growth differentiation factor 6 (GDF6) - coding DNA reference sequence

(used for variant description)

(last modified January 28, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001001557.2 in the GDF6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008981.1, covering GDF6 transcript NM_001001557.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     cccgaggagccgggccccggccgctgtccagccgctccgt       c.-61

 .         .         .         .         .         .                g.5100
 gccccgcgcgtcctgcgccgccgccaccgcctcctggggagacgcagccacttgcccgcc       c.-1

          .         .         .         .         .         .       g.5160
 ATGGATACTCCCAGGGTCCTGCTCTCGGCCGTCTTCCTCATCAGTTTTCTGTGGGATTTG       c.60
 M  D  T  P  R  V  L  L  S  A  V  F  L  I  S  F  L  W  D  L         p.20

          .         .         .         .         .         .       g.5220
 CCCGGTTTCCAGCAGGCTTCCATCTCATCCTCCTCGTCGTCCGCCGAGCTGGGTTCCACC       c.120
 P  G  F  Q  Q  A  S  I  S  S  S  S  S  S  A  E  L  G  S  T         p.40

          .         .         .         .         .         .       g.5280
 AAGGGCATGCGAAGCCGCAAGGAAGGCAAGATGCAGCGGGCGCCGCGCGACAGTGACGCG       c.180
 K  G  M  R  S  R  K  E  G  K  M  Q  R  A  P  R  D  S  D  A         p.60

          .         .         .         .         .         .       g.5340
 GGCCGGGAGGGCCAGGAACCACAGCCGCGGCCTCAGGACGAACCCCGGGCTCAGCAGCCC       c.240
 G  R  E  G  Q  E  P  Q  P  R  P  Q  D  E  P  R  A  Q  Q  P         p.80

          .         .         .         .         .         .       g.5400
 CGGGCGCAGGAGCCGCCAGGCAGGGGTCCGCGCGTGGTGCCCCACGAGTACATGCTGTCA       c.300
 R  A  Q  E  P  P  G  R  G  P  R  V  V  P  H  E  Y  M  L  S         p.100

          .         .         .         .         .         .       g.5460
 ATCTACAGGACTTACTCCATCGCTGAGAAGCTGGGCATCAATGCCAGCTTTTTCCAGTCT       c.360
 I  Y  R  T  Y  S  I  A  E  K  L  G  I  N  A  S  F  F  Q  S         p.120

          .         .         .         .       | 02 .         .    g.20282
 TCCAAGTCGGCTAATACGATCACCAGCTTTGTAGACAGGGGACTAG | ACGATCTCTCGCAC    c.420
 S  K  S  A  N  T  I  T  S  F  V  D  R  G  L  D |   D  L  S  H      p.140

          .         .         .         .         .         .       g.20342
 ACTCCTCTCCGGAGACAGAAGTATTTGTTTGATGTGTCCATGCTCTCAGACAAAGAAGAG       c.480
 T  P  L  R  R  Q  K  Y  L  F  D  V  S  M  L  S  D  K  E  E         p.160

          .         .         .         .         .         .       g.20402
 CTGGTGGGCGCGGAGCTGCGGCTCTTTCGCCAGGCGCCCTCAGCGCCCTGGGGGCCACCA       c.540
 L  V  G  A  E  L  R  L  F  R  Q  A  P  S  A  P  W  G  P  P         p.180

          .         .         .         .         .         .       g.20462
 GCCGGGCCGCTCCACGTGCAGCTCTTCCCTTGCCTTTCGCCCCTACTGCTGGACGCGCGG       c.600
 A  G  P  L  H  V  Q  L  F  P  C  L  S  P  L  L  L  D  A  R         p.200

          .         .         .         .         .         .       g.20522
 ACCCTGGACCCGCAGGGGGCGCCGCCGGCCGGCTGGGAAGTCTTCGACGTGTGGCAGGGC       c.660
 T  L  D  P  Q  G  A  P  P  A  G  W  E  V  F  D  V  W  Q  G         p.220

          .         .         .         .         .         .       g.20582
 CTGCGCCACCAGCCCTGGAAGCAGCTGTGCTTGGAGCTGCGGGCCGCATGGGGCGAGCTG       c.720
 L  R  H  Q  P  W  K  Q  L  C  L  E  L  R  A  A  W  G  E  L         p.240

          .         .         .         .         .         .       g.20642
 GACGCCGGGGAGGCCGAGGCGCGCGCGCGGGGACCCCAGCAACCGCCGCCCCCGGACCTG       c.780
 D  A  G  E  A  E  A  R  A  R  G  P  Q  Q  P  P  P  P  D  L         p.260

