glutamate decarboxylase 1 (brain, 67kDa) (GAD1) - coding DNA reference sequence

(used for variant description)

(last modified December 5, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_000817.2 in the GAD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering GAD1 transcript NM_000817.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5002
                                                           gc       c.-421

 .         .         .         .         .         .                g.5062
 aaaaccgtgagctggatttataatcgccctataaagctccagaggcggtcaggcacctgc       c.-361

 .         .         .         .         .         .                g.5122
 agaggagccccgccgctccgccgactagctgcccccgcgagcaacggcctcgtgatttcc       c.-301

 .         .         .         .         .         .                g.5182
 ccgccgatccggtccccgcctccccactctgcccccgcctaccccggagccgtgcagccg       c.-241

 .         .         .         .         .         .                g.5242
 cctctccgaatctctctcttctcctggcgctcgcgtgcgagagggaactagcgagaacga       c.-181

 .         .         .         .         .         .                g.5302
 ggaagcagctggaggtgacgccgggcagattacgcctgtcagggccgagccgagcggatc       c.-121

 .         .         .         .         .         .       | 02     g.6842
 gctgggcgctgtgcagaggaaaggcgggagtgcccggctcgctgtcgcagagccgag | cct    c.-61

 .         .         .         .         .         .                g.6902
 gtttctgcgccggaccagtcgaggactctggacagtagaggccccgggacgaccgagctg       c.-1

          .         .         .         .         .         .       g.6962
 ATGGCGTCTTCGACCCCATCTTCGTCCGCAACCTCCTCGAACGCGGGAGCGGACCCCAAT       c.60
 M  A  S  S  T  P  S  S  S  A  T  S  S  N  A  G  A  D  P  N         p.20

          .         .   | 03     .         .         .         .    g.10435
 ACCACTAACCTGCGCCCCACAA | CGTACGATACCTGGTGCGGCGTGGCCCATGGATGCACC    c.120
 T  T  N  L  R  P  T  T |   Y  D  T  W  C  G  V  A  H  G  C  T      p.40

          .         .      | 04  .         .         .         .    g.17820
 AGAAAACTGGGGCTCAAGATCTGCG | GCTTCTTGCAAAGGACCAACAGCCTGGAAGAGAAG    c.180
 R  K  L  G  L  K  I  C  G |   F  L  Q  R  T  N  S  L  E  E  K      p.60

          .         .         .         .         .         .       g.17880
 AGTCGCCTTGTGAGTGCCTTCAAGGAGAGGCAATCCTCCAAGAACCTGCTTTCCTGTGAA       c.240
 S  R  L  V  S  A  F  K  E  R  Q  S  S  K  N  L  L  S  C  E         p.80

          .         .         .         .         .         .       g.17940
 AACAGCGACCGGGATGCCCGCTTCCGGCGCACAGAGACTGACTTCTCTAATCTGTTTGCT       c.300
 N  S  D  R  D  A  R  F  R  R  T  E  T  D  F  S  N  L  F  A         p.100

      | 05   .         .         .         .         .         .    g.19316
 AGAG | ATCTGCTTCCGGCTAAGAACGGTGAGGAGCAAACCGTGCAATTCCTCCTGGAAGTG    c.360
 R  D |   L  L  P  A  K  N  G  E  E  Q  T  V  Q  F  L  L  E  V      p.120

          .         .         .         .         .         .       g.19376
 GTGGACATACTCCTCAACTATGTCCGCAAGACATTTGATCGCTCCACCAAGGTGCTGGAC       c.420
 V  D  I  L  L  N  Y  V  R  K  T  F  D  R  S  T  K  V  L  D         p.140

          .         .         .         .         .         .       g.19436
 TTTCATCACCCACACCAGTTGCTGGAAGGCATGGAGGGCTTCAACTTGGAGCTCTCTGAC       c.480
 F  H  H  P  H  Q  L  L  E  G  M  E  G  F  N  L  E  L  S  D         p.160

          .         .         .         .         .         .       g.19496
 CACCCCGAGTCCCTGGAGCAGATCCTGGTTGACTGCAGAGACACCTTGAAGTATGGGGTT       c.540
 H  P  E  S  L  E  Q  I  L  V  D  C  R  D  T  L  K  Y  G  V         p.180

         | 06.         .         .         .         .         .    g.25156
 CGCACAG | GTCATCCTCGATTTTTCAACCAGCTCTCCACTGGATTGGATATTATTGGCCTA    c.600
 R  T  G |   H  P  R  F  F  N  Q  L  S  T  G  L  D  I  I  G  L      p.200

