G elongation factor, mitochondrial 1 (GFM1) - coding DNA reference sequence

(used for variant description)

(last modified May 9, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_024996.5 in the GFM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008441.1, covering GFM1 transcript NM_024996.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              ctcttacaacattggctgccggcgtgactttgaccgcttcccggtgc       c.-61

 .         .         .         .         .         .                g.5107
 gttaccggcagctgaacccacccggcgccacgggactttgacgcgtgctctgcgcttgcc       c.-1

          .         .         .         .         .         .       g.5167
 ATGAGACTCCTGGGAGCTGCAGCCGTCGCGGCTCTGGGGCGCGGAAGGGCCCCCGCCTCC       c.60
 M  R  L  L  G  A  A  A  V  A  A  L  G  R  G  R  A  P  A  S         p.20

          .         .  | 02      .         .         .         .    g.6140
 CTAGGCTGGCAGAGGAAGCAG | GTTAATTGGAAGGCCTGCCGATGGTCTTCATCAGGGGTG    c.120
 L  G  W  Q  R  K  Q   | V  N  W  K  A  C  R  W  S  S  S  G  V      p.40

          .         .         .         .         .         .       g.6200
 ATTCCTAATGAAAAAATACGAAATATTGGAATCTCAGCTCACATTGATTCTGGGAAAACT       c.180
 I  P  N  E  K  I  R  N  I  G  I  S  A  H  I  D  S  G  K  T         p.60

          .         .         .         .         .     | 03   .    g.6643
 ACATTAACAGAACGAGTCCTTTACTACACTGGCAGAATTGCAAAGATGCATGAG | GTGAAA    c.240
 T  L  T  E  R  V  L  Y  Y  T  G  R  I  A  K  M  H  E   | V  K      p.80

          .         .         .         .         .         .       g.6703
 GGTAAAGATGGAGTTGGTGCTGTCATGGATTCCATGGAACTAGAGAGACAAAGAGGAATC       c.300
 G  K  D  G  V  G  A  V  M  D  S  M  E  L  E  R  Q  R  G  I         p.100

          .         .         .         .         .         .       g.6763
 ACTATTCAGTCAGCAGCCACTTACACCATGTGGAAAGATGTCAATATTAACATTATAGAT       c.360
 T  I  Q  S  A  A  T  Y  T  M  W  K  D  V  N  I  N  I  I  D         p.120

         | 04.         .         .         .         .         .    g.7268
 ACTCCTG | GGCATGTGGACTTCACAATAGAAGTGGAAAGGGCCCTGAGAGTGTTGGATGGT    c.420
 T  P  G |   H  V  D  F  T  I  E  V  E  R  A  L  R  V  L  D  G      p.140

          .         .         .         .         .         .       g.7328
 GCAGTCCTTGTTCTCTGTGCTGTTGGAGGGGTACAGTGCCAGACCATGACTGTCAATCGT       c.480
 A  V  L  V  L  C  A  V  G  G  V  Q  C  Q  T  M  T  V  N  R         p.160

          .         .         .         .         .         .       g.7388
 CAGATGAAGCGCTACAACGTTCCGTTTCTAACTTTTATTAACAAATTGGACCGAATGGGC       c.540
 Q  M  K  R  Y  N  V  P  F  L  T  F  I  N  K  L  D  R  M  G         p.180

          .         .         .   | 05     .         .         .    g.9541
 TCCAACCCAGCCAGGGCCCTGCAGCAAATGAG | GTCTAAACTAAATCATAATGCAGCGTTT    c.600
 S  N  P  A  R  A  L  Q  Q  M  R  |  S  K  L  N  H  N  A  A  F      p.200

          .         .         .         .         .         .       g.9601
 ATGCAGATACCCATGGGTTTGGAGGGTAATTTTAAAGGTATTGTAGATCTTATTGAGGAA       c.660
 M  Q  I  P  M  G  L  E  G  N  F  K  G  I  V  D  L  I  E  E         p.220

          .         .          | 06        .         .         .    g.12599
 CGAGCCATCTATTTTGATGGAGACTTTGG | TCAGATTGTTCGATATGGTGAGATTCCAGCT    c.720
 R  A  I  Y  F  D  G  D  F  G  |  Q  I  V  R  Y  G  E  I  P  A      p.240

          .         .         .         .         .         .       g.12659
 GAATTAAGGGCGGCGGCCACTGACCACCGGCAGGAGCTAATTGAATGTGTTGCCAATTCA       c.780
 E  L  R  A  A  A  T  D  H  R  Q  E  L  I  E  C  V  A  N  S         p.260

          .         .         .         .         .         .       g.12719
 GATGAACAGCTTGGTGAGATGTTTCTGGAAGAAAAAATCCCCTCGATTTCTGATTTAAAG       c.840
 D  E  Q  L  G  E  M  F  L  E  E  K  I  P  S  I  S  D  L  K         p.280

  | 07       .         .         .         .         .         .    g.13842
  | CTAGCAATTCGAAGAGCTACTCTGAAAAGATCATTTACTCCTGTATTTTTGGGAAGCGCC    c.900
  | L  A  I  R  R  A  T  L  K  R  S  F  T  P  V  F  L  G  S  A      p.300

