GATA binding protein 4 (GATA4) - coding DNA reference sequence

(used for variant description)

(last modified January 23, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_002052.3 in the GATA4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008177.1, covering GATA4 transcript NM_002052.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               ttggaggcggccgg       c.-541

 .         .         .         .         .         .                g.5074
 cgcaggggccgcgagaggcttcgtcgccgctgcagctccgggggctcccaggggagcgtg       c.-481

 .         .         .   | 02     .         .         .             g.8685
 cgcggaacctccaggcccagcag | gaccccggctgcggcgaggaggaaggagccagcctag    c.-421

 .         .         .         .         .         .                g.8745
 cagcttctgcgcctgtggccgcgggtgtcctggaggcctctcggtgtgacgagtggggga       c.-361

 .         .         .         .         .         .                g.8805
 cccgaaggctcgtgcgccacctccaggcctggacgctgccctccgtcttctgcccccaat       c.-301

 .         .         .         .         .         .                g.8865
 aggtgcgccggaccttcaggccctggggtgaattcagctgctcctacatcagcttccgga       c.-241

 .         .         .         .         .         .                g.8925
 accaccaaaaattcaaattgggattttccggagtaaacaagagcctagagccctttgctc       c.-181

 .         .         .         .         .         .                g.8985
 aatgctggatttaatacgtatatatttttaagcgagttggttttttcccctttgattttt       c.-121

 .         .         .         .         .         .                g.9045
 gatcttcgcgacagttcctcccacgcatattatcgttgttgccgtcgttttctctccccg       c.-61

 .         .         .         .         .         .                g.9105
 cgtggctccttgacctgcgagggagagagaggacaccgaagccgggagctcgcagggacc       c.-1

          .         .         .         .         .         .       g.9165
 ATGTATCAGAGCTTGGCCATGGCCGCCAACCACGGGCCGCCCCCCGGTGCCTACGAGGCG       c.60
 M  Y  Q  S  L  A  M  A  A  N  H  G  P  P  P  G  A  Y  E  A         p.20

          .         .         .         .         .         .       g.9225
 GGCGGCCCCGGCGCCTTCATGCACGGCGCGGGCGCCGCGTCCTCGCCAGTCTACGTGCCC       c.120
 G  G  P  G  A  F  M  H  G  A  G  A  A  S  S  P  V  Y  V  P         p.40

          .         .         .         .         .         .       g.9285
 ACACCGCGGGTGCCCTCCTCCGTGCTGGGCCTGTCCTACCTCCAGGGCGGAGGCGCGGGC       c.180
 T  P  R  V  P  S  S  V  L  G  L  S  Y  L  Q  G  G  G  A  G         p.60

          .         .         .         .         .         .       g.9345
 TCTGCGTCCGGAGGCGCCTCGGGCGGCAGCTCCGGTGGGGCCGCGTCTGGTGCGGGGCCC       c.240
 S  A  S  G  G  A  S  G  G  S  S  G  G  A  A  S  G  A  G  P         p.80

          .         .         .         .         .         .       g.9405
 GGGACCCAGCAGGGCAGCCCGGGATGGAGCCAGGCGGGAGCCGACGGAGCCGCTTACACC       c.300
 G  T  Q  Q  G  S  P  G  W  S  Q  A  G  A  D  G  A  A  Y  T         p.100

          .         .         .         .         .         .       g.9465
 CCGCCGCCGGTGTCGCCGCGCTTCTCCTTCCCGGGGACCACCGGGTCCCTGGCGGCCGCC       c.360
 P  P  P  V  S  P  R  F  S  F  P  G  T  T  G  S  L  A  A  A         p.120

          .         .         .         .         .         .       g.9525
 GCCGCCGCTGCCGCGGCCCGGGAAGCTGCGGCCTACAGCAGTGGCGGCGGAGCGGCGGGT       c.420
 A  A  A  A  A  A  R  E  A  A  A  Y  S  S  G  G  G  A  A  G         p.140

          .         .         .         .         .         .       g.9585
 GCGGGCCTGGCGGGCCGCGAGCAGTACGGGCGCGCCGGCTTCGCGGGCTCCTACTCCAGC       c.480
 A  G  L  A  G  R  E  Q  Y  G  R  A  G  F  A  G  S  Y  S  S         p.160

