gametogenetin (GGN) - coding DNA reference sequence

(used for variant description)

(last modified April 8, 2022)

This file was created to facilitate the description of sequence variants on transcript NM_152657.3 in the GGN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering GGN transcript NM_152657.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5015
                                              agaaggcctgggggc       c.-121

 .         .         .         .         | 02         .             g.5227
 gaggaacaagacctcggagtatttcaaggggagacctag | ttccctgccctgccccgggcc    c.-61

 .         .         .         .         . | 03       .             g.5767
 cagggcgccgcggtctgaactctgctcggctggaggactcg | tctccgagctccgtcagaa    c.-1

          .         .         .         .         .         .       g.5827
 ATGGGGAACTTGCAGTCGGAGCCATCCGCGGGCGGGGGCTCCCGAAAAGTGCAGCCCTCG       c.60
 M  G  N  L  Q  S  E  P  S  A  G  G  G  S  R  K  V  Q  P  S         p.20

          .         .         .         .         .         .       g.5887
 GACCGCGCCCCCGACTCCCGCCGGACGTCCCTGGTGGAGCCCGAGATGACCTCCCAGGCC       c.120
 D  R  A  P  D  S  R  R  T  S  L  V  E  P  E  M  T  S  Q  A         p.40

          .         .         .         .         .         .       g.5947
 ATGCGCCTGACTCGTGGGCTGGGTGTCTGGTTCCCTGGCAGCGCCACACCCCCGGGACTC       c.180
 M  R  L  T  R  G  L  G  V  W  F  P  G  S  A  T  P  P  G  L         p.60

          .         .         .         .         .         .       g.6007
 ATGGTACCCCGGGAGCCCCAGGCCTCACCCTCGACCCTGCCCCTCACCTTAGAACGGCCC       c.240
 M  V  P  R  E  P  Q  A  S  P  S  T  L  P  L  T  L  E  R  P         p.80

          .         .         .         .         .         .       g.6067
 TCTCCAGTGATGCCCCCTCCTGAAGAGGCGGCCGCGGTCTCTGCACCACCCCCGGCCCCC       c.300
 S  P  V  M  P  P  P  E  E  A  A  A  V  S  A  P  P  P  A  P         p.100

          .         .         .         .         .         .       g.6127
 GCGGGGACTCTGCTGCCCGGCCCGTCTAAATGGCAAAAGCCCGCGGGCACTCCAGTTCCC       c.360
 A  G  T  L  L  P  G  P  S  K  W  Q  K  P  A  G  T  P  V  P         p.120

          .         .         .         .         .         .       g.6187
 CGGATCCGCCGCCTGCTGGAGGCGAGCCATCGCGGCCAGGGCGACCCTCCGAGCCTCCGC       c.420
 R  I  R  R  L  L  E  A  S  H  R  G  Q  G  D  P  P  S  L  R         p.140

          .         .         .         .         .         .       g.6247
 CCGCTGAAGCCGCCGCCGCCGCCCCGGCAACTATCCGTGAAGGACACTGTCCCGAGGGCC       c.480
 P  L  K  P  P  P  P  P  R  Q  L  S  V  K  D  T  V  P  R  A         p.160

          .         .         .         .         .         .       g.6307
 CCATCCCAATTTCCGCCGCCCCTGGAGACTTGGAAGCCGCCACCACCATTACCTTCTGAA       c.540
 P  S  Q  F  P  P  P  L  E  T  W  K  P  P  P  P  L  P  S  E         p.180

          .         .         .         .         .         .       g.6367
 CGGCAGCCGGCGGACCGCAGAATCACTCCTGCTCTGGCCACACCCGCCTCACCCCCGACA       c.600
 R  Q  P  A  D  R  R  I  T  P  A  L  A  T  P  A  S  P  P  T         p.200

          .         .         .         .         .         .       g.6427
 GAAAGCCAGGCTGGGCCCCGCAACCAGGGCCAGACGGCCGGCAGGGCTCGCGGAGGGGCG       c.660
 E  S  Q  A  G  P  R  N  Q  G  Q  T  A  G  R  A  R  G  G  A         p.220

          .         .         .         .         .         .       g.6487
 CCTCCCCATGCGGGCGAAGGCGAAATGGCCCAGCCTGCGGATTCCGAGTCCGGTCTGAGC       c.720
 P  P  H  A  G  E  G  E  M  A  Q  P  A  D  S  E  S  G  L  S         p.240

          .         .         .         .         .         .       g.6547
 CTGCTGTGTAAAATCACCTTCAAGTCGAGGCCCTCTTTGGCCCCTCCGGCAGCCTCGAGT       c.780
 L  L  C  K  I  T  F  K  S  R  P  S  L  A  P  P  A  A  S  S         p.260

          .         .         .         .         .         .       g.6607
 TCCTTAGCAGCCAAAGCTTCGCTGGGGGGCGGCGGAGGCGGCGGCCTCTTTGCTGCCTCA       c.840
 S  L  A  A  K  A  S  L  G  G  G  G  G  G  G  L  F  A  A  S         p.280

          .         .         .         .         .         .       g.6667
 GGTGCCATCTCTTACGCCGAGGTCCTGAAGCAAGGGCCCCTGCCTCCTGGAGCCGCTCGC       c.900
 G  A  I  S  Y  A  E  V  L  K  Q  G  P  L  P  P  G  A  A  R         p.300

          .         .         .         .         .         .       g.6727
 CCCTTGGGAGAGGTTTCTCGAGGGGCACAGGAAGCCGAGGGAGGTGATGGAGACGGCGAA       c.960
 P  L  G  E  V  S  R  G  A  Q  E  A  E  G  G  D  G  D  G  E         p.320

