GATA binding protein 3 (GATA3) - coding DNA reference sequence

(used for variant description)

(last modified February 18, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001002295.1 in the GATA3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015859.1, covering GATA3 transcript NM_001002295.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            ggcgccgtcttgatact       c.-541

 .         .         .         .         .         .                g.5077
 ttcagaaagaatgcattccctgtaaaaaaaaaaaaaaaatactgagagagggagagagag       c.-481

 .         .         .         .         .         .                g.5137
 agagaagaagagagagagacggagggagagcgagacagagcgagcaacgcaatctgaccg       c.-421

 .         .         .         .         .         . | 02           g.5592
 agcaggtcgtacgccgccgcctcctcctcctctctgctcttcgctacccag | gtgacccga    c.-361

 .         .         .         .         .         .                g.5652
 ggagggactccgcctccgagcggctgaggaccccggtgcagaggagcctggctcgcagaa       c.-301

 .         .         .         .         .         .                g.5712
 ttgcagagtcgtcgcccctttttacaacctggtcccgttttattctgccgtacccagttt       c.-241

 .         .         .         .         .         .                g.5772
 ttggatttttgtcttccccttcttctctttgctaaacgacccctccaagataatttttaa       c.-181

 .         .         .         .         .         .                g.5832
 aaaaccttctcctttgctcacctttgcttcccagccttcccatccccccaccgaaagcaa       c.-121

 .         .         .         .         .         .                g.5892
 atcattcaacgacccccgaccctccgacggcaggagccccccgacctcccaggcggaccg       c.-61

 .         .         .         .         .         .                g.5952
 ccctccctccccgcgcgcgggttccgggcccggcgagagggcgcgagcacagccgaggcc       c.-1

          .         .         .         .         .         .       g.6012
 ATGGAGGTGACGGCGGACCAGCCGCGCTGGGTGAGCCACCACCACCCCGCCGTGCTCAAC       c.60
 M  E  V  T  A  D  Q  P  R  W  V  S  H  H  H  P  A  V  L  N         p.20

          .         .         .         .         .         .       g.6072
 GGGCAGCACCCGGACACGCACCACCCGGGCCTCAGCCACTCCTACATGGACGCGGCGCAG       c.120
 G  Q  H  P  D  T  H  H  P  G  L  S  H  S  Y  M  D  A  A  Q         p.40

          .         .         .         .         .         .       g.6132
 TACCCGCTGCCGGAGGAGGTGGATGTGCTTTTTAACATCGACGGTCAAGGCAACCACGTC       c.180
 Y  P  L  P  E  E  V  D  V  L  F  N  I  D  G  Q  G  N  H  V         p.60

          .         .         .         .         .         .       g.6192
 CCGCCCTACTACGGAAACTCGGTCAGGGCCACGGTGCAGAGGTACCCTCCGACCCACCAC       c.240
 P  P  Y  Y  G  N  S  V  R  A  T  V  Q  R  Y  P  P  T  H  H         p.80

   | 03      .         .         .         .         .         .    g.8660
 G | GGAGCCAGGTGTGCCGCCCGCCTCTGCTTCATGGATCCCTACCCTGGCTGGACGGCGGC    c.300
 G |   S  Q  V  C  R  P  P  L  L  H  G  S  L  P  W  L  D  G  G      p.100

          .         .         .         .         .         .       g.8720
 AAAGCCCTGGGCAGCCACCACACCGCCTCCCCCTGGAATCTCAGCCCCTTCTCCAAGACG       c.360
 K  A  L  G  S  H  H  T  A  S  P  W  N  L  S  P  F  S  K  T         p.120

          .         .         .         .         .         .       g.8780
 TCCATCCACCACGGCTCCCCGGGGCCCCTCTCCGTCTACCCCCCGGCCTCGTCCTCCTCC       c.420
 S  I  H  H  G  S  P  G  P  L  S  V  Y  P  P  A  S  S  S  S         p.140

