glial fibrillary acidic protein (GFAP) - coding DNA reference sequence

(used for variant description)

(last modified November 20, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_002055.4 in the GFAP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering GFAP transcript NM_002055.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       atcgcc       c.-61

 .         .         .         .         .         .                g.5066
 agtctagcccactccttcataaagccctcgcatcccaggagcgagcagagccagagcagg       c.-1

          .         .         .         .         .         .       g.5126
 ATGGAGAGGAGACGCATCACCTCCGCTGCTCGCCGCTCCTACGTCTCCTCAGGGGAGATG       c.60
 M  E  R  R  R  I  T  S  A  A  R  R  S  Y  V  S  S  G  E  M         p.20

          .         .         .         .         .         .       g.5186
 ATGGTGGGGGGCCTGGCTCCTGGCCGCCGTCTGGGTCCTGGCACCCGCCTCTCCCTGGCT       c.120
 M  V  G  G  L  A  P  G  R  R  L  G  P  G  T  R  L  S  L  A         p.40

          .         .         .         .         .         .       g.5246
 CGAATGCCCCCTCCACTCCCGACCCGGGTGGATTTCTCCCTGGCTGGGGCACTCAATGCT       c.180
 R  M  P  P  P  L  P  T  R  V  D  F  S  L  A  G  A  L  N  A         p.60

          .         .         .         .         .         .       g.5306
 GGCTTCAAGGAGACCCGGGCCAGTGAGCGGGCAGAGATGATGGAGCTCAATGACCGCTTT       c.240
 G  F  K  E  T  R  A  S  E  R  A  E  M  M  E  L  N  D  R  F         p.80

          .         .         .         .         .         .       g.5366
 GCCAGCTACATCGAGAAGGTTCGCTTCCTGGAACAGCAAAACAAGGCGCTGGCTGCTGAG       c.300
 A  S  Y  I  E  K  V  R  F  L  E  Q  Q  N  K  A  L  A  A  E         p.100

          .         .         .         .         .         .       g.5426
 CTGAACCAGCTGCGGGCCAAGGAGCCCACCAAGCTGGCAGACGTCTACCAGGCTGAGCTG       c.360
 L  N  Q  L  R  A  K  E  P  T  K  L  A  D  V  Y  Q  A  E  L         p.120

          .         .         .         .         .         .       g.5486
 CGAGAGCTGCGGCTGCGGCTCGATCAACTCACCGCCAACAGCGCCCGGCTGGAGGTTGAG       c.420
 R  E  L  R  L  R  L  D  Q  L  T  A  N  S  A  R  L  E  V  E         p.140

          .         .         .         .  | 02      .         .    g.6483
 AGGGACAATCTGGCACAGGACCTGGCCACTGTGAGGCAGAA | GCTCCAGGATGAAACCAAC    c.480
 R  D  N  L  A  Q  D  L  A  T  V  R  Q  K  |  L  Q  D  E  T  N      p.160

          .         .         .         .   | 03     .         .    g.6747
 CTGAGGCTGGAAGCCGAGAACAACCTGGCTGCCTATAGACAG | GAAGCAGATGAAGCCACC    c.540
 L  R  L  E  A  E  N  N  L  A  A  Y  R  Q   | E  A  D  E  A  T      p.180

          .         .         .         .         .         .       g.6807
 CTGGCCCGTCTGGATCTGGAGAGGAAGATTGAGTCGCTGGAGGAGGAGATCCGGTTCTTG       c.600
 L  A  R  L  D  L  E  R  K  I  E  S  L  E  E  E  I  R  F  L         p.200

          .         | 04         .         .         .         .    g.7164
 AGGAAGATCCACGAGGAG | GAGGTTCGGGAACTCCAGGAGCAGCTGGCCCGACAGCAGGTC    c.660
 R  K  I  H  E  E   | E  V  R  E  L  Q  E  Q  L  A  R  Q  Q  V      p.220