          .         .         .         .         .         .       g.9645
 CCCTACCCGGCTTACATGGCCGACGTGGGCGCGTCCTGGGCCGCAGCCGCCGCCGCCTCC       c.540
 P  Y  P  A  Y  M  A  D  V  G  A  S  W  A  A  A  A  A  A  S         p.180

          .         .         .         .         .         .       g.9705
 GCCGGCCCCTTCGACAGCCCGGTCCTGCACAGCCTGCCCGGCCGGGCCAACCCGGCCGCC       c.600
 A  G  P  F  D  S  P  V  L  H  S  L  P  G  R  A  N  P  A  A         p.200

          .       | 03 .         .         .         .         .    g.49755
 CGACACCCCAATCTCG | ATATGTTTGACGACTTCTCAGAAGGCAGAGAGTGTGTCAACTGT    c.660
 R  H  P  N  L  D |   M  F  D  D  F  S  E  G  R  E  C  V  N  C      p.220

          .         .         .         .         .         .       g.49815
 GGGGCTATGTCCACCCCGCTCTGGAGGCGAGATGGGACGGGTCACTATCTGTGCAACGCC       c.720
 G  A  M  S  T  P  L  W  R  R  D  G  T  G  H  Y  L  C  N  A         p.240

          .         .         .         .         .         .       g.49875
 TGCGGCCTCTACCACAAGATGAACGGCATCAACCGGCCGCTCATCAAGCCTCAGCGCCGG       c.780
 C  G  L  Y  H  K  M  N  G  I  N  R  P  L  I  K  P  Q  R  R         p.260

     | 04    .         .         .         .         .         .    g.50960
 CTG | TCCGCCTCCCGCCGAGTGGGCCTCTCCTGTGCCAACTGCCAGACCACCACCACCACG    c.840
 L   | S  A  S  R  R  V  G  L  S  C  A  N  C  Q  T  T  T  T  T      p.280

          .         .         .         .         .         .       g.51020
 CTGTGGCGCCGCAATGCGGAGGGCGAGCCTGTGTGCAATGCCTGCGGCCTCTACATGAAG       c.900
 L  W  R  R  N  A  E  G  E  P  V  C  N  A  C  G  L  Y  M  K         p.300

           | 05        .         .         .         .         .    g.55889
 CTCCACGGG | GTCCCCAGGCCTCTTGCAATGCGGAAAGAGGGGATCCAAACCAGAAAACGG    c.960
 L  H  G   | V  P  R  P  L  A  M  R  K  E  G  I  Q  T  R  K  R      p.320

          .         .         .        | 06.         .         .    g.57750
 AAGCCCAAGAACCTGAATAAATCTAAGACACCAGCAG | CTCCTTCAGGCAGTGAGAGCCTT    c.1020
 K  P  K  N  L  N  K  S  K  T  P  A  A |   P  S  G  S  E  S  L      p.340

          .         .         .         .         .         .       g.57810
 CCTCCCGCCAGCGGTGCTTCCAGCAACTCCAGCAACGCCACCACCAGCAGCAGCGAGGAG       c.1080
 P  P  A  S  G  A  S  S  N  S  S  N  A  T  T  S  S  S  E  E         p.360

          .         .         .         .         .         .       g.57870
 ATGCGTCCCATCAAGACGGAGCCTGGCCTGTCATCTCACTACGGGCACAGCAGCTCCGTG       c.1140
 M  R  P  I  K  T  E  P  G  L  S  S  H  Y  G  H  S  S  S  V         p.380

        | 07 .         .         .         .         .         .    g.59139
 TCCCAG | ACGTTCTCAGTCAGTGCGATGTCTGGCCATGGGCCCTCCATCCACCCTGTCCTC    c.1200
 S  Q   | T  F  S  V  S  A  M  S  G  H  G  P  S  I  H  P  V  L      p.400

          .         .         .         .         .         .       g.59199
 TCGGCCCTGAAGCTCTCCCCACAAGGCTATGCGTCTCCCGTCAGCCAGTCTCCACAGACC       c.1260
 S  A  L  K  L  S  P  Q  G  Y  A  S  P  V  S  Q  S  P  Q  T         p.420

          .         .         .         .         .         .       g.59259
 AGCTCCAAGCAGGACTCTTGGAACAGCCTGGTCTTGGCCGACAGTCACGGGGACATAATC       c.1320
 S  S  K  Q  D  S  W  N  S  L  V  L  A  D  S  H  G  D  I  I         p.440

