glucosidase, alpha; neutral AB (GANAB) - coding DNA reference sequence

(used for variant description)

(last modified November 15, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_198335.3 in the GANAB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_053018.1, covering GANAB transcript NM_198335.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      agacagc       c.-121

 .         .         .         .         .         .                g.5067
 tgcccggcggcgctcaggtcgaaccaatcataaggccggaaggggcgggaactaggatac       c.-61

 .         .         .         .         .         .                g.5127
 gtggctgagcgcgcgcgatggggcgggaggtttggggtcaaggagcaaactctgcacaag       c.-1

          .         .         .         | 02         .         .    g.12017
 ATGGCGGCGGTAGCGGCAGTGGCGGCGCGTAGGAGGCG | GTCTTGGGCGTCTTTGGTACTG    c.60
 M  A  A  V  A  A  V  A  A  R  R  R  R  |  S  W  A  S  L  V  L      p.20

          .         .         .         .         .         .       g.12077
 GCTTTTTTAGGGGTCTGCCTGGGGATTACCCTTGCTGTGGATAGAAGCAACTTTAAGACC       c.120
 A  F  L  G  V  C  L  G  I  T  L  A  V  D  R  S  N  F  K  T         p.40

          .         .    | 03    .         .         .         .    g.12296
 TGTGAAGAGAGTTCTTTCTGCAA | GCGACAGAGAAGCATACGGCCAGGCCTCTCTCCATAC    c.180
 C  E  E  S  S  F  C  K  |  R  Q  R  S  I  R  P  G  L  S  P  Y      p.60

          .         .         .         .         .         .       g.12356
 CGAGCCTTGCTGGACTCTCTACAGCTTGGTCCTGATTCCCTCACGGTCCATCTGATCCAT       c.240
 R  A  L  L  D  S  L  Q  L  G  P  D  S  L  T  V  H  L  I  H         p.80

          .   | 04     .         .         .         .         .    g.12664
 GAGGTCACCAAG | GTGTTGCTGGTGCTAGAGCTTCAGGGGCTTCAAAAGAACATGACTCGG    c.300
 E  V  T  K   | V  L  L  V  L  E  L  Q  G  L  Q  K  N  M  T  R      p.100

          .         .         .         .         .         .       g.12724
 TTCAGGATTGATGAGCTGGAGCCTCGGCGACCCCGATACCGTGTACCAGATGTTTTGGTG       c.360
 F  R  I  D  E  L  E  P  R  R  P  R  Y  R  V  P  D  V  L  V         p.120

          .         . | 05       .         .         .         .    g.16766
 GCTGATCCACCAATAGCCCG | GCTTTCTGTCTCTGGTCGTGATGAGAACAGTGTGGAGTTA    c.420
 A  D  P  P  I  A  R  |  L  S  V  S  G  R  D  E  N  S  V  E  L      p.140

          .         .         .         .         .         .       g.16826
 ACCATGGCTGAGGGACCCTACAAGATCATCTTGACAGCACGGCCATTCCGCCTTGACCTA       c.480
 T  M  A  E  G  P  Y  K  I  I  L  T  A  R  P  F  R  L  D  L         p.160

          .         .         .         .         .         .       g.16886
 CTAGAGGACCGAAGTCTTTTGCTTAGTGTCAATGCCCGAGGACTCTTGGAGTTTGAGCAT       c.540
 L  E  D  R  S  L  L  L  S  V  N  A  R  G  L  L  E  F  E  H         p.180

          .         . | 06       .         .         .         .    g.17391
 CAGAGGGCCCCTAGGGTCTC | TTTCTCGGATAAGGTTAATCTCACGCTTGGTAGCATATGG    c.600
 Q  R  A  P  R  V  S  |  F  S  D  K  V  N  L  T  L  G  S  I  W      p.200

          .         .       | 07 .         .         .         .    g.18246
 GATAAGATCAAGAACCTTTTCTCTAG | GCAAGGATCAAAAGACCCAGCTGAGGGCGATGGG    c.660
 D  K  I  K  N  L  F  S  R  |  Q  G  S  K  D  P  A  E  G  D  G      p.220

          .         .         .       | 08 .         .         .    g.18479
 GCCCAGCCTGAGGAAACACCCAGGGATGGCGACAAG | CCAGAGGAGACTCAGGGGAAGGCA    c.720
 A  Q  P  E  E  T  P  R  D  G  D  K   | P  E  E  T  Q  G  K  A      p.240

