glial cells missing homolog 2 (Drosophila) (GCM2) - coding DNA reference sequence

(used for variant description)

(last modified October 12, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_004752.3 in the GCM2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008970.1, covering GCM2 transcript NM_004752.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5012
                                                 cacctggcgcac       c.-61

 .         .         .         .         .         .                g.5072
 ctgtccttttttcttctatttttcagaaccctgggcggaaagcgcgagcgagttgggcag       c.-1

          .         .         .         .         .         .       g.5132
 ATGCCGGCGGCCGCGGTGCAGGAAGCGGTCGGCGTGTGCTCCTACGGGATGCAGCTCAGC       c.60
 M  P  A  A  A  V  Q  E  A  V  G  V  C  S  Y  G  M  Q  L  S         p.20

          .         .         . | 02       .         .         .    g.9503
 TGGGACATCAACGATCCGCAGATGCCTCAG | GAGCTGGCCCTCTTTGACCAATTCCGAGAG    c.120
 W  D  I  N  D  P  Q  M  P  Q   | E  L  A  L  F  D  Q  F  R  E      p.40

          .         .         .         .         .         .       g.9563
 TGGCCTGACGGCTATGTGCGCTTCATCTACAGCAGCGATGAGAAGAAGGCACAGCGTCAC       c.180
 W  P  D  G  Y  V  R  F  I  Y  S  S  D  E  K  K  A  Q  R  H         p.60

          .         .         .         .         .         .       g.9623
 CTGAGCGGCTGGGCCATGCGCAACACCAACAACCACAATGGCCACATCCTCAAGAAGTCG       c.240
 L  S  G  W  A  M  R  N  T  N  N  H  N  G  H  I  L  K  K  S         p.80

          .         .         .         .         .         .       g.9683
 TGCCTGGGTGTGGTGGTGTGTACACAGGCCTGCACCCTGCCCGACGGTTCCCGCCTGCAG       c.300
 C  L  G  V  V  V  C  T  Q  A  C  T  L  P  D  G  S  R  L  Q         p.100

          .         .         .         .    | 03    .         .    g.10325
 CTGAGGCCGGCCATCTGCGACAAGGCACGGCTGAAACAGCAGA | AGAAGGCATGCCCTAAC    c.360
 L  R  P  A  I  C  D  K  A  R  L  K  Q  Q  K |   K  A  C  P  N      p.120

          .         .         .         .         .         .       g.10385
 TGTCATTCTGCTTTGGAGTTGATTCCTTGTCGAGGGCACAGCGGATACCCCGTAACCAAC       c.420
 C  H  S  A  L  E  L  I  P  C  R  G  H  S  G  Y  P  V  T  N         p.140

          .         .         .       | 04 .         .         .    g.10873
 TTTTGGCGGCTTGATGGCAACGCGATCTTTTTTCAG | GCCAAGGGAGTTCATGATCATCCA    c.480
 F  W  R  L  D  G  N  A  I  F  F  Q   | A  K  G  V  H  D  H  P      p.160

          .         .         .         .         .         .       g.10933
 AGACCAGAGAGCAAATCAGAGACAGAAGCTAGAAGAAGCGCCATCAAGAGACAAATGGCC       c.540
 R  P  E  S  K  S  E  T  E  A  R  R  S  A  I  K  R  Q  M  A         p.180

          .         .         .         .   | 05     .         .    g.11950
 TCTTTCTACCAACCCCAGAAAAAGAGAATTCGAGAATCCGAG | GCAGAAGAAAATCAAGAC    c.600
 S  F  Y  Q  P  Q  K  K  R  I  R  E  S  E   | A  E  E  N  Q  D      p.200

          .         .         .         .         .         .       g.12010
 AGCAGTGGTCATTTCAGCAACATACCTCCCTTGGAAAATCCAGAAGACTTTGATATAGTT       c.660
 S  S  G  H  F  S  N  I  P  P  L  E  N  P  E  D  F  D  I  V         p.220

          .         .         .         .         .         .       g.12070
 ACTGAAACCAGCTTCCCTATTCCAGGGCAGCCTTGCCCTTCCTTCCCAAAGTCTGATGTT       c.720
 T  E  T  S  F  P  I  P  G  Q  P  C  P  S  F  P  K  S  D  V         p.240

          .         .         .         .         .         .       g.12130
 TACAAAGCTACCTGTGACCTAGCCACCTTTCAAGGAGACAAAATGCCACCCTTCCAGAAA       c.780
 Y  K  A  T  C  D  L  A  T  F  Q  G  D  K  M  P  P  F  Q  K         p.260

          .         .         .         .         .         .       g.12190
 TACTCAAGCCCAAGAATCTATTTGCCTAGGCCACCTTGCAGCTATGAATTGGCAAACCCT       c.840
 Y  S  S  P  R  I  Y  L  P  R  P  P  C  S  Y  E  L  A  N  P         p.280

          .         .         .         .         .         .       g.12250
 GGTTATACAAATTCAAGCCCATATCCCACCCTTTATAAGGATTCCACCAGTATCCCTAAT       c.900
 G  Y  T  N  S  S  P  Y  P  T  L  Y  K  D  S  T  S  I  P  N         p.300