          .         .         .         .         .         .       g.13902
 TTGAAGAACAAAGGAGTTCAGCCTCTTTTAGATGCTGTTTTAGAATACCTCCCAAATCCA       c.960
 L  K  N  K  G  V  Q  P  L  L  D  A  V  L  E  Y  L  P  N  P         p.320

          .         .         .         | 08         .         .    g.15041
 TCTGAAGTCCAGAACTATGCTATTCTCAATAAAGAGGA | TGACTCAAAAGAGAAAACCAAA    c.1020
 S  E  V  Q  N  Y  A  I  L  N  K  E  D  |  D  S  K  E  K  T  K      p.340

          .         .         .         .         .         .       g.15101
 ATCCTAATGAACTCCAGTAGAGACAATTCCCACCCATTTGTAGGCCTGGCTTTTAAACTG       c.1080
 I  L  M  N  S  S  R  D  N  S  H  P  F  V  G  L  A  F  K  L         p.360

     | 09    .         .         .         .         .         .    g.19451
 GAG | GTAGGTCGATTTGGACAATTAACTTATGTTCGCAGTTATCAGGGAGAGCTAAAGAAG    c.1140
 E   | V  G  R  F  G  Q  L  T  Y  V  R  S  Y  Q  G  E  L  K  K      p.380

          .         .         .         .         .         .       g.19511
 GGTGACACCATCTATAACACAAGGACAAGAAAGAAAGTACGGTTGCAACGGCTGGCTCGC       c.1200
 G  D  T  I  Y  N  T  R  T  R  K  K  V  R  L  Q  R  L  A  R         p.400

          .         .  | 10      .         .         .         .    g.21385
 ATGCATGCCGACATGATGGAG | GATGTTGAGGAAGTATATGCCGGAGACATCTGTGCATTG    c.1260
 M  H  A  D  M  M  E   | D  V  E  E  V  Y  A  G  D  I  C  A  L      p.420

          .         .         .         .         .         .       g.21445
 TTTGGCATTGACTGTGCTAGTGGAGACACATTCACAGACAAAGCCAACAGCGGCCTTTCT       c.1320
 F  G  I  D  C  A  S  G  D  T  F  T  D  K  A  N  S  G  L  S         p.440

     | 11    .         .         .         .         .         .    g.23157
 ATG | GAGTCAATTCATGTTCCTGATCCTGTCATTTCAATAGCAATGAAGCCTTCTAACAAG    c.1380
 M   | E  S  I  H  V  P  D  P  V  I  S  I  A  M  K  P  S  N  K      p.460

  | 12       .         .         .         .         .         .    g.25869
  | AACGATCTGGAAAAATTTTCAAAAGGTATTGGCAGGTTTACAAGAGAAGATCCCACATTT    c.1440
  | N  D  L  E  K  F  S  K  G  I  G  R  F  T  R  E  D  P  T  F      p.480

          .         .         .         .         .         .       g.25929
 AAAGTATACTTTGACACTGAGAACAAAGAGACAGTTATATCTGGAATGGGAGAATTACAC       c.1500
 K  V  Y  F  D  T  E  N  K  E  T  V  I  S  G  M  G  E  L  H         p.500

          .         | 13         .         .         .         .    g.26818
 CTGGAAATCTATGCTCAG | AGGCTGGAAAGAGAGTATGGCTGTCCTTGTATCACAGGAAAG    c.1560
 L  E  I  Y  A  Q   | R  L  E  R  E  Y  G  C  P  C  I  T  G  K      p.520

          .         .         .         .  | 14      .         .    g.42486
 CCAAAAGTTGCCTTTCGAGAGACCATTACTGCCCCTGTCCC | GTTTGACTTTACACATAAA    c.1620
 P  K  V  A  F  R  E  T  I  T  A  P  V  P  |  F  D  F  T  H  K      p.540

          .         .         .         .         .         .       g.42546
 AAACAATCAGGTGGTGCAGGCCAGTATGGAAAAGTAATAGGTGTCCTGGAGCCTCTGGAC       c.1680
 K  Q  S  G  G  A  G  Q  Y  G  K  V  I  G  V  L  E  P  L  D         p.560

          .         .         .         .         .         .       g.42606
 CCAGAGGACTACACTAAATTGGAATTTTCAGATGAAACATTCGGATCAAATATTCCAAAG       c.1740
 P  E  D  Y  T  K  L  E  F  S  D  E  T  F  G  S  N  I  P  K         p.580

          .         .     | 15   .         .         .         .    g.45032
 CAGTTTGTGCCTGCTGTAGAAAAG | GGGTTTTTAGATGCCTGCGAGAAGGGCCCTCTTTCT    c.1800
 Q  F  V  P  A  V  E  K   | G  F  L  D  A  C  E  K  G  P  L  S      p.600

          .         .         .         .         .         .       g.45092
 GGTCACAAGCTCTCTGGGCTCCGGTTTGTCCTGCAAGATGGAGCACACCACATGGTTGAT       c.1860
 G  H  K  L  S  G  L  R  F  V  L  Q  D  G  A  H  H  M  V  D         p.620