          .         .         .         | 07         .         .    g.32377
 GCTGGAGAATGGCTGACATCAACGGCCAATACCAACAT | GTTTACATATGAAATTGCACCA    c.660
 A  G  E  W  L  T  S  T  A  N  T  N  M  |  F  T  Y  E  I  A  P      p.220

          .         .         .         .         .         .       g.32437
 GTGTTTGTCCTCATGGAACAAATAACACTTAAGAAGATGAGAGAGATAGTTGGATGGTCA       c.720
 V  F  V  L  M  E  Q  I  T  L  K  K  M  R  E  I  V  G  W  S         p.240

          .         .         .  | 08      .         .         .    g.33845
 AGTAAAGATGGTGATGGGATATTTTCTCCTG | GGGGCGCCATATCCAACATGTACAGCATC    c.780
 S  K  D  G  D  G  I  F  S  P  G |   G  A  I  S  N  M  Y  S  I      p.260

          .         .         .         .         .         .       g.33905
 ATGGCTGCTCGCTACAAGTACTTCCCGGAAGTTAAGACAAAGGGCATGGCGGCTGTGCCT       c.840
 M  A  A  R  Y  K  Y  F  P  E  V  K  T  K  G  M  A  A  V  P         p.280

          .         .        | 09.         .         .         .    g.34049
 AAACTGGTCCTCTTCACCTCAGAACAG | AGTCACTATTCCATAAAGAAAGCTGGGGCTGCA    c.900
 K  L  V  L  F  T  S  E  Q   | S  H  Y  S  I  K  K  A  G  A  A      p.300

          .         .         .         .        | 10.         .    g.34332
 CTTGGCTTTGGAACTGACAATGTGATTTTGATAAAGTGCAATGAAAG | GGGGAAAATAATT    c.960
 L  G  F  G  T  D  N  V  I  L  I  K  C  N  E  R  |  G  K  I  I      p.320

          .         .         .         .   | 11     .         .    g.36004
 CCAGCTGATTTTGAGGCAAAAATTCTTGAAGCCAAACAGAAG | GGATATGTTCCCTTTTAT    c.1020
 P  A  D  F  E  A  K  I  L  E  A  K  Q  K   | G  Y  V  P  F  Y      p.340

          .         .         .         .         .         .       g.36064
 GTCAATGCAACTGCTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCA       c.1080
 V  N  A  T  A  G  T  T  V  Y  G  A  F  D  P  I  Q  E  I  A         p.360

          .         .         .          | 12        .         .    g.37617
 GATATATGTGAGAAATATAACCTTTGGTTGCATGTCGAT | GCTGCCTGGGGAGGTGGGCTG    c.1140
 D  I  C  E  K  Y  N  L  W  L  H  V  D   | A  A  W  G  G  G  L      p.380

          .         .         .         .     | 13   .         .    g.41040
 CTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAG | GGCCAACTCAGTCACC    c.1200
 L  M  S  R  K  H  R  H  K  L  N  G  I  E  R  |  A  N  S  V  T      p.400

          .         .         .         .         .         .       g.41100
 TGGAACCCTCACAAGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAA       c.1260
 W  N  P  H  K  M  M  G  V  L  L  Q  C  S  A  I  L  V  K  E         p.420

     | 14    .         .         .         .         .         .    g.42240
 AAG | GGTATACTCCAAGGATGCAACCAGATGTGTGCAGGATACCTCTTCCAGCCAGACAAG    c.1320
 K   | G  I  L  Q  G  C  N  Q  M  C  A  G  Y  L  F  Q  P  D  K      p.440

          .         .         .         .         .         .       g.42300
 CAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTGTGGCCGCCACGTGGAT       c.1380
 Q  Y  D  V  S  Y  D  T  G  D  K  A  I  Q  C  G  R  H  V  D         p.460

          .         .         .    | 15    .         .         .    g.45355
 ATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAG | GGCACAGTGGGATTTGAAAACCAGATC    c.1440
 I  F  K  F  W  L  M  W  K  A  K   | G  T  V  G  F  E  N  Q  I      p.480

          .         .         .         .         .         .       g.45415
 AACAAATGCCTGGAACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTT       c.1500
 N  K  C  L  E  L  A  E  Y  L  Y  A  K  I  K  N  R  E  E  F         p.500

