GATA binding protein 2 (GATA2) - coding DNA reference sequence

(used for variant description)

(last modified November 24, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001145661.1 in the GATA2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029334.1, covering GATA2 transcript NM_001145661.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.9672
                                              actgggtcaagcaca       c.-421

 .         .         .         .         .         .                g.9732
 gccctgagcggccgcgtgtccgaggcccaggtgccctctagagccctgtagttcctgccc       c.-361

 .         .         .         .         .         .                g.9792
 ctctctgcccctctcggctcctgctgttccgccgctgtcgtccgaaccatcccaaccccc       c.-301

 .         .         .         .         .    | 02    .             g.10282
 agtccacccagacagcgcccgagctaggggagggaacggtctgg | gagtcggcagctggcg    c.-241

 .         .         .         .         .         .                g.10342
 ccagggcggccggaggatgccgaggggccggagccgggagggcccgaggccgaggcgcac       c.-181

 .         .         .         .         .         .                g.10402
 tctacccccagctcctaccctgtaagccccgccagcctccggacgtgctgtccctgggcc       c.-121

 .         .         .         .         .         .                g.10462
 cgtcgccctcggggctcccgccggaactccttcactctcagaggccgagtccctcccctc       c.-61

 .         .     | 03   .         .         .         .             g.11156
 cccacggctgcgtgt | ggccgttgccgtctgcacccagaccctgagccgccgccgccggcc    c.-1

          .         .         .         .         .         .       g.11216
 ATGGAGGTGGCGCCCGAGCAGCCGCGCTGGATGGCGCACCCGGCCGTGCTGAATGCGCAG       c.60
 M  E  V  A  P  E  Q  P  R  W  M  A  H  P  A  V  L  N  A  Q         p.20

          .         .         .         .         .         .       g.11276
 CACCCCGACTCACACCACCCGGGCCTGGCGCACAACTACATGGAACCCGCGCAGCTGCTG       c.120
 H  P  D  S  H  H  P  G  L  A  H  N  Y  M  E  P  A  Q  L  L         p.40

          .         .         .         .         .         .       g.11336
 CCTCCAGACGAGGTGGACGTCTTCTTCAATCACCTCGACTCGCAGGGCAACCCCTACTAT       c.180
 P  P  D  E  V  D  V  F  F  N  H  L  D  S  Q  G  N  P  Y  Y         p.60

          .         .         .         .          | 04        .    g.11830
 GCCAACCCCGCTCACGCGCGGGCGCGCGTCTCCTACAGCCCCGCGCACG | CCCGCCTGACC    c.240
 A  N  P  A  H  A  R  A  R  V  S  Y  S  P  A  H  A |   R  L  T      p.80

          .         .         .         .         .         .       g.11890
 GGAGGCCAGATGTGCCGCCCACACTTGTTGCACAGCCCGGGTTTGCCCTGGCTGGACGGG       c.300
 G  G  Q  M  C  R  P  H  L  L  H  S  P  G  L  P  W  L  D  G         p.100

          .         .         .         .         .         .       g.11950
 GGCAAAGCAGCCCTCTCTGCCGCTGCGGCCCACCACCACAACCCCTGGACCGTGAGCCCC       c.360
 G  K  A  A  L  S  A  A  A  A  H  H  H  N  P  W  T  V  S  P         p.120

          .         .         .         .         .         .       g.12010
 TTCTCCAAGACGCCACTGCACCCCTCAGCTGCTGGAGGCCCTGGAGGCCCACTCTCTGTG       c.420
 F  S  K  T  P  L  H  P  S  A  A  G  G  P  G  G  P  L  S  V         p.140

          .         .         .         .         .         .       g.12070
 TACCCAGGGGCTGGGGGTGGGAGCGGGGGAGGCAGCGGGAGCTCAGTGGCCTCCCTCACC       c.480
 Y  P  G  A  G  G  G  S  G  G  G  S  G  S  S  V  A  S  L  T         p.160

          .         .         .         .         .         .       g.12130
 CCTACAGCAGCCCACTCTGGCTCCCACCTTTTCGGCTTCCCACCCACGCCACCCAAAGAA       c.540
 P  T  A  A  H  S  G  S  H  L  F  G  F  P  P  T  P  P  K  E         p.180

          .         .         .         .         .         .       g.12190
 GTGTCTCCTGACCCTAGCACCACGGGGGCTGCGTCTCCAGCCTCATCTTCCGCGGGGGGT       c.600
 V  S  P  D  P  S  T  T  G  A  A  S  P  A  S  S  S  A  G  G         p.200