          .         .         .         .          | 16        .    g.50646
 TCTAATGAAATCTCTTTCATCCGAGCAGGAGAAGGTGCTCTTAAACAAG | CCTTGGCAAAT    c.1920
 S  N  E  I  S  F  I  R  A  G  E  G  A  L  K  Q  A |   L  A  N      p.640

          .         .         .         .         .         .       g.50706
 GCAACATTATGTATTCTTGAACCTATTATGGCTGTGGAAGTTGTAGCTCCAAATGAATTT       c.1980
 A  T  L  C  I  L  E  P  I  M  A  V  E  V  V  A  P  N  E  F         p.660

          .         .         .         .         .         .       g.50766
 CAGGGACAAGTAATTGCAGGAATTAACCGACGCCATGGGGTAATCACTGGGCAAGATGGA       c.2040
 Q  G  Q  V  I  A  G  I  N  R  R  H  G  V  I  T  G  Q  D  G         p.680

          .         .         . | 17       .         .         .    g.51641
 GTTGAGGACTATTTTACACTGTATGCAGAT | GTCCCTCTAAATGATATGTTTGGTTATTCC    c.2100
 V  E  D  Y  F  T  L  Y  A  D   | V  P  L  N  D  M  F  G  Y  S      p.700

          .         .     | 18   .         .         .         .    g.51844
 ACTGAACTTAGGTCATGCACAGAG | GGAAAGGGAGAATACACAATGGAGTATAGCAGGTAT    c.2160
 T  E  L  R  S  C  T  E   | G  K  G  E  Y  T  M  E  Y  S  R  Y      p.720

          .         .         .         .         .         .       g.51904
 CAGCCATGTTTACCATCCACACAAGAAGACGTCATTAATAAGTATTTGGAAGCTACAGGT       c.2220
 Q  P  C  L  P  S  T  Q  E  D  V  I  N  K  Y  L  E  A  T  G         p.740

          .         .         .                                     g.51940
 CAACTTCCTGTTAAAAAAGGAAAAGCCAAGAACTAA                               c.2256
 Q  L  P  V  K  K  G  K  A  K  N  X                                 p.751

          .         .         .         .         .         .       g.52000
 ctttgcttactgtgagttgactgactctaattgaatctgcgtggttttgatactttgatg       c.*60

          .         .         .         .         .         .       g.52060
 gattccagtggaataaattcaggctgctgaaacaagaaattctgagcccaggaagcgggc       c.*120

          .         .         .         .         .         .       g.52120
 tcttctttcttcaaaagaagcccttcttgttcatattcaggagcttctgttatattcaaa       c.*180

          .         .         .         .         .         .       g.52180
 ggtaattctatgtctatctcaactctattgattggttttatagttcattgaaaatcctca       c.*240

          .         .         .         .         .         .       g.52240
 aataaaatataattattactgaaatatgtttaatatttaaggggaaaagagactaatttc       c.*300

          .         .         .         .         .         .       g.52300
 agttatacttttaagcttagaatgtatgttcatttccaaattttgtatcataagagtttt       c.*360

          .         .         .         .         .         .       g.52360
 caacatagagaaaagctgaaaaaatgcaaagaataaccacatactttccatctaccttcc       c.*420

          .         .         .         .         .         .       g.52420
 tttgttaacgggttgtttatcatataataatttgttttgtcatatttgctttcactgtct       c.*480

          .         .         .         .         .         .       g.52480
 attatctgtttaagtctcataactctatttttagtttgctgaagacttgaaagtgaatcg       c.*540

          .         .         .         .         .         .       g.52540
 catatatcatgacacttcttggagtgtcattaatgggcaggcttttctgttgaagagtgg       c.*600

          .         .         .         .         .         .       g.52600
 attccgtatgttcttcatagagagtgtttttcagattcttcattgggatattaaaatatt       c.*660

          .         .         .         .         .         .       g.52660
 agccaaatttctctctgttttatatatgtctgtttatttcagtttgtggtttctgcaaat       c.*720

          .         .         .         .         .         .       g.52720
 ttgtaactgcctctgttttaggagtataagtattacttccttgtggtctattgtgaagta       c.*780

          .         .         .         .         .         .       g.52780
 aaaagtagacccttgcatatactattcttgtttgtgttcatcttaatgtttttgtacagc       c.*840

          .         .         .         .         .         .       g.52840
 taaatcaaatgtaatttatagagttagtttcatcaacctaatgaatgctagttaaatttg       c.*900

          .         .         .         .         .         .       g.52900
 aattccttggaatttatcgtatattgtattcactgagattatgaagggacaaatgttaat       c.*960

          .         .         .         .         .         .       g.52960
 cttttgtttccagaaaaagttgggctttcccaagcagttctattacccggttcagaattg       c.*1020

          .         .         .         .         .         .       g.53020
 cttcatccaaaaatcatctgatggtatagatggatcctagtccttttcattacctgatgg       c.*1080

          .         .                                               g.53045
 tagaaataaaataattgattttaaa                                          c.*1105

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The G elongation factor, mitochondrial 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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