          .         .  | 16      .         .         .         .    g.47153
 GAGATGGTTTTCAATGGCGAG | CCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAA    c.1560
 E  M  V  F  N  G  E   | P  E  H  T  N  V  C  F  W  Y  I  P  Q      p.520

          .         .         .         .         .  | 17      .    g.48028
 AGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAG | GTGGCTCCA    c.1620
 S  L  R  G  V  P  D  S  P  Q  R  R  E  K  L  H  K   | V  A  P      p.540

          .         .         .         .         .         .       g.48088
 AAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGG       c.1680
 K  I  K  A  L  M  M  E  S  G  T  T  M  V  G  Y  Q  P  Q  G         p.560

          .         .         .         .         .         .       g.48148
 GACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATT       c.1740
 D  K  A  N  F  F  R  M  V  I  S  N  P  A  A  T  Q  S  D  I         p.580

          .         .         .         .                           g.48193
 GACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAA                      c.1785
 D  F  L  I  E  E  I  E  R  L  G  Q  D  L  X                        p.594

          .         .         .         .         .         .       g.48253
 tcatccttcgcagaacatgagtttatgggaatgccttttccctctggcactccagaacaa       c.*60

          .         .         .         .         .         .       g.48313
 acctctatatgttgctgaaacacacaggccatttcattgagggaaaacataatatcttga       c.*120

          .         .         .         .         .         .       g.48373
 agaatattgttaaaaccttacttaaagcttgtttgttctagttagcaggaaatagtgttc       c.*180

          .         .         .         .         .         .       g.48433
 tttttaaaaagttgcacattaggaacagagtatatatgtacagttatacatacctctctc       c.*240

          .         .         .         .         .         .       g.48493
 tatatatacatgtatagtgagtgtggcttagtaatagatcacggcatgtttcccgctcca       c.*300

          .         .         .         .         .         .       g.48553
 agagaattcactttaccttcagcagttaccgaggagctaaacatgctgccaaccagcttg       c.*360

          .         .         .         .         .         .       g.48613
 tccaacaactccaggaaaactgtttttcaaaacgccatgtcctaggggccgagggaaatg       c.*420

          .         .         .         .         .         .       g.48673
 ctgttggtgagaatcgacctcactgtcagcgtttctccacctgaagtgatgatggatgag       c.*480

          .         .         .         .         .         .       g.48733
 aaaaaacaccaccaaatgacaagtcacaccctccccattagtatcctgttaggggaaaat       c.*540

          .         .         .         .         .         .       g.48793
 agtagcagagtcattgttacaggtgtactatggctgtatttttagagattaatttgtgta       c.*600

          .         .         .         .         .         .       g.48853
 gattgtgtaaattcctgttgtctgaccttggtggtgggagggggagactatgtgtcatga       c.*660

          .         .         .         .         .         .       g.48913
 tttcaatgattgtttaattgtaggtcaatgaaatatttgcttatttatattcagagatgt       c.*720

          .         .         .         .         .         .       g.48973
 accatgttaaagaggcgtcttgtattttcttcccatttgtaatgtatcttatttatatat       c.*780

          .         .         .         .         .         .       g.49033
 gaagtaagttctgaaaactgtttatggtattttcgtgcatttgtgagccaaagagaaaag       c.*840

          .         .         .         .         .         .       g.49093
 attaaaattagtgagatttgtatttatattagagtgcccttaaaataatgatttaagcat       c.*900

          .         .         .         .         .         .       g.49153
 tttactgtctgtaagagaattctaagattgtacataaagtcatatatatggaaatcctgt       c.*960

          .         .         .         .         .         .       g.49213
 tacttaaatagcatctgctcttctcttacgctctctgtctggctgtacgtctggtgttct       c.*1020

          .         .         .         .         .         .       g.49273
 caatgcttttctagcaactgttggataataactagatctcctgtaattttgtagtagttg       c.*1080

          .         .         .         .         .         .       g.49333
 atgaccaatctctgtgactcgcttagctgaaacctaaggcaacatttccgaagaccttct       c.*1140

          .         .         .         .         .         .       g.49393
 gaagatctcagataaagtgaccaggctcacaactgtttttgaagaagggaaattcacact       c.*1200

          .         .         .         .         .         .       g.49453
 gtgcgttttagagtatgcaagaagaatataaataaataaaaatattctccatggagaatt       c.*1260

                                                                    g.49462
 tgaacaaaa                                                          c.*1269

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutamate decarboxylase 1 (brain, 67kDa) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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