          .         .         .         .         .         .       g.8840
 TTGTCGGGGGGCCACGCCAGCCCGCACCTCTTCACCTTCCCGCCCACCCCGCCGAAGGAC       c.480
 L  S  G  G  H  A  S  P  H  L  F  T  F  P  P  T  P  P  K  D         p.160

          .         .         .         .         .         .       g.8900
 GTCTCCCCGGACCCATCGCTGTCCACCCCAGGCTCGGCCGGCTCGGCCCGGCAGGACGAG       c.540
 V  S  P  D  P  S  L  S  T  P  G  S  A  G  S  A  R  Q  D  E         p.180

          .         .         .         .         .         .       g.8960
 AAAGAGTGCCTCAAGTACCAGGTGCCCCTGCCCGACAGCATGAAGCTGGAGTCGTCCCAC       c.600
 K  E  C  L  K  Y  Q  V  P  L  P  D  S  M  K  L  E  S  S  H         p.200

          .         .         .         .         .         .       g.9020
 TCCCGTGGCAGCATGACCGCCCTGGGTGGAGCCTCCTCGTCGACCCACCACCCCATCACC       c.660
 S  R  G  S  M  T  A  L  G  G  A  S  S  S  T  H  H  P  I  T         p.220

          .         .         .         .         .         .       g.9080
 ACCTACCCGCCCTACGTGCCCGAGTACAGCTCCGGACTCTTCCCCCCCAGCAGCCTGCTG       c.720
 T  Y  P  P  Y  V  P  E  Y  S  S  G  L  F  P  P  S  S  L  L         p.240

          .         .         .         .         .         | 04    g.14291
 GGCGGCTCCCCCACCGGCTTCGGATGCAAGTCCAGGCCCAAGGCCCGGTCCAGCACAG | AA    c.780
 G  G  S  P  T  G  F  G  C  K  S  R  P  K  A  R  S  S  T  E |       p.260

          .         .         .         .         .         .       g.14351
 GGCAGGGAGTGTGTGAACTGTGGGGCAACCTCGACCCCACTGTGGCGGCGAGATGGCACG       c.840
 G  R  E  C  V  N  C  G  A  T  S  T  P  L  W  R  R  D  G  T         p.280

          .         .         .         .         .         .       g.14411
 GGACACTACCTGTGCAACGCCTGCGGGCTCTATCACAAAATGAACGGACAGAACCGGCCC       c.900
 G  H  Y  L  C  N  A  C  G  L  Y  H  K  M  N  G  Q  N  R  P         p.300

          .         .     | 05   .         .         .         .    g.19805
 CTCATTAAGCCCAAGCGAAGGCTG | TCTGCAGCCAGGAGAGCAGGGACGTCCTGTGCGAAC    c.960
 L  I  K  P  K  R  R  L   | S  A  A  R  R  A  G  T  S  C  A  N      p.320

          .         .         .         .         .         .       g.19865
 TGTCAGACCACCACAACCACACTCTGGAGGAGGAATGCCAATGGGGACCCTGTCTGCAAT       c.1020
 C  Q  T  T  T  T  T  L  W  R  R  N  A  N  G  D  P  V  C  N         p.340

          .         .         . | 06       .         .         .    g.24065
 GCCTGTGGGCTCTACTACAAGCTTCACAAT | ATTAACAGACCCCTGACTATGAAGAAGGAA    c.1080
 A  C  G  L  Y  Y  K  L  H  N   | I  N  R  P  L  T  M  K  K  E      p.360

          .         .         .         .         .         .       g.24125
 GGCATCCAGACCAGAAACCGAAAAATGTCTAGCAAATCCAAAAAGTGCAAAAAAGTGCAT       c.1140
 G  I  Q  T  R  N  R  K  M  S  S  K  S  K  K  C  K  K  V  H         p.380

          .         .         .         .         .         .       g.24185
 GACTCACTGGAGGACTTCCCCAAGAACAGCTCGTTTAACCCGGCCGCCCTCTCCAGACAC       c.1200
 D  S  L  E  D  F  P  K  N  S  S  F  N  P  A  A  L  S  R  H         p.400