          .         .         .         .         .         .       g.18539
 GAGAAAGATGAGCCAGGAGCCTGGGAGGAGACATTCAAAACTCACTCTGACAGCAAGCCG       c.780
 E  K  D  E  P  G  A  W  E  E  T  F  K  T  H  S  D  S  K  P         p.260

      | 09   .         .         .         .         .         .    g.18681
 TATG | GCCCCATGTCTGTGGGTTTGGACTTCTCTCTGCCAGGCATGGAGCATGTCTATGGG    c.840
 Y  G |   P  M  S  V  G  L  D  F  S  L  P  G  M  E  H  V  Y  G      p.280

          .         .         .         .  | 10      .         .    g.19000
 ATCCCTGAGCATGCAGACAACCTGAGGCTGAAGGTCACTGA | GGGTGGGGAGCCATATCGC    c.900
 I  P  E  H  A  D  N  L  R  L  K  V  T  E  |  G  G  E  P  Y  R      p.300

          .         .         .         .         .         .       g.19060
 CTCTACAATTTGGATGTGTTCCAGTATGAGCTGTACAACCCAATGGCCTTGTATGGGTCT       c.960
 L  Y  N  L  D  V  F  Q  Y  E  L  Y  N  P  M  A  L  Y  G  S         p.320

          .         .         .         .         .         .       g.19120
 GTGCCTGTGCTCCTGGCACACAACCCTCATCGCGACTTGGGCATCTTCTGGCTCAATGCT       c.1020
 V  P  V  L  L  A  H  N  P  H  R  D  L  G  I  F  W  L  N  A         p.340

          .         .         .         .   | 11     .         .    g.20561
 GCAGAGACCTGGGTTGATATATCTTCCAACACTGCCGGGAAG | ACCCTGTTTGGGAAGATG    c.1080
 A  E  T  W  V  D  I  S  S  N  T  A  G  K   | T  L  F  G  K  M      p.360

          .         .         .         .         .         .       g.20621
 ATGGACTACCTGCAGGGCTCTGGGGAGACCCCACAGACAGATGTTCGCTGGATGTCAGAG       c.1140
 M  D  Y  L  Q  G  S  G  E  T  P  Q  T  D  V  R  W  M  S  E         p.380

          .         .         .         .         .         .       g.20681
 ACTGGCATCATTGACGTCTTCCTGCTGCTGGGGCCCTCCATCTCTGATGTTTTCCGGCAA       c.1200
 T  G  I  I  D  V  F  L  L  L  G  P  S  I  S  D  V  F  R  Q         p.400

          .       | 12 .         .         .         .         .    g.20934
 TATGCTAGTCTCACAG | GAACCCAGGCGTTGCCCCCACTCTTCTCCCTCGGCTACCACCAG    c.1260
 Y  A  S  L  T  G |   T  Q  A  L  P  P  L  F  S  L  G  Y  H  Q      p.420

          .         .         .         .         .         .       g.20994
 AGCCGTTGGAACTACCGGGACGAGGCTGATGTGCTGGAAGTGGATCAGGGCTTTGATGAT       c.1320
 S  R  W  N  Y  R  D  E  A  D  V  L  E  V  D  Q  G  F  D  D         p.440

          .         .         .         .         .         .       g.21054
 CACAACCTGCCCTGTGATGTCATCTGGCTAGACATTGAACATGCTGATGGCAAGCGGTAT       c.1380
 H  N  L  P  C  D  V  I  W  L  D  I  E  H  A  D  G  K  R  Y         p.460

          .         .         .         .         .         .       g.21114
 TTCACCTGGGACCCCAGTCGCTTCCCTCAGCCCCGCACCATGCTTGAGCGCTTGGCTTCT       c.1440
 F  T  W  D  P  S  R  F  P  Q  P  R  T  M  L  E  R  L  A  S         p.480

          .   | 13     .         .         .         .         .    g.21269
 AAGAGGCGGAAG | CTGGTGGCCATCGTAGACCCCCACATCAAGGTGGACTCCGGCTACCGA    c.1500
 K  R  R  K   | L  V  A  I  V  D  P  H  I  K  V  D  S  G  Y  R      p.500

          .         .         .         .         .         .       g.21329
 GTTCACGAGGAGCTGCGGAACCTGGGGCTGTATGTTAAAACCCGGGATGGCTCTGACTAT       c.1560
 V  H  E  E  L  R  N  L  G  L  Y  V  K  T  R  D  G  S  D  Y         p.520

          .          | 14        .         .         .         .    g.21491
 GAGGGCTGGTGCTGGCCAG | GCTCAGCTGGTTACCCTGACTTCACTAATCCCACGATGAGG    c.1620
 E  G  W  C  W  P  G |   S  A  G  Y  P  D  F  T  N  P  T  M  R      p.540