          .         .         .         .         .         .       g.12250
 AGTGCAGCCCGAGGAGAGGACAAGGACGGCGTCAAGTACCAGGTGTCACTGACGGAGAGC       c.660
 S  A  A  R  G  E  D  K  D  G  V  K  Y  Q  V  S  L  T  E  S         p.220

          .         .         .         .         .         .       g.12310
 ATGAAGATGGAAAGTGGCAGTCCCCTGCGCCCAGGCCTAGCTACTATGGGCACCCAGCCT       c.720
 M  K  M  E  S  G  S  P  L  R  P  G  L  A  T  M  G  T  Q  P         p.240

          .         .         .         .         .         .       g.12370
 GCTACACACCACCCCATCCCCACCTACCCCTCCTATGTGCCGGCGGCTGCCCACGACTAC       c.780
 A  T  H  H  P  I  P  T  Y  P  S  Y  V  P  A  A  A  H  D  Y         p.260

          .         .         .         .         .         .       g.12430
 AGCAGCGGACTCTTCCACCCCGGAGGCTTCCTGGGGGGACCGGCCTCCAGCTTCACCCCT       c.840
 S  S  G  L  F  H  P  G  G  F  L  G  G  P  A  S  S  F  T  P         p.280

          .         .         .  | 05      .         .         .    g.14211
 AAGCAGCGCAGCAAGGCTCGTTCCTGTTCAG | AAGGCCGGGAGTGTGTCAACTGTGGGGCC    c.900
 K  Q  R  S  K  A  R  S  C  S  E |   G  R  E  C  V  N  C  G  A      p.300

          .         .         .         .         .         .       g.14271
 ACAGCCACCCCTCTCTGGCGGCGGGACGGCACCGGCCACTACCTGTGCAATGCCTGTGGC       c.960
 T  A  T  P  L  W  R  R  D  G  T  G  H  Y  L  C  N  A  C  G         p.320

          .         .         .         .         .        | 06.    g.16246
 CTCTACCACAAGATGAATGGGCAGAACCGACCACTCATCAAGCCCAAGCGAAGACTG | TCG    c.1020
 L  Y  H  K  M  N  G  Q  N  R  P  L  I  K  P  K  R  R  L   | S      p.340

          .         .         .         .         .         .       g.16306
 GCCGCCAGAAGAGCCGGCACCTGTTGTGCAAATTGTCAGACGACAACCACCACCTTATGG       c.1080
 A  A  R  R  A  G  T  C  C  A  N  C  Q  T  T  T  T  T  L  W         p.360

          .         .         .         .         .         .       g.16366
 CGCCGAAACGCCAACGGGGACCCTGTCTGCAACGCCTGTGGCCTCTACTACAAGCTGCAC       c.1140
 R  R  N  A  N  G  D  P  V  C  N  A  C  G  L  Y  Y  K  L  H         p.380

     | 07    .         .         .         .         .         .    g.16926
 AAT | GTTAACAGGCCACTGACCATGAAGAAGGAAGGGATCCAGACTCGGAACCGGAAGATG    c.1200
 N   | V  N  R  P  L  T  M  K  K  E  G  I  Q  T  R  N  R  K  M      p.400

          .         .         .         .         .         .       g.16986
 TCCAACAAGTCCAAGAAGAGCAAGAAAGGGGCGGAGTGCTTCGAGGAGCTGTCAAAGTGC       c.1260
 S  N  K  S  K  K  S  K  K  G  A  E  C  F  E  E  L  S  K  C         p.420

          .         .         .         .         .         .       g.17046
 ATGCAGGAGAAGTCATCCCCCTTCAGTGCAGCTGCCCTGGCTGGACACATGGCACCTGTG       c.1320
 M  Q  E  K  S  S  P  F  S  A  A  A  L  A  G  H  M  A  P  V         p.440

          .         .         .         .         .         .       g.17106
 GGCCACCTCCCGCCCTTCAGCCACTCCGGACACATCCTGCCCACTCCGACGCCCATCCAC       c.1380
 G  H  L  P  P  F  S  H  S  G  H  I  L  P  T  P  T  P  I  H         p.460

          .         .         .         .         .         .       g.17166
 CCCTCCTCCAGCCTCTCCTTCGGCCACCCCCACCCGTCCAGCATGGTGACCGCCATGGGC       c.1440
 P  S  S  S  L  S  F  G  H  P  H  P  S  S  M  V  T  A  M  G         p.480