          .         .         .         .         .         .       g.20702
 CGGAGTCTGGGCTTCGGCCGGAGGGTGCGGCCTCCCCAGGAGCGGGCCCTGCTGGTGGTA       c.840
 R  S  L  G  F  G  R  R  V  R  P  P  Q  E  R  A  L  L  V  V         p.280

          .         .         .         .         .         .       g.20762
 TTCACCAGATCCCAGCGCAAGAACCTGTTCGCAGAGATGCGCGAGCAGCTGGGCTCGGCC       c.900
 F  T  R  S  Q  R  K  N  L  F  A  E  M  R  E  Q  L  G  S  A         p.300

          .         .         .         .         .         .       g.20822
 GAGGCTGCGGGCCCGGGCGCGGGCGCCGAGGGGTCGTGGCCGCCGCCGTCGGGCGCCCCG       c.960
 E  A  A  G  P  G  A  G  A  E  G  S  W  P  P  P  S  G  A  P         p.320

          .         .         .         .         .         .       g.20882
 GATGCCAGGCCTTGGCTGCCCTCGCCCGGCCGCCGGCGGCGGCGCACGGCCTTCGCCAGT       c.1020
 D  A  R  P  W  L  P  S  P  G  R  R  R  R  R  T  A  F  A  S         p.340

          .         .         .         .         .         .       g.20942
 CGCCATGGCAAGCGGCACGGCAAGAAGTCCAGGCTACGCTGCAGCAAGAAGCCCCTGCAC       c.1080
 R  H  G  K  R  H  G  K  K  S  R  L  R  C  S  K  K  P  L  H         p.360

          .         .         .         .         .         .       g.21002
 GTGAACTTCAAGGAGCTGGGCTGGGACGACTGGATTATCGCGCCCCTGGAGTACGAGGCC       c.1140
 V  N  F  K  E  L  G  W  D  D  W  I  I  A  P  L  E  Y  E  A         p.380

          .         .         .         .         .         .       g.21062
 TATCACTGCGAGGGTGTATGCGACTTCCCGCTGCGCTCGCACCTGGAGCCCACCAACCAC       c.1200
 Y  H  C  E  G  V  C  D  F  P  L  R  S  H  L  E  P  T  N  H         p.400

          .         .         .         .         .         .       g.21122
 GCCATCATCCAGACGCTGATGAACTCCATGGACCCCGGCTCCACCCCGCCCAGCTGCTGC       c.1260
 A  I  I  Q  T  L  M  N  S  M  D  P  G  S  T  P  P  S  C  C         p.420

          .         .         .         .         .         .       g.21182
 GTGCCCACCAAATTGACTCCCATCAGCATTCTATACATCGACGCGGGCAATAATGTGGTC       c.1320
 V  P  T  K  L  T  P  I  S  I  L  Y  I  D  A  G  N  N  V  V         p.440

          .         .         .         .                           g.21230
 TACAAGCAGTACGAGGACATGGTGGTGGAGTCGTGCGGCTGCAGGTAG                   c.1368
 Y  K  Q  Y  E  D  M  V  V  E  S  C  G  C  R  X                     p.455

          .         .         .         .         .         .       g.21290
 cggtgcctttcccgccgccttggcccggaaccaaggtgggccaaggtccgccttgcaggg       c.*60

          .         .         .         .         .         .       g.21350
 gaggcctggctgcagagaggcggaggaggaagctggcgctgggggaggctgagggtgagg       c.*120

          .         .         .         .         .         .       g.21410
 gaacagcctggatgtgagagccggtgggagagaagggagcgcagccttcccagtaacttc       c.*180

          .         .         .         .         .         .       g.21470
 tacctgccagcccagagggaaatatggattttcacaccttgcctggccaccctggaaaaa       c.*240

          .         .         .         .         .         .       g.21530
 caagccaaggaggatttcttttgttctgttttctctctctctctctctctctctctctct       c.*300

          .         .         .         .         .         .       g.21590
 ctctctctctctctctctattactgtggctttggatttccttatgtgtcttacaggcttt       c.*360

          .         .         .         .         .         .       g.21650
 gatagaaggggaggggaggagagatgcatacccgtttctcaactgctccatggattgaaa       c.*420

          .         .         .         .         .         .       g.21710
 aaataacagtttaaaaagggaaacaatgtgggaggaagaatcaccgttgacgcatcttga       c.*480

          .         .         .         .         .         .       g.21770
 tttggttggtttttacatgtgtaaagaaggtggggtctctggccatgtcatagcccatgt       c.*540

