggcaggtttgga       c.*1140

          .         .         .         .         .         .       g.35843
 gagctgcttccagtggatagttgatgagaatcctgaccaaaggaaggcacccttgactgt       c.*1200

          .         .         .         .         .         .       g.35903
 tgggatagacagatggacctatggggtgggaggtggtgtccctttcacactgtggtgtct       c.*1260

          .         .         .         .         .                 g.35958
 cttggggaaggatctccccgaatctcaataaaccagtgaacagtgtgactcggca            c.*1315

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Gamma-aminobutyric acid (GABA) B receptor, 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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