          .         .         .         .         .         .       g.24245
 ATGTCCTCCCTGAGCCACATCTCGCCCTTCAGCCACTCCAGCCACATGCTGACCACGCCC       c.1260
 M  S  S  L  S  H  I  S  P  F  S  H  S  S  H  M  L  T  T  P         p.420

          .         .         .         .         .         .       g.24305
 ACGCCGATGCACCCGCCATCCAGCCTGTCCTTTGGACCACACCACCCCTCCAGCATGGTC       c.1320
 T  P  M  H  P  P  S  S  L  S  F  G  P  H  H  P  S  S  M  V         p.440

          .                                                         g.24320
 ACCGCCATGGGTTAG                                                    c.1335
 T  A  M  G  X                                                      p.444

          .         .         .         .         .         .       g.24380
 agccctgctcgatgctcacagggcccccagcgagagtccctgcagtccctttcgacttgc       c.*60

          .         .         .         .         .         .       g.24440
 atttttgcaggagcagtatcatgaagcctaaacgcgatggatatatgtttttgaaggcag       c.*120

          .         .         .         .         .         .       g.24500
 aaagcaaaattatgtttgccactttgcaaaggagctcactgtggtgtctgtgttccaacc       c.*180

          .         .         .         .         .         .       g.24560
 actgaatctggaccccatctgtgaataagccattctgactcatatcccctatttaacagg       c.*240

          .         .         .         .         .         .       g.24620
 gtctctagtgctgtgaaaaaaaaaatgctgaacattgcatataacttatattgtaagaaa       c.*300

          .         .         .         .         .         .       g.24680
 tactgtacaatgactttattgcatctgggtagctgtaaggcatgaaggatgccaagaagt       c.*360

          .         .         .         .         .         .       g.24740
 ttaaggaatatgggagaaatagtgtggaaattaagaagaaactaggtctgatattcaaat       c.*420

          .         .         .         .         .         .       g.24800
 ggacaaactgccagttttgtttcctttcactggccacagttgtttgatgcattaaaagaa       c.*480

          .         .         .         .         .         .       g.24860
 aataaaaaaaagaaaaaagagaaaagaaaaaaaaagaaaaaagttgtaggcgaatcattt       c.*540

          .         .         .         .         .         .       g.24920
 gttcaaagctgttggcctctgcaaaggaaataccagttctgggcaatcagtgttaccgtt       c.*600

          .         .         .         .         .         .       g.24980
 caccagttgccgttgagggtttcagagagcctttttctaggcctacatgctttgtgaaca       c.*660

          .         .         .         .         .         .       g.25040
 agtccctgtaattgttgtttgtatgtataattcaaagcaccaaaataagaaaagatgtag       c.*720

          .         .         .         .         .         .       g.25100
 atttatttcatcatattatacagaccgaactgttgtataaatttatttactgctagtctt       c.*780

          .         .         .         .         .         .       g.25160
 aagaactgctttctttcgtttgtttgtttcaatattttccttctctctcaatttttggtt       c.*840

          .         .         .         .         .         .       g.25220
 gaataaactagattacattcagttggcctaaggtggttgtgctcggagggtttcttgttt       c.*900

          .         .         .         .         .         .       g.25280
 cttttccattttgtttttggatgatatttattaaatagcttctaagagtccggcggcatc       c.*960

          .         .         .         .         .         .       g.25340
 tgtcttgtccctattcctgcagcctgtgctgagggtagcagtgtatgagctaccagcgtg       c.*1020

          .         .         .         .         .         .       g.25400
 catgtcagcgaccctggcccgacaggccacgtcctgcaatcggcccggctgcctcttcgc       c.*1080

          .         .         .         .         .         .       g.25460
 cctgtcgtgttctgtgttagtgatcactgcctttaatacagtctgttggaataatattat       c.*1140

          .         .         .                                     g.25498
 aagcataataataaagtgaaaatattttaaaactacaa                             c.*1178

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GATA binding protein 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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