galactosylceramidase (GALC) - coding DNA reference sequence

(used for variant description)

(last modified September 27, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000153.3 in the GALC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011853.2, covering GALC transcript NM_000153.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5339
              actcaaaatggcggcggcggcgtcagcatcagcggcctcctgcccgt       c.-61

 .         .         .         .         .         .                g.5399
 atctatcgtggcggcgacgggacccgcctccctgggcgccggagtcatgtgacccacaca       c.-1

          .         .         .         .         .         .       g.5459
 ATGGCTGAGTGGCTACTCTCGGCTTCCTGGCAACGCCGAGCGAAAGCTATGACTGCGGCC       c.60
 M  A  E  W  L  L  S  A  S  W  Q  R  R  A  K  A  M  T  A  A         p.20

          .         .         .         .         .         .       g.5519
 GCGGGTTCGGCGGGCCGCGCCGCGGTGCCCTTGCTGCTGTGTGCGCTGCTGGCGCCCGGC       c.120
 A  G  S  A  G  R  A  A  V  P  L  L  L  C  A  L  L  A  P  G         p.40

          .         .         .         .         .         .       g.5579
 GGCGCGTACGTGCTCGACGACTCCGACGGGCTGGGCCGGGAGTTCGACGGCATCGGCGCG       c.180
 G  A  Y  V  L  D  D  S  D  G  L  G  R  E  F  D  G  I  G  A         p.60

          .      | 02  .         .         .         .         .    g.10085
 GTCAGCGGCGGCGGG | GCAACCTCCCGACTTCTAGTAAATTACCCAGAGCCCTATCGTTCT    c.240
 V  S  G  G  G   | A  T  S  R  L  L  V  N  Y  P  E  P  Y  R  S      p.80

          .         .     | 03   .         .         .         .    g.10392
 CAGATATTGGATTATCTCTTTAAG | CCGAATTTTGGTGCCTCTTTGCATATTTTAAAAGTG    c.300
 Q  I  L  D  Y  L  F  K   | P  N  F  G  A  S  L  H  I  L  K  V      p.100

          .         .         | 04         .         .         .    g.11993
 GAAATAGGTGGTGATGGGCAGACAACAG | ACGGCACTGAGCCCTCCCACATGCATTATGCA    c.360
 E  I  G  G  D  G  Q  T  T  D |   G  T  E  P  S  H  M  H  Y  A      p.120

          .         .         .         .         .         .       g.12053
 CTAGATGAGAATTATTTCCGAGGATACGAGTGGTGGTTGATGAAAGAAGCTAAGAAGAGG       c.420
 L  D  E  N  Y  F  R  G  Y  E  W  W  L  M  K  E  A  K  K  R         p.140

          .         .   | 05     .         .         .         .    g.14068
 AATCCCAATATTACACTCATTG | GGTTGCCATGGTCATTCCCTGGATGGCTGGGAAAAGGT    c.480
 N  P  N  I  T  L  I  G |   L  P  W  S  F  P  G  W  L  G  K  G      p.160

          .         .         .         .         .         .       g.14128
 TTCGACTGGCCTTATGTCAATCTTCAGCTGACTGCCTATTATGTCGTGACCTGGATTGTG       c.540
 F  D  W  P  Y  V  N  L  Q  L  T  A  Y  Y  V  V  T  W  I  V         p.180

          .         .         .         .   | 06     .         .    g.16338
 GGCGCCAAGCGTTACCATGATTTGGACATTGATTATATTGGA | ATTTGGAATGAGAGGTCA    c.600
 G  A  K  R  Y  H  D  L  D  I  D  Y  I  G   | I  W  N  E  R  S      p.200

          .         .  | 07      .         .         .         .    g.22114
 TATAATGCCAATTATATTAAG | ATATTAAGAAAAATGCTGAATTATCAAGGTCTCCAGCGA    c.660
 Y  N  A  N  Y  I  K   | I  L  R  K  M  L  N  Y  Q  G  L  Q  R      p.220