          .         .         .          | 15        .         .    g.21790
 GCCTGGTGGGCTAACATGTTCAGCTATGACAATTATGAG | GGCTCAGCTCCCAACCTCTTT    c.1680
 A  W  W  A  N  M  F  S  Y  D  N  Y  E   | G  S  A  P  N  L  F      p.560

          .         .         .         .         .         .       g.21850
 GTCTGGAATGACATGAACGAACCATCTGTGTTCAATGGTCCTGAGGTCACCATGCTCAAG       c.1740
 V  W  N  D  M  N  E  P  S  V  F  N  G  P  E  V  T  M  L  K         p.580

          .         .         .         .         .         .       g.21910
 GATGCCCAGCATTATGGGGGCTGGGAGCACCGGGATGTGCATAACATCTATGGCCTTTAT       c.1800
 D  A  Q  H  Y  G  G  W  E  H  R  D  V  H  N  I  Y  G  L  Y         p.600

     | 16    .         .         .         .         .         .    g.22099
 GTG | CACATGGCGACTGCTGATGGGCTGAGACAGCGCTCTGGGGGCATGGAACGCCCCTTT    c.1860
 V   | H  M  A  T  A  D  G  L  R  Q  R  S  G  G  M  E  R  P  F      p.620

          .         .         .         . | 17       .         .    g.22451
 GTCCTGGCCAGGGCCTTCTTCGCTGGCTCCCAGCGCTTTG | GAGCCGTGTGGACAGGGGAC    c.1920
 V  L  A  R  A  F  F  A  G  S  Q  R  F  G |   A  V  W  T  G  D      p.640

          .         .         .         .         .         .       g.22511
 AACACTGCCGAGTGGGACCATTTGAAGATCTCTATTCCTATGTGTCTCAGCTTGGGGCTG       c.1980
 N  T  A  E  W  D  H  L  K  I  S  I  P  M  C  L  S  L  G  L         p.660

          .         .   | 18     .         .         .         .    g.22752
 GTGGGACTTTCCTTCTGTGGGG | CGGATGTGGGTGGCTTCTTCAAAAACCCAGAGCCAGAG    c.2040
 V  G  L  S  F  C  G  A |   D  V  G  G  F  F  K  N  P  E  P  E      p.680

          .         .         .         .         .         .       g.22812
 CTGCTTGTGCGCTGGTACCAGATGGGTGCTTACCAGCCATTCTTCCGGGCACATGCCCAC       c.2100
 L  L  V  R  W  Y  Q  M  G  A  Y  Q  P  F  F  R  A  H  A  H         p.700

          .         .         .         .         .         .       g.22872
 TTGGACACTGGGCGACGAGAGCCATGGCTGTTACCATCTCAGCACAATGATATAATCCGA       c.2160
 L  D  T  G  R  R  E  P  W  L  L  P  S  Q  H  N  D  I  I  R         p.720

          .         .         .         .         .         .       g.22932
 GATGCCTTGGGCCAGCGATATTCTTTGCTGCCCTTCTGGTACACCCTCTTATATCAGGCC       c.2220
 D  A  L  G  Q  R  Y  S  L  L  P  F  W  Y  T  L  L  Y  Q  A         p.740

          .         .       | 19 .         .         .         .    g.24407
 CATCGGGAAGGCATTCCTGTCATGAG | GCCCCTGTGGGTGCAGTACCCTCAGGATGTGACT    c.2280
 H  R  E  G  I  P  V  M  R  |  P  L  W  V  Q  Y  P  Q  D  V  T      p.760

          .         .         .  | 20      .         .         .    g.24631
 ACCTTCAATATAGATGATCAGTACTTGCTTG | GGGATGCGTTGCTGGTTCACCCTGTATCA    c.2340
 T  F  N  I  D  D  Q  Y  L  L  G |   D  A  L  L  V  H  P  V  S      p.780

          .         .         .         .         | 21         .    g.24804
 GACTCTGGAGCCCATGGTGTCCAGGTCTATCTGCCTGGCCAAGGGGAG | GTGTGGTATGAC    c.2400
 D  S  G  A  H  G  V  Q  V  Y  L  P  G  Q  G  E   | V  W  Y  D      p.800

          .         .         .         .         .         .       g.24864
 ATTCAAAGCTACCAGAAGCATCATGGTCCCCAGACCCTGTACCTGCCTGTAACTCTAAGC       c.2460
 I  Q  S  Y  Q  K  H  H  G  P  Q  T  L  Y  L  P  V  T  L  S         p.820

     | 22    .         .         .         .         .         .    g.25099
 AGT | ATCCCTGTGTTCCAGCGTGGAGGGACAATCGTGCCTCGATGGATGCGAGTGCGGCGG    c.2520
 S   | I  P  V  F  Q  R  G  G  T  I  V  P  R  W  M  R  V  R  R      p.840

