galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS) - coding DNA reference sequence

(used for variant description)

(last modified October 28, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_000512.4 in the GALNS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering GALNS transcript NM_000512.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                aggccccgccccgcagcccagccggaagg       c.-61

 .         .         .         .         .         .                g.5089
 gccggcggacgctcgctaggtcggctcgctggccggggctccgcggctcccgtggttgcc       c.-1

          .         .         .         .         .         .       g.5149
 ATGGCGGCGGTTGTCGCGGCGACGAGGTGGTGGCAGCTGTTGCTGGTGCTCAGCGCCGCG       c.60
 M  A  A  V  V  A  A  T  R  W  W  Q  L  L  L  V  L  S  A  A         p.20

          .         .         .         .         .         .       g.5209
 GGGATGGGGGCCTCGGGCGCCCCGCAGCCCCCCAACATCCTGCTCCTGCTCATGGACGAC       c.120
 G  M  G  A  S  G  A  P  Q  P  P  N  I  L  L  L  L  M  D  D         p.40

  | 02       .         .         .         .         .         .    g.19197
  | ATGGGATGGGGTGACCTCGGGGTGTATGGAGAGCCCTCCAGAGAGACCCCGAATTTGGAC    c.180
  | M  G  W  G  D  L  G  V  Y  G  E  P  S  R  E  T  P  N  L  D      p.60

          .         .         .         .         .         .       g.19257
 CGGATGGCTGCAGAAGGGCTGCTTTTCCCAAACTTCTATTCTGCCAACCCTCTGTGCTCG       c.240
 R  M  A  A  E  G  L  L  F  P  N  F  Y  S  A  N  P  L  C  S         p.80

      | 03   .         .         .         .         .         .    g.20051
 CCAT | CGAGGGCGGCACTGCTCACAGGACGGCTACCCATCCGCAATGGCTTCTACACCACC    c.300
 P  S |   R  A  A  L  L  T  G  R  L  P  I  R  N  G  F  Y  T  T      p.100

          .          | 04        .         .         .         .    g.20913
 AACGCCCATGCCAGAAACG | CCTACACACCGCAGGAGATTGTGGGCGGCATCCCAGACTCG    c.360
 N  A  H  A  R  N  A |   Y  T  P  Q  E  I  V  G  G  I  P  D  S      p.120

          .         .         .         .         .         .       g.20973
 GAGCAGCTCCTGCCGGAGCTTCTGAAGAAGGCCGGCTACGTCAGCAAGATTGTCGGCAAG       c.420
 E  Q  L  L  P  E  L  L  K  K  A  G  Y  V  S  K  I  V  G  K         p.140

    | 05     .         .         .         .         .         .    g.24259
 TG | GCATCTGGGTCACAGGCCCCAGTTCCACCCCCTGAAGCACGGATTTGATGAGTGGTTT    c.480
 W  |  H  L  G  H  R  P  Q  F  H  P  L  K  H  G  F  D  E  W  F      p.160

          .         .         .         .         .         .       g.24319
 GGATCCCCCAACTGCCACTTTGGACCTTATGACAACAAGGCCAGGCCCAACATCCCTGTG       c.540
 G  S  P  N  C  H  F  G  P  Y  D  N  K  A  R  P  N  I  P  V         p.180

          .         .       | 06 .         .         .         .    g.25733
 TACAGGGACTGGGAGATGGTTGGCAG | ATATTATGAAGAATTTCCTATTAATCTGAAGACG    c.600
 Y  R  D  W  E  M  V  G  R  |  Y  Y  E  E  F  P  I  N  L  K  T      p.200

          .         .         .    | 07    .         .         .    g.26144
 GGGGAAGCCAACCTCACCCAGATCTACCTGCAG | GAAGCCCTGGACTTCATTAAGAGACAG    c.660
 G  E  A  N  L  T  Q  I  Y  L  Q   | E  A  L  D  F  I  K  R  Q      p.220

          .         .         .         .         .         .       g.26204
 GCACGGCACCACCCCTTTTTCCTCTACTGGGCTGTCGACGCCACGCACGCACCCGTCTAT       c.720
 A  R  H  H  P  F  F  L  Y  W  A  V  D  A  T  H  A  P  V  Y         p.240

          .         .         .         | 08         .         .    g.26636
 GCCTCCAAACCCTTCTTGGGCACCAGTCAGCGAGGGCG | GTATGGAGACGCCGTCCGGGAG    c.780
 A  S  K  P  F  L  G  T  S  Q  R  G  R  |  Y  G  D  A  V  R  E      p.260

          .         .         .         .         .         .       g.26696
 ATTGATGACAGCATTGGGAAGATACTGGAGCTCCTCCAAGACCTGCACGTCGCGGACAAC       c.840
 I  D  D  S  I  G  K  I  L  E  L  L  Q  D  L  H  V  A  D  N         p.280

          .         .         .         .         .         | 09    g.29867
 ACCTTCGTCTTCTTCACGTCGGACAACGGCGCTGCCCTCATTTCCGCCCCCGAACAAG | GT    c.900
 T  F  V  F  F  T  S  D  N  G  A  A  L  I  S  A  P  E  Q  G |       p.300

          .         .         .         .         .         .       g.29927
 GGCAGCAACGGCCCCTTTCTGTGTGGGAAGCAGACCACGTTTGAAGGAGGGATGAGGGAG       c.960
 G  S  N  G  P  F  L  C  G  K  Q  T  T  F  E  G  G  M  R  E         p.320