          .         .         .         .         .         .       g.22174
 GTGAAAATCATAGCAAGTGATAATCTCTGGGAGTCCATCTCTGCATCCATGCTCCTTGAT       c.720
 V  K  I  I  A  S  D  N  L  W  E  S  I  S  A  S  M  L  L  D         p.240

          .         .         .   | 08     .         .         .    g.30101
 GCCGAACTCTTCAAGGTGGTTGATGTTATAGG | GGCTCATTATCCTGGAACCCATTCAGCA    c.780
 A  E  L  F  K  V  V  D  V  I  G  |  A  H  Y  P  G  T  H  S  A      p.260

          .         .         .         .         .         .       g.30161
 AAAGATGCAAAGTTGACTGGGAAGAAGCTTTGGTCTTCTGAAGACTTTAGCACTTTAAAT       c.840
 K  D  A  K  L  T  G  K  K  L  W  S  S  E  D  F  S  T  L  N         p.280

          .         .         .         .         .         .       g.30221
 AGTGACATGGGTGCAGGCTGCTGGGGTCGCATTTTAAATCAGAATTATATCAATGGCTAT       c.900
 S  D  M  G  A  G  C  W  G  R  I  L  N  Q  N  Y  I  N  G  Y         p.300

          | 09         .         .         .         .         .    g.32986
 ATGACTTC | CACAATCGCATGGAATTTAGTGGCTAGTTACTATGAACAGTTGCCTTATGGG    c.960
 M  T  S  |  T  I  A  W  N  L  V  A  S  Y  Y  E  Q  L  P  Y  G      p.320

          .         .         .         .         .         .       g.33046
 AGATGCGGGTTGATGACGGCCCAGGAGCCATGGAGTGGGCACTACGTGGTAGAATCTCCT       c.1020
 R  C  G  L  M  T  A  Q  E  P  W  S  G  H  Y  V  V  E  S  P         p.340

          .    | 10    .         .         .         .         .    g.35099
 GTCTGGGTATCAG | CTCATACCACTCAGTTTACTCAACCTGGCTGGTATTACCTGAAGACA    c.1080
 V  W  V  S  A |   H  T  T  Q  F  T  Q  P  G  W  Y  Y  L  K  T      p.360

          .         .         .         .         .         .       g.35159
 GTTGGCCATTTAGAGAAAGGAGGAAGCTACGTAGCTCTGACTGATGGCTTAGGGAACCTC       c.1140
 V  G  H  L  E  K  G  G  S  Y  V  A  L  T  D  G  L  G  N  L         p.380

          .         .  | 11      .         .         .         .    g.47854
 ACCATCATCATTGAAACCATG | AGTCATAAACATTCTAAGTGCATACGGCCATTTCTTCCT    c.1200
 T  I  I  I  E  T  M   | S  H  K  H  S  K  C  I  R  P  F  L  P      p.400

          .         .         .         .         .  | 12      .    g.48641
 TATTTCAATGTGTCACAACAATTTGCCACCTTTGTTCTTAAGGGATCTTTT | AGTGAAATA    c.1260
 Y  F  N  V  S  Q  Q  F  A  T  F  V  L  K  G  S  F   | S  E  I      p.420

          .         .         .         .         .         .       g.48701
 CCAGAGCTACAGGTATGGTATACCAAACTTGGAAAAACATCCGAAAGATTTCTTTTTAAG       c.1320
 P  E  L  Q  V  W  Y  T  K  L  G  K  T  S  E  R  F  L  F  K         p.440

          .         | 13         .         .         .         .    g.50727
 CAGCTGGATTCTCTATGG | CTCCTTGACAGCGATGGCAGTTTCACACTGAGCCTGCATGAA    c.1380
 Q  L  D  S  L  W   | L  L  D  S  D  G  S  F  T  L  S  L  H  E      p.460

          .         .         .         .         .         .       g.50787
 GATGAGCTGTTCACACTCACCACTCTCACCACTGGTCGCAAAGGCAGCTACCCGCTTCCT       c.1440
 D  E  L  F  T  L  T  T  L  T  T  G  R  K  G  S  Y  P  L  P         p.480