          .         .         .         .         .         .       g.7224
 CATGTGGAGCTTGACGTGGCCAAGCCAGACCTCACCGCAGCCCTGAAAGAGATCCGCACG       c.720
 H  V  E  L  D  V  A  K  P  D  L  T  A  A  L  K  E  I  R  T         p.240

          .         .         .         .         .         .       g.7284
 CAGTATGAGGCAATGGCGTCCAGCAACATGCATGAAGCCGAAGAGTGGTACCGCTCCAAG       c.780
 Q  Y  E  A  M  A  S  S  N  M  H  E  A  E  E  W  Y  R  S  K         p.260

  | 05       .         .         .         .         .         .    g.8815
  | TTTGCAGACCTGACAGACGCTGCTGCCCGCAACGCGGAGCTGCTCCGCCAGGCCAAGCAC    c.840
  | F  A  D  L  T  D  A  A  A  R  N  A  E  L  L  R  Q  A  K  H      p.280

          .         .         .         .         .         .       g.8875
 GAAGCCAACGACTACCGGCGCCAGTTGCAGTCCTTGACCTGCGACCTGGAGTCTCTGCGC       c.900
 E  A  N  D  Y  R  R  Q  L  Q  S  L  T  C  D  L  E  S  L  R         p.300

        | 06 .         .         .         .         .         .    g.9150
 GGCACG | AACGAGTCCCTGGAGAGGCAGATGCGCGAGCAGGAGGAGCGGCACGTGCGGGAG    c.960
 G  T   | N  E  S  L  E  R  Q  M  R  E  Q  E  E  R  H  V  R  E      p.320

          .         .         .         .         .         .       g.9210
 GCGGCCAGTTATCAGGAGGCGCTGGCGCGGCTGGAGGAAGAGGGGCAGAGCCTCAAGGAC       c.1020
 A  A  S  Y  Q  E  A  L  A  R  L  E  E  E  G  Q  S  L  K  D         p.340

          .         .         .         .         .         .       g.9270
 GAGATGGCCCGCCACTTGCAGGAGTACCAGGACCTGCTCAATGTCAAGCTGGCCCTGGAC       c.1080
 E  M  A  R  H  L  Q  E  Y  Q  D  L  L  N  V  K  L  A  L  D         p.360

          .         .         .         .        | 07.         .    g.9907
 ATCGAGATCGCCACCTACAGGAAGCTGCTAGAGGGCGAGGAGAACCG | GATCACCATTCCC    c.1140
 I  E  I  A  T  Y  R  K  L  L  E  G  E  E  N  R  |  I  T  I  P      p.380

          .         .         .  | 08      .         .         .    g.12432
 GTGCAGACCTTCTCCAACCTGCAGATTCGAG | AAACCAGCCTGGACACCAAGTCTGTGTCA    c.1200
 V  Q  T  F  S  N  L  Q  I  R  E |   T  S  L  D  T  K  S  V  S      p.400

          .         .         .         .         .        | 09.    g.13167
 GAAGGCCACCTCAAGAGGAACATCGTGGTGAAGACCGTGGAGATGCGGGATGGAGAG | GTC    c.1260
 E  G  H  L  K  R  N  I  V  V  K  T  V  E  M  R  D  G  E   | V      p.420

          .         .         .                                     g.13206
 ATTAAGGAGTCCAAGCAGGAGCACAAGGATGTGATGTGA                            c.1299
 I  K  E  S  K  Q  E  H  K  D  V  M  X                              p.432

          .         .         .         .         .         .       g.13266
 ggcaggacccacctggtggcctctgccccgtctcatgaggggcccgagcagaagcaggat       c.*60

          .         .         .         .         .         .       g.13326
 agttgctccgcctctgctggcacatttccccagacctgagctccccaccaccccagctgc       c.*120

          .         .         .         .         .         .       g.13386
 tcccctccctcctctgtccctaggtcagcttgctgccctaggctccgtcagtatcaggcc       c.*180

          .         .         .         .         .         .       g.13446
 tgccagacggcacccacccagcacccagcaactccaactaacaagaaactcacccccaag       c.*240