                                                                    g.59268
 ACTGCGTAA                                                          c.1329
 T  A  X                                                            p.442

          .         .         .         .         .         .       g.59328
 tcttccctcttccctcctcaaattcctgcacggacctgggacttggaggatagcaaagaa       c.*60

          .         .         .         .         .         .       g.59388
 ggaggccctgggctcccaggggccggcctcctctgcctggtaatgactccagaacaacaa       c.*120

          .         .         .         .         .         .       g.59448
 ctgggaagaaacttgaagtcgacaatctggttaggggaagcgggtgttggattttctcag       c.*180

          .         .         .         .         .         .       g.59508
 atgcctttacacgctgatgggactggagggagcccacccttcagcacgagcacactgcat       c.*240

          .         .         .         .         .         .       g.59568
 ctctcctgtgagttggagacttctttcccaagatgtccttgtcccctgcgttccccactg       c.*300

          .         .         .         .         .         .       g.59628
 tggcctagaccgtgggttttgcattgtgtttctagcaccgaggatctgagaacaagcgga       c.*360

          .         .         .         .         .         .       g.59688
 gggccgggccctgggacccctgctccagcccgaatgacggcatctgtttgccatgtacct       c.*420

          .         .         .         .         .         .       g.59748
 ggatgcgacgggcccctggggacaggcccttgccccatccatccgcttgaggcatggcac       c.*480

          .         .         .         .         .         .       g.59808
 cgccctgcatccctaataccaaatctgactccaaaattgtggggtgtgacatacaagtga       c.*540

          .         .         .         .         .         .       g.59868
 ctgaacacttcctggggagctacaggggcacttaacccaccacagcacagcctcatcaaa       c.*600

          .         .         .         .         .         .       g.59928
 atgcagctggcaacttctcccccaggtgccttccccctgctgccggcctttgctccttca       c.*660

          .         .         .         .         .         .       g.59988
 cttccaacatctctcaaaataaaaatccctcttcccgctctgagcgattcagctctgccc       c.*720

          .         .         .         .         .         .       g.60048
 gcagcttgtacatgtctctcccctggcaaaacaagagctgggtagtttagccaaacggca       c.*780

          .         .         .         .         .         .       g.60108
 ccccctcgagttcactgcagacccttcgttcaccgtgtcacacatagaggggttctgagt       c.*840

          .         .         .         .         .         .       g.60168
 aagaacaaaacgttctgctgctcaagccagtctggcaagcactcagcccagcctcgaggt       c.*900

          .         .         .         .         .         .       g.60228
 ccttctggggagagtgtaagtggacagagtcctggtcagggggcaggagtgtcccaaggg       c.*960

          .         .         .         .         .         .       g.60288
 ctggcccacctgctgtctgtctgctcctcctagcccttggtcagatggcagccagagtcc       c.*1020

          .         .         .         .         .         .       g.60348
 ctcaggacctgcagcctcgccccggcagaagtcttttgtccaggaggcaaaaagccagag       c.*1080

          .         .         .         .         .         .       g.60408
 attctgcaacacgaattcgaagcaaacaaacacaacacaacagaattcctggaaagaaga       c.*1140

          .         .         .         .         .         .       g.60468
 cgactgctaagacacggcaggggggcctggagggagcctccgactctgagctgctccggg       c.*1200

          .         .         .         .         .         .       g.60528
 atctgccgcgttctcctctgcacattgctgtttctgcccctgatgctggagctcaaggag       c.*1260

          .         .         .         .         .         .       g.60588
 actccttcctctttctcagcagagctgtagctgactgtggcattactacgcctccccaca       c.*1320

          .         .         .         .         .         .       g.60648
 cgcccagacccctcactccaaaatcctactggctgtagcagagaatacctttgaaccaag       c.*1380

          .         .         .         .         .         .       g.60708
 attctgttttaatcatcatttacattgttttcttccaaaggccccctcgtataccctccc       c.*1440

          .         .         .         .         .         .       g.60768
 taacccacaaacctgttaacattgtcttaaggtgaaatggctggaaaatcagtatttaac       c.*1500

          .         .                                               g.60793
 taataaatttatctgtattcctctt                                          c.*1525

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The GATA binding protein 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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