          .         .         .         .          | 14        .    g.52841
 CCAAAATCCCAGCCCTTCCCAAGTACCTATAAGGATGATTTCAATGTTG | ATTACCCATTT    c.1500
 P  K  S  Q  P  F  P  S  T  Y  K  D  D  F  N  V  D |   Y  P  F      p.500

          .         .         .         .         .         .       g.52901
 TTTAGTGAAGCTCCAAACTTTGCTGATCAAACTGGTGTATTTGAATATTTTACAAATATT       c.1560
 F  S  E  A  P  N  F  A  D  Q  T  G  V  F  E  Y  F  T  N  I         p.520

          .         .         .         .         .         .       g.52961
 GAAGACCCTGGCGAGCATCACTTCACGCTACGCCAAGTTCTCAACCAGAGACCCATTACG       c.1620
 E  D  P  G  E  H  H  F  T  L  R  Q  V  L  N  Q  R  P  I  T         p.540

          .         .         .         .         . | 15       .    g.57015
 TGGGCTGCCGATGCATCCAACACAATCAGTATTATAGGAGACTACAACTG | GACCAATCTG    c.1680
 W  A  A  D  A  S  N  T  I  S  I  I  G  D  Y  N  W  |  T  N  L      p.560

          .         .         .         .         .         .       g.57075
 ACTATAAAGTGTGATGTATACATAGAGACCCCTGACACAGGAGGTGTGTTCATTGCAGGA       c.1740
 T  I  K  C  D  V  Y  I  E  T  P  D  T  G  G  V  F  I  A  G         p.580

          .         .         .         .         .         .       g.57135
 AGAGTAAATAAAGGTGGTATTTTGATTAGAAGTGCCAGAGGAATTTTCTTCTGGATTTTT       c.1800
 R  V  N  K  G  G  I  L  I  R  S  A  R  G  I  F  F  W  I  F         p.600

          .         .         .     | 16   .         .         .    g.58608
 GCAAATGGATCTTACAGGGTTACAGGTGATTTAG | CTGGATGGATTATATATGCTTTAGGA    c.1860
 A  N  G  S  Y  R  V  T  G  D  L  A |   G  W  I  I  Y  A  L  G      p.620

          .         .         .         .         .  | 17      .    g.63694
 CGTGTTGAAGTTACAGCAAAAAAATGGTATACACTCACGTTAACTATTAAG | GGTCATTTC    c.1920
 R  V  E  V  T  A  K  K  W  Y  T  L  T  L  T  I  K   | G  H  F      p.640

          .         .         .         .         .         .       g.63754
 ACCTCTGGCATGCTGAATGACAAGTCTCTGTGGACAGACATCCCTGTGAATTTTCCAAAG       c.1980
 T  S  G  M  L  N  D  K  S  L  W  T  D  I  P  V  N  F  P  K         p.660

          .         .         .         .         .         .       g.63814
 AATGGCTGGGCTGCAATTGGAACTCACTCCTTTGAATTTGCACAGTTTGACAACTTTCTT       c.2040
 N  G  W  A  A  I  G  T  H  S  F  E  F  A  Q  F  D  N  F  L         p.680

          .                                                         g.63832
 GTGGAAGCCACACGCTAA                                                 c.2058
 V  E  A  T  R  X                                                   p.685

          .         .         .         .         .         .       g.63892
 tacttaacagggcatcatagaatactctggattttcttcccttctttttggttttggttc       c.*60

          .         .         .         .         .         .       g.63952
 agagccaattcttgtttcattggaacagtatatgaggcttttgagactaaaaataatgaa       c.*120

          .         .         .         .         .         .       g.64012
 gagtaaaaggggagagaaatttatttttaatttaccctgtggaagattttattagaatta       c.*180

          .         .         .         .         .         .       g.64072
 attccaaggggaaaactggtgaatctttaacattacctggtgtgttccctaacattcaaa       c.*240