          .         .         .         .         .        | 23.    g.25282
 TCTTCAGAATGTATGAAGGATGACCCCATCACTCTCTTTGTTGCACTTAGCCCTCAG | GGT    c.2580
 S  S  E  C  M  K  D  D  P  I  T  L  F  V  A  L  S  P  Q   | G      p.860

          .         .         .         .         .         .       g.25342
 ACAGCTCAAGGAGAGCTCTTTCTGGATGATGGGCACACGTTCAACTATCAGACTCGCCAA       c.2640
 T  A  Q  G  E  L  F  L  D  D  G  H  T  F  N  Y  Q  T  R  Q         p.880

          .         .         .         .         . | 24       .    g.25571
 GAGTTCCTGCTGCGTCGATTCTCATTCTCTGGCAACACCCTTGTCTCCAG | CTCAGCAGAC    c.2700
 E  F  L  L  R  R  F  S  F  S  G  N  T  L  V  S  S  |  S  A  D      p.900

          .         .         .         .         .         .       g.25631
 CCTGAAGGACACTTTGAGACACCAATCTGGATTGAGCGGGTGGTGATAATAGGGGCTGGA       c.2760
 P  E  G  H  F  E  T  P  I  W  I  E  R  V  V  I  I  G  A  G         p.920

          .         .         .  | 25      .         .         .    g.25831
 AAGCCAGCAGCTGTGGTACTCCAGACAAAAG | GATCTCCAGAAAGCCGCCTGTCCTTCCAG    c.2820
 K  P  A  A  V  V  L  Q  T  K  G |   S  P  E  S  R  L  S  F  Q      p.940

          .         .         .         .         .         .       g.25891
 CATGACCCTGAGACCTCTGTGTTGGTCCTGCGCAAGCCTGGCATCAATGTGGCATCTGAT       c.2880
 H  D  P  E  T  S  V  L  V  L  R  K  P  G  I  N  V  A  S  D         p.960

          .         .                                               g.25912
 TGGAGTATTCACCTGCGATAA                                              c.2901
 W  S  I  H  L  R  X                                                p.966

          .         .         .         .         .         .       g.25972
 cccaagggatgttctgggttagggggagggaaggggagcattagtgctgagagatattct       c.*60

          .         .         .         .         .         .       g.26032
 ttcttctgccttggagttcggccctccccagacttcacttatgctagtctaagacccaga       c.*120

          .         .         .         .         .         .       g.26092
 ttctgccaacatttgggcaggatgagagggctgaccctgggctccaaattcctcttgtga       c.*180

          .         .         .         .         .         .       g.26152
 tctcctcacctctcccactccattgataccaactctttcccttcattcccccaacatcct       c.*240

          .         .         .         .         .         .       g.26212
 gttgctctaactggagcacattcacttacgaacaccaggaaaccacagggcccttgtcgc       c.*300

          .         .         .         .         .         .       g.26272
 cccttctctttcccttatttaggagccctgaactcccccagagtctatccattcatgcct       c.*360

          .         .         .         .         .         .       g.26332
 cttgtatgttgatgccacttcttggaagaagatgagggcaatgagttagggctccttttc       c.*420

          .         .         .         .         .         .       g.26392
 cccttccctcccaccagattgctctcccacctttcatttcttcctccaggctttactccc       c.*480

          .         .         .         .         .         .       g.26452
 ctttttatgccccaccgatacactgggaccaccccttaccccggacaggatgaatggatc       c.*540

          .         .         .         .         .         .       g.26512
 aaaggagtgaggttgctaaagaacatccttttccctctcattctacccttttcctctccc       c.*600

          .         .         .         .         .         .       g.26572
 cgattccttgtagagctgctgcaattcttagaggggcagttctacctcctctgtccctcg       c.*660

          .         .         .         .         .         .       g.26632
 gcagaaagacgtttccacacctcttaggggatgcgcattaaacttcttttgcccccttct       c.*720

          .         .         .         .         .         .       g.26692
 tgtcccctttgaggggcacttaagatggagaaatcagttgtggtttcagtgaatcatggt       c.*780

          .         .         .         .         .         .       g.26752
 cacctgtatttattgctaggagaagcctgagggtggggggagatgatcatgtgtgctcgg       c.*840

          .         .         .         .         .         .       g.26812
 ggttggctggaagccctgggtggggggttgggggaggactaatggggagtcggggaatat       c.*900

          .         .         .         .         .         .       g.26872
 ttgtgggtattttttttacttcctcttggttcccagctgtgacacgttttgatcaaagga       c.*960

          .         .                                               g.26901
 gaaacaataaagggataaaccataaataa                                      c.*989

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glucosidase, alpha; neutral AB protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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