          .         .         .         .         .         .       g.12310
 GACACAGACTGGGTTCATCTGAACACACTACAATGTAATGTCAATTCATACAGCAGCTAT       c.960
 D  T  D  W  V  H  L  N  T  L  Q  C  N  V  N  S  Y  S  S  Y         p.320

          .         .         .         .         .         .       g.12370
 GAGAGAAGCTTTGATTTCACCAACAAACAGCATGGCTGGAAACCAGCTCTTGGAAAACCC       c.1020
 E  R  S  F  D  F  T  N  K  Q  H  G  W  K  P  A  L  G  K  P         p.340

          .         .         .         .         .         .       g.12430
 AGCCTTGTGGAAAGGACTAACCATGGGCAGTTTCAGGCCATGGCCACTCGCCCTTATTAT       c.1080
 S  L  V  E  R  T  N  H  G  Q  F  Q  A  M  A  T  R  P  Y  Y         p.360

          .         .         .         .         .         .       g.12490
 AACCCAGAGCTTCCCTGCAGGTACCTCACGACTCCACCACCAGGTGCCCCTGCCCTACAA       c.1140
 N  P  E  L  P  C  R  Y  L  T  T  P  P  P  G  A  P  A  L  Q         p.380

          .         .         .         .         .         .       g.12550
 ACCGTGATCACCACCACCACTAAAGTGTCCTACCAGGCCTACCAGCCCCCTGCTATGAAA       c.1200
 T  V  I  T  T  T  T  K  V  S  Y  Q  A  Y  Q  P  P  A  M  K         p.400

          .         .         .         .         .         .       g.12610
 TACAGTGACAGTGTGCGAGAGGTGAAGAGCCTTTCGAGCTGTAACTATGCTCCTGAAGAT       c.1260
 Y  S  D  S  V  R  E  V  K  S  L  S  S  C  N  Y  A  P  E  D         p.420

          .         .         .         .         .         .       g.12670
 ACTGGGATGTCTGTCTATCCAGAACCCTGGGGTCCTCCGGTGACAGTCACCAGGGCAGCC       c.1320
 T  G  M  S  V  Y  P  E  P  W  G  P  P  V  T  V  T  R  A  A         p.440

          .         .         .         .         .         .       g.12730
 TCTCCTTCAGGGCCACCTCCTATGAAAATTGCAGGAGATTGCCGGGCCATCAGACCCACT       c.1380
 S  P  S  G  P  P  P  M  K  I  A  G  D  C  R  A  I  R  P  T         p.460

          .         .         .         .         .         .       g.12790
 GTGGCTATTCCCCACGAGCCAGTTTCCTCTAGGACAGATGAAGCAGAGACTTGGGATGTG       c.1440
 V  A  I  P  H  E  P  V  S  S  R  T  D  E  A  E  T  W  D  V         p.480

          .         .         .         .         .         .       g.12850
 TGTCTGTCTGGGCTGGGCTCCGCAGTCAGTTACTCAGACAGAGTGGGTCCCTTCTTTACC       c.1500
 C  L  S  G  L  G  S  A  V  S  Y  S  D  R  V  G  P  F  F  T         p.500

          .         .                                               g.12871
 TACAACAATGAGGATTTTTGA                                              c.1521
 Y  N  N  E  D  F  X                                                p.506

          .         .         .         .         .         .       g.12931
 aagacaatccaggggacataatagcagtgtgcatgcaggcaggaggcagggaaatgtgaa       c.*60

          .         .         .         .         .         .       g.12991
 atggcaatgatctcttattgagttgggagattcaccttgtgtgcaaagaaacacagatag       c.*120

          .         .         .         .         .         .       g.13051
 tagtaaaaattctgagtaactgagaaaataatcagttggaaatgattagataatatggga       c.*180

          .         .         .         .         .         .       g.13111
 aatttcacacagcattttgaaactggctacaatacatagaagtagtgaggaaagtgtgag       c.*240

          .         .         .         .         .         .       g.13171
 tctctcaaatgaacaaataagcaaactgtaggaggttaaatactgacctaagttcactta       c.*300

          .         .         .         .         .         .       g.13231
 gcttattagcaggagtagaagtcaaggattctggttcttattctaggacttttcccatta       c.*360

          .         .         .         .         .         .       g.13291
 gagcaccttagggaatttcacatccctagaggctgccaaaatagcttcaggaagaaattt       c.*420

          .         .         .         .         .         .       g.13351
 ttacaatcttatcacctgagtcatttcatgaaatttttgtttagcatttagaacctgtta       c.*480

          .         .         .         .         .         .       g.13411
 aactagcttcaggaagtaattttgattgttttatctccaacgtgtgtatctacagctttt       c.*540

          .         .         .         .         .         .       g.13471
 caaaaaatctctagcaatggtaaagttcagttgtttttaaaagattcaatattagctttt       c.*600

          .         .         .         .         .         .       g.13531
 cataacatgatagtttcctaaccttttcataaccttttcataacatgatagtttccataa       c.*660

          .         .         .         .         .         .       g.13591
 cagagacagcctaacaatgatgagttgtatttaatggattaccattgtactaaatacatt       c.*720

          .         .         .         .         .                 g.13643
 ttttttctgattaggtttcagaattataattaaaatgttttgctgaaataca               c.*772

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glial cells missing homolog 2 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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