          .         .         .         .         .         .       g.64132
 ctgtgcattggccatacccttaggagtggtttgagtagtacagacctcgaagccttgctg       c.*300

          .         .         .         .         .         .       g.64192
 ctaacactgaggtagctctcttcatcttatttgcaagcggtcctgtagatggcagtaact       c.*360

          .         .         .         .         .         .       g.64252
 tgatcatcactgagatgtatttatgcatgctgaccgtgtgtccaagtgagccagtgtctt       c.*420

          .         .         .         .         .         .       g.64312
 catcacaagatgatgctgccataatagaaagctgaagaacactagaagtagctttttgaa       c.*480

          .         .         .         .         .         .       g.64372
 aaccacttcaacctgttatgctttatgctctaaaaagtatttttttattttcctttttaa       c.*540

          .         .         .         .         .         .       g.64432
 gatgatacttttgaaatgcaggatatgatgagtgggatgattttaaaaatgcctctttaa       c.*600

          .         .         .         .         .         .       g.64492
 taaactacctctaacactatttctgcagtaatagatattagcagattaattgggttattt       c.*660

          .         .         .         .         .         .       g.64552
 gcattatttaatttttttgattccaagttttggtcttgtaaccactataactctctgtga       c.*720

          .         .         .         .         .         .       g.64612
 acgtttttccaggtggctggaagaaggaagaaaacctgatatagccaatgctgttgtagt       c.*780

          .         .         .         .         .         .       g.64672
 cgtttcctcagcctcatctcactgtgctgtggtctgtcctcacatgtgcactggtaacag       c.*840

          .         .         .         .         .         .       g.64732
 actcacacagctgatgaatgcttttctctccttatgtgtggaaggaggggagcacttaga       c.*900

          .         .         .         .         .         .       g.64792
 catttgctaactcccagaattggatcatctcctaagatgtacttactttttaaagtccaa       c.*960

          .         .         .         .         .         .       g.64852
 atatgtttatatttaaatatacgtgagcgtgttcatcatgttgtatgatttatactaagc       c.*1020

          .         .         .         .         .         .       g.64912
 attaatgtggctctatgtagcaaatcagttattcatgtaggtaaagtaaatctagaatta       c.*1080

          .         .         .         .         .         .       g.64972
 tttataagaattactcattgaactaattctactatttaggaatttgtaagagtctaacat       c.*1140

          .         .         .         .         .         .       g.65032
 aggcttagctacagtgaagttttgcattgcttttgaagacaagaagataagtgctagaat       c.*1200

          .         .         .         .         .         .       g.65092
 aaataagattacagagaaaattttttgttaaaaccaagtgatttccagctgatgtatcta       c.*1260

          .         .         .         .         .         .       g.65152
 atattttttaaaacgaacattatagaggtgtaatttatttacaataaaatgttcctactt       c.*1320

          .         .         .         .         .         .       g.65212
 taaatatacaattcagtgagttttgataaattgatatacccatgtaaccaacactccagt       c.*1380

          .         .         .         .         .         .       g.65272
 caagcttcagaatatttccatcaccccagaaggttctcttgtatacctgctcagtcagtt       c.*1440

          .         .         .         .         .         .       g.65332
 cctttcactcccaattgttggcagccattgataggaattctatcactataggttagtttt       c.*1500

          .         .         .         .         .         .       g.65392
 ctttgttccagaacatcatgaaagcggcgtcatgtactgtgtattcttatgaatggtttc       c.*1560

          .         .         .         .         .         .       g.65452
 tttccatcagcataatgatttgagatttgtccatgttgtgtgattcagtggtttgttcct       c.*1620

          .         .         .         .         .         .       g.65512
 tcttatttctgaagagttttccattgtatgaatataccacaatttgtttcctccccacca       c.*1680

          .         .         .                                     g.65550
 gtttctgatactacaattaaaactgtctacatttacaa                             c.*1718

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Galactosylceramidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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