          .         .         .         .         .         .       g.6787
 GGGTGCTCTGGTCCTCCCTCGGCGCCTGCGTCCCAAGCCCGGGCCCTACCGCCGCCACCC       c.1020
 G  C  S  G  P  P  S  A  P  A  S  Q  A  R  A  L  P  P  P  P         p.340

          .         .         .         .         .         .       g.6847
 TACACCACCTTCCCAGGCTCGAAGCCCAAATTCGACTGGGTTAGCGCTCCCGACGGCCCT       c.1080
 Y  T  T  F  P  G  S  K  P  K  F  D  W  V  S  A  P  D  G  P         p.360

          .         .         .         .         .         .       g.6907
 GAACGCCACTTCCGCTTCAACGGGGCTGGCGGAGGCATCGGGGCGCCGCGACGGCGTGCG       c.1140
 E  R  H  F  R  F  N  G  A  G  G  G  I  G  A  P  R  R  R  A         p.380

          .         .         .         .         .         .       g.6967
 GCCGCACTCTCTGGGCCTTGGGGCTCCCCTCCGCCACCACCAGAGCAGATACACTCAGCT       c.1200
 A  A  L  S  G  P  W  G  S  P  P  P  P  P  E  Q  I  H  S  A         p.400

          .         .         .         .         .         .       g.7027
 CCCGGGCCCCGGAGGCCCGCACCTGCCCTGCTGGCGCCGCCTACGTTCATCTTCCCAGCA       c.1260
 P  G  P  R  R  P  A  P  A  L  L  A  P  P  T  F  I  F  P  A         p.420

          .         .         .         .         .         .       g.7087
 CCCACCAATGGCGAGCCCATGCGCCCGGGGCCTCCAGGCCTGCAGGAGTTACCACCGCTG       c.1320
 P  T  N  G  E  P  M  R  P  G  P  P  G  L  Q  E  L  P  P  L         p.440

          .         .         .         .         .         .       g.7147
 CCACCGCCCACACCGCCGCCCACACTGCAGCCACCAGCGCTCCAGCCAACGCCGCTGCCG       c.1380
 P  P  P  T  P  P  P  T  L  Q  P  P  A  L  Q  P  T  P  L  P         p.460

          .         .         .         .         .         .       g.7207
 GTGGCTCCCCCGCTCACCCCGGGTCTGGGCCACAAGGAGTCAGCCCTGGCTCCCACCGCA       c.1440
 V  A  P  P  L  T  P  G  L  G  H  K  E  S  A  L  A  P  T  A         p.480

          .         .         .         .         .         .       g.7267
 GCCCCTGCTCTGCCCCCAGCCTTAGCCGCCGACCAGGCCCCGGCCCCATCCCCGGCTCCA       c.1500
 A  P  A  L  P  P  A  L  A  A  D  Q  A  P  A  P  S  P  A  P         p.500

          .         .         .         .         .         .       g.7327
 GCTCCCACCGTGGCTGAGCCCTCGCCGCCTGTGTCCGCGCCCGCACCCGCGGCTGCGCCC       c.1560
 A  P  T  V  A  E  P  S  P  P  V  S  A  P  A  P  A  A  A  P         p.520

          .         .         .         .         .         .       g.7387
 ATCAAGACCCGCACGCGCAGGAACAAGGGTTCCCGTGCAGCCCGGGGCGCGACCCGTAAG       c.1620
 I  K  T  R  T  R  R  N  K  G  S  R  A  A  R  G  A  T  R  K         p.540

          .         .         .         .         .         .       g.7447
 GATGGCTTGCATGGAGATGGTCCTCGCGAACGAGCTACAGCTACCGTGCCTGACAGCAGT       c.1680
 D  G  L  H  G  D  G  P  R  E  R  A  T  A  T  V  P  D  S  S         p.560

          .         .         .         .         .         .       g.7507
 GGTGGAGGGGGTGGTGGCAGCGGGGCCTCTCAGACTGGGGCAGCTAACACCCGCGCTGCG       c.1740
 G  G  G  G  G  G  S  G  A  S  Q  T  G  A  A  N  T  R  A  A         p.580

          .         .         .         .         .         .       g.7567
 CGCCACTGGCTGCCCTTCCAGGTGCTTAACTCCTGTCCCTGCAAGTGTTACTGCCACCAC       c.1800
 R  H  W  L  P  F  Q  V  L  N  S  C  P  C  K  C  Y  C  H  H         p.600

          .         .         .         .  | 04      .         .    g.8518
 CAGCCACGCCATCGCCGCCTGCCACGCAACGTCTCTGCCTG | GCTGAGCACATCCACCAAC    c.1860
 Q  P  R  H  R  R  L  P  R  N  V  S  A  W  |  L  S  T  S  T  N      p.620

          .         .         .         .         .         .       g.8578
 CACCTGGGCGAGCCACCCTGGGTTGCCACCATCAAGCTGTCCGGCTCTCTGGTGGCCAAG       c.1920
 H  L  G  E  P  P  W  V  A  T  I  K  L  S  G  S  L  V  A  K         p.640

          .         .         .                                     g.8617
 CTGGAGCACTACGACTTGCAGGCCACCCATTCCAACTGA                            c.1959
 L  E  H  Y  D  L  Q  A  T  H  S  N  X                              p.652

          .         .         .         .         .         .       g.8677
 gtgtagtcggctcaacaccctccaccttcccctccatgccaataaaataaccaatccaga       c.*60

 

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Gametogenetin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.