          .         .         .         .         .         .       g.21830
 cttgtgccctcccacacagaaagtgttagatagggaaattggcaaaaagaatagttaagt       c.*600

          .         .         .         .         .         .       g.21890
 caggaatggtcctgcctatagaagagctttgagagaggtgggcccacgggtgcccctctc       c.*660

          .         .         .         .         .         .       g.21950
 acccatttgtgtactctgtgagtttaccagctctgccctggcctctttcggtaccaggaa       c.*720

          .         .         .         .         .         .       g.22010
 ctggcaaccttcatctcactcctgagggcccaggtctctgccttcattgttgctttttct       c.*780

          .         .         .         .         .         .       g.22070
 ggtgggggcaaggggagctggtatggatggaatgacaagaattagtccaaatggaacccc       c.*840

          .         .         .         .         .         .       g.22130
 ttgaaggataatgagaaaccacaaggcctgcctctgactggggctgacacggaggtgcat       c.*900

          .         .         .         .         .         .       g.22190
 tagcccaggctggaggtagcccacccaaatgccctttctgattctaattgatttctttca       c.*960

          .         .         .         .         .         .       g.22250
 acagaatttgccaaaattcagacatgcacttctaaggggaaggtgattttccagttcaaa       c.*1020

          .         .         .         .         .         .       g.22310
 aaaatgggcaggagtggggaacaaaacaattaacgtaagagctacaaaggagggaaaagg       c.*1080

          .         .         .         .         .         .       g.22370
 aaccaagaagtagaaggagtcccatcaggagggaagatggtgggcctcagggaggatggg       c.*1140

          .         .         .         .         .         .       g.22430
 gatcaagggacaggccaggagccaggagtggggaagggagggatgaaaggggacacaagt       c.*1200

          .         .         .         .         .         .       g.22490
 ccctgtctctgaagtttctttaaaatctgagttccctcccctctctttgacattcctgaa       c.*1260

          .         .         .         .         .         .       g.22550
 agattaccagccagcaatagcccagggctcccccaaaagaattggttcagattgtaatta       c.*1320

          .         .         .         .         .         .       g.22610
 tcagttaggcaatgtttttaaaacttagtaatgagaaactgtgaaaagagccaagtgtta       c.*1380

          .         .         .         .         .         .       g.22670
 cattgagcttggggtgggagatggggaacaggcagtgaggaaggagacaggggtggaatt       c.*1440

          .         .         .         .         .         .       g.22730
 cgtcttctgggaggaagctggagagagcacagtgaaattgaaatacccattcccagatag       c.*1500

          .         .         .         .         .         .       g.22790
 tcaaaaacatgaactttcccccagcctgcaccagtattgttttcaaacattgcccatgag       c.*1560

          .         .         .         .         .         .       g.22850
 taggccctttgaagagttagcttcctcctcatctttgactataaaattgtttaatcaatg       c.*1620

          .         .         .         .         .         .       g.22910
 gaatttgtaccagccttttaaaaagttttagtttttcctaagtgattttgctctcttcca       c.*1680

          .         .         .         .         .         .       g.22970
 atctaaacctgttgcttgtttggttcagagaactacaaactgtcaaagaaagggtgggga       c.*1740

          .         .         .         .         .         .       g.23030
 tgataagaaatgctaatataaaaatgctaagtgaaaaaaagacttggccaggagaaataa       c.*1800

          .         .         .         .         .         .       g.23090
 tttaaaatgcacatttgctttggatgcactgttgttctgttaaggctgtatatatttgtt       c.*1860

          .         .         .         .         .         .       g.23150
 tatttaaggtgactgaaagtgcaaagaggaaatggacagcatgcaattcatcctaatgta       c.*1920

          .         .         .         .         .         .       g.23210
 caaaacgttatatgcactcaaatgttataatttctaatatttttaaagtttatattcgag       c.*1980

          .         .         .         .         .         .       g.23270
 ttgtacaaagttaagcattaatcagatatttcattttttcataatgttaccattttctta       c.*2040

          .         .         .         .         .         .       g.23330
 aatattattacaaaattttaagtctgtctaatggagagttttttttaaactgtctacctc       c.*2100

          .         .         .         .         .         .       g.23390
 atataatacaagtatttacaacgctaaagttaccagaggtcaatgaataatcaaaacatt       c.*2160

          .         .         .         .         .         .       g.23450
 ttttacagtacacctttcctggatgatatgcaatcgaatgctatattattaaacgcattt       c.*2220

          .                                                         g.23463
 ttctccttaataa                                                      c.*2233

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Growth differentiation factor 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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