          .         .         .         .         .         .       g.13506
 gggcagtctggaggggcatggccagcagcttgcgttagaatgaggaggaaggagagaagg       c.*300

          .         .         .         .         .         .       g.13566
 ggaggagggcggggggcacctactacatcgccctccacatccctgattcctgttgttatg       c.*360

          .         .         .         .         .         .       g.13626
 gaaactgttgccagagatggaggttctctcggagtatctgggaactgtgcctttgagttt       c.*420

          .         .         .         .         .         .       g.13686
 cctcaggctgctggaggaaaactgagactcagacaggaaagggaaggccccacagacaag       c.*480

          .         .         .         .         .         .       g.13746
 gtagccctggccagaggcttgttttgtcttttggtttttatgaggtgggatatccctatg       c.*540

          .         .         .         .         .         .       g.13806
 ctgcctaggctgaccttgaactcctgggctcaagcagtctacccacctcagcctcctgtg       c.*600

          .         .         .         .         .         .       g.13866
 tagctgggattatagattggagccaccatgcccagctcagagggttgttctcctagactg       c.*660

          .         .         .         .         .         .       g.13926
 accctgatcagtctaagatgggtggggacgtcctgccacctggggcagtcacctgcccag       c.*720

          .         .         .         .         .         .       g.13986
 atcccagaaggacctcctgagcgatgactcaagtgtctcagtccacctgagctgccatcc       c.*780

          .         .         .         .         .         .       g.14046
 agggatgccatctgtgggcacgctgtgggcaggtgggagcttgattctcagcacttgggg       c.*840

          .         .         .         .         .         .       g.14106
 gatctgttgtgtacgtggagagggatgaggtgctgggagggatagaggggggctgcctgg       c.*900

          .         .         .         .         .         .       g.14166
 cccccagctgtgggtacagagaggtcaagcccaggaggactgccccgtgcagactggagg       c.*960

          .         .         .         .         .         .       g.14226
 ggacgctggtagagatggaggaggaggcaattgggatggcgctaggcatacaagtagggg       c.*1020

          .         .         .         .         .         .       g.14286
 ttgtgggtgaccagttgcacttggcctctggattgtgggaattaaggaagtgactcatcc       c.*1080

          .         .         .         .         .         .       g.14346
 tcttgaagatgctgaaacaggagagaaaggggatgtatccatgggggcagggcatgactt       c.*1140

          .         .         .         .         .         .       g.14406
 tgtcccatttctaaaggcctcttccttgctgtgtcataccaggccgccccagcctctgag       c.*1200

          .         .         .         .         .         .       g.14466
 cccctgggactgctgcttcttaaccccagtaagccactgccacacgtctgaccctctcca       c.*1260

          .         .         .         .         .         .       g.14526
 ccccatagtgaccggctgcttttccctaagccaagggcctcttgcggtcccttcttactc       c.*1320

          .         .         .         .         .         .       g.14586
 acacacaaaatgtacccagtattctaggtagtgccctattttacaattgtaaaactgagg       c.*1380

          .         .         .         .         .         .       g.14646
 cacgagcaaagtgaagacactggctcatattcctgcagcctggaggccgggtgctcaggg       c.*1440

          .         .         .         .         .         .       g.14706
 ctgacacgtccaccccagtgcacccactctgctttgactgagcagactggtgagcagact       c.*1500

          .         .         .         .         .         .       g.14766
 ggtgggatctgtgcccagagatgggactgggagggcccacttcagggttctcctctcccc       c.*1560

          .         .         .         .         .         .       g.14826
 tctaaggccgaagaagggtccttccctctccccaagacttggtgtcctttccctccactc       c.*1620

          .         .         .         .         .         .       g.14886
 cttcctgccacctgctgctgctgctgctgctaatcttcagggcactgctgctgcctttag       c.*1680

          .         .         .         .                           g.14927
 tcgctgaggaaaaataaagacaaatgctgcgcccttcccca                          c.*1721

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glial fibrillary acidic protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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