          .         .         .         .   | 10     .         .    g.35146
 CCTGCCCTCGCATGGTGGCCAGGGCACGTCACTGCAGGCCAG | GTGAGCCACCAGCTGGGC    c.1020
 P  A  L  A  W  W  P  G  H  V  T  A  G  Q   | V  S  H  Q  L  G      p.340

          .         .         .         .         .         .       g.35206
 AGCATCATGGACCTCTTCACCACCAGCCTGGCCCTTGCGGGCCTGACGCCGCCCAGCGAC       c.1080
 S  I  M  D  L  F  T  T  S  L  A  L  A  G  L  T  P  P  S  D         p.360

          .         .         .         .         .          | 11    g.37098
 AGGGCCATTGATGGCCTCAACCTCCTCCCCACCCTCCTGCAGGGCCGGCTGATGGACAG | G    c.1140
 R  A  I  D  G  L  N  L  L  P  T  L  L  Q  G  R  L  M  D  R  |      p.380

          .         .         .         .         .         .       g.37158
 CCTATCTTCTATTACCGTGGCGACACGCTGATGGCGGCCACCCTCGGGCAGCACAAGGCT       c.1200
 P  I  F  Y  Y  R  G  D  T  L  M  A  A  T  L  G  Q  H  K  A         p.400

          .         .         .         .   | 12     .         .    g.39274
 CACTTCTGGACCTGGACCAACTCCTGGGAGAACTTCAGACAG | GGCATTGATTTCTGCCCT    c.1260
 H  F  W  T  W  T  N  S  W  E  N  F  R  Q   | G  I  D  F  C  P      p.420

          .         .         .         .         .         .       g.39334
 GGGCAGAACGTTTCAGGGGTCACAACTCACAATCTGGAAGACCACACGAAGCTGCCCCTG       c.1320
 G  Q  N  V  S  G  V  T  T  H  N  L  E  D  H  T  K  L  P  L         p.440

          .         .         .         .     | 13   .         .    g.43858
 ATCTTCCACCTGGGACGGGACCCAGGGGAGAGGTTCCCCCTCAG | CTTTGCCAGCGCCGAG    c.1380
 I  F  H  L  G  R  D  P  G  E  R  F  P  L  S  |  F  A  S  A  E      p.460

          .         .         .         .         .         .       g.43918
 TACCAGGAGGCCCTCAGCAGGATCACCTCGGTCGTCCAGCAGCACCAGGAGGCCTTGGTC       c.1440
 Y  Q  E  A  L  S  R  I  T  S  V  V  Q  Q  H  Q  E  A  L  V         p.480

          .         .         .         .   | 14     .         .    g.47459
 CCCGCGCAGCCCCAGCTCAACGTGTGCAACTGGGCGGTCATG | AACTGGGCACCTCCGGGC    c.1500
 P  A  Q  P  Q  L  N  V  C  N  W  A  V  M   | N  W  A  P  P  G      p.500

          .         .         .         .         .         .       g.47519
 TGTGAAAAGTTAGGGAAGTGTCTGACACCTCCAGAATCCATTCCCAAGAAGTGCCTCTGG       c.1560
 C  E  K  L  G  K  C  L  T  P  P  E  S  I  P  K  K  C  L  W         p.520

                                                                    g.47528
 TCCCACTAG                                                          c.1569
 S  H  X                                                            p.522

          .         .         .         .         .         .       g.47588
 cacctgcgcagactcaggccaggcctagaatctccggttggccctgcaagtgcctggagg       c.*60

          .         .         .         .         .         .       g.47648
 aaggatggctctggcctcggtcctcccccaaccctgcccaagccagacagacagcacctg       c.*120

          .         .         .         .         .         .       g.47708
 cagacgcagggggactgcacaattccacctgcccaggacctgaccctggcgtgtgcttgg       c.*180

          .         .         .         .         .         .       g.47768
 ccctcctcctcgcccacggcgcctcagatttcaggaccctcctcctcgcccacggcgcct       c.*240

          .         .         .         .         .         .       g.47828
 cagacctcaggaccctgccgtctcacgcctttgtgaaccccaaatatctgagaccagtct       c.*300

          .         .         .         .         .         .       g.47888
 cagtttattttgccaaggttaaggatgcacctgtgacagcctcaggaggtcctgacaaca       c.*360

          .         .         .         .         .         .       g.47948
 ggtgcctgaggtggctggggatacagtttgcctttatacatcttagggagacacaagatc       c.*420

          .         .         .         .         .         .       g.48008
 agtatgtgtatggcgtacattggttcagtcagccttccactgaatacacgattgagtctg       c.*480

          .         .         .         .         .         .       g.48068
 gcccagtgaatccgcatttttatgtaaacagtaagggaacggggcaatcatataagcgtt       c.*540

          .         .         .         .         .         .       g.48128
 tgtctcaggggagccccagagggatgacttccagttccgtctgtcctttgtccacaagga       c.*600

          .         .         .         .         .         .       g.48188
 atttccctggacgctaattatgagggaggcgtgtagcttcttatcattgtaactatgtta       c.*660

          .         .         .         .                           g.48233
 tttagaaataaaacgggaggcaggtttgcctaattcccagcttga                      c.*705

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Galactosamine (N-acetyl)-6-sulfate sulfatase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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