                                                                    g.17169
 TAG                                                                c.1443
 X                                                                  p.480

          .         .         .         .         .         .       g.17229
 ggaacagatggacgtcgaggaccgggcactcccgggatgggtggaccaaacccttagcag       c.*60

          .         .         .         .         .         .       g.17289
 cccagcatttcccgaaggccgacaccactcctgccagcccggctcggcccagcaccccct       c.*120

          .         .         .         .         .         .       g.17349
 ctcctggagggcgcccagcagcctgccagcagttactgtgaatgttccccaccgctgaga       c.*180

          .         .         .         .         .         .       g.17409
 ggctgcctccgcacctgaccgctgcccaggtggggtttcctgcatggacagttgtttgga       c.*240

          .         .         .         .         .         .       g.17469
 gaacaacaaggacaactttatgtagagaaaaggaggggacgggacagacgaaggcaacca       c.*300

          .         .         .         .         .         .       g.17529
 tttttagaaggaaaaaggattaggcaaaaataatttattttgctcttgtttctaacaagg       c.*360

          .         .         .         .         .         .       g.17589
 acttggagacttggtggtctgagctgtcccaagtcctccggttcttcctcgggattggcg       c.*420

          .         .         .         .         .         .       g.17649
 ggtccacttgccagggctctgggggcagatttgtggggacctcagcctgcaccctcttct       c.*480

          .         .         .         .         .         .       g.17709
 cctctggcttccctctctgaaatagccgaactccaggctgggctgagccaaagccagagt       c.*540

          .         .         .         .         .         .       g.17769
 ggccacggcccagggagggtgagctggtgcctgctttgacgggccaggccctggagggca       c.*600

          .         .         .         .         .         .       g.17829
 gagacaatcacgggcggtcctgcacagattcccaggccagggctgggtcacaggaaggaa       c.*660

          .         .         .         .         .         .       g.17889
 acaacattttcttgaaaggggaaacgtctcccagatcgctcccttggctttgaggccgaa       c.*720

          .         .         .         .         .         .       g.17949
 gctgctgtgactgtgtccccttactgagcgcaagccacagcctgtcttgtcaggtggacc       c.*780

          .         .         .         .         .         .       g.18009
 ctgtaaatacatcctttttctgctaacccttcaaccccctcgcctcctactctgagacaa       c.*840

          .         .         .         .         .         .       g.18069
 aagaaaaaatattaaaaaaatgcataggcttaactcgctgatgagttaattgttttattt       c.*900

          .         .         .         .         .         .       g.18129
 ttaaactctttttgggtccagttgattgtacgtagccacaggagccctgctatgaaagga       c.*960

          .         .         .         .         .         .       g.18189
 ataaaacctacacacaaggttggagctttgcaattctttttggaaaagagctgggatccc       c.*1020

          .         .         .         .         .         .       g.18249
 acagccctagtatgaaagctgggggtggggaggggcctttgctgcccttggtttctgggg       c.*1080

          .         .         .         .         .         .       g.18309
 gctggttggcatttgctggcctggcagggggtgaaggcaggagttgggggcaggtcagga       c.*1140

          .         .         .         .         .         .       g.18369
 ccaggacccagggagaggctgtgtccctgctggggtctcaggtccagctttactgtggct       c.*1200

          .         .         .         .         .         .       g.18429
 gtctggatccttcccaaggtacagctgtatataaacgtgtcccgagcttagattctgtat       c.*1260

          .         .         .         .         .         .       g.18489
 gcggtgacggcggggtgtggtggcctgtgaggggcccctggcccaggaggaggattgtgc       c.*1320

          .         .         .         .         .         .       g.18549
 tgatgtagtgaccaagtgcaatatgggcgggcagtcgctgcagggagcaccacggccaga       c.*1380

          .         .         .         .         .         .       g.18609
 agtaacttattttgtactagtgtccgcataagaaaaagaatcggcagtattttctgtttt       c.*1440

          .         .         .         .         .         .       g.18669
 tatgttttatttggcttgttttattttggattagtgaactaagttattgttaattatgta       c.*1500

          .         .         .         .         .         .       g.18729
 caacatttatatattgtctgtaaaaaatgtatgctatcctcttattcctttaaagtgagt       c.*1560

          .         .         .                                     g.18766
 actgttaagaataataaaatactttttgtgaatgccc                              c.*1597

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GATA binding protein 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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